Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes.

abstract：:The tyrosine kinase Fyn plays an important role in synaptic plasticity, learning, and memory. Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum (DMS) of mice but not in the other substriatal regions, the dorsolate...

journal_title：Frontiers in molecular neuroscience

authors： Phamluong K,Darcq E,Wu S,Sakhai SA,Ron D

更新日期：2017-08-31 00:00:00

abstract：:Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described...

journal_title：Frontiers in molecular neuroscience

authors： Ariazi J,Benowitz A,De Biasi V,Den Boer ML,Cherqui S,Cui H,Douillet N,Eugenin EA,Favre D,Goodman S,Gousset K,Hanein D,Israel DI,Kimura S,Kirkpatrick RB,Kuhn N,Jeong C,Lou E,Mailliard R,Maio S,Okafo G,Osswald M,

更新日期：2017-10-17 00:00:00

abstract：:Parkinson's disease (PD) is a progressive CNS disorder that is primarily associated with impaired movement. PD develops over decades and is linked to the gradual loss of dopamine delivery to the striatum, via the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). While the administration o...

journal_title：Frontiers in molecular neuroscience

authors： Lasbleiz C,Mestre-Francés N,Devau G,Luquin MR,Tenenbaum L,Kremer EJ,Verdier JM

更新日期：2019-02-11 00:00:00

abstract：:Age-progressive neurodegenerative pathologies, including Alzheimer's disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved in the etiology of neurological dis...

journal_title：Frontiers in molecular neuroscience

authors： Kakraba S,Ayyadevara S,Penthala NR,Balasubramaniam M,Ganne A,Liu L,Alla R,Bommagani SB,Barger SW,Griffin WST,Crooks PA,Shmookler Reis RJ

更新日期：2019-12-12 00:00:00

abstract：:Autism spectrum disorders (ASD) have a higher prevalence in male individuals compared to females, with a ratio of affected boys compared to girls of 4:1 for ASD and 11:1 for Asperger syndrome. Mutations in the SHANK genes (comprising SHANK1, SHANK2 and SHANK3) coding for postsynaptic scaffolding proteins have been tig...

journal_title：Frontiers in molecular neuroscience

authors： Berkel S,Eltokhi A,Fröhlich H,Porras-Gonzalez D,Rafiullah R,Sprengel R,Rappold GA

更新日期：2018-09-25 00:00:00

abstract：:Electroacupuncture (EA) could improve the hyperactivity of the hypothalamus pituitary adrenal (HPA) axis induced by hepatectomy. However, its underlying mechanism still remains largely unclear. Here, we found that hypothalamic corticotrophin releasing hormone (CRH) modulates the function of the HPA axis, while hepatec...

journal_title：Frontiers in molecular neuroscience

authors： Zhu J,Chen Z,Meng Z,Ju M,Zhang M,Wu G,Guo H,Tian Z

更新日期：2017-09-27 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two major forms of synaptic plasticity that are widely accepted as cellular mechanisms involved in learning and memory. Metaplasticity is a process whereby modifications in synaptic processes shift the threshold for subsequent plasticity. While metaplasti...

journal_title：Frontiers in molecular neuroscience

authors： Zhong L,Gerges NZ

更新日期：2020-01-24 00:00:00

abstract：:The balance between excitatory and inhibitory neurotransmitter systems is crucial for the modulation of neuronal excitability in the central nervous system (CNS). The activation of transient receptor potential vanilloid 4 (TRPV4) is reported to enhance the response of hippocampal glutamate receptors, but whether the i...

journal_title：Frontiers in molecular neuroscience

authors： Hong Z,Tian Y,Qi M,Li Y,Du Y,Chen L,Liu W,Chen L

更新日期：2016-08-26 00:00:00

abstract：:The constitutively active protein glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, acts paradoxically as a tumor suppressor in some cancers while potentiates growth in others. Deciphering what governs its actions is vital for understanding many pathological conditions, including brain cancer. What are see...

journal_title：Frontiers in molecular neuroscience

authors： Mills CN,Nowsheen S,Bonner JA,Yang ES

更新日期：2011-11-25 00:00:00

abstract：:Mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease (PD) and, as such, LRRK2 is considered a promising therapeutic target for age-related neurodegeneration. Although the cellular functions of LRRK2 in health and disease are incompletely understood, robust evidence indicates that P...

journal_title：Frontiers in molecular neuroscience

authors： Civiero L,Cogo S,Kiekens A,Morganti C,Tessari I,Lobbestael E,Baekelandt V,Taymans JM,Chartier-Harlin MC,Franchin C,Arrigoni G,Lewis PA,Piccoli G,Bubacco L,Cookson MR,Pinton P,Greggio E

