mRNA Transcriptomics of Galectins Unveils Heterogeneous Organization in Mouse and Human Brain.

abstract：:Many human neurodegenerative diseases are associated with amyloid fibril formation. Inhibition of amyloid formation is of importance for therapeutics of the related diseases. However, the development of selective potent amyloid inhibitors remains challenging. Here based on the structures of amyloid β (Aβ) fibrils and ...

journal_title：Frontiers in molecular neuroscience

authors： Lu J,Cao Q,Wang C,Zheng J,Luo F,Xie J,Li Y,Ma X,He L,Eisenberg D,Nowick J,Jiang L,Li D

更新日期：2019-03-04 00:00:00

abstract：:Atypical Parkinson syndromes (APSs) often have symptoms that overlap with those of Parkinson's disease (PD), especially early in the disease, making these disorders difficult to diagnose. Previous studies have demonstrated an association of oligomeric α-synuclein (α-Syn), a key element in the pathogenesis of PD, with ...

journal_title：Frontiers in molecular neuroscience

authors： Singh AP,Ramana G,Bajaj T,Singh V,Dwivedi S,Behari M,Dey AB,Dey S

更新日期：2019-06-12 00:00:00

abstract：:Spinal cord injury (SCI) can result in an irreversible disability due to loss of sensorimotor function below the lesion. Presently, clinical treatments for SCI mainly include surgery, drugs and postoperative rehabilitation. The prospective roles of bioscaffolds and exosomes in several neurological diseases have been r...

journal_title：Frontiers in molecular neuroscience

authors： Wang X,Botchway BOA,Zhang Y,Yuan J,Liu X

更新日期：2019-04-12 00:00:00

abstract：:Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis). One highly regulated cell-non-autonomous switch controls proteostatic capacity in Caenorhabditis elegans adulthood. Signals ...

journal_title：Frontiers in molecular neuroscience

authors： Shemesh N,Meshnik L,Shpigel N,Ben-Zvi A

更新日期：2017-08-09 00:00:00

abstract：:Collateral sprouting of surviving axons contributes to the synaptic reorganization after brain injury. To study this clinically relevant phenomenon, we used complex organotypic tissue cultures of mouse entorhinal cortex (EC) and hippocampus (H). Single EC-H cultures were generated to analyze associational sprouting, a...

journal_title：Frontiers in molecular neuroscience

authors： Del Turco D,Paul MH,Beeg Moreno VJ,Hildebrandt-Einfeldt L,Deller T

更新日期：2019-11-12 00:00:00

abstract：:The central, lateral and basolateral amygdala (BLA) nuclei are essential for the formation of long-term memories including emotional and drug-related memories. Studying cellular and molecular mechanisms of memory in amygdala may lead to better understanding of how memory is formed and of fear and addiction-related dis...

journal_title：Frontiers in molecular neuroscience

authors： Lamprecht R

更新日期：2016-03-31 00:00:00

abstract：:The dorsal root ganglion (DRG) contains heterogeneous populations of sensory neurons including primary nociceptive neurons and C-fibers implicated in pain signaling. Recent studies have demonstrated DRG hyperexcitability associated with downregulation of A-type K(+) channels; however, the molecular correlate of the co...

journal_title：Frontiers in molecular neuroscience

authors： Phuket TR,Covarrubias M

更新日期：2009-07-07 00:00:00

abstract：:Thiol groups can undergo numerous modifications, making cysteine a unique molecular switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione, contributing to maintain redox homeostasis and regulate signaling within and amongst cells. Not surprisingly therefore, cysteines are associated...

journal_title：Frontiers in molecular neuroscience

authors： Fra A,Yoboue ED,Sitia R

更新日期：2017-06-06 00:00:00

abstract：:Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory function is unclear due to conflicts in published results. To addres...

journal_title：Frontiers in molecular neuroscience

authors： Zorzi V,Paciello F,Ziraldo G,Peres C,Mazzarda F,Nardin C,Pasquini M,Chiani F,Raspa M,Scavizzi F,Carrer A,Crispino G,Ciubotaru CD,Monyer H,Fetoni AR,M Salvatore A,Mammano F

更新日期：2017-11-28 00:00:00

abstract：:Transient global cerebral ischemia (tGCI) causes excessive release of glutamate from neurons. Astrocytic glutamate transporter-1 (GLT-1) and glutamine synthetase (GS) together play a predominant role in maintaining glutamate at normal extracellular concentrations. Though our previous studies reported the alleviation o...

