Insulin Resistance Is a Risk Factor for Overall Cerebral Small Vessel Disease Burden in Old Nondiabetic Healthy Adult Population.

abstract：:The auditory mismatch negativity (MMN) is an event-related potential (ERP) peaking about 100-250 ms after the onset of a deviant tone in a sequence of identical (standard) tones. Depending on the interstimulus interval (ISI) between standard and deviant tones, the MMN is suitable to investigate the pre-attentive audit...

journal_title：Frontiers in aging neuroscience

authors： Laptinskaya D,Thurm F,Küster OC,Fissler P,Schlee W,Kolassa S,von Arnim CAF,Kolassa IT

更新日期：2018-02-02 00:00:00

abstract：:The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) and their effects on cognition have rarely been investigated. We aimed to examine brain iron deposition in svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we aimed to investigate the correl...

journal_title：Frontiers in aging neuroscience

authors： Sun Y,Ge X,Han X,Cao W,Wang Y,Ding W,Cao M,Zhang Y,Xu Q,Zhou Y,Xu J

更新日期：2017-03-30 00:00:00

abstract：:Microglia are dependent on signaling through the colony stimulating factor-1 receptor (CSF-1R/CD115) for growth and survival. Activation of CSF-1R can lead to cell division, while blocking CSF-1R can lead to rapid microglia cell death. CSF-1R has two ligands, the growth factors colony stimulating factor-1 (CSF-1) and ...

journal_title：Frontiers in aging neuroscience

authors： Walker DG,Tang TM,Lue LF

更新日期：2017-08-09 00:00:00

abstract：:Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and ...

journal_title：Frontiers in aging neuroscience

authors： Cloyd RA,Koren SA,Abisambra JF

更新日期：2018-12-13 00:00:00

abstract：:It is relevant to unravel the factors that may mediate the cognitive decline observed during aging. Previous reports indicate that education has a positive influence on cognitive performance, while age, female gender and, especially, depressed mood were associated with poorer performances across multiple cognitive dim...

journal_title：Frontiers in aging neuroscience

authors： Santos NC,Costa PS,Cunha P,Portugal-Nunes C,Amorim L,Cotter J,Cerqueira JJ,Palha JA,Sousa N

更新日期：2014-02-24 00:00:00

abstract：:Amyloid-beta (Aβ) in Alzheimer's disease (AD) appeared to be a promising target for disease-modifying therapeutic strategies like passive immunotherapy with anti-Aβ monoclonal antibodies (mAbs). Biochemical markers in cerebrospinal fluid (CSF) include alterations of Aβ that allow the diagnosis of AD. Biomarker strateg...

journal_title：Frontiers in aging neuroscience

authors： Moreth J,Mavoungou C,Schindowski K

更新日期：2013-07-02 00:00:00

abstract：INTRODUCTION:Cross-sectional studies have identified long chain omega-3 polyunsaturated fatty acids (eicosapentaenoic acid 20:5n-3 and docosahexaenoic acid 22:6n-3 (O3PUFA) in association with fewer white matter lesions and better executive function in older adults. We hypothesized that O3PUFA are associated with less ...

journal_title：Frontiers in aging neuroscience

authors： Bowman GL,Dodge HH,Mattek N,Barbey AK,Silbert LC,Shinto L,Howieson DB,Kaye JA,Quinn JF

更新日期：2013-12-16 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) is a clinical stage indicating a prodromal phase of dementia. This practical concept could be used also for fronto-temporal dementia (FTD). Progranulin (PGRN) has been recently recognized as a useful diagnostic biomarker for fronto-temporal lobe degeneration (FTLD) due to GRN ...

journal_title：Frontiers in aging neuroscience

authors： Moretti DV,Benussi L,Fostinelli S,Ciani M,Binetti G,Ghidoni R

更新日期：2016-02-29 00:00:00

abstract：:Previous studies investigating working memory performance in patients with mild cognitive impairment (MCI) have mainly focused on the neural mechanisms of alterations in activation. To date, very few studies have investigated background network alterations in the working memory state. Therefore, the present study inve...

