Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle.

abstract：:The central, lateral and basolateral amygdala (BLA) nuclei are essential for the formation of long-term memories including emotional and drug-related memories. Studying cellular and molecular mechanisms of memory in amygdala may lead to better understanding of how memory is formed and of fear and addiction-related dis...

journal_title：Frontiers in molecular neuroscience

authors： Lamprecht R

更新日期：2016-03-31 00:00:00

abstract：:The basic helix-loop-helix (bHLH) protein family has previously been shown to be involved in the development of mesodiencephalic dopaminergic (mdDA) neurons in the murine midbrain. Specifically, Ngn2 and Mash1 are known to have a role in the specification of neural progenitors in the ventricular zone (VZ) of the midbr...

journal_title：Frontiers in molecular neuroscience

authors： Mesman S,Smidt MP

更新日期：2017-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are key post transcriptional regulators of their multiple target genes. However, the detailed profile of miRNA expression in Parkinson's disease, the second most common neurodegenerative disease worldwide and the first motor disorder has not been charted yet. Here, we report comprehensive miRNA prof...

journal_title：Frontiers in molecular neuroscience

authors： Soreq L,Salomonis N,Bronstein M,Greenberg DS,Israel Z,Bergman H,Soreq H

更新日期：2013-05-13 00:00:00

abstract：:Aim: Traumatic brain injury (TBI) is a leading cause of mortality/morbidity and is associated with chronic neuroinflammation. Melanocortin receptor agonists including adrenocorticotropic hormone (ACTH) ameliorate inflammation and provide a novel therapeutic approach. We examined the effect of long-acting cosyntropin (...

journal_title：Frontiers in molecular neuroscience

authors： Siebold L,Krueger AC,Abdala JA,Figueroa JD,Bartnik-Olson B,Holshouser B,Wilson CG,Ashwal S

更新日期：2020-06-26 00:00:00

abstract：:Although second harmonic generation (SHG) microscopy provides unique imaging advantages for voltage imaging and other biological applications, genetically-encoded SHG chromophores remain relatively unexplored. SHG only arises from non-centrosymmetric media, so an anisotropic arrangement of chromophores is essential to...

journal_title：Frontiers in molecular neuroscience

authors： Jinno Y,Shoda K,Rial-Verde E,Yuste R,Miyawaki A,Tsutsui H

更新日期：2014-11-27 00:00:00

abstract：:There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology. Previous studies indicate that Tmod1 and Tmod2 regulate morphology of the dendritic arbor and spines. Tmod3, which is expressed in the brain, had only a min...

journal_title：Frontiers in molecular neuroscience

authors： Gray KT,Stefen H,Ly TNA,Keller CJ,Colpan M,Wayman GA,Pate E,Fath T,Kostyukova AS

更新日期：2018-10-09 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive disease with early degeneration of the central cholinergic neurons. Currently, three of four AD drugs act by inhibiting the acetylcholine (ACh) degrading enzyme, acetylcholinesterase (AChE). Efficacy of these drugs depends on available amount of ACh, which is biosynthesized by...

journal_title：Frontiers in molecular neuroscience

authors： Karami A,Eriksdotter M,Kadir A,Almkvist O,Nordberg A,Darreh-Shori T

更新日期：2019-10-11 00:00:00

abstract：:Maternal cigarette smoke exposure (SE) causes detrimental changes associated with the development of chronic neurological diseases in the offspring as a result of oxidative mitochondrial damage. Maternal L-Carnitine administration has been shown to reduce renal oxidative stress in SE offspring, but its effect in the b...

journal_title：Frontiers in molecular neuroscience

authors： Chan YL,Saad S,Al-Odat I,Oliver BG,Pollock C,Jones NM,Chen H

更新日期：2017-02-13 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two major forms of synaptic plasticity that are widely accepted as cellular mechanisms involved in learning and memory. Metaplasticity is a process whereby modifications in synaptic processes shift the threshold for subsequent plasticity. While metaplasti...

journal_title：Frontiers in molecular neuroscience

authors： Zhong L,Gerges NZ

更新日期：2020-01-24 00:00:00

abstract：:Membrane bound guanylate cyclases are expressed in rod and cone cells of the vertebrate retina and mutations in several domains of rod outer segment guanylate cyclase 1 (ROS-GC1 encoded by the gene GUCY2D) correlate with different forms of retinal degenerations. In the present work we investigated the biochemical cons...

