Cone Phosphodiesterase-6γ' Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits.

abstract：:Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is a neurodegenerative disorder caused by loss-of-function mutations in the cystatin B (CSTB) gene. Progression of the clinical symptoms in EPM1 patients, including stimulus-sensitive myoclonus, tonic-clonic seizures, and ataxia, are well described. How...

journal_title：Frontiers in molecular neuroscience

authors： Gorski K,Spoljaric A,Nyman TA,Kaila K,Battersby BJ,Lehesjoki AE

更新日期：2020-11-13 00:00:00

abstract：:Eukaryotic cells release different types of extracellular vesicles (EVs) including exosomes, ectosomes, and microvesicles. Exosomes are nanovesicles, 30-200 nm in diameter, that carry cell- and cell-state-specific cargo of proteins, lipids, and nucleic acids, including mRNA and miRNA. Recent studies have shown that ce...

journal_title：Frontiers in molecular neuroscience

authors： Hornung S,Dutta S,Bitan G

更新日期：2020-03-19 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a subtype of stroke with highest mortality and morbidity. We have previously demonstrated that dipotassium bisperoxo (picolinato) oxovanadate (V), (bpV[pic]) inhibits phosphatase and tensin homolog (PTEN) and activates extracellular signal-regulated kinase (ERK)1/2. In this study, we ...

journal_title：Frontiers in molecular neuroscience

authors： Zhao D,Qin XP,Chen SF,Liao XY,Cheng J,Liu R,Lei Y,Zhang ZF,Wan Q

更新日期：2019-12-05 00:00:00

abstract：:The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale. These disorders are heterogeneous, yet they share common behavioral symptomatology as well as o...

journal_title：Frontiers in molecular neuroscience

authors： Ali Rodriguez R,Joya C,Hines RM

更新日期：2018-04-24 00:00:00

abstract：:Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation encoding an expanded polyglutamine tract in the huntingtin protein, which leads to cognitive, psychiatric and motor dysfunction. Exposure to environmental enrichment (EE), which enhances levels of cognitive stimulation and phy...

journal_title：Frontiers in molecular neuroscience

authors： Zajac MS,Renoir T,Perreau VM,Li S,Adams W,van den Buuse M,Hannan AJ

更新日期：2018-12-10 00:00:00

abstract：:The basic helix-loop-helix (bHLH) protein family has previously been shown to be involved in the development of mesodiencephalic dopaminergic (mdDA) neurons in the murine midbrain. Specifically, Ngn2 and Mash1 are known to have a role in the specification of neural progenitors in the ventricular zone (VZ) of the midbr...

journal_title：Frontiers in molecular neuroscience

authors： Mesman S,Smidt MP

更新日期：2017-11-01 00:00:00

abstract：:Using a high resolution in situ hybridization technique we have measured PIEZO1, PIEZO2, and TRPV1 transcripts in mouse dorsal root ganglion (DRG) neurons. Consistent with previous studies, PIEZO2 transcripts were highly expressed in DRG neurons of all sizes, including most notably the largest diameter neurons implica...

journal_title：Frontiers in molecular neuroscience

authors： Wang J,La JH,Hamill OP

更新日期：2019-07-19 00:00:00

abstract：:The degeneration of dopaminergic neurons during Parkinson's disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in several biological proc...

journal_title：Frontiers in molecular neuroscience

authors： Aufschnaiter A,Habernig L,Kohler V,Diessl J,Carmona-Gutierrez D,Eisenberg T,Keller W,Büttner S

更新日期：2017-06-30 00:00:00

abstract：:N-methyl-d-aspartate receptors (NMDARs) play an important role in many aspects of nervous system function such as synaptic plasticity and neuronal development. NMDARs are heteromers consisting of an obligate NR1 and most commonly one or two kinds of NR2 subunits. While the receptors have been well characterized in som...

journal_title：Frontiers in molecular neuroscience

authors： Ewald RC,Cline HT

更新日期：2009-09-11 00:00:00

abstract：:Immune checkpoints restrain the immune system following its activation and their inhibition unleashes anti-tumor immune responses. Immune checkpoint inhibitors revolutionized the treatment of several cancer types, including melanoma, and immune checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies is becoming ...