journal_title：Frontiers in aging neuroscience

authors： Wang P,Li R,Liu B,Wang C,Huang Z,Dai R,Song B,Yuan X,Yu J,Li J

更新日期：2019-06-28 00:00:00

abstract：:Background: Hypersensitivity to general anesthetics may predict poor postoperative outcomes, especially among the older subjects. Therefore, it is essential to elucidate the mechanism underlying hypersensitivity to volatile anesthetics in the aging population. Given the fact that isoflurane sensitivity increases with ...

journal_title：Frontiers in aging neuroscience

authors： Gong C,Zhang D,Ou W,Ou M,Liang P,Liao D,Zhang W,Zhu T,Liu J,Zhou C

更新日期：2020-12-03 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) increases risk for dementia, including Alzheimer's disease (AD). Many previous studies of brain changes underlying cognitive impairment in T2DM have applied conventional structural magnetic resonance imaging (MRI) to detect macrostructural changes associated with cerebrovascular disease...

journal_title：Frontiers in aging neuroscience

authors： Bangen KJ,Werhane ML,Weigand AJ,Edmonds EC,Delano-Wood L,Thomas KR,Nation DA,Evangelista ND,Clark AL,Liu TT,Bondi MW

更新日期：2018-09-10 00:00:00

abstract：:To expose cortical involvement in age-related changes in motor performance, we compared steadiness (force fluctuations) and fatigability of submaximal isometric contractions with the ankle dorsiflexor muscles in older and young adults and with varying levels of cognitive demand imposed. Sixteen young (20.4 ± 2.1 year:...

journal_title：Frontiers in aging neuroscience

authors： Vanden Noven ML,Pereira HM,Yoon T,Stevens AA,Nielson KA,Hunter SK

更新日期：2014-05-22 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary tangles. Copper, iron,...

journal_title：Frontiers in aging neuroscience

authors： Wong BX,Hung YH,Bush AI,Duce JA

更新日期：2014-05-15 00:00:00

abstract：:Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, ...

journal_title：Frontiers in aging neuroscience

authors： Sakuma K,Aoi W,Yamaguchi A

更新日期：2014-08-29 00:00:00

abstract：:Previous research suggests specific deficits in face perception and memory in older adults, which could reflect a dedifferentiation in the context of a general broadening of cognitive architecture with advanced age. Such dedifferentiation could manifest in a less specialized face processing system. A promising tool to...

journal_title：Frontiers in aging neuroscience

authors： Komes J,Schweinberger SR,Wiese H

更新日期：2014-04-04 00:00:00

abstract：:Aging is associated with impairment of sensorial functions and with the onset of neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) bioavailability progressively decreases, we see a direct correlation with sensory impairment and cognitive performance in older humans. Age-related...

journal_title：Frontiers in aging neuroscience

authors： Rodríguez-de la Rosa L,Lassaletta L,Calvino M,Murillo-Cuesta S,Varela-Nieto I

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:A physically active lifestyle has the potential to prevent cognitive decline and dementia, yet the optimal type of physical activity/exercise remains unclear. Dance is of special interest as it complex sensorimotor rhythmic activity with additional cognitive, social, and affective dimensions. OBJECTIVES:To ...

journal_title：Frontiers in aging neuroscience

authors： Merom D,Grunseit A,Eramudugolla R,Jefferis B,Mcneill J,Anstey KJ

更新日期：2016-02-22 00:00:00

abstract：:Similar to humans, the normal aged rat population is not homogeneous in terms of cognitive function. Two distinct subpopulations of aged Sprague-Dawley rats can be identified on the basis of spatial memory performance in the hole-board paradigm. It was the aim of the study to reveal protein changes relevant to aging a...

journal_title：Frontiers in aging neuroscience

authors： Lubec J,Smidak R,Malikovic J,Feyissa DD,Korz V,Höger H,Lubec G

更新日期：2019-07-31 00:00:00

abstract：:Late adulthood is associated with atrophy of brain areas, which contribute to cognitive deterioration and increase the risk of depression. On the other hand, aerobic exercise can improve learning and memory function, ameliorate mood, and prevent neurodegenerative changes. This study demonstrates the effect of Nordic w...

journal_title：Frontiers in aging neuroscience

authors： Domaszewska K,Koper M,Wochna K,Czerniak U,Marciniak K,Wilski M,Bukowska D

更新日期：2020-10-19 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular ph...

