Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes.

abstract：:Alzheimer's disease treatment is still an open problem. The diversity of symptoms, the alterations in common pathophysiology, the existence of asymptomatic cases, the different types of sporadic and familial Alzheimer's and their relevance with other types of dementia and comorbidities, have already created a myth-fea...

journal_title：Frontiers in aging neuroscience

authors： Alexiou A,Mantzavinos VD,Greig NH,Kamal MA

更新日期：2017-03-31 00:00:00

abstract：:Hearing loss is an important risk factor for dementia. However, the mechanisms that relate these disorders are still unknown. As a proxy of this relationship, we studied the structural brain changes associated with functional impairment in activities of daily living in subjects with age related hearing loss, or presby...

journal_title：Frontiers in aging neuroscience

authors： Belkhiria C,Vergara RC,San Martin S,Leiva A,Martinez M,Marcenaro B,Andrade M,Delano PH,Delgado C

更新日期：2020-04-28 00:00:00

abstract：:Recent studies have shown that Liuwei Dihuang pills (LWPs) can positively affect learning, memory and neurogenesis. However, the underlying molecular mechanisms are not understood. In the present study, we developed ALWPs, a mixture of Antler and LWPs, and investigated whether ALWPs can affect neuroinflammatory respon...

journal_title：Frontiers in aging neuroscience

authors： Lee JY,Joo B,Nam JH,Nam HY,Lee W,Nam Y,Seo Y,Kang HJ,Cho HJ,Jang YP,Kim J,We YM,Koo JW,Hoe HS

更新日期：2018-09-26 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) includes a spectrum of disorders characterized by changes of personality and social behavior and, often, a gradual and progressive language dysfunction. In the last years, several efforts have been fulfilled in identifying both genetic mutations and pathological proteins associ...

journal_title：Frontiers in aging neuroscience

authors： Piscopo P,Albani D,Castellano AE,Forloni G,Confaloni A

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Previous studies reported that old adults, relative to young adults, showed improvement of emotional stability and increased experiences of positive affects. METHODS:In order to better understand the neural underpinnings behind the aging-related enhancement of positive affects, it is necessary to investigat...

journal_title：Frontiers in aging neuroscience

authors： Meng X,Yang J,Cai AY,Ding XS,Liu W,Li H,Yuan JJ

更新日期：2015-08-06 00:00:00

abstract：:Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows...

journal_title：Frontiers in aging neuroscience

authors： Stoessel D,Schulte C,Teixeira Dos Santos MC,Scheller D,Rebollo-Mesa I,Deuschle C,Walther D,Schauer N,Berg D,Nogueira da Costa A,Maetzler W

更新日期：2018-03-05 00:00:00

abstract：:EEG research conducted in the past 5 years on multiple object processing has begun to define how the aging brain tracks the numerosity of the objects presented in the visual field for different goals. We review the recent EEG findings in healthy older individuals (age range: 65-75 years approximately) on perceptual, a...

journal_title：Frontiers in aging neuroscience

authors： Mazza V,Brignani D

更新日期：2016-03-02 00:00:00

abstract：:The dorsal raphe nucleus (DRN) has been repeatedly implicated as having a significant relationship with depression, along with its serotoninergic innervation. However, functional connectivity of the DRN in depression is not well understood. The current study aimed to isolate functional connectivity of the DRN distinct...

journal_title：Frontiers in aging neuroscience

authors： Ikuta T,Matsuo K,Harada K,Nakashima M,Hobara T,Higuchi N,Higuchi F,Otsuki K,Shibata T,Watanuki T,Matsubara T,Yamagata H,Watanabe Y

更新日期：2017-08-02 00:00:00

abstract：:Mouse models are key tools for studying cochlear alterations in noise-induced hearing loss (NIHL) and for evaluating new therapies. Stimuli used to induce deafness in mice are usually white and octave band noises that include very low frequencies, considering the large mouse auditory range. We designed different sound...

journal_title：Frontiers in aging neuroscience

authors： Sanz L,Murillo-Cuesta S,Cobo P,Cediel-Algovia R,Contreras J,Rivera T,Varela-Nieto I,Avendaño C

更新日期：2015-02-16 00:00:00

abstract：:Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques, neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the brain. AD research has, in large part, been dedicated to the understanding of Aβ and NFT deposition as well as to the pharmacological reduction of th...

journal_title：Frontiers in aging neuroscience

authors： Frost GR,Jonas LA,Li YM

更新日期：2019-12-10 00:00:00

abstract：:Many of the molecular and pathological features associated with human Alzheimer disease (AD) are mirrored in the naturally occurring age-associated neuropathology in the canine species. In aged dogs with declining learned behavior and memory the severity of cognitive dysfunction parallels the progressive build up and ...