journal_title：Frontiers in molecular neuroscience

authors： Li K,Zhou H,Zhan L,Shi Z,Sun W,Liu D,Liu L,Liang D,Tan Y,Xu W,Xu E

更新日期：2018-10-01 00:00:00

abstract：:The bioactive lipid sphingosine-1-phosphate (S1P) is an important regulator in the nervous system. Here, we explored the role of S1P and its receptors in vitro and in preclinical models of peripheral nerve regeneration. Adult sensory neurons and motor neuron-like cells were exposed to S1P in an in vitro assay, and vir...

journal_title：Frontiers in molecular neuroscience

authors： Quarta S,Camprubí-Robles M,Schweigreiter R,Matusica D,Haberberger RV,Proia RL,Bandtlow CE,Ferrer-Montiel A,Kress M

更新日期：2017-10-10 00:00:00

abstract：:There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology. Previous studies indicate that Tmod1 and Tmod2 regulate morphology of the dendritic arbor and spines. Tmod3, which is expressed in the brain, had only a min...

journal_title：Frontiers in molecular neuroscience

authors： Gray KT,Stefen H,Ly TNA,Keller CJ,Colpan M,Wayman GA,Pate E,Fath T,Kostyukova AS

更新日期：2018-10-09 00:00:00

abstract：:Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, differentiation, oxidative stress, inflammation and apoptosis. Endocannabinoids (eCBs) and lys...

journal_title：Frontiers in molecular neuroscience

authors： González de San Román E,Manuel I,Ledent C,Chun J,Rodríguez de Fonseca F,Estivill-Torrús G,Santín LJ,Rodríguez Puertas R

更新日期：2019-09-19 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as an important regulatory control in biological systems. Though the field of lncRNA has been progressing rapidly, a complete understanding of the role of lncRNAs in neuroblastoma pathogenesis is still lacking. To identify the abrogated lncRNAs in primary neuroblastoma and i...

journal_title：Frontiers in molecular neuroscience

authors： Prajapati B,Fatma M,Fatima M,Khan MT,Sinha S,Seth PK

更新日期：2019-12-12 00:00:00

abstract：:Although numerous studies have indicated that chronic stress causes cognitive dysfunction with the impairment of synaptic structures and functions, the relationship between cognitive deficits induced by repeated restraint stress and the level of NMDA receptors in the subregion of the hippocampus has been relatively un...

journal_title：Frontiers in molecular neuroscience

authors： Sun DS,Zhong G,Cao HX,Hu Y,Hong XY,Li T,Li X,Liu Q,Wang Q,Ke D,Liu GP,Ma RH,Luo DJ

更新日期：2020-10-19 00:00:00

abstract：:Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is a neurodegenerative disorder caused by loss-of-function mutations in the cystatin B (CSTB) gene. Progression of the clinical symptoms in EPM1 patients, including stimulus-sensitive myoclonus, tonic-clonic seizures, and ataxia, are well described. How...

journal_title：Frontiers in molecular neuroscience

authors： Gorski K,Spoljaric A,Nyman TA,Kaila K,Battersby BJ,Lehesjoki AE

更新日期：2020-11-13 00:00:00

abstract：:Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS). GLT-1 dysregulation occurs in various neurological diseases including Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's disease ...

journal_title：Frontiers in molecular neuroscience

authors： Peterson AR,Binder DK

更新日期：2019-07-09 00:00:00

abstract：:In recent years, signaling through ubiquitin has been shown to be of great importance for normal brain development. Indeed, fluctuations in ubiquitin levels and spontaneous mutations in (de)ubiquitination enzymes greatly perturb synapse formation and neuronal transmission. In the brain, expression of lysine (K) 48-lin...

journal_title：Frontiers in molecular neuroscience

authors： Pinto MJ,Pedro JR,Costa RO,Almeida RD

更新日期：2016-06-10 00:00:00

abstract：:The role of ion channels in neurons and muscles has been well characterized. However, recent work has demonstrated both the presence and necessity of ion channels in diverse cell types for morphological development. For example, mutations that disrupt ion channels give rise to abnormal structural development in specie...

journal_title：Frontiers in molecular neuroscience

authors： Ozekin YH,Isner T,Bates EA

更新日期：2020-06-09 00:00:00

abstract：:Human achaete-scute homolog-1 (hASH1), encoded by the human ASCL1 gene, belongs to the family of basic helix-loop-helix transcription factors. hASH1 and its mammalian homolog Mash1 are expressed in the central and peripheral nervous system during development, and promote early neuronal differentiation. Furthermore, hA...

