Kv4 Channels Underlie the Subthreshold-Operating A-type K-current in Nociceptive Dorsal Root Ganglion Neurons.

abstract：:Time-Place learning (TPL) refers to the ability of animals to remember important events that vary in both time and place. This ability is thought to be functional to optimize resource localization and predator avoidance in a circadian changing environment. Various studies have indicated that animals use their circadia...

journal_title：Frontiers in molecular neuroscience

authors： Mulder CK,Gerkema MP,Van der Zee EA

更新日期：2013-04-11 00:00:00

abstract：:Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain. It has been found that a synergistic relationship between these two proteins may contribute to their roles in disease progression. However, how Aβ...

journal_title：Frontiers in molecular neuroscience

authors： Shin WS,Di J,Murray KA,Sun C,Li B,Bitan G,Jiang L

更新日期：2019-11-08 00:00:00

abstract：:Alzheimer's disease (AD) is a widely distributed neurodegenerative disease characterized clinically by cognitive deficits and pathologically by formation of amyloid-β (Aβ) plaque and neurofibrillary tangles (NFTs) in the brain. Vanadium is a biological trace element that has a function to mimic insulin for diabetes. B...

journal_title：Frontiers in molecular neuroscience

authors： He Z,Han S,Zhu H,Hu X,Li X,Hou C,Wu C,Xie Q,Li N,Du X,Ni J,Liu Q

更新日期：2020-03-10 00:00:00

abstract：:Ca2+ signaling plays a significant role in the development of the vertebrate nervous system where it regulates neurite growth as well as synapse and neurotransmitter specification. Elucidating the role of Ca2+ signaling in mammalian neuronal development has been largely restricted to either small animal models or prim...

journal_title：Frontiers in molecular neuroscience

authors： Gopurappilly R,Deb BK,Chakraborty P,Hasan G

更新日期：2018-06-11 00:00:00

abstract：:Immune checkpoints restrain the immune system following its activation and their inhibition unleashes anti-tumor immune responses. Immune checkpoint inhibitors revolutionized the treatment of several cancer types, including melanoma, and immune checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies is becoming ...

journal_title：Frontiers in molecular neuroscience

authors： Lorger M,Andreou T,Fife C,James F

更新日期：2019-11-21 00:00:00

abstract：:Thiol groups can undergo numerous modifications, making cysteine a unique molecular switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione, contributing to maintain redox homeostasis and regulate signaling within and amongst cells. Not surprisingly therefore, cysteines are associated...

journal_title：Frontiers in molecular neuroscience

authors： Fra A,Yoboue ED,Sitia R

更新日期：2017-06-06 00:00:00

abstract：:Neuroendocrine cells store and secrete bulk amounts of neuropeptides, and display morphological and molecular characteristics distinct from neurons signaling with classical neurotransmitters. In Drosophila the transcription factor Dimmed (Dimm), is a prime organizer of neuroendocrine capacity in a majority of the pept...

journal_title：Frontiers in molecular neuroscience

authors： Luo J,Liu Y,Nässel DR

更新日期：2017-08-14 00:00:00

abstract：:We earlier reported that the male mice lacking the Wdr13 gene (Wdr13-/0) showed mild anxiety, better memory retention, and up-regulation of synaptic proteins in the hippocampus. With increasing evidences from parallel studies in our laboratory about the possible role of Wdr13 in stress response, we investigated its ro...

journal_title：Frontiers in molecular neuroscience

authors： Mitra S,Sameer Kumar GS,Jyothi Lakshmi B,Thakur S,Kumar S

更新日期：2018-04-25 00:00:00

abstract：:Hoxa5 is a member of the Hox gene family that plays critical roles in successive steps of the central nervous system formation during embryonic and fetal development. In the mouse, Hoxa5 was recently shown to be expressed in the medulla oblongata and the pons from fetal stages to adulthood. In these territories, Hoxa5...

journal_title：Frontiers in molecular neuroscience

authors： Lizen B,Moens C,Mouheiche J,Sacré T,Ahn MT,Jeannotte L,Salti A,Gofflot F

更新日期：2017-11-15 00:00:00

abstract：:Maternal cigarette smoke exposure (SE) causes detrimental changes associated with the development of chronic neurological diseases in the offspring as a result of oxidative mitochondrial damage. Maternal L-Carnitine administration has been shown to reduce renal oxidative stress in SE offspring, but its effect in the b...

