Achaete-Scute Homolog 1 Expression Controls Cellular Differentiation of Neuroblastoma.

abstract：:Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation encoding an expanded polyglutamine tract in the huntingtin protein, which leads to cognitive, psychiatric and motor dysfunction. Exposure to environmental enrichment (EE), which enhances levels of cognitive stimulation and phy...

journal_title：Frontiers in molecular neuroscience

authors： Zajac MS,Renoir T,Perreau VM,Li S,Adams W,van den Buuse M,Hannan AJ

更新日期：2018-12-10 00:00:00

abstract：:Spinal cord injury (SCI) causes the death of neurons and glial cells due to the initial mechanical forces (i.e., primary injury) and through a cascade of secondary molecular events (e.g., inflammation or excitotoxicity) that exacerbate cell death. The loss of neurons and glial cells that are not replaced after the inj...

journal_title：Frontiers in molecular neuroscience

authors： Sobrido-Cameán D,Barreiro-Iglesias A

更新日期：2018-04-03 00:00:00

abstract：:The molecular mechanisms underlying plastic changes in the strength and connectivity of excitatory synapses have been studied extensively for the past few decades and remain the most attractive cellular models of learning and memory. One of the major mechanisms that regulate synaptic plasticity is the dynamic adjustme...

journal_title：Frontiers in molecular neuroscience

authors： Widagdo J,Guntupalli S,Jang SE,Anggono V

更新日期：2017-10-26 00:00:00

abstract：:The neuromuscular junction (NMJ) is the chemical synapse connecting motor neurons and skeletal muscle fibers. NMJs allow all voluntary movements, and ensure vital functions like breathing. Changes in the structure and function of NMJs are hallmarks of numerous pathological conditions that affect muscle function includ...

journal_title：Frontiers in molecular neuroscience

authors： Castets P,Ham DJ,Rüegg MA

更新日期：2020-08-28 00:00:00

abstract：:We propose that brain energy deficit is an important pre-symptomatic feature of Alzheimer's disease (AD) that requires closer attention in the development of AD therapeutics. Our rationale is fourfold: (i) Glucose uptake is lower in the frontal cortex of people >65 years-old despite cognitive scores that are normal fo...

journal_title：Frontiers in molecular neuroscience

authors： Cunnane SC,Courchesne-Loyer A,Vandenberghe C,St-Pierre V,Fortier M,Hennebelle M,Croteau E,Bocti C,Fulop T,Castellano CA

更新日期：2016-07-08 00:00:00

abstract：:We earlier reported that the male mice lacking the Wdr13 gene (Wdr13-/0) showed mild anxiety, better memory retention, and up-regulation of synaptic proteins in the hippocampus. With increasing evidences from parallel studies in our laboratory about the possible role of Wdr13 in stress response, we investigated its ro...

journal_title：Frontiers in molecular neuroscience

authors： Mitra S,Sameer Kumar GS,Jyothi Lakshmi B,Thakur S,Kumar S

更新日期：2018-04-25 00:00:00

abstract：:The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale. These disorders are heterogeneous, yet they share common behavioral symptomatology as well as o...

journal_title：Frontiers in molecular neuroscience

authors： Ali Rodriguez R,Joya C,Hines RM

更新日期：2018-04-24 00:00:00

abstract：:The competitive ectodomain shedding of amyloid-β precursor protein (APP) by α-secretase and β-secretase, and the subsequent regulated intramembrane proteolysis by γ-secretase are the key processes in amyloid-β peptides (Aβ) generation. Previous studies indicate that secretases form binary complex and the interactions ...

journal_title：Frontiers in molecular neuroscience

authors： Wang X,Pei G

更新日期：2018-11-27 00:00:00

abstract：:Inter-relationships ordinarily exist between mRNA expression of GABA(A) subunits in the frontopolar cortex (FPC) of individuals that had died suddenly from causes other than suicide. However, these correlations were largely absent in persons that had died by suicide. In the present investigation, these findings were e...

journal_title：Frontiers in molecular neuroscience

authors： Poulter MO,Du L,Zhurov V,Palkovits M,Faludi G,Merali Z,Anisman H

更新日期：2010-03-29 00:00:00

abstract：:The balance between excitatory and inhibitory neurotransmitter systems is crucial for the modulation of neuronal excitability in the central nervous system (CNS). The activation of transient receptor potential vanilloid 4 (TRPV4) is reported to enhance the response of hippocampal glutamate receptors, but whether the i...

