abstract：:Parkinson's disease (PD) is characterized by non-motor symptoms as well as motor deficits. The non-motor symptoms rarely appear individually and occur simultaneously with motor deficits or independently. However, a comprehensive research on the non-motor symptoms using an experimental model of PD remains poorly unders...

journal_title：Frontiers in aging neuroscience

authors： Han NR,Kim YK,Ahn S,Hwang TY,Lee H,Park HJ

更新日期：2021-01-13 00:00:00

abstract：:Background and Purpose: Subarachnoid hemorrhage (SAH) has long been classified into two main forms, aneurysmal SAH (aSAH) and non-aneurysmal SAH (naSAH), but the related risk factors for aSAH and naSAH are heterogeneous. Our objective was to determine the risk factors for SAH of known or unknown origin with respect to...

journal_title：Frontiers in aging neuroscience

authors： Wang MD,Fu QH,Song MJ,Ma WB,Zhang JH,Wang ZX

更新日期：2021-01-11 00:00:00

abstract：:Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified...

journal_title：Frontiers in aging neuroscience

authors： Cui L,Hou NN,Wu HM,Zuo X,Lian YZ,Zhang CN,Wang ZF,Zhang X,Zhu JH

更新日期：2020-12-21 00:00:00

abstract：:Background and Objective: Ventricle volume is closely related to hydrocephalus, brain atrophy, Alzheimer's, Parkinson's syndrome, and other diseases. To accurately measure the volume of the ventricles for elderly patients, we use deep learning to establish a systematic and comprehensive automated ventricle segmentatio...

journal_title：Frontiers in aging neuroscience

authors： Zhou X,Ye Q,Jiang Y,Wang M,Niu Z,Menpes-Smith W,Fang EF,Liu Z,Xia J,Yang G

更新日期：2020-12-16 00:00:00

abstract：:Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients aged 65 years and older. There are currently no proven neurorestorative treatments for chronic stroke. To address the complex problem of restoring function in ischemic brain tissue, stem...

journal_title：Frontiers in aging neuroscience

authors： He JQ,Sussman ES,Steinberg GK

更新日期：2020-12-14 00:00:00

abstract：:Background and Purpose: Olfactory dysfunction (OD) is a common non-motor symptom of Parkinson disease (PD). However, the relationship between OD and neuropathologic proteins in cerebrospinal fluid (CSF) from PD patients remains unclear. Methods: 166 PD patients were included in the study. Overall olfactory function wa...

journal_title：Frontiers in aging neuroscience

authors： Guo P,Wang RD,Lian TH,Ding DY,Zhang YN,Zhang WJ,Li DN,Li LX,Li JH,Guan HY,Yu SY,Liu L,Hu Y,Zuo LJ,Yu QJ,Wang XM,Zhang W

更新日期：2020-12-11 00:00:00

abstract：:Background: Hypersensitivity to general anesthetics may predict poor postoperative outcomes, especially among the older subjects. Therefore, it is essential to elucidate the mechanism underlying hypersensitivity to volatile anesthetics in the aging population. Given the fact that isoflurane sensitivity increases with ...

journal_title：Frontiers in aging neuroscience

authors： Gong C,Zhang D,Ou W,Ou M,Liang P,Liao D,Zhang W,Zhu T,Liu J,Zhou C

更新日期：2020-12-03 00:00:00

abstract：Background and Purpose:To identify clinical, laboratory, and magnetic resonance imaging (MRI) features in predicting incident stroke and dementia in Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Materials and Methods:We enrolled 87 Korean CAD...

journal_title：Frontiers in aging neuroscience

authors： Lee JS,Ko KH,Oh JH,Kim JG,Kang CH,Song SK,Kang SY,Kang JH,Park JH,Koh MJ,Lee HK,Choi JC

