Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target.

abstract：:Unbiased "omics" techniques, such as next generation RNA-sequencing, can provide entirely novel insights into biological systems. However, cellular heterogeneity presents a significant barrier to analysis and interpretation of these datasets. The neurons of the dorsal root ganglia (DRG) are an important model for stud...

journal_title：Frontiers in molecular neuroscience

authors： Thakur M,Crow M,Richards N,Davey GI,Levine E,Kelleher JH,Agley CC,Denk F,Harridge SD,McMahon SB

更新日期：2014-11-11 00:00:00

abstract：:GABAergic interneuron diversity is a key feature in the brain that helps to create different brain activity patterns and behavioral states. Cell type classification schemes-based on anatomical, physiological and molecular features-have provided us with a detailed understanding of the distinct types that constitute thi...

journal_title：Frontiers in molecular neuroscience

authors： Que L,Winterer J,Földy C

更新日期：2019-05-07 00:00:00

abstract：:Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy. Unfortunately, current treatment strategies are limited and innovative new approaches are ...

journal_title：Frontiers in molecular neuroscience

authors： Fisher NM,Seto M,Lindsley CW,Niswender CM

更新日期：2018-10-23 00:00:00

abstract：:Immune checkpoints restrain the immune system following its activation and their inhibition unleashes anti-tumor immune responses. Immune checkpoint inhibitors revolutionized the treatment of several cancer types, including melanoma, and immune checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies is becoming ...

journal_title：Frontiers in molecular neuroscience

authors： Lorger M,Andreou T,Fife C,James F

更新日期：2019-11-21 00:00:00

abstract：:Collateral sprouting of surviving axons contributes to the synaptic reorganization after brain injury. To study this clinically relevant phenomenon, we used complex organotypic tissue cultures of mouse entorhinal cortex (EC) and hippocampus (H). Single EC-H cultures were generated to analyze associational sprouting, a...

journal_title：Frontiers in molecular neuroscience

authors： Del Turco D,Paul MH,Beeg Moreno VJ,Hildebrandt-Einfeldt L,Deller T

更新日期：2019-11-12 00:00:00

abstract：:Numerous animal studies have demonstrated that commonly used general anesthetics may result in cognitive impairment in the immature brain. The prevailing theory is that general anesthetics could induce developmental neurotoxicity via enhanced apoptosis. In addition, inhibited proliferation induced by anesthetics has a...

journal_title：Frontiers in molecular neuroscience

authors： Li X,Wu Z,Zhang Y,Xu Y,Han G,Zhao P

更新日期：2017-12-22 00:00:00

abstract：:Previous reports have shown that running wheel activity or voluntary exercise prevents hyperphagia and obesity in various animal models of obesity, but such effects seem only minimal in obese animals lacking leptin or leptin receptors. The mechanisms underlying this ineffectiveness remain unclear. Here, we identified ...

journal_title：Frontiers in molecular neuroscience

authors： Zhang N,Yang L,Guo L,Bi S

更新日期：2018-05-29 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a subtype of stroke with highest mortality and morbidity. We have previously demonstrated that dipotassium bisperoxo (picolinato) oxovanadate (V), (bpV[pic]) inhibits phosphatase and tensin homolog (PTEN) and activates extracellular signal-regulated kinase (ERK)1/2. In this study, we ...

journal_title：Frontiers in molecular neuroscience

authors： Zhao D,Qin XP,Chen SF,Liao XY,Cheng J,Liu R,Lei Y,Zhang ZF,Wan Q

更新日期：2019-12-05 00:00:00

abstract：:The degeneration of dopaminergic neurons during Parkinson's disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in several biological proc...

journal_title：Frontiers in molecular neuroscience

authors： Aufschnaiter A,Habernig L,Kohler V,Diessl J,Carmona-Gutierrez D,Eisenberg T,Keller W,Büttner S

更新日期：2017-06-30 00:00:00

abstract：:Epilepsy is a chronic brain dysfunction induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Recently, accumulating studies have revealed a close relationship between inflammation and epilepsy. Specifically, microglia and astrocytes are important inflammatory cells in the central ...

journal_title：Frontiers in molecular neuroscience

authors： Chen L,Zhu L,Lu D,Wu Z,Han Y,Xu P,Chang L,Wu Q

更新日期：2020-09-04 00:00:00

abstract：:The balance between excitatory and inhibitory neurotransmitter systems is crucial for the modulation of neuronal excitability in the central nervous system (CNS). The activation of transient receptor potential vanilloid 4 (TRPV4) is reported to enhance the response of hippocampal glutamate receptors, but whether the i...