journal_title：Frontiers in aging neuroscience

authors： Rusbridge C,Salguero FJ,David MA,Faller KME,Bras JT,Guerreiro RJ,Richard-Londt AC,Grainger D,Head E,Brandner SGP,Summers B,Hardy J,Tayebi M

更新日期：2018-01-30 00:00:00

abstract：:Cognitive demands for postural control increase with aging and cognitive-motor interference (CMI) exists for a number of walking situations, especially with visuo-spatial cognitive tasks. Such interference also influences spatial learning abilities among older adults; however, this is rarely considered in research on ...

journal_title：Frontiers in aging neuroscience

authors： Agathos CP,Ramanoël S,Bécu M,Bernardin D,Habas C,Arleo A

更新日期：2020-11-12 00:00:00

abstract：:It is relevant to unravel the factors that may mediate the cognitive decline observed during aging. Previous reports indicate that education has a positive influence on cognitive performance, while age, female gender and, especially, depressed mood were associated with poorer performances across multiple cognitive dim...

journal_title：Frontiers in aging neuroscience

authors： Santos NC,Costa PS,Cunha P,Portugal-Nunes C,Amorim L,Cotter J,Cerqueira JJ,Palha JA,Sousa N

更新日期：2014-02-24 00:00:00

abstract：:Background and Purpose: Previous studies of voxel-based morphometry (VBM) have found that patients with type 2 diabetes mellitus (T2DM) exhibit gray matter alterations, but these findings are inconsistent and have not been quantitatively reviewed. Therefore, the aim of this study was to conduct a quantitative meta-ana...

journal_title：Frontiers in aging neuroscience

authors： Liu J,Liu T,Wang W,Ma L,Ma X,Shi S,Gong Q,Wang M

更新日期：2017-05-22 00:00:00

abstract：:Age-related cognitive decline has been linked to a diverse set of neurobiological mechanisms, including bidirectional changes in proteins critical for neuron function. Importantly, these alterations are not uniform across the brain. For example, the hippocampus (HPC) and prefrontal cortex (PFC) show distinct patterns ...

journal_title：Frontiers in aging neuroscience

authors： Hernandez AR,Hernandez CM,Campos K,Truckenbrod L,Federico Q,Moon B,McQuail JA,Maurer AP,Bizon JL,Burke SN

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND:The cognitive status is generally considered as a major determinant of rehabilitation outcome in Parkinson's disease (PD). No studies about the effect of cognitive impairment on motor rehabilitation outcomes in PD have been performed before. OBJECTIVE:This study is aimed to evaluate the impact of cognitive ...

journal_title：Frontiers in aging neuroscience

authors： Ferrazzoli D,Ortelli P,Maestri R,Bera R,Giladi N,Ghilardi MF,Pezzoli G,Frazzitta G

更新日期：2016-08-11 00:00:00

abstract：:Current society has to deal with major challenges related to our constantly increasing population of older adults. Since, motor performance generally deteriorates at older age, research investigating the effects of different types of training on motor improvement is particularly important. Here, we tested the effects ...

journal_title：Frontiers in aging neuroscience

authors： Pauwels L,Vancleef K,Swinnen SP,Beets IA

更新日期：2015-08-11 00:00:00

abstract：:miR-146a is a microRNA (miRNA) involved in neuroinflammation and aging; alterations in its expression were described in Alzheimer's disease (AD). However, most of the studies conducted so far on this miRNA included a limited number of participants and produced contradictory results. We compared miR-146a levels in plas...

journal_title：Frontiers in aging neuroscience

authors： Maffioletti E,Milanesi E,Ansari A,Zanetti O,Galluzzi S,Geroldi C,Gennarelli M,Bocchio-Chiavetto L

更新日期：2020-01-17 00:00:00

abstract：:The semantic verbal fluency task is broadly used in the neuropsychological assessment of elderly subjects. Even some studies have identified differences in verbal fluency clustering and switching measures between subjects with normal aging and a clinical condition such as mild cognitive impairment (MCI) and Alzheimer'...

journal_title：Frontiers in aging neuroscience

authors： Bertola L,Cunha Lima ML,Romano-Silva MA,de Moraes EN,Diniz BS,Malloy-Diniz LF

更新日期：2014-07-01 00:00:00

abstract：:An inverse association may exist between cancers and neurodegenerative diseases, although convenient biomarkers for verifying this inverse association are lacking. Plasma neurofilament light chain (NfL) is a novel biomarker for neurodegenerative diseases, such as Alzheimer's disease (AD), but it has not been measured ...

journal_title：Frontiers in aging neuroscience

authors： Liu S,Huang Z,Zhang L,Pan J,Lei Q,Meng Y,Li Z

更新日期：2020-01-29 00:00:00

abstract：:Neuromodulation techniques such as deep brain stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia. However, the outcomes of such treatments appear to be somewhat paradoxical, in that these techniques can both disrupt and enhance memory even when applied t...

