Abstract:
:Sex-determining region Y box 2 (Sox2), expressed in neural tissues, plays an important role as a transcription factor not only in the pluripotency and proliferation of neuronal cells but also in the opposite function of cell differentiation. Nevertheless, how Sox2 is linked to motor neuron development remains unknown. Here, we showed that Sox2 was localized in the motor neurons of spinal cord by in situ hybridization and cell separation, which acted as a positive regulator of motor neuron development. The deficiency of Sox2 in zebrafish larvae resulted in abnormal PMN development, including truncated but excessively branched CaP axons, loss of MiP, and increase of undifferentiated neuron cells. Importantly, transcriptome analysis showed that Sox2-depleted embryos caused many neurogenesis, axonogenesis, axon guidance, and differentiation-related gene expression changes, which further support the vital function of Sox2 in motor neuron development. Taken together, these data indicate that Sox2 plays a crucial role in the motor neuron development by regulating neuron differentiation and morphology of neuron axons.
journal_name
Front Mol Neuroscijournal_title
Frontiers in molecular neuroscienceauthors
Gong J,Hu S,Huang Z,Hu Y,Wang X,Zhao J,Qian P,Wang C,Sheng J,Lu X,Wei G,Liu Ddoi
10.3389/fnmol.2020.00034subject
Has Abstractpub_date
2020-03-27 00:00:00pages
34issn
1662-5099journal_volume
13pub_type
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