journal_title：Frontiers in molecular neuroscience

authors： Zägel P,Koch KW

更新日期：2014-02-26 00:00:00

abstract：:The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) are major excitatory receptors that mediate fast neurotransmission in the mammalian brain. The surface expression of functional AMPARs is crucial for synaptic transmission and plasticity. AMPAR auxiliary subunits control ...

journal_title：Frontiers in molecular neuroscience

authors： Wei M,Jia M,Zhang J,Yu L,Zhao Y,Chen Y,Ma Y,Zhang W,Shi YS,Zhang C

更新日期：2017-03-02 00:00:00

abstract：:It has been 200 years since Parkinson's disease (PD) was first described, yet many aspects of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative disorder caused by genetic and environmental factors including aging, nutrition, pesticides and exposure to heavy metals. DNA methylation ...

journal_title：Frontiers in molecular neuroscience

authors： Miranda-Morales E,Meier K,Sandoval-Carrillo A,Salas-Pacheco J,Vázquez-Cárdenas P,Arias-Carrión O

更新日期：2017-07-18 00:00:00

abstract：:Neuronal gap junctions formed by connexin36 (Cx36) and chemical synapses share striking similarities in terms of plasticity. Ca2+/calmodulin-dependent protein kinase II (CaMKII), an enzyme known to induce memory formation at chemical synapses, has recently been described to potentiate electrical coupling in the retina...

journal_title：Frontiers in molecular neuroscience

authors： Tetenborg S,Yadav SC,Brüggen B,Zoidl GR,Hormuzdi SG,Monyer H,van Woerden GM,Janssen-Bienhold U,Dedek K

更新日期：2019-08-28 00:00:00

abstract：:Some therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons through neurotrophin signaling. The wide range of cross-interactions between Trk receptors and neurot...

journal_title：Frontiers in molecular neuroscience

authors： Haddad Y,Adam V,Heger Z

更新日期：2017-05-03 00:00:00

abstract：:Ion channels are expressed throughout nervous system development. The type and diversity of conductances and gating mechanisms vary at different developmental stages and with the progressive maturational status of neural cells. The variety of ion channels allows for distinct signaling mechanisms in developing neural c...

journal_title：Frontiers in molecular neuroscience

authors： Goyal R,Spencer KA,Borodinsky LN

更新日期：2020-04-24 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are nuclear hormone receptors that act as transcription factors in response to endogenous lipid messengers. The fibrates and thiazolidinediones are synthetic PPAR agonists used clinically to treat dyslipidemia and Type 2 Diabetes Mellitus, respectively, but also impr...

journal_title：Frontiers in molecular neuroscience

authors： Ferguson LB,Zhang L,Wang S,Bridges C,Harris RA,Ponomarev I

更新日期：2018-09-19 00:00:00

abstract：:Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Her...

journal_title：Frontiers in molecular neuroscience

authors： Huang C,Lu F,Li P,Cao C,Liu Z

更新日期：2017-06-28 00:00:00

abstract：:Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is a neurodegenerative disorder caused by loss-of-function mutations in the cystatin B (CSTB) gene. Progression of the clinical symptoms in EPM1 patients, including stimulus-sensitive myoclonus, tonic-clonic seizures, and ataxia, are well described. How...

journal_title：Frontiers in molecular neuroscience

authors： Gorski K,Spoljaric A,Nyman TA,Kaila K,Battersby BJ,Lehesjoki AE

更新日期：2020-11-13 00:00:00

abstract：:Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied in the field of endocrinology, the bioactivity of the proinsulin ...

journal_title：Frontiers in molecular neuroscience

authors： de Pablo F,Hernández-Sánchez C,de la Rosa EJ

更新日期：2018-11-26 00:00:00

abstract：:Microglia plays a critical role in neuroinflammation after ischemic stroke by releasing diverse inflammatory cytokines. Long non-coding RNA taurine up-regulated gene 1 (lncRNA TUG1) is widely expressed in adult brain and has been reported to participate in multiple biological processes associated with nervous system d...

