Transient Receptor Potential Vanilloid 4 Inhibits γ-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons.

abstract：:Status epilepticus (SE, a prolonged seizure activity) leads to reactive astrogliosis and astroglial apoptosis in the regional specific manners, independent of hemodynamics. Poly(ADP-ribose) polymerase-1 (PARP1) activity is relevant to these distinct astroglial responses. Since various regulatory signaling molecules be...

journal_title：Frontiers in molecular neuroscience

authors： Kim JE,Kang TC

更新日期：2019-07-24 00:00:00

abstract：:In the brain, metabolic supply and demand is directly coupled to neuronal activation. Methods for culturing primary rodent brain cells have come of age and are geared toward sophisticated modeling of human brain physiology and pathology. However, the impact of the culture microenvironment on neuronal function is rarel...

journal_title：Frontiers in molecular neuroscience

authors： Sünwoldt J,Bosche B,Meisel A,Mergenthaler P

更新日期：2017-09-29 00:00:00

abstract：:Background: An imbalance between total training load and total recovery may cause overtraining (OT). The purpose of the present study was to verify the effects of OT on the expression of brain-derived neurotrophic factor (BDNF), its receptor tropomyosin receptor kinase B (TrkB) and p75 and the dynamic expression patte...

journal_title：Frontiers in molecular neuroscience

authors： Xu L,Zheng YL,Yin X,Xu SJ,Tian D,Zhang CY,Wang S,Ma JZ

更新日期：2020-01-30 00:00:00

abstract：:We earlier reported that the male mice lacking the Wdr13 gene (Wdr13-/0) showed mild anxiety, better memory retention, and up-regulation of synaptic proteins in the hippocampus. With increasing evidences from parallel studies in our laboratory about the possible role of Wdr13 in stress response, we investigated its ro...

journal_title：Frontiers in molecular neuroscience

authors： Mitra S,Sameer Kumar GS,Jyothi Lakshmi B,Thakur S,Kumar S

更新日期：2018-04-25 00:00:00

abstract：:Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis). One highly regulated cell-non-autonomous switch controls proteostatic capacity in Caenorhabditis elegans adulthood. Signals ...

journal_title：Frontiers in molecular neuroscience

authors： Shemesh N,Meshnik L,Shpigel N,Ben-Zvi A

更新日期：2017-08-09 00:00:00

abstract：:Eukaryotic cells release different types of extracellular vesicles (EVs) including exosomes, ectosomes, and microvesicles. Exosomes are nanovesicles, 30-200 nm in diameter, that carry cell- and cell-state-specific cargo of proteins, lipids, and nucleic acids, including mRNA and miRNA. Recent studies have shown that ce...

journal_title：Frontiers in molecular neuroscience

authors： Hornung S,Dutta S,Bitan G

更新日期：2020-03-19 00:00:00

abstract：:The dorsal root ganglion (DRG) contains heterogeneous populations of sensory neurons including primary nociceptive neurons and C-fibers implicated in pain signaling. Recent studies have demonstrated DRG hyperexcitability associated with downregulation of A-type K(+) channels; however, the molecular correlate of the co...

journal_title：Frontiers in molecular neuroscience

authors： Phuket TR,Covarrubias M

更新日期：2009-07-07 00:00:00

abstract：:Time-Place learning (TPL) refers to the ability of animals to remember important events that vary in both time and place. This ability is thought to be functional to optimize resource localization and predator avoidance in a circadian changing environment. Various studies have indicated that animals use their circadia...

journal_title：Frontiers in molecular neuroscience

authors： Mulder CK,Gerkema MP,Van der Zee EA

更新日期：2013-04-11 00:00:00

abstract：:Membrane fusion is one of the most fundamental physiological processes in eukaryotes for triggering the fusion of lipid and content, as well as the neurotransmission. However, the architecture features of neurotransmitter release machinery and interdependent mechanism of synaptic membrane fusion have not been extensiv...

journal_title：Frontiers in molecular neuroscience

authors： Yang Z,Gou L,Chen S,Li N,Zhang S,Zhang L

更新日期：2017-06-07 00:00:00

abstract：:Cryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of circadian rhythmicity. Moreover, CRYs are sensing magnetic fields in insects as well as in ...

journal_title：Frontiers in molecular neuroscience

authors： Schlichting M,Rieger D,Cusumano P,Grebler R,Costa R,Mazzotta GM,Helfrich-Förster C

