Circadian clocks and memory: time-place learning.

abstract：:Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described...

journal_title：Frontiers in molecular neuroscience

authors： Ariazi J,Benowitz A,De Biasi V,Den Boer ML,Cherqui S,Cui H,Douillet N,Eugenin EA,Favre D,Goodman S,Gousset K,Hanein D,Israel DI,Kimura S,Kirkpatrick RB,Kuhn N,Jeong C,Lou E,Mailliard R,Maio S,Okafo G,Osswald M,

更新日期：2017-10-17 00:00:00

abstract：:Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain. It has been found that a synergistic relationship between these two proteins may contribute to their roles in disease progression. However, how Aβ...

journal_title：Frontiers in molecular neuroscience

authors： Shin WS,Di J,Murray KA,Sun C,Li B,Bitan G,Jiang L

更新日期：2019-11-08 00:00:00

abstract：:Lithium has long been used for the treatment of psychiatric disorders, due to its robust beneficial effect as a mood stabilizing drug. Lithium's effectiveness for improving neurological function is therefore well-described, stimulating the investigation of its potential use in several neurodegenerative conditions incl...

journal_title：Frontiers in molecular neuroscience

authors： Kerr F,Bjedov I,Sofola-Adesakin O

更新日期：2018-08-28 00:00:00

abstract：:The role of ion channels in neurons and muscles has been well characterized. However, recent work has demonstrated both the presence and necessity of ion channels in diverse cell types for morphological development. For example, mutations that disrupt ion channels give rise to abnormal structural development in specie...

journal_title：Frontiers in molecular neuroscience

authors： Ozekin YH,Isner T,Bates EA

更新日期：2020-06-09 00:00:00

abstract：:Rod and cone phosphodiesterase 6 (PDE6) are key effector enzymes of the vertebrate phototransduction pathway. Rod PDE6 consists of two catalytic subunits PDE6α and PDE6β and two identical inhibitory PDE6γ subunits, while cone PDE6 is composed of two identical PDE6α' catalytic subunits and two identical cone-specific P...

journal_title：Frontiers in molecular neuroscience

authors： Deng WT,Kolandaivelu S,Dinculescu A,Li J,Zhu P,Chiodo VA,Ramamurthy V,Hauswirth WW

更新日期：2018-07-09 00:00:00

abstract：:Although numerous studies have indicated that chronic stress causes cognitive dysfunction with the impairment of synaptic structures and functions, the relationship between cognitive deficits induced by repeated restraint stress and the level of NMDA receptors in the subregion of the hippocampus has been relatively un...

journal_title：Frontiers in molecular neuroscience

authors： Sun DS,Zhong G,Cao HX,Hu Y,Hong XY,Li T,Li X,Liu Q,Wang Q,Ke D,Liu GP,Ma RH,Luo DJ

更新日期：2020-10-19 00:00:00

abstract：:Oxidative stress-induced neuronal damage has been implicated to play a dominant role in neurodegenerative disorders, such as Alzheimer's disease (AD). Nicotine, a principal additive compound for tobacco users, is thought as a candidate to attenuate amyloid-β-mediated neurotoxicity and NMDA-induced excitotoxicity. Prev...

journal_title：Frontiers in molecular neuroscience

authors： Dong Y,Bi W,Zheng K,Zhu E,Wang S,Xiong Y,Chang J,Jiang J,Liu B,Lu Z,Cheng Y

更新日期：2020-11-12 00:00:00

abstract：:Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels. The cryo-EM structure of the homopentameric α1 glycine receptor (GlyR) demonstrated an involvement of the ...

journal_title：Frontiers in molecular neuroscience

authors： Janzen D,Schaefer N,Delto C,Schindelin H,Villmann C

更新日期：2017-10-09 00:00:00

abstract：:This review will consider the impact of compromised PTEN signaling in brain patterning. We approach understanding the contribution of PTEN to nervous system development by surveying the findings from the numerous genetic loss-of-function models that have been generated as well as other forms of PTEN inactivation. By e...

journal_title：Frontiers in molecular neuroscience

authors： Veleva-Rotse BO,Barnes AP

更新日期：2014-05-14 00:00:00

abstract：:Mecp2 is a DNA methylation reader that plays a critical role in experience-dependent plasticity. Increasing evidence supports a role for epigenetic modifications in activity-induced gene expression. Hence, candidate genes related to such phenomena are of great interest. Ryanodine receptors are intracellular calcium ch...