journal_title：Frontiers in molecular neuroscience

authors： Wang H,Liao S,Li H,Chen Y,Yu J

更新日期：2019-09-10 00:00:00

abstract：:The anterior cingulate cortex (ACC) is an important brain area for the regulation of neuropathic pain. The α2A adrenoceptor is a good target for pain management. However, the role of cingulate α2A adrenoceptors in the regulation of neuropathic pain has been less studied. In this study, we investigated the involvement ...

journal_title：Frontiers in molecular neuroscience

authors： Wang YJ,Zuo ZX,Wu C,Liu L,Feng ZH,Li XY

更新日期：2017-09-12 00:00:00

abstract：:Cell signaling in response to an array of diverse stress stimuli converges on the phosphorylation of eukaryotic initiation factor-2α (eIF2α). Evidence is accumulating that persistent eIF2α phosphorylation at Ser51 through prolonged overactivation of regulatory kinases occurs in neurodegenerative diseases such as Alzhe...

journal_title：Frontiers in molecular neuroscience

authors： Ohno M

更新日期：2014-04-16 00:00:00

abstract：:The competitive ectodomain shedding of amyloid-β precursor protein (APP) by α-secretase and β-secretase, and the subsequent regulated intramembrane proteolysis by γ-secretase are the key processes in amyloid-β peptides (Aβ) generation. Previous studies indicate that secretases form binary complex and the interactions ...

journal_title：Frontiers in molecular neuroscience

authors： Wang X,Pei G

更新日期：2018-11-27 00:00:00

abstract：:Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, differentiation, oxidative stress, inflammation and apoptosis. Endocannabinoids (eCBs) and lys...

journal_title：Frontiers in molecular neuroscience

authors： González de San Román E,Manuel I,Ledent C,Chun J,Rodríguez de Fonseca F,Estivill-Torrús G,Santín LJ,Rodríguez Puertas R

更新日期：2019-09-19 00:00:00

abstract：:Lithium has long been used for the treatment of psychiatric disorders, due to its robust beneficial effect as a mood stabilizing drug. Lithium's effectiveness for improving neurological function is therefore well-described, stimulating the investigation of its potential use in several neurodegenerative conditions incl...

journal_title：Frontiers in molecular neuroscience

authors： Kerr F,Bjedov I,Sofola-Adesakin O

更新日期：2018-08-28 00:00:00

abstract：:Neuronal identity is generated by the cell-surface expression of clustered protocadherin (Pcdh) isoforms. In mice, 58 isoforms from three gene clusters, Pcdhα, Pcdhβ, and Pcdhγ, are differentially expressed in neurons. Since cis-heteromeric Pcdh oligomers on the cell surface interact homophilically with that in other ...

journal_title：Frontiers in molecular neuroscience

authors： Hasegawa S,Kobayashi H,Kumagai M,Nishimaru H,Tarusawa E,Kanda H,Sanbo M,Yoshimura Y,Hirabayashi M,Hirabayashi T,Yagi T

更新日期：2017-04-24 00:00:00

abstract：:Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain. It has been found that a synergistic relationship between these two proteins may contribute to their roles in disease progression. However, how Aβ...

journal_title：Frontiers in molecular neuroscience

authors： Shin WS,Di J,Murray KA,Sun C,Li B,Bitan G,Jiang L

更新日期：2019-11-08 00:00:00

abstract：:GABAergic inhibitory neurotransmission contributes to diverse aspects of brain development and adult plasticity, including the expression of complex cognitive processes. This is afforded for in part by the dynamic adaptations occurring at inhibitory synapses, which show great heterogeneity both in terms of upstream si...

journal_title：Frontiers in molecular neuroscience

authors： Campbell BFN,Tyagarajan SK

更新日期：2019-08-13 00:00:00

abstract：:The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer's disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain. AQP4 polarity can be influenced by the ratio of two AQP4 isoforms M1 and M23 (AQP4-M1/M23), however, it is unknown whether the ra...

journal_title：Frontiers in molecular neuroscience

authors： Zhang J,Zhan Z,Li X,Xing A,Jiang C,Chen Y,Shi W,An L

更新日期：2017-11-29 00:00:00

abstract：:The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale. These disorders are heterogeneous, yet they share common behavioral symptomatology as well as o...

journal_title：Frontiers in molecular neuroscience

authors： Ali Rodriguez R,Joya C,Hines RM

更新日期：2018-04-24 00:00:00