更新日期：2018-07-18 00:00:00

abstract：:Control of proper protein synthesis, function, and turnover is essential for the health of all cells. In neurons these demands take on the additional importance of supporting and regulating the highly dynamic connections between neurons that are necessary for cognitive function, learning, and memory. Regulating multip...

journal_title：Frontiers in molecular neuroscience

authors： Atkin G,Paulson H

更新日期：2014-07-08 00:00:00

abstract：:Atypical Parkinson syndromes (APSs) often have symptoms that overlap with those of Parkinson's disease (PD), especially early in the disease, making these disorders difficult to diagnose. Previous studies have demonstrated an association of oligomeric α-synuclein (α-Syn), a key element in the pathogenesis of PD, with ...

journal_title：Frontiers in molecular neuroscience

authors： Singh AP,Ramana G,Bajaj T,Singh V,Dwivedi S,Behari M,Dey AB,Dey S

更新日期：2019-06-12 00:00:00

abstract：:Dysfunctions in hearing and balance are largely connected with hair cell (HC) loss. Although regeneration of HCs in the adult cochlea does not occur, there is still limited capacity for HC regeneration in the mammalian utricle from a distinct population of supporting cells (SCs). In response to HC damage, these Lgr5+ ...

journal_title：Frontiers in molecular neuroscience

authors： You D,Guo L,Li W,Sun S,Chen Y,Chai R,Li H

更新日期：2018-04-30 00:00:00

abstract：:SYNGAP1, a Synaptic Ras-GTPase activating protein, regulates synapse maturation during a critical developmental window. Heterozygous mutation in SYNGAP1 (SYNGAP1-/+) has been shown to cause Intellectual Disability (ID) in children. Recent studies have provided evidence for altered neuronal protein synthesis in a mouse...

journal_title：Frontiers in molecular neuroscience

authors： Paul A,Nawalpuri B,Shah D,Sateesh S,Muddashetty RS,Clement JP

更新日期：2019-05-09 00:00:00

abstract：:Previous reports have shown that running wheel activity or voluntary exercise prevents hyperphagia and obesity in various animal models of obesity, but such effects seem only minimal in obese animals lacking leptin or leptin receptors. The mechanisms underlying this ineffectiveness remain unclear. Here, we identified ...

journal_title：Frontiers in molecular neuroscience

authors： Zhang N,Yang L,Guo L,Bi S

更新日期：2018-05-29 00:00:00

abstract：:Parkinson's disease (PD) is a debilitating neurodegenerative disease characterized primarily by the selective death of dopaminergic (DA) neurons in the substantia nigra pars compacta of the midbrain. Although several genetic forms of PD have been identified, the precise molecular mechanisms underlying DA neuron loss i...

journal_title：Frontiers in molecular neuroscience

authors： Heman-Ackah SM,Hallegger M,Rao MS,Wood MJ

更新日期：2013-11-20 00:00:00

abstract：:[This corrects the article on p. 257 in vol. 10, PMID: 28855859.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Sun Y,Chen X,Zhang X,Shen X,Wang M,Wang X,Liu WC,Liu CF,Liu J,Liu W,Jin X

更新日期：2017-11-20 00:00:00

abstract：:It is widely accepted that glutamate is the most important excitatory neurotransmitter in the central nervous system (CNS). However, there is also a large amount of glutamate in the blood. Generally, the concentration gradient of glutamate between intraparenchymal and blood environments is stable. However, this gradie...

journal_title：Frontiers in molecular neuroscience

authors： Bai W,Zhou YG

更新日期：2017-12-05 00:00:00

abstract：:Rod and cone phosphodiesterase 6 (PDE6) are key effector enzymes of the vertebrate phototransduction pathway. Rod PDE6 consists of two catalytic subunits PDE6α and PDE6β and two identical inhibitory PDE6γ subunits, while cone PDE6 is composed of two identical PDE6α' catalytic subunits and two identical cone-specific P...

journal_title：Frontiers in molecular neuroscience

authors： Deng WT,Kolandaivelu S,Dinculescu A,Li J,Zhu P,Chiodo VA,Ramamurthy V,Hauswirth WW

更新日期：2018-07-09 00:00:00

abstract：:The ubiquitin proteasome system (UPS) is crucial for intracellular protein homeostasis and for degradation of aberrant and damaged proteins. The accumulation of ubiquitinated proteins is a hallmark of many neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer's, Parkinson's, and Huntington's d...

