Neurogranin Regulates Metaplasticity.

abstract：:The bioactive lipid sphingosine-1-phosphate (S1P) is an important regulator in the nervous system. Here, we explored the role of S1P and its receptors in vitro and in preclinical models of peripheral nerve regeneration. Adult sensory neurons and motor neuron-like cells were exposed to S1P in an in vitro assay, and vir...

journal_title：Frontiers in molecular neuroscience

authors： Quarta S,Camprubí-Robles M,Schweigreiter R,Matusica D,Haberberger RV,Proia RL,Bandtlow CE,Ferrer-Montiel A,Kress M

更新日期：2017-10-10 00:00:00

abstract：:Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Her...

journal_title：Frontiers in molecular neuroscience

authors： Huang C,Lu F,Li P,Cao C,Liu Z

更新日期：2017-06-28 00:00:00

abstract：:Growth of postmitotic neurons occurs during different stages of development, including metamorphosis, and may also be part of neuronal plasticity and regeneration. Recently we showed that growth of post-mitotic neuroendocrine cells expressing the basic helix loop helix (bHLH) transcription factor Dimmed (Dimm) in Dros...

journal_title：Frontiers in molecular neuroscience

authors： Liu Y,Luo J,Nässel DR

更新日期：2016-10-13 00:00:00

abstract：:Maternal cigarette smoke exposure (SE) causes detrimental changes associated with the development of chronic neurological diseases in the offspring as a result of oxidative mitochondrial damage. Maternal L-Carnitine administration has been shown to reduce renal oxidative stress in SE offspring, but its effect in the b...

journal_title：Frontiers in molecular neuroscience

authors： Chan YL,Saad S,Al-Odat I,Oliver BG,Pollock C,Jones NM,Chen H

更新日期：2017-02-13 00:00:00

abstract：:The astrocyte-specific enzyme glutamine synthetase (GS), which catalyzes the amidation of glutamate to glutamine, plays an essential role in supporting neurotransmission and in limiting NH4+ toxicity. Accordingly, deficits in GS activity contribute to epilepsy and neurodegeneration. Despite its central role in brain p...

journal_title：Frontiers in molecular neuroscience

authors： Huyghe D,Denninger AR,Voss CM,Frank P,Gao N,Brandon N,Waagepetersen HS,Ferguson AD,Pangalos M,Doig P,Moss SJ

更新日期：2019-05-21 00:00:00

abstract：:Glycine receptors (GlyRs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. Mutations in GLRA2 are associated with autism spectrum disorder, but the unde...

journal_title：Frontiers in molecular neuroscience

authors： Comhair J,Devoght J,Morelli G,Harvey RJ,Briz V,Borrie SC,Bagni C,Rigo JM,Schiffmann SN,Gall D,Brône B,Molchanova SM

更新日期：2018-10-15 00:00:00

abstract：:Cytoplasmic FMR1-interacting protein 2 (CYFIP2) is a key component of the WAVE regulatory complex (WRC) which regulates actin polymerization and branching in diverse cellular compartments. Recent whole exome sequencing studies identified de novo hotspot variants in CYFIP2 from patients with early-onset epileptic encep...

journal_title：Frontiers in molecular neuroscience

authors： Zhang Y,Kang H,Lee Y,Kim Y,Lee B,Kim JY,Jin C,Kim S,Kim H,Han K

更新日期：2019-01-04 00:00:00

abstract：:Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS). GLT-1 dysregulation occurs in various neurological diseases including Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's disease ...

journal_title：Frontiers in molecular neuroscience

authors： Peterson AR,Binder DK

更新日期：2019-07-09 00:00:00

abstract：:The degeneration of dopaminergic neurons during Parkinson's disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in several biological proc...

journal_title：Frontiers in molecular neuroscience

authors： Aufschnaiter A,Habernig L,Kohler V,Diessl J,Carmona-Gutierrez D,Eisenberg T,Keller W,Büttner S

更新日期：2017-06-30 00:00:00

abstract：:Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. However, the mechanistic aspects and properties of cannabis remain remarkably poorly characterized. In this study we aimed to investigate the immune-cell modulatory pr...

journal_title：Frontiers in molecular neuroscience

authors： Utomo WK,de Vries M,Braat H,Bruno MJ,Parikh K,Comalada M,Peppelenbosch MP,van Goor H,Fuhler GM

