Trk Receptors and Neurotrophin Cross-Interactions: New Perspectives Toward Manipulating Therapeutic Side-Effects.

abstract：:Alzheimer's disease (AD) is the most common type of senile dementia, characterized by neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were devoted to the interference with the production and accumulation of amyloid-β peptide (Aβ), which plays a causal role in the pathogenesis of ...

journal_title：Frontiers in molecular neuroscience

authors： Zhao J,Liu X,Xia W,Zhang Y,Wang C

更新日期：2020-08-04 00:00:00

abstract：:Aging cognitive decline has been associated to impairment of the Hypothalamus Pituitary Adrenals (HPA) axis activity and a higher level of the systemic inflammation. However, little is known about the molecules driving this process at peripheral level. In addition, the cognitive function is to some extent modifiable w...

journal_title：Frontiers in molecular neuroscience

authors： Pesce M,Tatangelo R,La Fratta I,Rizzuto A,Campagna G,Turli C,Ferrone A,Franceschelli S,Speranza L,Verrocchio MC,De Lutiis MA,Felaco M,Grilli A

更新日期：2017-07-24 00:00:00

abstract：:MiRNAs are key regulators of the mammalian transcriptome that have been increasingly linked to degenerative diseases of the motor neurons. Although many of the miRNAs currently incriminated as participants in the pathogenesis of these diseases are also important to the normal development and function of motor neurons,...

journal_title：Frontiers in molecular neuroscience

authors： Hawley ZCE,Campos-Melo D,Droppelmann CA,Strong MJ

更新日期：2017-05-04 00:00:00

abstract：:Unlike a number of amyloid-forming proteins, stefins, and in particular stefin B (cystatin B) form amyloids under conditions where the native state predominates. In order to trigger oligomerization processes, the stability of the protein needs to be compromised, favoring structural re-arrangement however, accelerating...

journal_title：Frontiers in molecular neuroscience

authors： Paramore R,Morgan GJ,Davis PJ,Sharma CA,Hounslow A,Taler-Verčič A,Zerovnik E,Waltho JP,Cliff MJ,Staniforth RA

更新日期：2012-10-12 00:00:00

abstract：:Transient global cerebral ischemia (tGCI) causes excessive release of glutamate from neurons. Astrocytic glutamate transporter-1 (GLT-1) and glutamine synthetase (GS) together play a predominant role in maintaining glutamate at normal extracellular concentrations. Though our previous studies reported the alleviation o...

journal_title：Frontiers in molecular neuroscience

authors： Li K,Zhou H,Zhan L,Shi Z,Sun W,Liu D,Liu L,Liang D,Tan Y,Xu W,Xu E

更新日期：2018-10-01 00:00:00

abstract：:Age-progressive neurodegenerative pathologies, including Alzheimer's disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved in the etiology of neurological dis...

journal_title：Frontiers in molecular neuroscience

authors： Kakraba S,Ayyadevara S,Penthala NR,Balasubramaniam M,Ganne A,Liu L,Alla R,Bommagani SB,Barger SW,Griffin WST,Crooks PA,Shmookler Reis RJ

更新日期：2019-12-12 00:00:00

abstract：:Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis. Impaired KCC2 function accelerates or facilitates seizure onset. Calpain, with two main subtypes of m- and μ-calpai...

journal_title：Frontiers in molecular neuroscience

authors： Wan L,Ren L,Chen L,Wang G,Liu X,Wang BH,Wang Y

更新日期：2018-08-21 00:00:00

abstract：:Neuronal calcium sensor-1 (NCS-1) protein is abundantly expressed in the central nervous system and retinal neurons, where it regulates many vital processes such as synaptic transmission. It coordinates three calcium ions by EF-hands 2-4, thereby transducing Ca2+ signals to a wide range of protein targets, including G...

journal_title：Frontiers in molecular neuroscience

authors： Tsvetkov PO,Roman AY,Baksheeva VE,Nazipova AA,Shevelyova MP,Vladimirov VI,Buyanova MF,Zinchenko DV,Zamyatnin AA Jr,Devred F,Golovin AV,Permyakov SE,Zernii EY

更新日期：2018-12-14 00:00:00

abstract：:The polycomb group proteins (PcGs) are a group of epigenetic factors associated with gene silencing. They are found in several families of multiprotein complexes, including polycomb repressive complex 2 (PRC2). EZH2, EED and SUZ12 form the core components of the PRC2 complex, which is responsible for the mono, di- and...

journal_title：Frontiers in molecular neuroscience

authors： Wever I,Wagemans CMRJ,Smidt MP

更新日期：2019-04-09 00:00:00

abstract：:Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. However, the mechanistic aspects and properties of cannabis remain remarkably poorly characterized. In this study we aimed to investigate the immune-cell modulatory pr...