journal_title：Frontiers in aging neuroscience

authors： Finelli MJ

更新日期：2020-09-03 00:00:00

abstract：:Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after 2-months, corroborates the epidemiological association previously described between vitamin deficiency and this sensory impairment. However, this strain is prone to early hearing loss, and hence we decided to analyze whether the effects ex...

journal_title：Frontiers in aging neuroscience

authors： Martínez-Vega R,Murillo-Cuesta S,Partearroyo T,Varela-Moreiras G,Varela-Nieto I,Pajares MA

更新日期：2016-08-31 00:00:00

abstract：:Neuroinflammation and autophagy dysfunction are closely related to the development of neurodegeneration such as Parkinson's disease (PD). However, the role of autophagy in microglia polarization and neuroinflammation is poorly understood. TNF-α, which is highly toxic to dopaminergic neurons, is implicated as a major m...

journal_title：Frontiers in aging neuroscience

authors： Jin MM,Wang F,Qi D,Liu WW,Gu C,Mao CJ,Yang YP,Zhao Z,Hu LF,Liu CF

更新日期：2018-11-20 00:00:00

abstract：:Most therapeutic agents are designed to target a molecule or pathway without consideration of the mechanisms involved in the physiological turnover or removal of that target. In light of this and in particular for Alzheimer's disease, a number of therapeutic interventions are presently being developed/investigated whi...

journal_title：Frontiers in aging neuroscience

authors： Morrone CD,Liu M,Black SE,McLaurin J

更新日期：2015-05-05 00:00:00

abstract：:Manganese (Mn) is an essential metal and has important physiological functions for human health. However, exposure to excess levels of Mn in occupational settings or from environmental sources has been associated with a neurological syndrome comprising cognitive deficits, neuropsychological abnormalities and parkinson...

journal_title：Frontiers in aging neuroscience

authors： Guilarte TR

更新日期：2013-06-24 00:00:00

abstract：:Delirium is a common and morbid condition in elderly hospitalized patients. Its pathophysiology is poorly understood but inflammation has been implicated based on a clinical association with systemic infection and surgery and preclinical data showing that systemic inflammation adversely affects hippocampus-dependent m...

journal_title：Frontiers in aging neuroscience

authors： Culley DJ,Snayd M,Baxter MG,Xie Z,Lee IH,Rudolph J,Inouye SK,Marcantonio ER,Crosby G

更新日期：2014-06-10 00:00:00

abstract：:Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows...

journal_title：Frontiers in aging neuroscience

authors： Stoessel D,Schulte C,Teixeira Dos Santos MC,Scheller D,Rebollo-Mesa I,Deuschle C,Walther D,Schauer N,Berg D,Nogueira da Costa A,Maetzler W

更新日期：2018-03-05 00:00:00

abstract：:Objective: Increased variability in cognition with age has been argued as an indication of pathological processes. Focusing on early detection of neurodegenerative disorders, we investigated variability in cognition in healthy middle-aged adults. In order to understand possible determinants of this variability, we als...

journal_title：Frontiers in aging neuroscience

authors： Ferreira D,Machado A,Molina Y,Nieto A,Correia R,Westman E,Barroso J

更新日期：2017-06-09 00:00:00

abstract：:In mammals, melanopsin-expressing retinal ganglion cells (mRGCs) are, among other things, involved in several non-image-forming visual functions, including light entrainment of circadian rhythms. Considering the profound impact of aging on visual function and ophthalmic diseases, here we evaluate changes in mRGCs thro...

journal_title：Frontiers in aging neuroscience

authors： Esquiva G,Lax P,Pérez-Santonja JJ,García-Fernández JM,Cuenca N

更新日期：2017-04-04 00:00:00

abstract：:Objectives: To explore the transfer effects of cognitive training on working memory among older Chinese adults with mild cognitive impairment (MCI). Methods: Sixty-two MCI participants aged more than 60 years old were recruited by holding recruitment sessions in communities in China [33 for cognitive training, and 29 ...

journal_title：Frontiers in aging neuroscience

authors： Weng W,Liang J,Xue J,Zhu T,Jiang Y,Wang J,Chen S

更新日期：2019-08-14 00:00:00

abstract：:Background: Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations of leisure-time PA and psychological distress with dementia-related mortality, and whether the ass...

journal_title：Frontiers in aging neuroscience

authors： Zotcheva E,Selbæk G,Bjertness E,Ernstsen L,Strand BH

更新日期：2018-05-25 00:00:00