journal_title：Frontiers in molecular neuroscience

authors： Benko E,Winkelmann A,Meier JC,Persson PB,Scholz H,Fähling M

更新日期：2011-02-07 00:00:00

abstract：:Genetic studies have managed to explain many cases of familial amyotrophic lateral sclerosis (ALS) through mutations in several genes. However, the cause of a majority of sporadic cases remains unknown. Recently, epigenetics, especially miRNA studies, show some promising aspects. We aimed to evaluate the differential ...

journal_title：Frontiers in molecular neuroscience

authors： Vrabec K,Boštjančič E,Koritnik B,Leonardis L,Dolenc Grošelj L,Zidar J,Rogelj B,Glavač D,Ravnik-Glavač M

更新日期：2018-04-04 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) complex plays important roles in virtually all cells of the body. The enzymatic activity of PI3K to phosphorylate phosphoinositides in the membrane is mediated by a group of catalytic and regulatory subunits. Among those, the class I catalytic subunits, p110α, p110β, p110γ, and p11...

journal_title：Frontiers in molecular neuroscience

authors： Gross C,Bassell GJ

更新日期：2014-02-13 00:00:00

abstract：:Emerging studies have demonstrated that interleukin (IL)-33 and its receptor ST2 act as key factors in inflammatory diseases. Moreover, accumulating evidence has suggested that cytokines, including tumor necrosis factor (TNF)-α and IL-1β, trigger an inflammatory cascade. SIRT1 has been shown to suppress the expression...

journal_title：Frontiers in molecular neuroscience

authors： Zeng Y,Shi Y,Zhan H,Liu W,Cai G,Zhong H,Wang Y,Chen S,Huang S,Wu W

更新日期：2020-02-12 00:00:00

abstract：:M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In the present study, we demonstrate that suppression of M/Kv7 channe...

journal_title：Frontiers in molecular neuroscience

authors： Zhang D,Men H,Zhang L,Gao X,Wang J,Li L,Zhu Q,Zhang H,Jia Z

更新日期：2020-06-30 00:00:00

abstract：:It is widely accepted that glutamate is the most important excitatory neurotransmitter in the central nervous system (CNS). However, there is also a large amount of glutamate in the blood. Generally, the concentration gradient of glutamate between intraparenchymal and blood environments is stable. However, this gradie...

journal_title：Frontiers in molecular neuroscience

authors： Bai W,Zhou YG

更新日期：2017-12-05 00:00:00

abstract：:Dysfunctions in hearing and balance are largely connected with hair cell (HC) loss. Although regeneration of HCs in the adult cochlea does not occur, there is still limited capacity for HC regeneration in the mammalian utricle from a distinct population of supporting cells (SCs). In response to HC damage, these Lgr5+ ...

journal_title：Frontiers in molecular neuroscience

authors： You D,Guo L,Li W,Sun S,Chen Y,Chai R,Li H

更新日期：2018-04-30 00:00:00

abstract：:Glycine receptors (GlyRs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. Mutations in GLRA2 are associated with autism spectrum disorder, but the unde...

journal_title：Frontiers in molecular neuroscience

authors： Comhair J,Devoght J,Morelli G,Harvey RJ,Briz V,Borrie SC,Bagni C,Rigo JM,Schiffmann SN,Gall D,Brône B,Molchanova SM

更新日期：2018-10-15 00:00:00

abstract：:Microglial activation and the inflammatory response in the central nervous system (CNS) play important roles in secondary damage after traumatic brain injury (TBI). Transcriptional activation of genes that limit secondary damage to the CNS are mediated by a cis-acting element called the antioxidant responsive element ...

journal_title：Frontiers in molecular neuroscience

authors： Chen X,Wang H,Zhou M,Li X,Fang Z,Gao H,Li Y,Hu W

更新日期：2018-04-17 00:00:00

abstract：:The basic helix-loop-helix (bHLH) protein family has previously been shown to be involved in the development of mesodiencephalic dopaminergic (mdDA) neurons in the murine midbrain. Specifically, Ngn2 and Mash1 are known to have a role in the specification of neural progenitors in the ventricular zone (VZ) of the midbr...

journal_title：Frontiers in molecular neuroscience

authors： Mesman S,Smidt MP

更新日期：2017-11-01 00:00:00

abstract：:Spinal cord injury (SCI) causes the death of neurons and glial cells due to the initial mechanical forces (i.e., primary injury) and through a cascade of secondary molecular events (e.g., inflammation or excitotoxicity) that exacerbate cell death. The loss of neurons and glial cells that are not replaced after the inj...

journal_title：Frontiers in molecular neuroscience

authors： Sobrido-Cameán D,Barreiro-Iglesias A

更新日期：2018-04-03 00:00:00