journal_title：Frontiers in molecular neuroscience

authors： Lorger M,Andreou T,Fife C,James F

更新日期：2019-11-21 00:00:00

abstract：:Thiol groups can undergo numerous modifications, making cysteine a unique molecular switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione, contributing to maintain redox homeostasis and regulate signaling within and amongst cells. Not surprisingly therefore, cysteines are associated...

journal_title：Frontiers in molecular neuroscience

authors： Fra A,Yoboue ED,Sitia R

更新日期：2017-06-06 00:00:00

abstract：:Maternal cigarette smoke exposure (SE) causes detrimental changes associated with the development of chronic neurological diseases in the offspring as a result of oxidative mitochondrial damage. Maternal L-Carnitine administration has been shown to reduce renal oxidative stress in SE offspring, but its effect in the b...

journal_title：Frontiers in molecular neuroscience

authors： Chan YL,Saad S,Al-Odat I,Oliver BG,Pollock C,Jones NM,Chen H

更新日期：2017-02-13 00:00:00

abstract：:In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of plasma membrane (PM) Ca2+ channels following the release of Ca2+ from intracellular stores. Upon depletion of Ca2+ store, the stromal interac...

journal_title：Frontiers in molecular neuroscience

authors： Secondo A,Bagetta G,Amantea D

更新日期：2018-03-22 00:00:00

abstract：:Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patients with TLE. However, whether KA activates KA receptors (KARs) as an a...

journal_title：Frontiers in molecular neuroscience

authors： Falcón-Moya R,Sihra TS,Rodríguez-Moreno A

更新日期：2018-06-22 00:00:00

abstract：:Ischemic stroke is one of the most common causes of death and disability worldwide. Neuroinflammation is a major pathological event involved in the process of ischemic injury and repair. In particular, microglia play a dual role in neuroinflammation. During the acute phase of stroke onset, M2 microglia are the dominan...

journal_title：Frontiers in molecular neuroscience

authors： Lian L,Zhang Y,Liu L,Yang L,Cai Y,Zhang J,Xu S

更新日期：2021-01-07 00:00:00

abstract：:Corticotropin releasing factor (CRF) has been shown to induce various behavioral changes related to adaptation to stress. Dysregulation of the CRF system at any point can lead to a variety of psychiatric disorders, including substance use disorders (SUDs). CRF has been associated with stress-induced drug reinforcement...

journal_title：Frontiers in molecular neuroscience

authors： Haass-Koffler CL,Bartlett SE

更新日期：2012-09-06 00:00:00

abstract：:Electroacupuncture (EA) could improve the hyperactivity of the hypothalamus pituitary adrenal (HPA) axis induced by hepatectomy. However, its underlying mechanism still remains largely unclear. Here, we found that hypothalamic corticotrophin releasing hormone (CRH) modulates the function of the HPA axis, while hepatec...

journal_title：Frontiers in molecular neuroscience

authors： Zhu J,Chen Z,Meng Z,Ju M,Zhang M,Wu G,Guo H,Tian Z

更新日期：2017-09-27 00:00:00

abstract：:Parkinson's disease (PD) is a progressive CNS disorder that is primarily associated with impaired movement. PD develops over decades and is linked to the gradual loss of dopamine delivery to the striatum, via the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). While the administration o...

journal_title：Frontiers in molecular neuroscience

authors： Lasbleiz C,Mestre-Francés N,Devau G,Luquin MR,Tenenbaum L,Kremer EJ,Verdier JM

更新日期：2019-02-11 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00177.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Belin S,Herron J,VerPlank JJS,Park Y,Feltri LM,Poitelon Y

更新日期：2019-10-18 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) are essential epigenetic regulators with critical roles in tumor initiation and malignant progression. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of gliomas are not fully understood. With the development of deep sequencing analyses, an extensive...

journal_title：Frontiers in molecular neuroscience

authors： Yan Y,Xu Z,Li Z,Sun L,Gong Z

更新日期：2017-02-28 00:00:00

abstract：:Neuronal calcium sensor-1 (NCS-1) protein is abundantly expressed in the central nervous system and retinal neurons, where it regulates many vital processes such as synaptic transmission. It coordinates three calcium ions by EF-hands 2-4, thereby transducing Ca2+ signals to a wide range of protein targets, including G...

