Mitochondrial Dysfunction in Astrocytes Impairs the Generation of Reactive Astrocytes and Enhances Neuronal Cell Death in the Cortex Upon Photothrombotic Lesion.

abstract：:Neuroendocrine cells store and secrete bulk amounts of neuropeptides, and display morphological and molecular characteristics distinct from neurons signaling with classical neurotransmitters. In Drosophila the transcription factor Dimmed (Dimm), is a prime organizer of neuroendocrine capacity in a majority of the pept...

journal_title：Frontiers in molecular neuroscience

authors： Luo J,Liu Y,Nässel DR

更新日期：2017-08-14 00:00:00

abstract：:M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In the present study, we demonstrate that suppression of M/Kv7 channe...

journal_title：Frontiers in molecular neuroscience

authors： Zhang D,Men H,Zhang L,Gao X,Wang J,Li L,Zhu Q,Zhang H,Jia Z

更新日期：2020-06-30 00:00:00

abstract：:Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels. The cryo-EM structure of the homopentameric α1 glycine receptor (GlyR) demonstrated an involvement of the ...

journal_title：Frontiers in molecular neuroscience

authors： Janzen D,Schaefer N,Delto C,Schindelin H,Villmann C

更新日期：2017-10-09 00:00:00

abstract：:Maternal cigarette smoke exposure (SE) causes detrimental changes associated with the development of chronic neurological diseases in the offspring as a result of oxidative mitochondrial damage. Maternal L-Carnitine administration has been shown to reduce renal oxidative stress in SE offspring, but its effect in the b...

journal_title：Frontiers in molecular neuroscience

authors： Chan YL,Saad S,Al-Odat I,Oliver BG,Pollock C,Jones NM,Chen H

更新日期：2017-02-13 00:00:00

abstract：:Autism spectrum disorders (ASD) have a higher prevalence in male individuals compared to females, with a ratio of affected boys compared to girls of 4:1 for ASD and 11:1 for Asperger syndrome. Mutations in the SHANK genes (comprising SHANK1, SHANK2 and SHANK3) coding for postsynaptic scaffolding proteins have been tig...

journal_title：Frontiers in molecular neuroscience

authors： Berkel S,Eltokhi A,Fröhlich H,Porras-Gonzalez D,Rafiullah R,Sprengel R,Rappold GA

更新日期：2018-09-25 00:00:00

abstract：:The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer's disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain. AQP4 polarity can be influenced by the ratio of two AQP4 isoforms M1 and M23 (AQP4-M1/M23), however, it is unknown whether the ra...

journal_title：Frontiers in molecular neuroscience

authors： Zhang J,Zhan Z,Li X,Xing A,Jiang C,Chen Y,Shi W,An L

更新日期：2017-11-29 00:00:00

abstract：:The competitive ectodomain shedding of amyloid-β precursor protein (APP) by α-secretase and β-secretase, and the subsequent regulated intramembrane proteolysis by γ-secretase are the key processes in amyloid-β peptides (Aβ) generation. Previous studies indicate that secretases form binary complex and the interactions ...

journal_title：Frontiers in molecular neuroscience

authors： Wang X,Pei G

更新日期：2018-11-27 00:00:00

abstract：:Blast induced neurotrauma (BINT) is a prevalent injury within military and civilian populations. The injury is characterized by persistent inflammation at the cellular level which manifests as a multitude of cognitive and functional impairments. Epigenetic regulation of transcription offers an important control mechan...

journal_title：Frontiers in molecular neuroscience

authors： Bailey ZS,Grinter MB,VandeVord PJ

更新日期：2016-08-08 00:00:00

abstract：:GABAergic inhibitory neurotransmission contributes to diverse aspects of brain development and adult plasticity, including the expression of complex cognitive processes. This is afforded for in part by the dynamic adaptations occurring at inhibitory synapses, which show great heterogeneity both in terms of upstream si...

journal_title：Frontiers in molecular neuroscience

authors： Campbell BFN,Tyagarajan SK

更新日期：2019-08-13 00:00:00

abstract：:Following axotomy, the activation of multiple intracellular signaling cascades causes the expression of a cocktail of regeneration-associated transcription factors which interact with each other to determine the fate of the injured neurons. The nerve injury response is channeled through manifold and parallel pathways,...