journal_title：Frontiers in molecular neuroscience

authors： Chan YL,Saad S,Al-Odat I,Oliver BG,Pollock C,Jones NM,Chen H

更新日期：2017-02-13 00:00:00

abstract：:MicroRNAs (miRNAs) are key post transcriptional regulators of their multiple target genes. However, the detailed profile of miRNA expression in Parkinson's disease, the second most common neurodegenerative disease worldwide and the first motor disorder has not been charted yet. Here, we report comprehensive miRNA prof...

journal_title：Frontiers in molecular neuroscience

authors： Soreq L,Salomonis N,Bronstein M,Greenberg DS,Israel Z,Bergman H,Soreq H

更新日期：2013-05-13 00:00:00

abstract：:The degeneration of dopaminergic neurons during Parkinson's disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in several biological proc...

journal_title：Frontiers in molecular neuroscience

authors： Aufschnaiter A,Habernig L,Kohler V,Diessl J,Carmona-Gutierrez D,Eisenberg T,Keller W,Büttner S

更新日期：2017-06-30 00:00:00

abstract：:Caenorhabditis elegans somatic protein homeostasis (proteostasis) is actively remodeled at the onset of reproduction. This proteostatic collapse is regulated cell-nonautonomously by signals from the reproductive system that transmit the commitment to reproduction to somatic cells. Here, we asked whether the link betwe...

journal_title：Frontiers in molecular neuroscience

authors： Shemesh N,Shai N,Meshnik L,Katalan R,Ben-Zvi A

更新日期：2017-04-20 00:00:00

abstract：:Autism spectrum disorders (ASD) have a higher prevalence in male individuals compared to females, with a ratio of affected boys compared to girls of 4:1 for ASD and 11:1 for Asperger syndrome. Mutations in the SHANK genes (comprising SHANK1, SHANK2 and SHANK3) coding for postsynaptic scaffolding proteins have been tig...

journal_title：Frontiers in molecular neuroscience

authors： Berkel S,Eltokhi A,Fröhlich H,Porras-Gonzalez D,Rafiullah R,Sprengel R,Rappold GA

更新日期：2018-09-25 00:00:00

abstract：:Human achaete-scute homolog-1 (hASH1), encoded by the human ASCL1 gene, belongs to the family of basic helix-loop-helix transcription factors. hASH1 and its mammalian homolog Mash1 are expressed in the central and peripheral nervous system during development, and promote early neuronal differentiation. Furthermore, hA...

journal_title：Frontiers in molecular neuroscience

authors： Benko E,Winkelmann A,Meier JC,Persson PB,Scholz H,Fähling M

更新日期：2011-02-07 00:00:00

abstract：:Electroacupuncture (EA) could improve the hyperactivity of the hypothalamus pituitary adrenal (HPA) axis induced by hepatectomy. However, its underlying mechanism still remains largely unclear. Here, we found that hypothalamic corticotrophin releasing hormone (CRH) modulates the function of the HPA axis, while hepatec...

journal_title：Frontiers in molecular neuroscience

authors： Zhu J,Chen Z,Meng Z,Ju M,Zhang M,Wu G,Guo H,Tian Z

更新日期：2017-09-27 00:00:00

abstract：:The application of super-resolution optical microscopy to investigating synaptic structures has revealed a highly heterogeneous and variable intra-synaptic organization. Dense subsynaptic protein assemblies named subsynaptic domains or SSDs have been proposed as structural units that regulate the efficacy of neuronal ...

journal_title：Frontiers in molecular neuroscience

authors： Yang X,Specht CG

更新日期：2019-07-02 00:00:00

abstract：:Neuroblastoma, the major cause of infant cancer deaths, results from fast proliferation of undifferentiated neuroblasts. Treatment of high-risk neuroblastoma includes differentiation with retinoic acid (RA); however, the resistance of many of these tumors to RA-induced differentiation poses a considerable challenge. H...

journal_title：Frontiers in molecular neuroscience

authors： Kasim M,Heß V,Scholz H,Persson PB,Fähling M

更新日期：2016-12-21 00:00:00

abstract：:In recent years, signaling through ubiquitin has been shown to be of great importance for normal brain development. Indeed, fluctuations in ubiquitin levels and spontaneous mutations in (de)ubiquitination enzymes greatly perturb synapse formation and neuronal transmission. In the brain, expression of lysine (K) 48-lin...