journal_title：Frontiers in molecular neuroscience

authors： Hong Z,Tian Y,Qi M,Li Y,Du Y,Chen L,Liu W,Chen L

更新日期：2016-08-26 00:00:00

abstract：:Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy. Unfortunately, current treatment strategies are limited and innovative new approaches are ...

journal_title：Frontiers in molecular neuroscience

authors： Fisher NM,Seto M,Lindsley CW,Niswender CM

更新日期：2018-10-23 00:00:00

abstract：:Cleavage of the amyloid precursor protein (APP) by α-secretase generates an extracellularly released fragment termed secreted APP-alpha (APPsα). Not only is this process of interest due to the cleavage of APP within the amyloid-beta sequence, but APPsα itself has many physiological properties that suggest its great po...

journal_title：Frontiers in molecular neuroscience

authors： Mockett BG,Richter M,Abraham WC,Müller UC

更新日期：2017-02-07 00:00:00

abstract：:Microglial activation and the inflammatory response in the central nervous system (CNS) play important roles in secondary damage after traumatic brain injury (TBI). Transcriptional activation of genes that limit secondary damage to the CNS are mediated by a cis-acting element called the antioxidant responsive element ...

journal_title：Frontiers in molecular neuroscience

authors： Chen X,Wang H,Zhou M,Li X,Fang Z,Gao H,Li Y,Hu W

更新日期：2018-04-17 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00177.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Belin S,Herron J,VerPlank JJS,Park Y,Feltri LM,Poitelon Y

更新日期：2019-10-18 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00099.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Yadav SC,Tetenborg S,Dedek K

更新日期：2019-06-12 00:00:00

abstract：:Mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease (PD) and, as such, LRRK2 is considered a promising therapeutic target for age-related neurodegeneration. Although the cellular functions of LRRK2 in health and disease are incompletely understood, robust evidence indicates that P...

journal_title：Frontiers in molecular neuroscience

authors： Civiero L,Cogo S,Kiekens A,Morganti C,Tessari I,Lobbestael E,Baekelandt V,Taymans JM,Chartier-Harlin MC,Franchin C,Arrigoni G,Lewis PA,Piccoli G,Bubacco L,Cookson MR,Pinton P,Greggio E

更新日期：2017-12-14 00:00:00

abstract：:Membrane bound guanylate cyclases are expressed in rod and cone cells of the vertebrate retina and mutations in several domains of rod outer segment guanylate cyclase 1 (ROS-GC1 encoded by the gene GUCY2D) correlate with different forms of retinal degenerations. In the present work we investigated the biochemical cons...

journal_title：Frontiers in molecular neuroscience

authors： Zägel P,Koch KW

更新日期：2014-02-26 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive primary intracranial tumor of adults and confers a poor prognosis due to high vascularization. Hence anti-angiogenic therapy has become a promising strategy for GBM treatment. In this study, the transcription factor nuclear factor of activated T-cells 5 (NFAT5) was significant...

journal_title：Frontiers in molecular neuroscience

authors： Yu H,Zheng J,Liu X,Xue Y,Shen S,Zhao L,Li Z,Liu Y

更新日期：2017-09-21 00:00:00

abstract：:Time-Place learning (TPL) refers to the ability of animals to remember important events that vary in both time and place. This ability is thought to be functional to optimize resource localization and predator avoidance in a circadian changing environment. Various studies have indicated that animals use their circadia...

journal_title：Frontiers in molecular neuroscience

authors： Mulder CK,Gerkema MP,Van der Zee EA

更新日期：2013-04-11 00:00:00

abstract：:Oxidative stress-induced neuronal damage has been implicated to play a dominant role in neurodegenerative disorders, such as Alzheimer's disease (AD). Nicotine, a principal additive compound for tobacco users, is thought as a candidate to attenuate amyloid-β-mediated neurotoxicity and NMDA-induced excitotoxicity. Prev...

journal_title：Frontiers in molecular neuroscience

authors： Dong Y,Bi W,Zheng K,Zhu E,Wang S,Xiong Y,Chang J,Jiang J,Liu B,Lu Z,Cheng Y

更新日期：2020-11-12 00:00:00

abstract：:The cells of the neural crest, often referred to as neural crest stem cells, give rise to a number of sub-lineages, one of which is Schwann cells, the glial cells of peripheral nerves. Crest cells transform to adult Schwann cells through the generation of two well defined intermediate stages, the Schwann cell precurso...