journal_title：Frontiers in molecular neuroscience

authors： Patodia S,Raivich G

更新日期：2012-02-10 00:00:00

abstract：:The ubiquitous metabolic intermediary and nucleoside adenosine is a "master regulator" in all living systems. Under baseline conditions adenosine kinase (ADK) is the primary enzyme for the metabolic clearance of adenosine. By regulating the availability of adenosine, ADK is a critical upstream regulator of complex hom...

journal_title：Frontiers in molecular neuroscience

authors： Kiese K,Jablonski J,Boison D,Kobow K

更新日期：2016-10-20 00:00:00

abstract：:Emerging studies have demonstrated that interleukin (IL)-33 and its receptor ST2 act as key factors in inflammatory diseases. Moreover, accumulating evidence has suggested that cytokines, including tumor necrosis factor (TNF)-α and IL-1β, trigger an inflammatory cascade. SIRT1 has been shown to suppress the expression...

journal_title：Frontiers in molecular neuroscience

authors： Zeng Y,Shi Y,Zhan H,Liu W,Cai G,Zhong H,Wang Y,Chen S,Huang S,Wu W

更新日期：2020-02-12 00:00:00

abstract：:Microglial activation and the inflammatory response in the central nervous system (CNS) play important roles in secondary damage after traumatic brain injury (TBI). Transcriptional activation of genes that limit secondary damage to the CNS are mediated by a cis-acting element called the antioxidant responsive element ...

journal_title：Frontiers in molecular neuroscience

authors： Chen X,Wang H,Zhou M,Li X,Fang Z,Gao H,Li Y,Hu W

更新日期：2018-04-17 00:00:00

abstract：:Neuroblastoma, the major cause of infant cancer deaths, results from fast proliferation of undifferentiated neuroblasts. Treatment of high-risk neuroblastoma includes differentiation with retinoic acid (RA); however, the resistance of many of these tumors to RA-induced differentiation poses a considerable challenge. H...

journal_title：Frontiers in molecular neuroscience

authors： Kasim M,Heß V,Scholz H,Persson PB,Fähling M

更新日期：2016-12-21 00:00:00

abstract：:The cells of the neural crest, often referred to as neural crest stem cells, give rise to a number of sub-lineages, one of which is Schwann cells, the glial cells of peripheral nerves. Crest cells transform to adult Schwann cells through the generation of two well defined intermediate stages, the Schwann cell precurso...

journal_title：Frontiers in molecular neuroscience

authors： Jessen KR,Mirsky R

更新日期：2019-03-26 00:00:00

abstract：:Previous reports have shown that running wheel activity or voluntary exercise prevents hyperphagia and obesity in various animal models of obesity, but such effects seem only minimal in obese animals lacking leptin or leptin receptors. The mechanisms underlying this ineffectiveness remain unclear. Here, we identified ...

journal_title：Frontiers in molecular neuroscience

authors： Zhang N,Yang L,Guo L,Bi S

更新日期：2018-05-29 00:00:00

abstract：:Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways that facilitate these responses can result in severe deficits, including hearing loss and vestibular dysfunction. Hearing is affected by both en...

journal_title：Frontiers in molecular neuroscience

authors： Mittal R,Nguyen D,Patel AP,Debs LH,Mittal J,Yan D,Eshraghi AA,Van De Water TR,Liu XZ

更新日期：2017-07-31 00:00:00

abstract：:Neuroimaging studies have demonstrated that irritable bowel syndrome (IBS)-a relapsing functional bowel disorder-presents with disrupted brain connections. However, little is known about the alterations of interhemispheric functional connectivity and underlying structural connectivity in IBS. This study combined resti...

journal_title：Frontiers in molecular neuroscience

authors： Qi R,Liu C,Weng Y,Xu Q,Chen L,Wang F,Zhang LJ,Lu GM

更新日期：2016-12-06 00:00:00

abstract：:Parkinson's disease (PD) is a debilitating neurodegenerative disease characterized primarily by the selective death of dopaminergic (DA) neurons in the substantia nigra pars compacta of the midbrain. Although several genetic forms of PD have been identified, the precise molecular mechanisms underlying DA neuron loss i...

journal_title：Frontiers in molecular neuroscience

authors： Heman-Ackah SM,Hallegger M,Rao MS,Wood MJ

更新日期：2013-11-20 00:00:00

abstract：:Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. However, the mechanistic aspects and properties of cannabis remain remarkably poorly characterized. In this study we aimed to investigate the immune-cell modulatory pr...

journal_title：Frontiers in molecular neuroscience

authors： Utomo WK,de Vries M,Braat H,Bruno MJ,Parikh K,Comalada M,Peppelenbosch MP,van Goor H,Fuhler GM