journal_title：Frontiers in molecular neuroscience

authors： Torres RF,Hidalgo C,Kerr B

更新日期：2017-06-13 00:00:00

abstract：:Neuronal identity is generated by the cell-surface expression of clustered protocadherin (Pcdh) isoforms. In mice, 58 isoforms from three gene clusters, Pcdhα, Pcdhβ, and Pcdhγ, are differentially expressed in neurons. Since cis-heteromeric Pcdh oligomers on the cell surface interact homophilically with that in other ...

journal_title：Frontiers in molecular neuroscience

authors： Hasegawa S,Kobayashi H,Kumagai M,Nishimaru H,Tarusawa E,Kanda H,Sanbo M,Yoshimura Y,Hirabayashi M,Hirabayashi T,Yagi T

更新日期：2017-04-24 00:00:00

abstract：:Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. However, the mechanistic aspects and properties of cannabis remain remarkably poorly characterized. In this study we aimed to investigate the immune-cell modulatory pr...

journal_title：Frontiers in molecular neuroscience

authors： Utomo WK,de Vries M,Braat H,Bruno MJ,Parikh K,Comalada M,Peppelenbosch MP,van Goor H,Fuhler GM

更新日期：2017-01-24 00:00:00

abstract：:Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways that facilitate these responses can result in severe deficits, including hearing loss and vestibular dysfunction. Hearing is affected by both en...

journal_title：Frontiers in molecular neuroscience

authors： Mittal R,Nguyen D,Patel AP,Debs LH,Mittal J,Yan D,Eshraghi AA,Van De Water TR,Liu XZ

更新日期：2017-07-31 00:00:00

abstract：:Among all organs of an adult animal, the central nervous system stands out because of its vast complexity and morphological diversity. During early development, the entire central nervous system develops from an apparently homogenous group of progenitors that differentiate into all neural cell types. Therefore, unders...

journal_title：Frontiers in molecular neuroscience

authors： Contreras EG,Sierralta J,Oliva C

更新日期：2019-05-31 00:00:00

abstract：:Despite numerous clinical studies, which have investigated the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) in various brain diseases, our knowledge of the cellular and molecular mechanisms underlying rTMS-based therapies remains limited. Thus, a deeper understanding of rTMS-induced neu...

journal_title：Frontiers in molecular neuroscience

authors： Müller-Dahlhaus F,Vlachos A

更新日期：2013-12-17 00:00:00

abstract：:Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy (SMA) are chronic, progressive, and age-associated neurological disorders characterized by neuronal deterioration in specific brain regions. Although the specific path...

journal_title：Frontiers in molecular neuroscience

authors： Chang X,Wang J,Jiang H,Shi L,Xie J

更新日期：2019-06-05 00:00:00

abstract：:Ca2+ signaling plays a significant role in the development of the vertebrate nervous system where it regulates neurite growth as well as synapse and neurotransmitter specification. Elucidating the role of Ca2+ signaling in mammalian neuronal development has been largely restricted to either small animal models or prim...

journal_title：Frontiers in molecular neuroscience

authors： Gopurappilly R,Deb BK,Chakraborty P,Hasan G

更新日期：2018-06-11 00:00:00

abstract：:Although several agents have been identified to provide therapeutic benefits in Huntington disease (HD), the number of conventionally used treatments remains limited and only symptomatic. Thus, it is plausible that the need to identify new therapeutic targets for the development of alternative and more effective treat...

journal_title：Frontiers in molecular neuroscience

authors： Di Pardo A,Pepe G,Castaldo S,Marracino F,Capocci L,Amico E,Madonna M,Giova S,Jeong SK,Park BM,Park BD,Maglione V

更新日期：2019-04-24 00:00:00

abstract：:The application of super-resolution optical microscopy to investigating synaptic structures has revealed a highly heterogeneous and variable intra-synaptic organization. Dense subsynaptic protein assemblies named subsynaptic domains or SSDs have been proposed as structural units that regulate the efficacy of neuronal ...

journal_title：Frontiers in molecular neuroscience

authors： Yang X,Specht CG

更新日期：2019-07-02 00:00:00

abstract：:In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of plasma membrane (PM) Ca2+ channels following the release of Ca2+ from intracellular stores. Upon depletion of Ca2+ store, the stromal interac...