journal_title：Frontiers in molecular neuroscience

authors： Jessen KR,Mirsky R

更新日期：2019-03-26 00:00:00

abstract：:Inhibition of nerve growth and plasticity in the CNS is to a large part mediated by Nogo-like signaling, now encompassing a plethora of ligands, receptors, co-receptors and modulators. Here we describe the distribution and levels of mRNA encoding 11 key genes involved in Nogo-like signaling (Nogo-A, Oligodendrocyte-My...

journal_title：Frontiers in molecular neuroscience

authors： Karlsson TE,Wellfelt K,Olson L

更新日期：2017-04-11 00:00:00

abstract：:The ubiquitin proteasome system (UPS) is crucial for intracellular protein homeostasis and for degradation of aberrant and damaged proteins. The accumulation of ubiquitinated proteins is a hallmark of many neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer's, Parkinson's, and Huntington's d...

journal_title：Frontiers in molecular neuroscience

authors： Jansen AH,Reits EA,Hol EM

更新日期：2014-08-08 00:00:00

abstract：:Status epilepticus (SE, a prolonged seizure activity) leads to reactive astrogliosis and astroglial apoptosis in the regional specific manners, independent of hemodynamics. Poly(ADP-ribose) polymerase-1 (PARP1) activity is relevant to these distinct astroglial responses. Since various regulatory signaling molecules be...

journal_title：Frontiers in molecular neuroscience

authors： Kim JE,Kang TC

更新日期：2019-07-24 00:00:00

abstract：:Age-progressive neurodegenerative pathologies, including Alzheimer's disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved in the etiology of neurological dis...

journal_title：Frontiers in molecular neuroscience

authors： Kakraba S,Ayyadevara S,Penthala NR,Balasubramaniam M,Ganne A,Liu L,Alla R,Bommagani SB,Barger SW,Griffin WST,Crooks PA,Shmookler Reis RJ

更新日期：2019-12-12 00:00:00

abstract：:The central, lateral and basolateral amygdala (BLA) nuclei are essential for the formation of long-term memories including emotional and drug-related memories. Studying cellular and molecular mechanisms of memory in amygdala may lead to better understanding of how memory is formed and of fear and addiction-related dis...

journal_title：Frontiers in molecular neuroscience

authors： Lamprecht R

更新日期：2016-03-31 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive disease with early degeneration of the central cholinergic neurons. Currently, three of four AD drugs act by inhibiting the acetylcholine (ACh) degrading enzyme, acetylcholinesterase (AChE). Efficacy of these drugs depends on available amount of ACh, which is biosynthesized by...

journal_title：Frontiers in molecular neuroscience

authors： Karami A,Eriksdotter M,Kadir A,Almkvist O,Nordberg A,Darreh-Shori T

更新日期：2019-10-11 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and malignant primary tumor. Angiogenesis plays a critical role in the progression of GBM. Previous studies have indicated that long non-coding RNAs (lncRNAs) are abnormally expressed in various cancers and participate in the regulation of the malignant behaviors of tumors. Th...

journal_title：Frontiers in molecular neuroscience

authors： Yang C,Zheng J,Xue Y,Yu H,Liu X,Ma J,Liu L,Wang P,Li Z,Cai H,Liu Y

更新日期：2018-01-09 00:00:00

abstract：:Sex-determining region Y box 2 (Sox2), expressed in neural tissues, plays an important role as a transcription factor not only in the pluripotency and proliferation of neuronal cells but also in the opposite function of cell differentiation. Nevertheless, how Sox2 is linked to motor neuron development remains unknown....

journal_title：Frontiers in molecular neuroscience

authors： Gong J,Hu S,Huang Z,Hu Y,Wang X,Zhao J,Qian P,Wang C,Sheng J,Lu X,Wei G,Liu D

更新日期：2020-03-27 00:00:00

abstract：:Epilepsy is a chronic brain dysfunction induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Recently, accumulating studies have revealed a close relationship between inflammation and epilepsy. Specifically, microglia and astrocytes are important inflammatory cells in the central ...

journal_title：Frontiers in molecular neuroscience

authors： Chen L,Zhu L,Lu D,Wu Z,Han Y,Xu P,Chang L,Wu Q

更新日期：2020-09-04 00:00:00