Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids.

abstract：:Neuroimaging studies have demonstrated that irritable bowel syndrome (IBS)-a relapsing functional bowel disorder-presents with disrupted brain connections. However, little is known about the alterations of interhemispheric functional connectivity and underlying structural connectivity in IBS. This study combined resti...

journal_title：Frontiers in molecular neuroscience

authors： Qi R,Liu C,Weng Y,Xu Q,Chen L,Wang F,Zhang LJ,Lu GM

更新日期：2016-12-06 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that results from the loss of upper and lower motor neurons. One of the key pathological hallmarks in diseased neurons is the mislocalization of disease-associated proteins and the formation of cytoplasmic aggregates of these proteins and their intera...

journal_title：Frontiers in molecular neuroscience

authors： Ramesh N,Pandey UB

更新日期：2017-08-22 00:00:00

abstract：:Cryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of circadian rhythmicity. Moreover, CRYs are sensing magnetic fields in insects as well as in ...

journal_title：Frontiers in molecular neuroscience

authors： Schlichting M,Rieger D,Cusumano P,Grebler R,Costa R,Mazzotta GM,Helfrich-Förster C

更新日期：2018-07-18 00:00:00

abstract：:Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patients with TLE. However, whether KA activates KA receptors (KARs) as an a...

journal_title：Frontiers in molecular neuroscience

authors： Falcón-Moya R,Sihra TS,Rodríguez-Moreno A

更新日期：2018-06-22 00:00:00

abstract：:γ-Aminobutyric acid type A receptors (GABAARs) mediate the majority of fast synaptic inhibition in the central nervous system (CNS). GABAARs belong to the Cys-loop superfamily of pentameric ligand-gated ion channels (pLGIC) and are assembled from 19 different subunits. As dysfunctional GABAergic neurotransmission mani...

journal_title：Frontiers in molecular neuroscience

authors： Kasaragod VB,Schindelin H

更新日期：2019-08-07 00:00:00

abstract：:Stroke results in high morbidity and high mortality worldwide, with ischemic stroke accounting for 80% to 85%. As effective treatments for ischemic stroke remain limited because of the narrow therapeutic time window, a better understanding of the pathologic mechanism and new therapeutic intervention targets are needed...

journal_title：Frontiers in molecular neuroscience

authors： Chen R,Xu X,Huang L,Zhong W,Cui L

更新日期：2019-03-22 00:00:00

abstract：:The polycomb group proteins (PcGs) are a group of epigenetic factors associated with gene silencing. They are found in several families of multiprotein complexes, including polycomb repressive complex 2 (PRC2). EZH2, EED and SUZ12 form the core components of the PRC2 complex, which is responsible for the mono, di- and...

journal_title：Frontiers in molecular neuroscience

authors： Wever I,Wagemans CMRJ,Smidt MP

更新日期：2019-04-09 00:00:00

abstract：:Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or...

journal_title：Frontiers in molecular neuroscience

authors： Bartholome O,Van den Ackerveken P,Sánchez Gil J,de la Brassinne Bonardeaux O,Leprince P,Franzen R,Rogister B

更新日期：2017-05-22 00:00:00

abstract：:The low-density lipoprotein receptor-related protein 1, LRP1, interacts with APP and affects its processing. This is assumed to be mostly caused by the impact of LRP1 on APP endocytosis. More recently, also an interaction of APP and LRP1 early in the secretory pathway was reported whereat retention of LRP1 in the ER l...

journal_title：Frontiers in molecular neuroscience

authors： Herr UM,Strecker P,Storck SE,Thomas C,Rabiej V,Junker A,Schilling S,Schmidt N,Dowds CM,Eggert S,Pietrzik CU,Kins S

更新日期：2017-04-27 00:00:00

abstract：:Although second harmonic generation (SHG) microscopy provides unique imaging advantages for voltage imaging and other biological applications, genetically-encoded SHG chromophores remain relatively unexplored. SHG only arises from non-centrosymmetric media, so an anisotropic arrangement of chromophores is essential to...