更新日期：2020-11-20 00:00:00

abstract：:Abnormal cerebral blood flow (CBF) and resting-state functional connectivity (rs-FC) are sensitive biomarkers of disease progression and prognosis. This study investigated neural underpinnings of motor and cognitive recovery by longitudinally studying the changes of CBF and FC in pontine infarction (PI). Twenty patien...

journal_title：Frontiers in aging neuroscience

authors： Wei Y,Wu L,Wang Y,Liu J,Miao P,Wang K,Wang C,Cheng J

更新日期：2020-11-19 00:00:00

abstract：:Cognitive demands for postural control increase with aging and cognitive-motor interference (CMI) exists for a number of walking situations, especially with visuo-spatial cognitive tasks. Such interference also influences spatial learning abilities among older adults; however, this is rarely considered in research on ...

journal_title：Frontiers in aging neuroscience

authors： Agathos CP,Ramanoël S,Bécu M,Bernardin D,Habas C,Arleo A

更新日期：2020-11-12 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease, for which aging remains the major risk factor. Aging is under a consistent pressure of increasing brain entropy (BEN) due to the progressive brain deteriorations. Noticeably, the brain constantly consumes a large amount of energy to maintain its func...

journal_title：Frontiers in aging neuroscience

authors： Wang Z,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-11-10 00:00:00

abstract：:Aggregated tau is a hallmark neuropathological feature in numerous neurodegenerative disorders. Previous studies aiming to validate aggregated tau pathology as a pathogenic driver of neurodegeneration in correlation to characteristic behavioral phenotypes have had shortcomings. Although studies on soluble tau patholog...

journal_title：Frontiers in aging neuroscience

authors： Mahendran TS,Suresh SN,Garimella L,Manjithaya R

更新日期：2020-11-05 00:00:00

abstract：Background:Age-related cognitive decline begins in middle age and persists with age. Leukocyte telomere length (LTL) decreases with age and is enhanced by inflammation and oxidative stress. However, whether shorter LTL correlates with cognitive decline remains controversial. Aims:We aimed to investigate the relationsh...

journal_title：Frontiers in aging neuroscience

authors： Linghui D,Shi Q,Chi C,Xiaolei L,Lixing Z,Zhiliang Z,Birong D

更新日期：2020-10-30 00:00:00

abstract：Objective:To investigate dysregulated molecules in preoperative cerebrospinal fluid (CSF) of elderly hip fracture patients with postoperative delirium (POD), in order to identify potential pathological mechanisms and biomarkers for pre-stage POD. Materials and Methods:This nested case control study used untargeted met...

journal_title：Frontiers in aging neuroscience

authors： Han Y,Zhang W,Liu J,Song Y,Liu T,Li Z,Wang X,Yang N,Li Y,Han D,Mi X,Zhou Y,Li M,Guo X,Zhong L,Wang G,Yuan Y

更新日期：2020-10-22 00:00:00

abstract：:Late adulthood is associated with atrophy of brain areas, which contribute to cognitive deterioration and increase the risk of depression. On the other hand, aerobic exercise can improve learning and memory function, ameliorate mood, and prevent neurodegenerative changes. This study demonstrates the effect of Nordic w...

journal_title：Frontiers in aging neuroscience

authors： Domaszewska K,Koper M,Wochna K,Czerniak U,Marciniak K,Wilski M,Bukowska D

更新日期：2020-10-19 00:00:00

abstract：:Stroke is a major public health problem worldwide with a high burden of neurological disability and mortality. Long noncoding RNAs (lncRNAs) have attracted much attention in the past decades because of their newly discovered roles in pathophysiological processes in many diseases. The abundance of lncRNAs in the nervou...

journal_title：Frontiers in aging neuroscience

authors： Fan J,Saft M,Sadanandan N,Gonzales-Portillo B,Park YJ,Sanberg PR,Borlongan CV,Luo Y