journal_title：Frontiers in aging neuroscience

authors： Tan SZK,Du R,Perucho JAU,Chopra SS,Vardhanabhuti V,Lim LW

更新日期：2020-09-14 00:00:00

abstract：Objective:Studies have shown preliminary support for mindfulness-based interventions benefitting people with dementia and their caregivers. However, most studies focus on these two groups separately. This study examined whether it would be possible and beneficial for people with dementia and their caregiver to jointly ...

journal_title：Frontiers in aging neuroscience

authors： Berk L,Warmenhoven F,Stiekema APM,van Oorsouw K,van Os J,de Vugt M,van Boxtel M

更新日期：2019-04-24 00:00:00

abstract：:As the population ages and dementia becomes a growing healthcare concern, it is increasingly important to identify targets for intervention to delay or attenuate cognitive decline. Research has shown that the most successful interventions aim at altering lifestyle factors. Thus, this study examined how involvement in ...

journal_title：Frontiers in aging neuroscience

authors： Seider TR,Fieo RA,O'Shea A,Porges EC,Woods AJ,Cohen RA

更新日期：2016-05-02 00:00:00

abstract：:The McGill-R-Thy1-APP transgenic rat is an animal model of the familial form of Alzheimer's disease (AD). This model mirrors several neuropathological hallmarks of the disease, including the accumulation of beta-amyloid and the formation of amyloid plaques (in homozygous animals only), neuroinflammation and the gradua...

journal_title：Frontiers in aging neuroscience

authors： Petrasek T,Vojtechova I,Lobellova V,Popelikova A,Janikova M,Brozka H,Houdek P,Sladek M,Sumova A,Kristofikova Z,Vales K,Stuchlík A

更新日期：2018-08-28 00:00:00

abstract：:The recent application of graph theory to brain networks promises to shed light on complex diseases such as Parkinson's disease (PD). This study aimed to investigate functional changes in sensorimotor and cognitive networks in Parkinsonian patients, with a focus on inter- and intra-connectivity organization in the dis...

journal_title：Frontiers in aging neuroscience

authors： Koshimori Y,Cho SS,Criaud M,Christopher L,Jacobs M,Ghadery C,Coakeley S,Harris M,Mizrahi R,Hamani C,Lang AE,Houle S,Strafella AP

更新日期：2016-11-10 00:00:00

abstract：:Exercise may be the most commonly offered yet least consistently followed therapeutic advice for people with Parkinson's disease (PD). Epidemiological studies of prospectively followed cohorts have shown a lower risk for later developing PD in healthy people who report moderate to high levels of physical activity, and...

journal_title：Frontiers in aging neuroscience

authors： Crotty GF,Schwarzschild MA

更新日期：2020-06-19 00:00:00

abstract：:Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after 2-months, corroborates the epidemiological association previously described between vitamin deficiency and this sensory impairment. However, this strain is prone to early hearing loss, and hence we decided to analyze whether the effects ex...

journal_title：Frontiers in aging neuroscience

authors： Martínez-Vega R,Murillo-Cuesta S,Partearroyo T,Varela-Moreiras G,Varela-Nieto I,Pajares MA

更新日期：2016-08-31 00:00:00

abstract：:Parkinson's disease (PD) is a debilitating neurodegenerative disorder defined by a loss of dopamine-producing neurons in the substantia nigra in the brain. It is associated with cytosolic inclusions known as Lewy bodies. The major component of Lewy bodies is aggregated alpha-synuclein. The molecular mechanism of alpha...

journal_title：Frontiers in aging neuroscience

authors： Hernandez SM,Tikhonova EB,Karamyshev AL

更新日期：2020-03-17 00:00:00

abstract：:Alzheimer's disease (AD) is associated with cognitive and non-cognitive symptoms for which there are currently no effective therapies. We have previously reported that cotinine, a natural product obtained from tobacco leaves, prevented memory loss and diminished amyloid-β (Aβ) plaque pathology in transgenic 6799 mice ...

journal_title：Frontiers in aging neuroscience

authors： Patel S,Grizzell JA,Holmes R,Zeitlin R,Solomon R,Sutton TL,Rohani A,Charry LC,Iarkov A,Mori T,Echeverria Moran V

更新日期：2014-07-23 00:00:00

abstract：:Aging is associated with cognitive decline and alterations in early perceptual processes. Studies in the auditory and visual sensory modalities have shown that the mismatch negativity [or the mismatch response (MMR)], an event-related potential (ERP) elicited by a deviant stimulus in a background of homogenous events,...

journal_title：Frontiers in aging neuroscience

authors： Strömmer JM,Tarkka IM,Astikainen P

更新日期：2014-10-27 00:00:00