更新日期：2017-12-14 00:00:00

abstract：:Aquatic vertebrates possess diverse types of sensory cells in their skin to detect stimuli in the water. In the adult zebrafish, a common model organism, the presence of such cells in fins has only rarely been studied. Here, we identified scattered serotonin (5-HT)-positive cells in the epidermis of the caudal fin. Th...

journal_title：Frontiers in molecular neuroscience

authors： König D,Dagenais P,Senk A,Djonov V,Aegerter CM,Jaźwińska A

更新日期：2019-09-19 00:00:00

abstract：:Collateral sprouting of surviving axons contributes to the synaptic reorganization after brain injury. To study this clinically relevant phenomenon, we used complex organotypic tissue cultures of mouse entorhinal cortex (EC) and hippocampus (H). Single EC-H cultures were generated to analyze associational sprouting, a...

journal_title：Frontiers in molecular neuroscience

authors： Del Turco D,Paul MH,Beeg Moreno VJ,Hildebrandt-Einfeldt L,Deller T

更新日期：2019-11-12 00:00:00

abstract：:Numerous animal studies have demonstrated that commonly used general anesthetics may result in cognitive impairment in the immature brain. The prevailing theory is that general anesthetics could induce developmental neurotoxicity via enhanced apoptosis. In addition, inhibited proliferation induced by anesthetics has a...

journal_title：Frontiers in molecular neuroscience

authors： Li X,Wu Z,Zhang Y,Xu Y,Han G,Zhao P

更新日期：2017-12-22 00:00:00

abstract：:Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis). One highly regulated cell-non-autonomous switch controls proteostatic capacity in Caenorhabditis elegans adulthood. Signals ...

journal_title：Frontiers in molecular neuroscience

authors： Shemesh N,Meshnik L,Shpigel N,Ben-Zvi A

更新日期：2017-08-09 00:00:00

abstract：:Glycine receptors (GlyRs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. Mutations in GLRA2 are associated with autism spectrum disorder, but the unde...

journal_title：Frontiers in molecular neuroscience

authors： Comhair J,Devoght J,Morelli G,Harvey RJ,Briz V,Borrie SC,Bagni C,Rigo JM,Schiffmann SN,Gall D,Brône B,Molchanova SM

更新日期：2018-10-15 00:00:00

abstract：:In the brain, metabolic supply and demand is directly coupled to neuronal activation. Methods for culturing primary rodent brain cells have come of age and are geared toward sophisticated modeling of human brain physiology and pathology. However, the impact of the culture microenvironment on neuronal function is rarel...

journal_title：Frontiers in molecular neuroscience

authors： Sünwoldt J,Bosche B,Meisel A,Mergenthaler P

更新日期：2017-09-29 00:00:00

abstract：:Hoxa5 is a member of the Hox gene family that plays critical roles in successive steps of the central nervous system formation during embryonic and fetal development. In the mouse, Hoxa5 was recently shown to be expressed in the medulla oblongata and the pons from fetal stages to adulthood. In these territories, Hoxa5...

journal_title：Frontiers in molecular neuroscience

authors： Lizen B,Moens C,Mouheiche J,Sacré T,Ahn MT,Jeannotte L,Salti A,Gofflot F

更新日期：2017-11-15 00:00:00

abstract：:In this review we provide an overview of key in vivo experiments undertaken in the cat spinal cord in the 1950s and 1960s, and point out their contributions to our present understanding of glycine receptor (GlyR) function. Importantly, some of these discoveries were made well before an inhibitory receptor, or its agon...

journal_title：Frontiers in molecular neuroscience

authors： Callister RJ,Graham BA

更新日期：2010-05-21 00:00:00

abstract：:Aim: Traumatic brain injury (TBI) is a leading cause of mortality/morbidity and is associated with chronic neuroinflammation. Melanocortin receptor agonists including adrenocorticotropic hormone (ACTH) ameliorate inflammation and provide a novel therapeutic approach. We examined the effect of long-acting cosyntropin (...

journal_title：Frontiers in molecular neuroscience

authors： Siebold L,Krueger AC,Abdala JA,Figueroa JD,Bartnik-Olson B,Holshouser B,Wilson CG,Ashwal S

更新日期：2020-06-26 00:00:00

abstract：:Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy. Unfortunately, current treatment strategies are limited and innovative new approaches are ...

journal_title：Frontiers in molecular neuroscience

authors： Fisher NM,Seto M,Lindsley CW,Niswender CM

更新日期：2018-10-23 00:00:00

abstract：:Unbiased "omics" techniques, such as next generation RNA-sequencing, can provide entirely novel insights into biological systems. However, cellular heterogeneity presents a significant barrier to analysis and interpretation of these datasets. The neurons of the dorsal root ganglia (DRG) are an important model for stud...