journal_title：Frontiers in molecular neuroscience

authors： Jinno Y,Shoda K,Rial-Verde E,Yuste R,Miyawaki A,Tsutsui H

更新日期：2014-11-27 00:00:00

abstract：:The central, lateral and basolateral amygdala (BLA) nuclei are essential for the formation of long-term memories including emotional and drug-related memories. Studying cellular and molecular mechanisms of memory in amygdala may lead to better understanding of how memory is formed and of fear and addiction-related dis...

journal_title：Frontiers in molecular neuroscience

authors： Lamprecht R

更新日期：2016-03-31 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two major forms of synaptic plasticity that are widely accepted as cellular mechanisms involved in learning and memory. Metaplasticity is a process whereby modifications in synaptic processes shift the threshold for subsequent plasticity. While metaplasti...

journal_title：Frontiers in molecular neuroscience

authors： Zhong L,Gerges NZ

更新日期：2020-01-24 00:00:00

abstract：:Background: An imbalance between total training load and total recovery may cause overtraining (OT). The purpose of the present study was to verify the effects of OT on the expression of brain-derived neurotrophic factor (BDNF), its receptor tropomyosin receptor kinase B (TrkB) and p75 and the dynamic expression patte...

journal_title：Frontiers in molecular neuroscience

authors： Xu L,Zheng YL,Yin X,Xu SJ,Tian D,Zhang CY,Wang S,Ma JZ

更新日期：2020-01-30 00:00:00

abstract：:The tyrosine kinase Fyn plays an important role in synaptic plasticity, learning, and memory. Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum (DMS) of mice but not in the other substriatal regions, the dorsolate...

journal_title：Frontiers in molecular neuroscience

authors： Phamluong K,Darcq E,Wu S,Sakhai SA,Ron D

更新日期：2017-08-31 00:00:00

abstract：:GABA(A) receptors are located on the majority of neurons in the central and peripheral nervous system, where they mediate important actions of the neurotransmitter gamma-aminobutyric acid. Early in development the trophic properties of GABA allow a healthy development of the nervous system. Most neurons have a high in...

journal_title：Frontiers in molecular neuroscience

authors： Tretter V,Moss SJ

更新日期：2008-05-30 00:00:00

abstract：:Genetic studies have managed to explain many cases of familial amyotrophic lateral sclerosis (ALS) through mutations in several genes. However, the cause of a majority of sporadic cases remains unknown. Recently, epigenetics, especially miRNA studies, show some promising aspects. We aimed to evaluate the differential ...

journal_title：Frontiers in molecular neuroscience

authors： Vrabec K,Boštjančič E,Koritnik B,Leonardis L,Dolenc Grošelj L,Zidar J,Rogelj B,Glavač D,Ravnik-Glavač M

更新日期：2018-04-04 00:00:00

abstract：:Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis). One highly regulated cell-non-autonomous switch controls proteostatic capacity in Caenorhabditis elegans adulthood. Signals ...

journal_title：Frontiers in molecular neuroscience

authors： Shemesh N,Meshnik L,Shpigel N,Ben-Zvi A

更新日期：2017-08-09 00:00:00

abstract：:Mecp2 is a DNA methylation reader that plays a critical role in experience-dependent plasticity. Increasing evidence supports a role for epigenetic modifications in activity-induced gene expression. Hence, candidate genes related to such phenomena are of great interest. Ryanodine receptors are intracellular calcium ch...

journal_title：Frontiers in molecular neuroscience

authors： Torres RF,Hidalgo C,Kerr B

更新日期：2017-06-13 00:00:00

abstract：:Maternal cigarette smoke exposure (SE) causes detrimental changes associated with the development of chronic neurological diseases in the offspring as a result of oxidative mitochondrial damage. Maternal L-Carnitine administration has been shown to reduce renal oxidative stress in SE offspring, but its effect in the b...

journal_title：Frontiers in molecular neuroscience

authors： Chan YL,Saad S,Al-Odat I,Oliver BG,Pollock C,Jones NM,Chen H

更新日期：2017-02-13 00:00:00

abstract：:Age-progressive neurodegenerative pathologies, including Alzheimer's disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved in the etiology of neurological dis...

journal_title：Frontiers in molecular neuroscience

authors： Kakraba S,Ayyadevara S,Penthala NR,Balasubramaniam M,Ganne A,Liu L,Alla R,Bommagani SB,Barger SW,Griffin WST,Crooks PA,Shmookler Reis RJ