journal_title：Frontiers in molecular neuroscience

authors： Jansen AH,Reits EA,Hol EM

更新日期：2014-08-08 00:00:00

abstract：:Following axotomy, the activation of multiple intracellular signaling cascades causes the expression of a cocktail of regeneration-associated transcription factors which interact with each other to determine the fate of the injured neurons. The nerve injury response is channeled through manifold and parallel pathways,...

journal_title：Frontiers in molecular neuroscience

authors： Patodia S,Raivich G

更新日期：2012-02-10 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) complex plays important roles in virtually all cells of the body. The enzymatic activity of PI3K to phosphorylate phosphoinositides in the membrane is mediated by a group of catalytic and regulatory subunits. Among those, the class I catalytic subunits, p110α, p110β, p110γ, and p11...

journal_title：Frontiers in molecular neuroscience

authors： Gross C,Bassell GJ

更新日期：2014-02-13 00:00:00

abstract：:Spinal cord injury (SCI) can result in an irreversible disability due to loss of sensorimotor function below the lesion. Presently, clinical treatments for SCI mainly include surgery, drugs and postoperative rehabilitation. The prospective roles of bioscaffolds and exosomes in several neurological diseases have been r...

journal_title：Frontiers in molecular neuroscience

authors： Wang X,Botchway BOA,Zhang Y,Yuan J,Liu X

更新日期：2019-04-12 00:00:00

abstract：:Neuroblastoma, the major cause of infant cancer deaths, results from fast proliferation of undifferentiated neuroblasts. Treatment of high-risk neuroblastoma includes differentiation with retinoic acid (RA); however, the resistance of many of these tumors to RA-induced differentiation poses a considerable challenge. H...

journal_title：Frontiers in molecular neuroscience

authors： Kasim M,Heß V,Scholz H,Persson PB,Fähling M

更新日期：2016-12-21 00:00:00

abstract：:Following the discovery that the amyloid precursor protein (APP) is the source of β-amyloid peptides (Aβ) that accumulate in Alzheimer's disease (AD), structural analyses suggested that the holoprotein resembles a transmembrane receptor. Initial studies using reconstituted membranes demonstrated that APP can directly ...

journal_title：Frontiers in molecular neuroscience

authors： Copenhaver PF,Kögel D

更新日期：2017-01-31 00:00:00

abstract：:The molecular mechanisms underlying plastic changes in the strength and connectivity of excitatory synapses have been studied extensively for the past few decades and remain the most attractive cellular models of learning and memory. One of the major mechanisms that regulate synaptic plasticity is the dynamic adjustme...

journal_title：Frontiers in molecular neuroscience

authors： Widagdo J,Guntupalli S,Jang SE,Anggono V

更新日期：2017-10-26 00:00:00

abstract：:Neuroendocrine cells store and secrete bulk amounts of neuropeptides, and display morphological and molecular characteristics distinct from neurons signaling with classical neurotransmitters. In Drosophila the transcription factor Dimmed (Dimm), is a prime organizer of neuroendocrine capacity in a majority of the pept...

journal_title：Frontiers in molecular neuroscience

authors： Luo J,Liu Y,Nässel DR

更新日期：2017-08-14 00:00:00

abstract：:Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patients with TLE. However, whether KA activates KA receptors (KARs) as an a...

journal_title：Frontiers in molecular neuroscience

authors： Falcón-Moya R,Sihra TS,Rodríguez-Moreno A

更新日期：2018-06-22 00:00:00

abstract：:The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) are major excitatory receptors that mediate fast neurotransmission in the mammalian brain. The surface expression of functional AMPARs is crucial for synaptic transmission and plasticity. AMPAR auxiliary subunits control ...

journal_title：Frontiers in molecular neuroscience

authors： Wei M,Jia M,Zhang J,Yu L,Zhao Y,Chen Y,Ma Y,Zhang W,Shi YS,Zhang C

更新日期：2017-03-02 00:00:00

abstract：:Convulsive seizures promote adult hippocampal neurogenesis (AHN) through a transient activation of neural stem/progenitor cells (NSPCs) in the subgranular zone (SGZ) of the dentate gyrus (DG). However, in a significant population of epilepsy patients, non-convulsive seizures (ncSZ) are observed. The response of NSPCs ...

journal_title：Frontiers in molecular neuroscience

authors： Bielefeld P,Schouten M,Meijer GM,Breuk MJ,Geijtenbeek K,Karayel S,Tiaglik A,Vuuregge AH,Willems RAL,Witkamp D,Lucassen PJ,Encinas JM,Fitzsimons CP

更新日期：2019-02-19 00:00:00