Progranulin Mutations Affects Brain Oscillatory Activity in Fronto-Temporal Dementia.

abstract：:Background and Purpose: This study aimed to investigate the association between insulin resistance (IR) and the overall cerebral small vessel disease (CSVD) burden. Methods: We recruited elderly, nondiabetic, healthy subjects prospectively. The overall effect of CSVD on the brain was described by a validated CSVD scor...

journal_title：Frontiers in aging neuroscience

authors： Yang X,Zhang S,Dong Z,Zi Y,Luo Y,Jin Z,Shi L,Li C,Ren C,Wu D

更新日期：2019-06-12 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) includes a spectrum of disorders characterized by changes of personality and social behavior and, often, a gradual and progressive language dysfunction. In the last years, several efforts have been fulfilled in identifying both genetic mutations and pathological proteins associ...

journal_title：Frontiers in aging neuroscience

authors： Piscopo P,Albani D,Castellano AE,Forloni G,Confaloni A

更新日期：2016-02-09 00:00:00

abstract：:There is no disease-modifying treatment currently available for AD, one of the more impacting neurodegenerative diseases affecting more than 47.5 million people worldwide. The definition of new approaches for the design of proper clinical trials is highly demanded in order to achieve non-confounding results and assess...

journal_title：Frontiers in aging neuroscience

authors： Salvatore C,Cerasa A,Castiglioni I

更新日期：2018-05-24 00:00:00

abstract：:Neuromodulation techniques such as deep brain stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia. However, the outcomes of such treatments appear to be somewhat paradoxical, in that these techniques can both disrupt and enhance memory even when applied t...

journal_title：Frontiers in aging neuroscience

authors： Tan SZK,Du R,Perucho JAU,Chopra SS,Vardhanabhuti V,Lim LW

更新日期：2020-09-14 00:00:00

abstract：:There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinical trials for HD are limited by a lack of knowledge of the natural hi...

journal_title：Frontiers in aging neuroscience

authors： Paulsen JS,Long JD,Johnson HJ,Aylward EH,Ross CA,Williams JK,Nance MA,Erwin CJ,Westervelt HJ,Harrington DL,Bockholt HJ,Zhang Y,McCusker EA,Chiu EM,Panegyres PK,PREDICT-HD Investigators and Coordinators of the Huntington Stu

更新日期：2014-04-22 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) is a severe neurodegenerative disorder that is diagnosed with increasing frequency in clinical setting. Currently, no therapy is available and in addition the molecular basis of the disease are far from being elucidated. Consequently, it is of pivotal importance to develop reli...

journal_title：Frontiers in aging neuroscience

authors： Tunesi M,Fusco F,Fiordaliso F,Corbelli A,Biella G,Raimondi MT

更新日期：2016-06-22 00:00:00

abstract：:The acquisition and retention of motor skills is necessary for everyday functioning in the elderly and may be critical in the context of motor rehabilitation. Recent studies indicate that motor training closely followed by sleep may result in better engagement of procedural ("how to") memory consolidation processes in...

journal_title：Frontiers in aging neuroscience

authors： Gal C,Gabitov E,Maaravi-Hesseg R,Karni A,Korman M

更新日期：2019-11-22 00:00:00

abstract：:Background: There has been much research devoted to examining the short-term effects of different interventions for improving memory functioning of older adults with memory complaints. Nevertheless, very few studies have examined the long-term effects of these interventions. Thus, the present study compared the sustai...

journal_title：Frontiers in aging neuroscience

authors： Chan AS,Cheung WK,Yeung MK,Lee TL

更新日期：2018-08-07 00:00:00

abstract：:Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with in...

journal_title：Frontiers in aging neuroscience

authors： Toricelli M,Evangelista SR,Oliveira LR,Viel TA,Buck HS

更新日期：2019-07-12 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnagi.2019.00312.]. ...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Zhang Y,Zhang J,Sang L,Li P,Yan R,Qiu M,Liu C

更新日期：2020-07-08 00:00:00

abstract：:Life-time experiences are thought to influence the risk to develop the neurodegenerative disorder Alzheimer's disease (AD). In particular, early-life stress (ES) may modulate the onset and progression of AD. There is recent evidence by our group and others that AD-related neuropathological progression and the associat...

