Loss of Melanopsin-Expressing Ganglion Cell Subtypes and Dendritic Degeneration in the Aging Human Retina.

Abstract:

:In mammals, melanopsin-expressing retinal ganglion cells (mRGCs) are, among other things, involved in several non-image-forming visual functions, including light entrainment of circadian rhythms. Considering the profound impact of aging on visual function and ophthalmic diseases, here we evaluate changes in mRGCs throughout the life span in humans. In 24 post-mortem retinas from anonymous human donors aged 10-81 years, we assessed the distribution, number and morphology of mRGCs by immunostaining vertical retinal sections and whole-mount retinas with antibodies against melanopsin. Human retinas showed melanopsin immunoreactivity in the cell body, axon and dendrites of a subset of ganglion cells at all ages tested. Nearly half of the mRGCs (51%) were located within the ganglion cell layer (GCL), and stratified in the outer (M1, 12%) or inner (M2, 16%) margin of the inner plexiform layer (IPL) or in both plexuses (M3, 23%). M1 and M2 cells conformed fairly irregular mosaics, while M3 cell distribution was slightly more regular. The rest of the mRGCs were more regularly arranged in the inner nuclear layer (INL) and stratified in the outer margin of the IPL (M1d, 49%). The quantity of each cell type decrease after age 70, when the total number of mRGCs was 31% lower than in donors aged 30-50 years. Moreover, in retinas with an age greater than 50 years, mRGCs evidenced a decrease in the dendritic area that was both progressive and age-dependent, as well as fewer branch points and terminal neurite tips per cell and a smaller Sholl area. After 70 years of age, the distribution profile of the mRGCs was closer to a random pattern than was observed in younger retinas. We conclude that advanced age is associated with a loss in density and dendritic arborization of the mRGCs in human retinas, possibly accounting for the more frequent occurrence of circadian rhythm disorders in elderly persons.

journal_name

Front Aging Neurosci

authors

Esquiva G,Lax P,Pérez-Santonja JJ,García-Fernández JM,Cuenca N

doi

10.3389/fnagi.2017.00079

subject

Has Abstract

pub_date

2017-04-04 00:00:00

pages

79

issn

1663-4365

journal_volume

9

pub_type

杂志文章
  • Distinct Disruptive Patterns of Default Mode Subnetwork Connectivity Across the Spectrum of Preclinical Alzheimer's Disease.

    abstract::Background: The early progression continuum of Alzheimer's disease (AD) has been considered to advance through subjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI). Altered functional connectivity (FC) in the default mode network (DMN) is reg...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2019.00307

    authors: Xue C,Yuan B,Yue Y,Xu J,Wang S,Wu M,Ji N,Zhou X,Zhao Y,Rao J,Yang W,Xiao C,Chen J

    更新日期:2019-11-13 00:00:00

  • Pathological Changes in Microvascular Morphology, Density, Size and Responses Following Comorbid Cerebral Injury.

    abstract::Aberrations in brain microcirculation and the associated increase in blood-brain-barrier (BBB) permeability in addition to neuroinflammation and Aβ deposition observed in Alzheimer's disease (AD) and ischemia have gained considerable attention recently. However, the role of microvascular homeostasis as a pathogenic su...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2019.00047

    authors: Amtul Z,Yang J,Lee TY,Cechetto DF

    更新日期:2019-03-27 00:00:00

  • Differential effects of emotional information on interference task performance across the life span.

    abstract::While functioning in multiple domains declines with age, emotional regulation appears to remain preserved in older adults. The Emotion Inhibition (Emotional Stroop) Test requires participants to name the ink color in which neutrally and emotionally valenced words are printed. It was employed in the current investigati...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2010.00141

    authors: Lamonica HM,Keefe RS,Harvey PD,Gold JM,Goldberg TE

    更新日期:2010-09-30 00:00:00

  • Characterizing healthy samples for studies of human cognitive aging.

    abstract::Characterizing the cognitive declines associated with aging, and differentiating them from the effects of disease in older adults, are important goals for human neuroscience researchers. This is also an issue of public health urgency in countries with rapidly aging populations. Progress toward understanding cognitive ...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2012.00023

    authors: Geldmacher DS,Levin BE,Wright CB

    更新日期:2012-09-12 00:00:00

  • Is abeta a sufficient biomarker for monitoring anti-abeta clinical studies? A critical review.