journal_title：Frontiers in molecular neuroscience

authors： Hong Z,Tian Y,Qi M,Li Y,Du Y,Chen L,Liu W,Chen L

更新日期：2016-08-26 00:00:00

abstract：:The ubiquitous metabolic intermediary and nucleoside adenosine is a "master regulator" in all living systems. Under baseline conditions adenosine kinase (ADK) is the primary enzyme for the metabolic clearance of adenosine. By regulating the availability of adenosine, ADK is a critical upstream regulator of complex hom...

journal_title：Frontiers in molecular neuroscience

authors： Kiese K,Jablonski J,Boison D,Kobow K

更新日期：2016-10-20 00:00:00

abstract：:Mercury is a toxic metal that can be found in the environment in three different forms - elemental, organic and inorganic. Inorganic mercury has a lower liposolubility, which results in a lower organism absorption and reduced passage through the blood-brain barrier. For this reason, exposure models that use inorganic ...

journal_title：Frontiers in molecular neuroscience

authors： Teixeira FB,de Oliveira ACA,Leão LKR,Fagundes NCF,Fernandes RM,Fernandes LMP,da Silva MCF,Amado LL,Sagica FES,de Oliveira EHC,Crespo-Lopez ME,Maia CSF,Lima RR

更新日期：2018-05-15 00:00:00

abstract：:Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, differentiation, oxidative stress, inflammation and apoptosis. Endocannabinoids (eCBs) and lys...

journal_title：Frontiers in molecular neuroscience

authors： González de San Román E,Manuel I,Ledent C,Chun J,Rodríguez de Fonseca F,Estivill-Torrús G,Santín LJ,Rodríguez Puertas R

更新日期：2019-09-19 00:00:00

abstract：:Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or...

journal_title：Frontiers in molecular neuroscience

authors： Bartholome O,Van den Ackerveken P,Sánchez Gil J,de la Brassinne Bonardeaux O,Leprince P,Franzen R,Rogister B

更新日期：2017-05-22 00:00:00

abstract：:Hoxa5 is a member of the Hox gene family that plays critical roles in successive steps of the central nervous system formation during embryonic and fetal development. In the mouse, Hoxa5 was recently shown to be expressed in the medulla oblongata and the pons from fetal stages to adulthood. In these territories, Hoxa5...

journal_title：Frontiers in molecular neuroscience

authors： Lizen B,Moens C,Mouheiche J,Sacré T,Ahn MT,Jeannotte L,Salti A,Gofflot F

更新日期：2017-11-15 00:00:00

abstract：:Transient global cerebral ischemia (tGCI) causes excessive release of glutamate from neurons. Astrocytic glutamate transporter-1 (GLT-1) and glutamine synthetase (GS) together play a predominant role in maintaining glutamate at normal extracellular concentrations. Though our previous studies reported the alleviation o...

journal_title：Frontiers in molecular neuroscience

authors： Li K,Zhou H,Zhan L,Shi Z,Sun W,Liu D,Liu L,Liang D,Tan Y,Xu W,Xu E

更新日期：2018-10-01 00:00:00

abstract：:Neuronal gap junctions formed by connexin36 (Cx36) and chemical synapses share striking similarities in terms of plasticity. Ca2+/calmodulin-dependent protein kinase II (CaMKII), an enzyme known to induce memory formation at chemical synapses, has recently been described to potentiate electrical coupling in the retina...

journal_title：Frontiers in molecular neuroscience

authors： Tetenborg S,Yadav SC,Brüggen B,Zoidl GR,Hormuzdi SG,Monyer H,van Woerden GM,Janssen-Bienhold U,Dedek K

更新日期：2019-08-28 00:00:00

abstract：:A fundamental characteristic of neurons is the relationship between the architecture of the polarized neuron and synaptic transmission between neurons. Intracellular membrane trafficking is paramount to establish and maintain neuronal structure; perturbation in trafficking results in defects in neurodevelopment and ne...

journal_title：Frontiers in molecular neuroscience

authors： Wang J,Fourriere L,Gleeson PA

更新日期：2020-11-26 00:00:00

abstract：:Aquatic vertebrates possess diverse types of sensory cells in their skin to detect stimuli in the water. In the adult zebrafish, a common model organism, the presence of such cells in fins has only rarely been studied. Here, we identified scattered serotonin (5-HT)-positive cells in the epidermis of the caudal fin. Th...

journal_title：Frontiers in molecular neuroscience

authors： König D,Dagenais P,Senk A,Djonov V,Aegerter CM,Jaźwińska A

更新日期：2019-09-19 00:00:00

abstract：:Cleavage of the amyloid precursor protein (APP) by α-secretase generates an extracellularly released fragment termed secreted APP-alpha (APPsα). Not only is this process of interest due to the cleavage of APP within the amyloid-beta sequence, but APPsα itself has many physiological properties that suggest its great po...