更新日期：2017-01-24 00:00:00

abstract：:Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patients with TLE. However, whether KA activates KA receptors (KARs) as an a...

journal_title：Frontiers in molecular neuroscience

authors： Falcón-Moya R,Sihra TS,Rodríguez-Moreno A

更新日期：2018-06-22 00:00:00

abstract：:Recoverin (Rcv) is a low molecular-weight, neuronal calcium sensor (NCS) primarily located in photoreceptor outer segments of the vertebrate retina. Calcium ions (Ca2+)-bound Rcv has been proposed to inhibit G-protein-coupled receptor kinase (GRKs) in darkness. During the light response, the Ca2+-free Rcv releases GRK...

journal_title：Frontiers in molecular neuroscience

authors： Zang J,Neuhauss SCF

更新日期：2018-12-20 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and malignant primary tumor. Angiogenesis plays a critical role in the progression of GBM. Previous studies have indicated that long non-coding RNAs (lncRNAs) are abnormally expressed in various cancers and participate in the regulation of the malignant behaviors of tumors. Th...

journal_title：Frontiers in molecular neuroscience

authors： Yang C,Zheng J,Xue Y,Yu H,Liu X,Ma J,Liu L,Wang P,Li Z,Cai H,Liu Y

更新日期：2018-01-09 00:00:00

abstract：:Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis). One highly regulated cell-non-autonomous switch controls proteostatic capacity in Caenorhabditis elegans adulthood. Signals ...

journal_title：Frontiers in molecular neuroscience

authors： Shemesh N,Meshnik L,Shpigel N,Ben-Zvi A

更新日期：2017-08-09 00:00:00

abstract：:The tyrosine kinase Fyn plays an important role in synaptic plasticity, learning, and memory. Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum (DMS) of mice but not in the other substriatal regions, the dorsolate...

journal_title：Frontiers in molecular neuroscience

authors： Phamluong K,Darcq E,Wu S,Sakhai SA,Ron D

更新日期：2017-08-31 00:00:00

abstract：:Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating neuromuscular disease caused by mutations in the LAMA2 gene. These mutations result in the complete absence or truncated expression of the laminin-α2 chain. The α2-chain is a major component of the laminin-211 and laminin-221 isoforms, the p...

journal_title：Frontiers in molecular neuroscience

authors： Barraza-Flores P,Bates CR,Oliveira-Santos A,Burkin DJ

更新日期：2020-02-11 00:00:00

abstract：:Non-invasive molecular imaging techniques can enhance diagnosis to achieve successful treatment, as well as reveal underlying pathogenic mechanisms in disorders such as multiple sclerosis (MS). The cooperation of advanced multimodal imaging techniques and increased knowledge of the MS disease mechanism allows both mon...

journal_title：Frontiers in molecular neuroscience

authors： Poutiainen P,Jaronen M,Quintana FJ,Brownell AL

更新日期：2016-09-15 00:00:00

abstract：:Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) is a gatekeeper of mitochondrial quality control. The present study was aimed to examine whether PINK1 possesses a protective function against gentamicin (GM)-induced sensory hair cell (HC) damage in vitro. The formation of parkin particles (a mar...

journal_title：Frontiers in molecular neuroscience

authors： Yang Q,Zhou Y,Yin H,Li H,Zhou M,Sun G,Cao Z,Man R,Wang H,Li J

更新日期：2018-11-12 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a subtype of stroke with highest mortality and morbidity. We have previously demonstrated that dipotassium bisperoxo (picolinato) oxovanadate (V), (bpV[pic]) inhibits phosphatase and tensin homolog (PTEN) and activates extracellular signal-regulated kinase (ERK)1/2. In this study, we ...

journal_title：Frontiers in molecular neuroscience

authors： Zhao D,Qin XP,Chen SF,Liao XY,Cheng J,Liu R,Lei Y,Zhang ZF,Wan Q

更新日期：2019-12-05 00:00:00

abstract：:The anterior cingulate cortex (ACC) is an important brain area for the regulation of neuropathic pain. The α2A adrenoceptor is a good target for pain management. However, the role of cingulate α2A adrenoceptors in the regulation of neuropathic pain has been less studied. In this study, we investigated the involvement ...