    abstract::Amyloid-beta (Aβ) in Alzheimer's disease (AD) appeared to be a promising target for disease-modifying therapeutic strategies like passive immunotherapy with anti-Aβ monoclonal antibodies (mAbs). Biochemical markers in cerebrospinal fluid (CSF) include alterations of Aβ that allow the diagnosis of AD. Biomarker strateg...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2013.00025

    authors: Moreth J,Mavoungou C,Schindowski K

    更新日期:2013-07-02 00:00:00

  • Impaired generation of new subcategories and switching in a semantic verbal fluency test in older adults with mild cognitive impairment.

    abstract::The semantic verbal fluency task is broadly used in the neuropsychological assessment of elderly subjects. Even some studies have identified differences in verbal fluency clustering and switching measures between subjects with normal aging and a clinical condition such as mild cognitive impairment (MCI) and Alzheimer'...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2014.00141

    authors: Bertola L,Cunha Lima ML,Romano-Silva MA,de Moraes EN,Diniz BS,Malloy-Diniz LF

    更新日期:2014-07-01 00:00:00

  • Coping with brief periods of food restriction: mindfulness matters.

    abstract::The obesity epidemic had spawned considerable interest in understanding peoples' responses to palatable food cues that are plentiful in obesogenic environments. In this paper we examine how trait mindfulness of older, obese adults may moderate brain networks that arise from exposure to such cues. Nineteen older, obese...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2012.00013

    authors: Paolini B,Burdette JH,Laurienti PJ,Morgan AR,Williamson DA,Rejeski WJ

    更新日期:2012-06-06 00:00:00

  • Alterations in the Interplay between Neurons, Astrocytes and Microglia in the Rat Dentate Gyrus in Experimental Models of Neurodegeneration.

    abstract::The hippocampus is negatively affected by aging and neurodegenerative diseases leading to impaired learning and memory abilities. A diverse series of progressive modifications in the intercellular communication among neurons, astrocytes and microglia occur in the hippocampus during aging or inflammation. A detailed un...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2017.00296

    authors: Lana D,Ugolini F,Nosi D,Wenk GL,Giovannini MG

    更新日期:2017-09-11 00:00:00

  • Crossmodal Connections of Primary Sensory Cortices Largely Vanish During Normal Aging.

    abstract::During aging, human response times (RTs) to unisensory and crossmodal stimuli decrease. However, the elderly benefit more from crossmodal stimulus representations than younger people. The underlying short-latency multisensory integration process is mediated by direct crossmodal connections at the level of primary sens...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2018.00052

    authors: Henschke JU,Ohl FW,Budinger E

    更新日期:2018-03-02 00:00:00

  • Systematic and Comprehensive Automated Ventricle Segmentation on Ventricle Images of the Elderly Patients: A Retrospective Study.

    abstract::Background and Objective: Ventricle volume is closely related to hydrocephalus, brain atrophy, Alzheimer's, Parkinson's syndrome, and other diseases. To accurately measure the volume of the ventricles for elderly patients, we use deep learning to establish a systematic and comprehensive automated ventricle segmentatio...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2020.618538

    authors: Zhou X,Ye Q,Jiang Y,Wang M,Niu Z,Menpes-Smith W,Fang EF,Liu Z,Xia J,Yang G

    更新日期:2020-12-16 00:00:00

  • Cotinine halts the advance of Alzheimer's disease-like pathology and associated depressive-like behavior in Tg6799 mice.

    abstract::Alzheimer's disease (AD) is associated with cognitive and non-cognitive symptoms for which there are currently no effective therapies. We have previously reported that cotinine, a natural product obtained from tobacco leaves, prevented memory loss and diminished amyloid-β (Aβ) plaque pathology in transgenic 6799 mice ...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2014.00162

    authors: Patel S,Grizzell JA,Holmes R,Zeitlin R,Solomon R,Sutton TL,Rohani A,Charry LC,Iarkov A,Mori T,Echeverria Moran V

    更新日期:2014-07-23 00:00:00

  • Variations in brain DNA.

    abstract::It is assumed that DNA sequences are conserved in the diverse cell types present in a multicellular organism like the human being. Thus, in order to compare the sequences in the genome of DNA from different individuals, nucleic acid is commonly isolated from a single tissue. In this regard, blood cells are widely used...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnagi.2014.00323

    authors: Avila J,Gómez-Ramos A,Soriano E

    更新日期:2014-11-25 00:00:00

  • Consolidation in older adults depends upon competition between resting-state networks.

    abstract::Memory encoding and retrieval problems are inherent to aging. To date, however, the effect of aging upon the neural correlates of forming memory traces remains poorly understood. Resting-state fMRI connectivity can be used to investigate initial consolidation. We compared within and between network connectivity differ...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2014.00344

    authors: Jacobs HI,Dillen KN,Risius O,Göreci Y,Onur OA,Fink GR,Kukolja J

    更新日期:2015-01-09 00:00:00

  • Leisure-Time Physical Activity Is Associated With Reduced Risk of Dementia-Related Mortality in Adults With and Without Psychological Distress: The Cohort of Norway.