journal_title：Frontiers in molecular neuroscience

authors： Thakur M,Crow M,Richards N,Davey GI,Levine E,Kelleher JH,Agley CC,Denk F,Harridge SD,McMahon SB

更新日期：2014-11-11 00:00:00

abstract：:There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology. Previous studies indicate that Tmod1 and Tmod2 regulate morphology of the dendritic arbor and spines. Tmod3, which is expressed in the brain, had only a min...

journal_title：Frontiers in molecular neuroscience

authors： Gray KT,Stefen H,Ly TNA,Keller CJ,Colpan M,Wayman GA,Pate E,Fath T,Kostyukova AS

更新日期：2018-10-09 00:00:00

abstract：:Mercury is a toxic metal that can be found in the environment in three different forms - elemental, organic and inorganic. Inorganic mercury has a lower liposolubility, which results in a lower organism absorption and reduced passage through the blood-brain barrier. For this reason, exposure models that use inorganic ...

journal_title：Frontiers in molecular neuroscience

authors： Teixeira FB,de Oliveira ACA,Leão LKR,Fagundes NCF,Fernandes RM,Fernandes LMP,da Silva MCF,Amado LL,Sagica FES,de Oliveira EHC,Crespo-Lopez ME,Maia CSF,Lima RR

更新日期：2018-05-15 00:00:00

abstract：:The competitive ectodomain shedding of amyloid-β precursor protein (APP) by α-secretase and β-secretase, and the subsequent regulated intramembrane proteolysis by γ-secretase are the key processes in amyloid-β peptides (Aβ) generation. Previous studies indicate that secretases form binary complex and the interactions ...

journal_title：Frontiers in molecular neuroscience

authors： Wang X,Pei G

更新日期：2018-11-27 00:00:00

abstract：:Using a high resolution in situ hybridization technique we have measured PIEZO1, PIEZO2, and TRPV1 transcripts in mouse dorsal root ganglion (DRG) neurons. Consistent with previous studies, PIEZO2 transcripts were highly expressed in DRG neurons of all sizes, including most notably the largest diameter neurons implica...

journal_title：Frontiers in molecular neuroscience

authors： Wang J,La JH,Hamill OP

更新日期：2019-07-19 00:00:00

abstract：:The ubiquitous metabolic intermediary and nucleoside adenosine is a "master regulator" in all living systems. Under baseline conditions adenosine kinase (ADK) is the primary enzyme for the metabolic clearance of adenosine. By regulating the availability of adenosine, ADK is a critical upstream regulator of complex hom...

journal_title：Frontiers in molecular neuroscience

authors： Kiese K,Jablonski J,Boison D,Kobow K

更新日期：2016-10-20 00:00:00

abstract：:The bioactive lipid sphingosine-1-phosphate (S1P) is an important regulator in the nervous system. Here, we explored the role of S1P and its receptors in vitro and in preclinical models of peripheral nerve regeneration. Adult sensory neurons and motor neuron-like cells were exposed to S1P in an in vitro assay, and vir...

journal_title：Frontiers in molecular neuroscience

authors： Quarta S,Camprubí-Robles M,Schweigreiter R,Matusica D,Haberberger RV,Proia RL,Bandtlow CE,Ferrer-Montiel A,Kress M

更新日期：2017-10-10 00:00:00

abstract：:Stroke results in high morbidity and high mortality worldwide, with ischemic stroke accounting for 80% to 85%. As effective treatments for ischemic stroke remain limited because of the narrow therapeutic time window, a better understanding of the pathologic mechanism and new therapeutic intervention targets are needed...

journal_title：Frontiers in molecular neuroscience

authors： Chen R,Xu X,Huang L,Zhong W,Cui L

更新日期：2019-03-22 00:00:00

abstract：:The ventrolateral hypothalamic parvafox (formerly called PV1-Foxb1) nucleus is an anatomical entity of recent discovery and unknown function. With a view to gaining an insight into its putative functional role(s), we conducted a gene-microarray analysis and, armed with the forthcoming data, controlled the results with...

journal_title：Frontiers in molecular neuroscience

authors： Szabolcsi V,Albisetti GW,Celio MR

更新日期：2017-01-23 00:00:00

abstract：:Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) is a gatekeeper of mitochondrial quality control. The present study was aimed to examine whether PINK1 possesses a protective function against gentamicin (GM)-induced sensory hair cell (HC) damage in vitro. The formation of parkin particles (a mar...

journal_title：Frontiers in molecular neuroscience

authors： Yang Q,Zhou Y,Yin H,Li H,Zhou M,Sun G,Cao Z,Man R,Wang H,Li J

更新日期：2018-11-12 00:00:00