更新日期：2020-10-19 00:00:00

abstract：:Background: Gait disturbance is an early, cardinal feature of Parkinson's disease (PD) associated with falls and reduced physical activity. Progression of gait impairment in Parkinson's disease is not well characterized and a better understanding is imperative to mitigate impairment. Subtle gait impairments progress i...

journal_title：Frontiers in aging neuroscience

authors： Wilson J,Alcock L,Yarnall AJ,Lord S,Lawson RA,Morris R,Taylor JP,Burn DJ,Rochester L,Galna B

更新日期：2020-10-15 00:00:00

abstract：:Synapse loss occurs early in Alzheimer's disease (AD) patients and animal models. Alterations at synaptic level are a major morphological correlate of the memory deficits and related symptoms of AD. Given the predominant roles of synaptic AMPA receptors (AMPARs) in excitatory synaptic transmission in the brain, change...

journal_title：Frontiers in aging neuroscience

authors： Martín-Belmonte A,Aguado C,Alfaro-Ruíz R,Itakura M,Moreno-Martínez AE,de la Ossa L,Molnár E,Fukazawa Y,Luján R

更新日期：2020-10-06 00:00:00

abstract：:Neuromodulation techniques such as deep brain stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia. However, the outcomes of such treatments appear to be somewhat paradoxical, in that these techniques can both disrupt and enhance memory even when applied t...

journal_title：Frontiers in aging neuroscience

authors： Tan SZK,Du R,Perucho JAU,Chopra SS,Vardhanabhuti V,Lim LW

更新日期：2020-09-14 00:00:00

abstract：:Background and Purpose: Previous studies found inconsistent results regarding the relationship between Alzheimer's disease (AD) and catecholamines, such as dopamine (DA), norepinephrine (NE), and epinephrine (EPI). Therefore, the purpose of this study was to perform a systematic review and meta-analysis to evaluate th...

journal_title：Frontiers in aging neuroscience

authors： Pan X,Kaminga AC,Jia P,Wen SW,Acheampong K,Liu A

更新日期：2020-09-11 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular ph...

journal_title：Frontiers in aging neuroscience

authors： Finelli MJ

更新日期：2020-09-03 00:00:00

abstract：:The microtubule-associated protein tau is closely correlated with hypometabolism in Alzheimer's disease (AD). α-lipoic acid (LA), which is a naturally occurring cofactor in mitochondrial, has been shown to have properties that can inhibit the tau pathology and neuronal damage in our previous research. However, if LA a...

journal_title：Frontiers in aging neuroscience

authors： Zhang YH,Yan XZ,Xu SF,Pang ZQ,Li LB,Yang Y,Fan YG,Wang Z,Yu X,Guo C,Ao Q

更新日期：2020-08-21 00:00:00

abstract：:DNA methylation is an essential epigenetic mechanism involving in gene transcription modulation. An age-related increase in promoter methylation has been observed for neuronal activity and memory genes, and participates in neurological disorders. However, the position and precise mechanism of DNA methylation for memor...

journal_title：Frontiers in aging neuroscience

authors： Ni C,Qian M,Geng J,Qu Y,Tian Y,Yang N,Li S,Zheng H

更新日期：2020-08-18 00:00:00

abstract：Objective:To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 103) over time among cognitively normal older people. Methods:We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with normal...

journal_title：Frontiers in aging neuroscience

authors： Li X,Tong Q,Gao J,Liu C,Alzheimer’s Disease Neuroimaging Initiative.,Liu Y

更新日期：2020-08-14 00:00:00

abstract：:Background: Gray matter (GM) alterations in Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD) have been demonstrated in many neuroimaging studies using voxel-based morphometry (VBM). However, the inconsistent findings between studies cannot be applied to clinical practice as a neu...

journal_title：Frontiers in aging neuroscience

authors： Yang C,Chang J,Liang X,Bao X,Wang R

更新日期：2020-08-12 00:00:00

abstract：:Background: Cognitive frailty (CF) is defined as the simultaneous presence of physical frailty and cognitive impairment among older adults without dementia. Previous studies have revealed that neuropathological changes may contribute to the degeneration of subcortical nuclei in the process of cognitive impairment. How...