journal_title：Frontiers in aging neuroscience

authors： Hoeijmakers L,Amelianchik A,Verhaag F,Kotah J,Lucassen PJ,Korosi A

更新日期：2018-03-07 00:00:00

abstract：:Although older adults exhibit normal accuracy in performing word retrieval and generation (lexical production; e.g., object naming), they are generally slower in responding than younger adults. To maintain accuracy, older adults recruit compensatory mechanisms and strategies. We focused on two such possible compensato...

journal_title：Frontiers in aging neuroscience

authors： Hoyau E,Boudiaf N,Cousin E,Pichat C,Fournet N,Krainik A,Jaillard A,Baciu M

更新日期：2017-05-09 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) increases risk for dementia, including Alzheimer's disease (AD). Many previous studies of brain changes underlying cognitive impairment in T2DM have applied conventional structural magnetic resonance imaging (MRI) to detect macrostructural changes associated with cerebrovascular disease...

journal_title：Frontiers in aging neuroscience

authors： Bangen KJ,Werhane ML,Weigand AJ,Edmonds EC,Delano-Wood L,Thomas KR,Nation DA,Evangelista ND,Clark AL,Liu TT,Bondi MW

更新日期：2018-09-10 00:00:00

abstract：:The functional neuroanatomy of finger movements has been characterized with neuroimaging in young adults. However, less is known about the aging motor system. Several studies have contrasted movement-related activity in older versus young adults, but there is inconsistency among their findings. To address this, we con...

journal_title：Frontiers in aging neuroscience

authors： Turesky TK,Turkeltaub PE,Eden GF

更新日期：2016-10-17 00:00:00

abstract：:Activity-dependent neuroprotective protein (ADNP) is deregulated in Alzheimer's disease (AD) and in schizophrenia and mutated in autism. In mice, ADNP is essential for brain formation and ADNP haploinsufficiency is associated with cognitive and social deficits and tauopathy. Tauopathy, a major pathology in AD, is also...

journal_title：Frontiers in aging neuroscience

authors： Gozes I,Ivashko-Pachima Y

更新日期：2015-10-29 00:00:00

abstract：:It is well known that Alzheimer's disease (AD) is one of the most common progressive neurodegenerative diseases; it begins gradually, and therefore no effective medicine is administered in the beginning. Thus, early diagnosis and prevention of AD are crucial. The present study focused on comparing the plasma protein c...

journal_title：Frontiers in aging neuroscience

authors： Cheng Z,Yin J,Yuan H,Jin C,Zhang F,Wang Z,Liu X,Wu Y,Wang T,Xiao S

更新日期：2018-12-17 00:00:00

abstract：:Background: Smart Aging is a Serious games (SGs) platform in a 3D virtual environment in which users perform a set of screening tests that address various cognitive skills. The tests are structured as 5 tasks of activities of daily life in a familiar environment. The main goal of the present study is to compare a cogn...

journal_title：Frontiers in aging neuroscience

authors： Bottiroli S,Tassorelli C,Lamonica M,Zucchella C,Cavallini E,Bernini S,Sinforiani E,Pazzi S,Cristiani P,Vecchi T,Tost D,Sandrini G

更新日期：2017-11-21 00:00:00

abstract：:Predicting future brain topography can give insight into neural correlates of aging and neurodegeneration. Due to variability in the aging process, it has been challenging to precisely estimate brain topographical change according to aging. Here, we predict age-related brain metabolic change by generating future brain...

journal_title：Frontiers in aging neuroscience

authors： Choi H,Kang H,Lee DS,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2018-07-12 00:00:00

abstract：:Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic neurons, and the presence of intracellular insoluble proteinaceous inclusions, known as Lewy Bodies. Although PD etiopathogenesis remains elusive, the leading h...

journal_title：Frontiers in aging neuroscience

authors： Branco DM,Arduino DM,Esteves AR,Silva DF,Cardoso SM,Oliveira CR

更新日期：2010-05-21 00:00:00

abstract：:Associative processes, such as the encoding of associations between words in a list, can enhance episodic memory performance and are thought to deteriorate with age. Here, we examine the nature of age-related deficits in the encoding of associations, by using a free recall paradigm with visual arrays of objects. Fifty...

journal_title：Frontiers in aging neuroscience

authors： Suzin G,Ravona-Springer R,Ash EL,Davelaar EJ,Usher M

更新日期：2019-11-12 00:00:00

abstract：:Neuroimaging-based age prediction using machine learning is proposed as a biomarker of brain aging, relating to cognitive performance, health outcomes and progression of neurodegenerative disease. However, even leading age-prediction algorithms contain measurement error, motivating efforts to improve experimental pipe...