更新日期：2017-01-24 00:00:00

abstract：:Parkinson's disease (PD) is a progressive CNS disorder that is primarily associated with impaired movement. PD develops over decades and is linked to the gradual loss of dopamine delivery to the striatum, via the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). While the administration o...

journal_title：Frontiers in molecular neuroscience

authors： Lasbleiz C,Mestre-Francés N,Devau G,Luquin MR,Tenenbaum L,Kremer EJ,Verdier JM

更新日期：2019-02-11 00:00:00

abstract：:ADP-ribosylation of the P2X7k splice variant on mouse T cells by Ecto-ADP-ribosyltransferase ARTC2.2 in response to its substrate extracellular nicotinamide adenine dinucleotide (NAD+) triggers cell death. Since NAD+ is released as a danger signal during tissue damage, this NAD+-induced cell death (NICD) may impact th...

journal_title：Frontiers in molecular neuroscience

authors： Rissiek B,Stabernack J,Cordes M,Duan Y,Behr S,Menzel S,Magnus T,Koch-Nolte F

更新日期：2020-01-14 00:00:00

abstract：:Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu. Our understanding of the structure-function relationship of connexin channels relies on X-ray crystallographic data for human connexin 26 (hCx26) ...

journal_title：Frontiers in molecular neuroscience

authors： Zonta F,Buratto D,Crispino G,Carrer A,Bruno F,Yang G,Mammano F,Pantano S

更新日期：2018-05-31 00:00:00

abstract：:Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. It is caused by the overexpansion of cytosine-guanine-guanine (CGG) trinucleotide in Fmr1 gene, resulting in complete loss of the fragile X mental retardation protein (FMRP). Previous studies using Fmr1 knockout (Fmr1 KO) mice have ...

journal_title：Frontiers in molecular neuroscience

authors： Yau SY,Bettio L,Chiu J,Chiu C,Christie BR

更新日期：2019-01-17 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that results from the loss of upper and lower motor neurons. One of the key pathological hallmarks in diseased neurons is the mislocalization of disease-associated proteins and the formation of cytoplasmic aggregates of these proteins and their intera...

journal_title：Frontiers in molecular neuroscience

authors： Ramesh N,Pandey UB

更新日期：2017-08-22 00:00:00

abstract：:Membrane fusion is one of the most fundamental physiological processes in eukaryotes for triggering the fusion of lipid and content, as well as the neurotransmission. However, the architecture features of neurotransmitter release machinery and interdependent mechanism of synaptic membrane fusion have not been extensiv...

journal_title：Frontiers in molecular neuroscience

authors： Yang Z,Gou L,Chen S,Li N,Zhang S,Zhang L

更新日期：2017-06-07 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and malignant primary tumor. Angiogenesis plays a critical role in the progression of GBM. Previous studies have indicated that long non-coding RNAs (lncRNAs) are abnormally expressed in various cancers and participate in the regulation of the malignant behaviors of tumors. Th...

journal_title：Frontiers in molecular neuroscience

authors： Yang C,Zheng J,Xue Y,Yu H,Liu X,Ma J,Liu L,Wang P,Li Z,Cai H,Liu Y

更新日期：2018-01-09 00:00:00

abstract：:[This corrects the article on p. 257 in vol. 10, PMID: 28855859.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Sun Y,Chen X,Zhang X,Shen X,Wang M,Wang X,Liu WC,Liu CF,Liu J,Liu W,Jin X

更新日期：2017-11-20 00:00:00

abstract：:The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) are major excitatory receptors that mediate fast neurotransmission in the mammalian brain. The surface expression of functional AMPARs is crucial for synaptic transmission and plasticity. AMPAR auxiliary subunits control ...

journal_title：Frontiers in molecular neuroscience

authors： Wei M,Jia M,Zhang J,Yu L,Zhao Y,Chen Y,Ma Y,Zhang W,Shi YS,Zhang C

更新日期：2017-03-02 00:00:00

abstract：:Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is a neurodegenerative disorder caused by loss-of-function mutations in the cystatin B (CSTB) gene. Progression of the clinical symptoms in EPM1 patients, including stimulus-sensitive myoclonus, tonic-clonic seizures, and ataxia, are well described. How...

journal_title：Frontiers in molecular neuroscience

authors： Gorski K,Spoljaric A,Nyman TA,Kaila K,Battersby BJ,Lehesjoki AE

更新日期：2020-11-13 00:00:00