journal_title：Frontiers in molecular neuroscience

authors： Wang YJ,Zuo ZX,Wu C,Liu L,Feng ZH,Li XY

更新日期：2017-09-12 00:00:00

abstract：:SYNGAP1, a Synaptic Ras-GTPase activating protein, regulates synapse maturation during a critical developmental window. Heterozygous mutation in SYNGAP1 (SYNGAP1-/+) has been shown to cause Intellectual Disability (ID) in children. Recent studies have provided evidence for altered neuronal protein synthesis in a mouse...

journal_title：Frontiers in molecular neuroscience

authors： Paul A,Nawalpuri B,Shah D,Sateesh S,Muddashetty RS,Clement JP

更新日期：2019-05-09 00:00:00

abstract：:Epilepsy, one of the most prevalent neurological conditions, presents as a complex disorder of network homeostasis characterized by spontaneous non-provoked seizures and associated comorbidities. Currently used antiepileptic drugs have been designed to suppress neuronal hyperexcitability and thereby to suppress epilep...

journal_title：Frontiers in molecular neuroscience

authors： Boison D

更新日期：2016-04-13 00:00:00

abstract：:The constitutively active protein glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, acts paradoxically as a tumor suppressor in some cancers while potentiates growth in others. Deciphering what governs its actions is vital for understanding many pathological conditions, including brain cancer. What are see...

journal_title：Frontiers in molecular neuroscience

authors： Mills CN,Nowsheen S,Bonner JA,Yang ES

更新日期：2011-11-25 00:00:00

abstract：:The role of ion channels in neurons and muscles has been well characterized. However, recent work has demonstrated both the presence and necessity of ion channels in diverse cell types for morphological development. For example, mutations that disrupt ion channels give rise to abnormal structural development in specie...

journal_title：Frontiers in molecular neuroscience

authors： Ozekin YH,Isner T,Bates EA

更新日期：2020-06-09 00:00:00

abstract：:It has been 200 years since Parkinson's disease (PD) was first described, yet many aspects of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative disorder caused by genetic and environmental factors including aging, nutrition, pesticides and exposure to heavy metals. DNA methylation ...

journal_title：Frontiers in molecular neuroscience

authors： Miranda-Morales E,Meier K,Sandoval-Carrillo A,Salas-Pacheco J,Vázquez-Cárdenas P,Arias-Carrión O

更新日期：2017-07-18 00:00:00

abstract：:Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels. The cryo-EM structure of the homopentameric α1 glycine receptor (GlyR) demonstrated an involvement of the ...

journal_title：Frontiers in molecular neuroscience

authors： Janzen D,Schaefer N,Delto C,Schindelin H,Villmann C

更新日期：2017-10-09 00:00:00

abstract：:GABAergic interneuron diversity is a key feature in the brain that helps to create different brain activity patterns and behavioral states. Cell type classification schemes-based on anatomical, physiological and molecular features-have provided us with a detailed understanding of the distinct types that constitute thi...

journal_title：Frontiers in molecular neuroscience

authors： Que L,Winterer J,Földy C

更新日期：2019-05-07 00:00:00

abstract：:Genetic studies have managed to explain many cases of familial amyotrophic lateral sclerosis (ALS) through mutations in several genes. However, the cause of a majority of sporadic cases remains unknown. Recently, epigenetics, especially miRNA studies, show some promising aspects. We aimed to evaluate the differential ...

journal_title：Frontiers in molecular neuroscience

authors： Vrabec K,Boštjančič E,Koritnik B,Leonardis L,Dolenc Grošelj L,Zidar J,Rogelj B,Glavač D,Ravnik-Glavač M

更新日期：2018-04-04 00:00:00

abstract：:It is widely accepted that glutamate is the most important excitatory neurotransmitter in the central nervous system (CNS). However, there is also a large amount of glutamate in the blood. Generally, the concentration gradient of glutamate between intraparenchymal and blood environments is stable. However, this gradie...

journal_title：Frontiers in molecular neuroscience

authors： Bai W,Zhou YG

更新日期：2017-12-05 00:00:00

abstract：:Cell signaling in response to an array of diverse stress stimuli converges on the phosphorylation of eukaryotic initiation factor-2α (eIF2α). Evidence is accumulating that persistent eIF2α phosphorylation at Ser51 through prolonged overactivation of regulatory kinases occurs in neurodegenerative diseases such as Alzhe...

journal_title：Frontiers in molecular neuroscience

authors： Ohno M

更新日期：2014-04-16 00:00:00