journal_title：Frontiers in aging neuroscience

authors： Lancaster J,Lorenz R,Leech R,Cole JH

更新日期：2018-02-12 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic nigrostriatal neurons, with reductions in the function and amount of dopaminergic synapses. Therefore, synapse loss and membrane-related pathology provide relevant targets for interventions in PD. We previously showed the benefic...

journal_title：Frontiers in aging neuroscience

authors： Perez-Pardo P,de Jong EM,Broersen LM,van Wijk N,Attali A,Garssen J,Kraneveld AD

更新日期：2017-03-20 00:00:00

abstract：:Pilot studies using technology-aided programs to promote verbal reminiscence and mild physical activity (i.e., positive forms of engagement) in persons with moderate or severe Alzheimer's disease have provided promising results (Lancioni et al., 2015a,b). The present two studies were aimed at upgrading and/or extendin...

journal_title：Frontiers in aging neuroscience

authors： Lancioni GE,Singh NN,O'Reilly MF,Sigafoos J,D'Amico F,Renna C,Pinto K

更新日期：2016-04-21 00:00:00

abstract：:Microglia can transform into proinflammatory/classically activated (M1) or anti-inflammatory/alternatively activated (M2) phenotypes following environmental signals related to physiological conditions or brain lesions. An adequate transition from the M1 (proinflammatory) to M2 (immunoregulatory) phenotype is necessary...

journal_title：Frontiers in aging neuroscience

authors： Labandeira-Garcia JL,Rodríguez-Perez AI,Garrido-Gil P,Rodriguez-Pallares J,Lanciego JL,Guerra MJ

更新日期：2017-05-03 00:00:00

abstract：:It is common wisdom that practice makes perfect; but why do some adults learn better than others? Here, we investigate individuals' cognitive and social profiles to test which variables account for variability in learning ability across the lifespan. In particular, we focused on visual learning using tasks that test t...

journal_title：Frontiers in aging neuroscience

authors： Christian J,Goldstone A,Kuai SG,Chin W,Abrams D,Kourtzi Z

更新日期：2015-06-10 00:00:00

abstract：:Background and purpose: The aggregation of vascular risk factors (VRFs) can aggravate cognitive impairment in stroke-free patients. Metabolites in serum and cerebrospinal fluid (CSF) may irreversibly reflect early functional deterioration. This study evaluated small-molecule metabolites (<1,000 Da) in the serum and CS...

journal_title：Frontiers in aging neuroscience

authors： Peng S,Shen Y,Wang M,Zhang J

更新日期：2020-07-22 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder associated with the progressive dysfunction of cognitive ability. Previous research has indicated that the default mode network (DMN) is closely related to cognition and is impaired in Alzheimer's disease. Because recent studies have shown that different frequen...

journal_title：Frontiers in aging neuroscience

authors： Li Y,Yao H,Lin P,Zheng L,Li C,Zhou B,Wang P,Zhang Z,Wang L,An N,Wang J,Zhang X

更新日期：2017-08-03 00:00:00

abstract：:Neuroinflammation and autophagy dysfunction are closely related to the development of neurodegeneration such as Parkinson's disease (PD). However, the role of autophagy in microglia polarization and neuroinflammation is poorly understood. TNF-α, which is highly toxic to dopaminergic neurons, is implicated as a major m...

journal_title：Frontiers in aging neuroscience

authors： Jin MM,Wang F,Qi D,Liu WW,Gu C,Mao CJ,Yang YP,Zhao Z,Hu LF,Liu CF

更新日期：2018-11-20 00:00:00

abstract：:A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in dementia research has expanded to brain imaging analyses with auditory function. The aim of this study was to investigate the link between hearing ability, which was assessed using pure-tone audiometry, an...

journal_title：Frontiers in aging neuroscience

authors： Uchida Y,Nishita Y,Kato T,Iwata K,Sugiura S,Suzuki H,Sone M,Tange C,Otsuka R,Ando F,Shimokata H,Nakamura A

更新日期：2018-10-16 00:00:00

abstract：:The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer's disease (AD). The heavy public burden of AD, along with the urgent to prevent and treat the disease before the irreversible damage to the brain, calls for a sensitive and speci...

journal_title：Frontiers in aging neuroscience

authors： Liao H,Zhu Z,Peng Y

更新日期：2018-06-22 00:00:00