    abstract::Background: Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations of leisure-time PA and psychological distress with dementia-related mortality, and whether the ass...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2018.00151

    authors: Zotcheva E,Selbæk G,Bjertness E,Ernstsen L,Strand BH

    更新日期:2018-05-25 00:00:00

  • Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.

    abstract::Background: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer'sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important risk factor for AD. H...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2020.00183

    authors: Zhang Q,Wu L,Du C,Xu K,Sun J,Zhang J,Li H,Li X

    更新日期:2020-06-30 00:00:00

  • Early Detection and Prevention of Alzheimer's Disease: Role of Oxidative Markers and Natural Antioxidants.

    abstract::Oxidative stress (OS) contributes to Alzheimer's disease (AD) pathology. OS can be a result of increased reactive oxygen/nitrogen species, reduced antioxidants, oxidatively damaged molecules, and/or a combination of these factors. Scientific literature is scarce for the markers of OS-specific for detecting AD at an ea...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnagi.2020.00231

    authors: Arslan J,Jamshed H,Qureshi H

    更新日期:2020-07-27 00:00:00

  • Role of Neurofilament Light Chain as a Potential Biomarker for Alzheimer's Disease: A Correlative Meta-Analysis.

    abstract::Neurofilament light (NFL) is a putative biomarker of neurodegeneration. This study evaluates the correlative association of NFL with Alzheimer's disease (AD) indices. Relevant studies were identified after a literature search in electronic databases and study selection was based on pre-determined eligibility criteria....

    journal_title:Frontiers in aging neuroscience

    pub_type:

    doi:10.3389/fnagi.2019.00254

    authors: Jin M,Cao L,Dai YP

    更新日期:2019-09-13 00:00:00

  • Cerebrospinal Fluid Aβ43 Is Reduced in Early-Onset Compared to Late-Onset Alzheimer's Disease, But Has Similar Diagnostic Accuracy to Aβ42.

    abstract::Background: Amyloid beta 1-43 (Aβ43) may be a useful additional biomarker for diagnosing Alzheimer's disease (AD). We have investigated cerebrospinal fluid (CSF) levels of Aβ43 in patients with early-onset AD in contrast to levels in late-onset AD. For comparison, in addition to the 'core' biomarkers, several other an...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2017.00210

    authors: Lauridsen C,Sando SB,Møller I,Berge G,Pomary PK,Grøntvedt GR,Salvesen Ø,Bråthen G,White LR

    更新日期:2017-06-28 00:00:00

  • Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis.

    abstract::Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2020.603854

    authors: Cui L,Hou NN,Wu HM,Zuo X,Lian YZ,Zhang CN,Wang ZF,Zhang X,Zhu JH

    更新日期:2020-12-21 00:00:00

  • Clinical and Biomarker Changes in Premanifest Huntington Disease Show Trial Feasibility: A Decade of the PREDICT-HD Study.

    abstract::There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinical trials for HD are limited by a lack of knowledge of the natural hi...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2014.00078

    authors: Paulsen JS,Long JD,Johnson HJ,Aylward EH,Ross CA,Williams JK,Nance MA,Erwin CJ,Westervelt HJ,Harrington DL,Bockholt HJ,Zhang Y,McCusker EA,Chiu EM,Panegyres PK,PREDICT-HD Investigators and Coordinators of the Huntington Stu

    更新日期:2014-04-22 00:00:00

  • Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography.

    abstract::Hypertension has a profound influence on the structure and function of blood vessels. Cerebral vessels undergo both structural and functional changes in hypertensive animals. However, dynamic changes of cerebrovasculature and the factors involved in this process are largely unknown. In this study, we explored the dyna...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2017.00359

    authors: Wang L,Mu Z,Lin X,Geng J,Xiao TQ,Zhang Z,Wang Y,Guan Y,Yang GY

    更新日期:2017-11-02 00:00:00

  • Mindfulness-Based Intervention for People With Dementia and Their Partners: Results of a Mixed-Methods Study.

    abstract:Objective:Studies have shown preliminary support for mindfulness-based interventions benefitting people with dementia and their caregivers. However, most studies focus on these two groups separately. This study examined whether it would be possible and beneficial for people with dementia and their caregiver to jointly ...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2019.00092

    authors: Berk L,Warmenhoven F,Stiekema APM,van Oorsouw K,van Os J,de Vugt M,van Boxtel M