journal_title：Frontiers in molecular neuroscience

authors： Tsvetkov PO,Roman AY,Baksheeva VE,Nazipova AA,Shevelyova MP,Vladimirov VI,Buyanova MF,Zinchenko DV,Zamyatnin AA Jr,Devred F,Golovin AV,Permyakov SE,Zernii EY

更新日期：2018-12-14 00:00:00

abstract：:Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu. Our understanding of the structure-function relationship of connexin channels relies on X-ray crystallographic data for human connexin 26 (hCx26) ...

journal_title：Frontiers in molecular neuroscience

authors： Zonta F,Buratto D,Crispino G,Carrer A,Bruno F,Yang G,Mammano F,Pantano S

更新日期：2018-05-31 00:00:00

abstract：:Following the discovery that the amyloid precursor protein (APP) is the source of β-amyloid peptides (Aβ) that accumulate in Alzheimer's disease (AD), structural analyses suggested that the holoprotein resembles a transmembrane receptor. Initial studies using reconstituted membranes demonstrated that APP can directly ...

journal_title：Frontiers in molecular neuroscience

authors： Copenhaver PF,Kögel D

更新日期：2017-01-31 00:00:00

abstract：:We propose that brain energy deficit is an important pre-symptomatic feature of Alzheimer's disease (AD) that requires closer attention in the development of AD therapeutics. Our rationale is fourfold: (i) Glucose uptake is lower in the frontal cortex of people >65 years-old despite cognitive scores that are normal fo...

journal_title：Frontiers in molecular neuroscience

authors： Cunnane SC,Courchesne-Loyer A,Vandenberghe C,St-Pierre V,Fortier M,Hennebelle M,Croteau E,Bocti C,Fulop T,Castellano CA

更新日期：2016-07-08 00:00:00

abstract：:Background: An imbalance between total training load and total recovery may cause overtraining (OT). The purpose of the present study was to verify the effects of OT on the expression of brain-derived neurotrophic factor (BDNF), its receptor tropomyosin receptor kinase B (TrkB) and p75 and the dynamic expression patte...

journal_title：Frontiers in molecular neuroscience

authors： Xu L,Zheng YL,Yin X,Xu SJ,Tian D,Zhang CY,Wang S,Ma JZ

更新日期：2020-01-30 00:00:00

abstract：:Despite numerous clinical studies, which have investigated the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) in various brain diseases, our knowledge of the cellular and molecular mechanisms underlying rTMS-based therapies remains limited. Thus, a deeper understanding of rTMS-induced neu...

journal_title：Frontiers in molecular neuroscience

authors： Müller-Dahlhaus F,Vlachos A

更新日期：2013-12-17 00:00:00

abstract：:Caenorhabditis elegans somatic protein homeostasis (proteostasis) is actively remodeled at the onset of reproduction. This proteostatic collapse is regulated cell-nonautonomously by signals from the reproductive system that transmit the commitment to reproduction to somatic cells. Here, we asked whether the link betwe...

journal_title：Frontiers in molecular neuroscience

authors： Shemesh N,Shai N,Meshnik L,Katalan R,Ben-Zvi A

更新日期：2017-04-20 00:00:00

abstract：:SYNGAP1, a Synaptic Ras-GTPase activating protein, regulates synapse maturation during a critical developmental window. Heterozygous mutation in SYNGAP1 (SYNGAP1-/+) has been shown to cause Intellectual Disability (ID) in children. Recent studies have provided evidence for altered neuronal protein synthesis in a mouse...

journal_title：Frontiers in molecular neuroscience

authors： Paul A,Nawalpuri B,Shah D,Sateesh S,Muddashetty RS,Clement JP

更新日期：2019-05-09 00:00:00

abstract：:Inhibition of nerve growth and plasticity in the CNS is to a large part mediated by Nogo-like signaling, now encompassing a plethora of ligands, receptors, co-receptors and modulators. Here we describe the distribution and levels of mRNA encoding 11 key genes involved in Nogo-like signaling (Nogo-A, Oligodendrocyte-My...

journal_title：Frontiers in molecular neuroscience

authors： Karlsson TE,Wellfelt K,Olson L

更新日期：2017-04-11 00:00:00

abstract：:Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied in the field of endocrinology, the bioactivity of the proinsulin ...

journal_title：Frontiers in molecular neuroscience

authors： de Pablo F,Hernández-Sánchez C,de la Rosa EJ

更新日期：2018-11-26 00:00:00