journal_title：Frontiers in molecular neuroscience

authors： Utomo WK,de Vries M,Braat H,Bruno MJ,Parikh K,Comalada M,Peppelenbosch MP,van Goor H,Fuhler GM

更新日期：2017-01-24 00:00:00

abstract：:Background: An imbalance between total training load and total recovery may cause overtraining (OT). The purpose of the present study was to verify the effects of OT on the expression of brain-derived neurotrophic factor (BDNF), its receptor tropomyosin receptor kinase B (TrkB) and p75 and the dynamic expression patte...

journal_title：Frontiers in molecular neuroscience

authors： Xu L,Zheng YL,Yin X,Xu SJ,Tian D,Zhang CY,Wang S,Ma JZ

更新日期：2020-01-30 00:00:00

abstract：:The tyrosine kinase Fyn plays an important role in synaptic plasticity, learning, and memory. Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum (DMS) of mice but not in the other substriatal regions, the dorsolate...

journal_title：Frontiers in molecular neuroscience

authors： Phamluong K,Darcq E,Wu S,Sakhai SA,Ron D

更新日期：2017-08-31 00:00:00

abstract：:Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) is a gatekeeper of mitochondrial quality control. The present study was aimed to examine whether PINK1 possesses a protective function against gentamicin (GM)-induced sensory hair cell (HC) damage in vitro. The formation of parkin particles (a mar...

journal_title：Frontiers in molecular neuroscience

authors： Yang Q,Zhou Y,Yin H,Li H,Zhou M,Sun G,Cao Z,Man R,Wang H,Li J

更新日期：2018-11-12 00:00:00

abstract：:Autism spectrum disorders (ASD) have a higher prevalence in male individuals compared to females, with a ratio of affected boys compared to girls of 4:1 for ASD and 11:1 for Asperger syndrome. Mutations in the SHANK genes (comprising SHANK1, SHANK2 and SHANK3) coding for postsynaptic scaffolding proteins have been tig...

journal_title：Frontiers in molecular neuroscience

authors： Berkel S,Eltokhi A,Fröhlich H,Porras-Gonzalez D,Rafiullah R,Sprengel R,Rappold GA

更新日期：2018-09-25 00:00:00

abstract：:Sex-determining region Y box 2 (Sox2), expressed in neural tissues, plays an important role as a transcription factor not only in the pluripotency and proliferation of neuronal cells but also in the opposite function of cell differentiation. Nevertheless, how Sox2 is linked to motor neuron development remains unknown....

journal_title：Frontiers in molecular neuroscience

authors： Gong J,Hu S,Huang Z,Hu Y,Wang X,Zhao J,Qian P,Wang C,Sheng J,Lu X,Wei G,Liu D

更新日期：2020-03-27 00:00:00

abstract：:Corticotropin releasing factor (CRF) has been shown to induce various behavioral changes related to adaptation to stress. Dysregulation of the CRF system at any point can lead to a variety of psychiatric disorders, including substance use disorders (SUDs). CRF has been associated with stress-induced drug reinforcement...

journal_title：Frontiers in molecular neuroscience

authors： Haass-Koffler CL,Bartlett SE

更新日期：2012-09-06 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are nuclear hormone receptors that act as transcription factors in response to endogenous lipid messengers. The fibrates and thiazolidinediones are synthetic PPAR agonists used clinically to treat dyslipidemia and Type 2 Diabetes Mellitus, respectively, but also impr...

journal_title：Frontiers in molecular neuroscience

authors： Ferguson LB,Zhang L,Wang S,Bridges C,Harris RA,Ponomarev I

更新日期：2018-09-19 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and is characterized by the buildup of β-amyloid plaques and neurofibrillary Tau tangles. This leads to decreased synaptic efficacy, cell death, and, consequently, brain atrophy in patients. Behaviorally, this manifests as memory loss and confusion. Using a...

journal_title：Frontiers in molecular neuroscience

authors： Greene AN,Parks LG,Solomon MB,Privette Vinnedge LM

更新日期：2020-11-16 00:00:00

abstract：:The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical foldi...

journal_title：Frontiers in molecular neuroscience

authors： Venø MT,Venø ST,Rehberg K,van Asperen JV,Clausen BH,Holm IE,Pasterkamp RJ,Finsen B,Kjems J

更新日期：2017-02-09 00:00:00

abstract：:The brain contains an enormous, but finite, number of neurons. The ability of this limited number of neurons to produce nearly limitless neural information over a lifetime is typically explained by combinatorial explosion; that is, by the exponential amplification of each neuron's contribution through its incorporatio...