    更新日期:2019-04-24 00:00:00

  • Sustained Effects of Memory and Lifestyle Interventions on Memory Functioning of Older Adults: An 18-Month Follow-Up Study.

    abstract::Background: There has been much research devoted to examining the short-term effects of different interventions for improving memory functioning of older adults with memory complaints. Nevertheless, very few studies have examined the long-term effects of these interventions. Thus, the present study compared the sustai...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2018.00240

    authors: Chan AS,Cheung WK,Yeung MK,Lee TL

    更新日期:2018-08-07 00:00:00

  • Assessment of Age-Related Morphometric Changes of Subcortical Structures in Healthy People Using Ultra-High Field 7 Tesla Magnetic Resonance Imaging.

    abstract::Objective: To assess the age-related morphometric changes of subcortical structures in healthy people. Materials and Methods: Ultra-high field 7 tesla magnetic resonance (MR) imaging in humans was used to visualize the subcortical structures of healthy young, middle-aged and elderly participants. Using the magnetizati...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2016.00224

    authors: Wang XY,Zhao L,Yu T,Qiao L,Ni DY,Zhang GJ,Li YJ

    更新日期:2016-09-26 00:00:00

  • Exosome α-Synuclein Release in Plasma May be Associated With Postoperative Delirium in Hip Fracture Patients.

    abstract::Background: Little is known about the underlying mechanisms of the similarities in the core features of postoperative delirium (POD) and α-synuclein (α-syn)-related cognitive disorders. We herein investigated associations between fluctuated levels of exosomal α-syn in the plasma and POD presentation in geriatric hip f...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2020.00067

    authors: Yuan Y,Li Z,Yang N,Han Y,Ji X,Han D,Wang X,Li Y,Liu T,Yuan F,He J,Liu Y,Ni C,Zou P,Wang G,Guo X,Zhou Y

    更新日期:2020-03-13 00:00:00

  • A delicate balance: Iron metabolism and diseases of the brain.

    abstract::Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransmitter synthesis, myelination of neurons, and mitochondrial function. Redox cycling between ferrous and ferric iron is utilized in biology for various electron transfer reactions essential t...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2013.00034

    authors: Hare D,Ayton S,Bush A,Lei P

    更新日期:2013-07-18 00:00:00

  • Socio-cognitive profiles for visual learning in young and older adults.

    abstract::It is common wisdom that practice makes perfect; but why do some adults learn better than others? Here, we investigate individuals' cognitive and social profiles to test which variables account for variability in learning ability across the lifespan. In particular, we focused on visual learning using tasks that test t...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2015.00105

    authors: Christian J,Goldstone A,Kuai SG,Chin W,Abrams D,Kourtzi Z

    更新日期:2015-06-10 00:00:00

  • Cognitive Benefits of Social Dancing and Walking in Old Age: The Dancing Mind Randomized Controlled Trial.

    abstract:BACKGROUND:A physically active lifestyle has the potential to prevent cognitive decline and dementia, yet the optimal type of physical activity/exercise remains unclear. Dance is of special interest as it complex sensorimotor rhythmic activity with additional cognitive, social, and affective dimensions. OBJECTIVES:To ...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2016.00026

    authors: Merom D,Grunseit A,Eramudugolla R,Jefferis B,Mcneill J,Anstey KJ

    更新日期:2016-02-22 00:00:00

  • Prevalence and Atypical Clinical Characteristics of NOTCH3 Mutations Among Patients Admitted for Acute Lacunar Infarctions.

    abstract::Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary small vessel disease, with reported frequencies of 2-5/100,000 individuals. Recently, it has been reported that some patients with NOTCH3 gene mutations show atypical clinical ...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2020.00130

    authors: Okada T,Washida K,Irie K,Saito S,Noguchi M,Tomita T,Koga M,Toyoda K,Okazaki S,Koizumi T,Mizuta I,Mizuno T,Ihara M

    更新日期:2020-05-14 00:00:00

  • Measuring the Moment-to-Moment Variability of Tinnitus: The TrackYourTinnitus Smart Phone App.

    abstract::Tinnitus, the phantom perception of sound without a corresponding external sound, is a frequent disorder which causes significant morbidity. So far there is no treatment available that reliably reduces the tinnitus perception. The research is hampered by the large heterogeneity of tinnitus and the fact that the tinnit...

    journal_title:Frontiers in aging neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnagi.2016.00294

    authors: Schlee W,Pryss RC,Probst T,Schobel J,Bachmeier A,Reichert M,Langguth B

    更新日期:2016-12-15 00:00:00