更新日期：2019-12-12 00:00:00

abstract：:Immune checkpoints restrain the immune system following its activation and their inhibition unleashes anti-tumor immune responses. Immune checkpoint inhibitors revolutionized the treatment of several cancer types, including melanoma, and immune checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies is becoming ...

journal_title：Frontiers in molecular neuroscience

authors： Lorger M,Andreou T,Fife C,James F

更新日期：2019-11-21 00:00:00

abstract：:Epilepsy, one of the most prevalent neurological conditions, presents as a complex disorder of network homeostasis characterized by spontaneous non-provoked seizures and associated comorbidities. Currently used antiepileptic drugs have been designed to suppress neuronal hyperexcitability and thereby to suppress epilep...

journal_title：Frontiers in molecular neuroscience

authors： Boison D

更新日期：2016-04-13 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as an important regulatory control in biological systems. Though the field of lncRNA has been progressing rapidly, a complete understanding of the role of lncRNAs in neuroblastoma pathogenesis is still lacking. To identify the abrogated lncRNAs in primary neuroblastoma and i...

journal_title：Frontiers in molecular neuroscience

authors： Prajapati B,Fatma M,Fatima M,Khan MT,Sinha S,Seth PK

更新日期：2019-12-12 00:00:00

abstract：:Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain. It has been found that a synergistic relationship between these two proteins may contribute to their roles in disease progression. However, how Aβ...

journal_title：Frontiers in molecular neuroscience

authors： Shin WS,Di J,Murray KA,Sun C,Li B,Bitan G,Jiang L

更新日期：2019-11-08 00:00:00

abstract：:Following axotomy, the activation of multiple intracellular signaling cascades causes the expression of a cocktail of regeneration-associated transcription factors which interact with each other to determine the fate of the injured neurons. The nerve injury response is channeled through manifold and parallel pathways,...

journal_title：Frontiers in molecular neuroscience

authors： Patodia S,Raivich G

更新日期：2012-02-10 00:00:00

abstract：:Microglial activation and the inflammatory response in the central nervous system (CNS) play important roles in secondary damage after traumatic brain injury (TBI). Transcriptional activation of genes that limit secondary damage to the CNS are mediated by a cis-acting element called the antioxidant responsive element ...

journal_title：Frontiers in molecular neuroscience

authors： Chen X,Wang H,Zhou M,Li X,Fang Z,Gao H,Li Y,Hu W

更新日期：2018-04-17 00:00:00

abstract：:Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Her...

journal_title：Frontiers in molecular neuroscience

authors： Huang C,Lu F,Li P,Cao C,Liu Z

更新日期：2017-06-28 00:00:00

abstract：:Non-invasive molecular imaging techniques can enhance diagnosis to achieve successful treatment, as well as reveal underlying pathogenic mechanisms in disorders such as multiple sclerosis (MS). The cooperation of advanced multimodal imaging techniques and increased knowledge of the MS disease mechanism allows both mon...

journal_title：Frontiers in molecular neuroscience

authors： Poutiainen P,Jaronen M,Quintana FJ,Brownell AL

更新日期：2016-09-15 00:00:00

abstract：:Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is a neurodegenerative disorder caused by loss-of-function mutations in the cystatin B (CSTB) gene. Progression of the clinical symptoms in EPM1 patients, including stimulus-sensitive myoclonus, tonic-clonic seizures, and ataxia, are well described. How...

journal_title：Frontiers in molecular neuroscience

authors： Gorski K,Spoljaric A,Nyman TA,Kaila K,Battersby BJ,Lehesjoki AE

更新日期：2020-11-13 00:00:00

abstract：:Although numerous studies have indicated that chronic stress causes cognitive dysfunction with the impairment of synaptic structures and functions, the relationship between cognitive deficits induced by repeated restraint stress and the level of NMDA receptors in the subregion of the hippocampus has been relatively un...

journal_title：Frontiers in molecular neuroscience

authors： Sun DS,Zhong G,Cao HX,Hu Y,Hong XY,Li T,Li X,Liu Q,Wang Q,Ke D,Liu GP,Ma RH,Luo DJ

更新日期：2020-10-19 00:00:00