journal_title：Frontiers in molecular neuroscience

authors： Yagi T

更新日期：2012-04-12 00:00:00

abstract：:Neuronal gap junctions formed by connexin36 (Cx36) and chemical synapses share striking similarities in terms of plasticity. Ca2+/calmodulin-dependent protein kinase II (CaMKII), an enzyme known to induce memory formation at chemical synapses, has recently been described to potentiate electrical coupling in the retina...

journal_title：Frontiers in molecular neuroscience

authors： Tetenborg S,Yadav SC,Brüggen B,Zoidl GR,Hormuzdi SG,Monyer H,van Woerden GM,Janssen-Bienhold U,Dedek K

更新日期：2019-08-28 00:00:00

abstract：:Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory function is unclear due to conflicts in published results. To addres...

journal_title：Frontiers in molecular neuroscience

authors： Zorzi V,Paciello F,Ziraldo G,Peres C,Mazzarda F,Nardin C,Pasquini M,Chiani F,Raspa M,Scavizzi F,Carrer A,Crispino G,Ciubotaru CD,Monyer H,Fetoni AR,M Salvatore A,Mammano F

更新日期：2017-11-28 00:00:00

abstract：:Control of proper protein synthesis, function, and turnover is essential for the health of all cells. In neurons these demands take on the additional importance of supporting and regulating the highly dynamic connections between neurons that are necessary for cognitive function, learning, and memory. Regulating multip...

journal_title：Frontiers in molecular neuroscience

authors： Atkin G,Paulson H

更新日期：2014-07-08 00:00:00

abstract：:Neuroendocrine cells store and secrete bulk amounts of neuropeptides, and display morphological and molecular characteristics distinct from neurons signaling with classical neurotransmitters. In Drosophila the transcription factor Dimmed (Dimm), is a prime organizer of neuroendocrine capacity in a majority of the pept...

journal_title：Frontiers in molecular neuroscience

authors： Luo J,Liu Y,Nässel DR

更新日期：2017-08-14 00:00:00

abstract：:Following axotomy, the activation of multiple intracellular signaling cascades causes the expression of a cocktail of regeneration-associated transcription factors which interact with each other to determine the fate of the injured neurons. The nerve injury response is channeled through manifold and parallel pathways,...

journal_title：Frontiers in molecular neuroscience

authors： Patodia S,Raivich G

更新日期：2012-02-10 00:00:00

abstract：:Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating neuromuscular disease caused by mutations in the LAMA2 gene. These mutations result in the complete absence or truncated expression of the laminin-α2 chain. The α2-chain is a major component of the laminin-211 and laminin-221 isoforms, the p...

journal_title：Frontiers in molecular neuroscience

authors： Barraza-Flores P,Bates CR,Oliveira-Santos A,Burkin DJ

更新日期：2020-02-11 00:00:00

abstract：:A fundamental characteristic of neurons is the relationship between the architecture of the polarized neuron and synaptic transmission between neurons. Intracellular membrane trafficking is paramount to establish and maintain neuronal structure; perturbation in trafficking results in defects in neurodevelopment and ne...

journal_title：Frontiers in molecular neuroscience

authors： Wang J,Fourriere L,Gleeson PA

更新日期：2020-11-26 00:00:00

abstract：:Hoxa5 is a member of the Hox gene family that plays critical roles in successive steps of the central nervous system formation during embryonic and fetal development. In the mouse, Hoxa5 was recently shown to be expressed in the medulla oblongata and the pons from fetal stages to adulthood. In these territories, Hoxa5...

journal_title：Frontiers in molecular neuroscience

authors： Lizen B,Moens C,Mouheiche J,Sacré T,Ahn MT,Jeannotte L,Salti A,Gofflot F

更新日期：2017-11-15 00:00:00

abstract：:Mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease (PD) and, as such, LRRK2 is considered a promising therapeutic target for age-related neurodegeneration. Although the cellular functions of LRRK2 in health and disease are incompletely understood, robust evidence indicates that P...

journal_title：Frontiers in molecular neuroscience

authors： Civiero L,Cogo S,Kiekens A,Morganti C,Tessari I,Lobbestael E,Baekelandt V,Taymans JM,Chartier-Harlin MC,Franchin C,Arrigoni G,Lewis PA,Piccoli G,Bubacco L,Cookson MR,Pinton P,Greggio E

更新日期：2017-12-14 00:00:00

abstract：:The dorsal root ganglion (DRG) contains heterogeneous populations of sensory neurons including primary nociceptive neurons and C-fibers implicated in pain signaling. Recent studies have demonstrated DRG hyperexcitability associated with downregulation of A-type K(+) channels; however, the molecular correlate of the co...

journal_title：Frontiers in molecular neuroscience

authors： Phuket TR,Covarrubias M

更新日期：2009-07-07 00:00:00