journal_title：Frontiers in molecular neuroscience

authors： Pinto MJ,Pedro JR,Costa RO,Almeida RD

更新日期：2016-06-10 00:00:00

abstract：:Microglia are the innate sentinels of the central nervous system (CNS) and are responsible for the homeostasis and immune defense of the CNS. Under the influence of the local environment and cell-cell interaction, microglia exhibit a multidimensional and context-dependent phenotypes that can be cytotoxic and neuroprot...

journal_title：Frontiers in molecular neuroscience

authors： Siew JJ,Chern Y

更新日期：2018-05-14 00:00:00

abstract：:Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels. The cryo-EM structure of the homopentameric α1 glycine receptor (GlyR) demonstrated an involvement of the ...

journal_title：Frontiers in molecular neuroscience

authors： Janzen D,Schaefer N,Delto C,Schindelin H,Villmann C

更新日期：2017-10-09 00:00:00

abstract：:Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy. Unfortunately, current treatment strategies are limited and innovative new approaches are ...

journal_title：Frontiers in molecular neuroscience

authors： Fisher NM,Seto M,Lindsley CW,Niswender CM

更新日期：2018-10-23 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) complex plays important roles in virtually all cells of the body. The enzymatic activity of PI3K to phosphorylate phosphoinositides in the membrane is mediated by a group of catalytic and regulatory subunits. Among those, the class I catalytic subunits, p110α, p110β, p110γ, and p11...

journal_title：Frontiers in molecular neuroscience

authors： Gross C,Bassell GJ

更新日期：2014-02-13 00:00:00

abstract：:The cells of the neural crest, often referred to as neural crest stem cells, give rise to a number of sub-lineages, one of which is Schwann cells, the glial cells of peripheral nerves. Crest cells transform to adult Schwann cells through the generation of two well defined intermediate stages, the Schwann cell precurso...

journal_title：Frontiers in molecular neuroscience

authors： Jessen KR,Mirsky R

更新日期：2019-03-26 00:00:00

abstract：:Among all organs of an adult animal, the central nervous system stands out because of its vast complexity and morphological diversity. During early development, the entire central nervous system develops from an apparently homogenous group of progenitors that differentiate into all neural cell types. Therefore, unders...

journal_title：Frontiers in molecular neuroscience

authors： Contreras EG,Sierralta J,Oliva C

更新日期：2019-05-31 00:00:00

abstract：:MiRNAs are key regulators of the mammalian transcriptome that have been increasingly linked to degenerative diseases of the motor neurons. Although many of the miRNAs currently incriminated as participants in the pathogenesis of these diseases are also important to the normal development and function of motor neurons,...

journal_title：Frontiers in molecular neuroscience

authors： Hawley ZCE,Campos-Melo D,Droppelmann CA,Strong MJ

更新日期：2017-05-04 00:00:00

abstract：:The central, lateral and basolateral amygdala (BLA) nuclei are essential for the formation of long-term memories including emotional and drug-related memories. Studying cellular and molecular mechanisms of memory in amygdala may lead to better understanding of how memory is formed and of fear and addiction-related dis...

journal_title：Frontiers in molecular neuroscience

authors： Lamprecht R

更新日期：2016-03-31 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00177.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Belin S,Herron J,VerPlank JJS,Park Y,Feltri LM,Poitelon Y

更新日期：2019-10-18 00:00:00

abstract：:Many genes controlling neuronal development also regulate adult neurogenesis. We investigated in vivo the effect of Sonic hedgehog (Shh) signaling activation on patterning and neurogenesis of the hippocampus and behavior of Patched1 (Ptch1) heterozygous mice (Ptch1+/- ). We demonstrated for the first time, that Ptch1+...

journal_title：Frontiers in molecular neuroscience

authors： Antonelli F,Casciati A,Tanori M,Tanno B,Linares-Vidal MV,Serra N,Bellés M,Pannicelli A,Saran A,Pazzaglia S

更新日期：2018-05-23 00:00:00

abstract：:The brain is complex and heterogeneous. Even though numerous independent studies indicate cortical hyperexcitability as a potential contributor to amyotrophic lateral sclerosis (ALS) pathology, the mechanisms that are responsible for upper motor neuron (UMN) vulnerability remain elusive. To reveal the electrophysiolog...

journal_title：Frontiers in molecular neuroscience

authors： Jara JH,Sheets PL,Nigro MJ,Perić M,Brooks C,Heller DB,Martina M,Andjus PR,Ozdinler PH

更新日期：2020-05-19 00:00:00