journal_title：Frontiers in molecular neuroscience

authors： Secondo A,Bagetta G,Amantea D

更新日期：2018-03-22 00:00:00

abstract：:In the brain, metabolic supply and demand is directly coupled to neuronal activation. Methods for culturing primary rodent brain cells have come of age and are geared toward sophisticated modeling of human brain physiology and pathology. However, the impact of the culture microenvironment on neuronal function is rarel...

journal_title：Frontiers in molecular neuroscience

authors： Sünwoldt J,Bosche B,Meisel A,Mergenthaler P

更新日期：2017-09-29 00:00:00

abstract：:N-methyl-d-aspartate receptors (NMDARs) play an important role in many aspects of nervous system function such as synaptic plasticity and neuronal development. NMDARs are heteromers consisting of an obligate NR1 and most commonly one or two kinds of NR2 subunits. While the receptors have been well characterized in som...

journal_title：Frontiers in molecular neuroscience

authors： Ewald RC,Cline HT

更新日期：2009-09-11 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive primary intracranial tumor of adults and confers a poor prognosis due to high vascularization. Hence anti-angiogenic therapy has become a promising strategy for GBM treatment. In this study, the transcription factor nuclear factor of activated T-cells 5 (NFAT5) was significant...

journal_title：Frontiers in molecular neuroscience

authors： Yu H,Zheng J,Liu X,Xue Y,Shen S,Zhao L,Li Z,Liu Y

更新日期：2017-09-21 00:00:00

abstract：:Spinal cord injury (SCI) can result in an irreversible disability due to loss of sensorimotor function below the lesion. Presently, clinical treatments for SCI mainly include surgery, drugs and postoperative rehabilitation. The prospective roles of bioscaffolds and exosomes in several neurological diseases have been r...

journal_title：Frontiers in molecular neuroscience

authors： Wang X,Botchway BOA,Zhang Y,Yuan J,Liu X

更新日期：2019-04-12 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy (SBMA) are two motoneuron diseases (MNDs) characterized by aberrant protein behavior in affected cells. In familial ALS (fALS) and in SBMA specific gene mutations lead to the production of neurotoxic proteins or peptides prone to misfold, which...

journal_title：Frontiers in molecular neuroscience

authors： Rusmini P,Cristofani R,Galbiati M,Cicardi ME,Meroni M,Ferrari V,Vezzoli G,Tedesco B,Messi E,Piccolella M,Carra S,Crippa V,Poletti A

更新日期：2017-06-21 00:00:00

abstract：:In this review we provide an overview of key in vivo experiments undertaken in the cat spinal cord in the 1950s and 1960s, and point out their contributions to our present understanding of glycine receptor (GlyR) function. Importantly, some of these discoveries were made well before an inhibitory receptor, or its agon...

journal_title：Frontiers in molecular neuroscience

authors： Callister RJ,Graham BA

更新日期：2010-05-21 00:00:00

abstract：:Epilepsy, one of the most prevalent neurological conditions, presents as a complex disorder of network homeostasis characterized by spontaneous non-provoked seizures and associated comorbidities. Currently used antiepileptic drugs have been designed to suppress neuronal hyperexcitability and thereby to suppress epilep...

journal_title：Frontiers in molecular neuroscience

authors： Boison D

更新日期：2016-04-13 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00177.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Belin S,Herron J,VerPlank JJS,Park Y,Feltri LM,Poitelon Y

更新日期：2019-10-18 00:00:00

abstract：:GABAergic interneuron diversity is a key feature in the brain that helps to create different brain activity patterns and behavioral states. Cell type classification schemes-based on anatomical, physiological and molecular features-have provided us with a detailed understanding of the distinct types that constitute thi...

journal_title：Frontiers in molecular neuroscience

authors： Que L,Winterer J,Földy C

更新日期：2019-05-07 00:00:00

abstract：:Ion channels are expressed throughout nervous system development. The type and diversity of conductances and gating mechanisms vary at different developmental stages and with the progressive maturational status of neural cells. The variety of ion channels allows for distinct signaling mechanisms in developing neural c...

journal_title：Frontiers in molecular neuroscience

authors： Goyal R,Spencer KA,Borodinsky LN

更新日期：2020-04-24 00:00:00