Abstract:
:Parkinson's disease (PD) is a progressive CNS disorder that is primarily associated with impaired movement. PD develops over decades and is linked to the gradual loss of dopamine delivery to the striatum, via the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). While the administration of L-dopa and deep brain stimulation are potent therapies, their costs, side effects and gradual loss of efficacy underlines the need to develop other approaches. Unfortunately, the lack of pertinent animal models that reproduce DA neuron loss and behavior deficits-in a timeline that mimics PD progression-has hindered the identification of alternative therapies. A complementary approach to transgenic animals is the use of nonhuman primates (NHPs) combined with the overexpression of disease-related genes using viral vectors. This approach may induce phenotypes that are not influenced by developmental compensation mechanisms, and that take into account the personality of animals. In this review article, we discuss the combination of gene transfer and NHPs to develop "genetic" models of PD that are suitable for testing therapeutic approaches.
journal_name
Front Mol Neuroscijournal_title
Frontiers in molecular neuroscienceauthors
Lasbleiz C,Mestre-Francés N,Devau G,Luquin MR,Tenenbaum L,Kremer EJ,Verdier JMdoi
10.3389/fnmol.2019.00010subject
Has Abstractpub_date
2019-02-11 00:00:00pages
10issn
1662-5099journal_volume
12pub_type
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