journal_title：Frontiers in molecular neuroscience

authors： Mockett BG,Richter M,Abraham WC,Müller UC

更新日期：2017-02-07 00:00:00

abstract：:Lithium has long been used for the treatment of psychiatric disorders, due to its robust beneficial effect as a mood stabilizing drug. Lithium's effectiveness for improving neurological function is therefore well-described, stimulating the investigation of its potential use in several neurodegenerative conditions incl...

journal_title：Frontiers in molecular neuroscience

authors： Kerr F,Bjedov I,Sofola-Adesakin O

更新日期：2018-08-28 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) complex plays important roles in virtually all cells of the body. The enzymatic activity of PI3K to phosphorylate phosphoinositides in the membrane is mediated by a group of catalytic and regulatory subunits. Among those, the class I catalytic subunits, p110α, p110β, p110γ, and p11...

journal_title：Frontiers in molecular neuroscience

authors： Gross C,Bassell GJ

更新日期：2014-02-13 00:00:00

abstract：:Mitochondria are key organelles in regulating the metabolic state of a cell. In the brain, mitochondrial oxidative metabolism is the prevailing mechanism for neurons to generate ATP. While it is firmly established that neuronal function is highly dependent on mitochondrial metabolism, it is less well-understood how as...

journal_title：Frontiers in molecular neuroscience

authors： Fiebig C,Keiner S,Ebert B,Schäffner I,Jagasia R,Lie DC,Beckervordersandforth R

更新日期：2019-02-22 00:00:00

abstract：:Status epilepticus (SE, a prolonged seizure activity) leads to reactive astrogliosis and astroglial apoptosis in the regional specific manners, independent of hemodynamics. Poly(ADP-ribose) polymerase-1 (PARP1) activity is relevant to these distinct astroglial responses. Since various regulatory signaling molecules be...

journal_title：Frontiers in molecular neuroscience

authors： Kim JE,Kang TC

更新日期：2019-07-24 00:00:00

abstract：:Aging cognitive decline has been associated to impairment of the Hypothalamus Pituitary Adrenals (HPA) axis activity and a higher level of the systemic inflammation. However, little is known about the molecules driving this process at peripheral level. In addition, the cognitive function is to some extent modifiable w...

journal_title：Frontiers in molecular neuroscience

authors： Pesce M,Tatangelo R,La Fratta I,Rizzuto A,Campagna G,Turli C,Ferrone A,Franceschelli S,Speranza L,Verrocchio MC,De Lutiis MA,Felaco M,Grilli A

更新日期：2017-07-24 00:00:00

abstract：:The molecular mechanisms underlying plastic changes in the strength and connectivity of excitatory synapses have been studied extensively for the past few decades and remain the most attractive cellular models of learning and memory. One of the major mechanisms that regulate synaptic plasticity is the dynamic adjustme...

journal_title：Frontiers in molecular neuroscience

authors： Widagdo J,Guntupalli S,Jang SE,Anggono V

更新日期：2017-10-26 00:00:00

abstract：:Neuroimaging studies have demonstrated that irritable bowel syndrome (IBS)-a relapsing functional bowel disorder-presents with disrupted brain connections. However, little is known about the alterations of interhemispheric functional connectivity and underlying structural connectivity in IBS. This study combined resti...

journal_title：Frontiers in molecular neuroscience

authors： Qi R,Liu C,Weng Y,Xu Q,Chen L,Wang F,Zhang LJ,Lu GM

更新日期：2016-12-06 00:00:00

abstract：:Eukaryotic cells release different types of extracellular vesicles (EVs) including exosomes, ectosomes, and microvesicles. Exosomes are nanovesicles, 30-200 nm in diameter, that carry cell- and cell-state-specific cargo of proteins, lipids, and nucleic acids, including mRNA and miRNA. Recent studies have shown that ce...

journal_title：Frontiers in molecular neuroscience

authors： Hornung S,Dutta S,Bitan G

更新日期：2020-03-19 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as an important regulatory control in biological systems. Though the field of lncRNA has been progressing rapidly, a complete understanding of the role of lncRNAs in neuroblastoma pathogenesis is still lacking. To identify the abrogated lncRNAs in primary neuroblastoma and i...

journal_title：Frontiers in molecular neuroscience

authors： Prajapati B,Fatma M,Fatima M,Khan MT,Sinha S,Seth PK

更新日期：2019-12-12 00:00:00