journal_title：Frontiers in aging neuroscience

authors： Wan M,Xia R,Lin H,Qiu P,He J,Ye Y,Tao J,Chen L,Zheng G

更新日期：2020-07-28 00:00:00

abstract：:Oxidative stress (OS) contributes to Alzheimer's disease (AD) pathology. OS can be a result of increased reactive oxygen/nitrogen species, reduced antioxidants, oxidatively damaged molecules, and/or a combination of these factors. Scientific literature is scarce for the markers of OS-specific for detecting AD at an ea...

journal_title：Frontiers in aging neuroscience

authors： Arslan J,Jamshed H,Qureshi H

更新日期：2020-07-27 00:00:00

abstract：:Background and purpose: The aggregation of vascular risk factors (VRFs) can aggravate cognitive impairment in stroke-free patients. Metabolites in serum and cerebrospinal fluid (CSF) may irreversibly reflect early functional deterioration. This study evaluated small-molecule metabolites (<1,000 Da) in the serum and CS...

journal_title：Frontiers in aging neuroscience

authors： Peng S,Shen Y,Wang M,Zhang J

更新日期：2020-07-22 00:00:00

abstract：:Alzheimer disease (AD) has an insidious onset and heterogeneous clinical symptoms. The well-accepted biomarkers for clinical diagnosis of AD include β-amyloid (Aβ) deposition and pathologic tau level within cerebral spinal fluid (CSF) and imaging AD pathology such as positive emission tomography (PET) imaging of the a...

journal_title：Frontiers in aging neuroscience

authors： Jiao F,Yi F,Wang Y,Zhang S,Guo Y,Du W,Gao Y,Ren J,Zhang H,Liu L,Song H,Wang L

更新日期：2020-07-21 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnagi.2019.00312.]. ...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Zhang Y,Zhang J,Sang L,Li P,Yan R,Qiu M,Liu C

更新日期：2020-07-08 00:00:00

abstract：:Background: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer'sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important risk factor for AD. H...

journal_title：Frontiers in aging neuroscience

authors： Zhang Q,Wu L,Du C,Xu K,Sun J,Zhang J,Li H,Li X

更新日期：2020-06-30 00:00:00

abstract：:Exercise may be the most commonly offered yet least consistently followed therapeutic advice for people with Parkinson's disease (PD). Epidemiological studies of prospectively followed cohorts have shown a lower risk for later developing PD in healthy people who report moderate to high levels of physical activity, and...

journal_title：Frontiers in aging neuroscience

authors： Crotty GF,Schwarzschild MA

更新日期：2020-06-19 00:00:00

abstract：:Background: Decreased bone mineral density (BMD) was associated with poorer cognitive function and increased risk of Alzheimer's disease (AD). However, objective evidence for the relationship between osteoporosis and AD in humans has not been extensively described. Objectives: We aimed to evaluate the relationships be...

journal_title：Frontiers in aging neuroscience

authors： Takano Y,Tatewaki Y,Mutoh T,Morota N,Matsudaira I,Thyreau B,Nagasaka T,Odagiri H,Yamamoto S,Arai H,Taki Y

更新日期：2020-06-17 00:00:00

abstract：:Aging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer's disease. However, due to mixed findings, it is unclear if changes in resting-state networ...

journal_title：Frontiers in aging neuroscience

authors： Hausman HK,O'Shea A,Kraft JN,Boutzoukas EM,Evangelista ND,Van Etten EJ,Bharadwaj PK,Smith SG,Porges E,Hishaw GA,Wu S,DeKosky S,Alexander GE,Marsiske M,Cohen R,Woods AJ

更新日期：2020-06-12 00:00:00

abstract：:Background: Mild cognitive impairment (MCI) is the early phase of Alzheimer's disease (AD). The aim of early intervention for MCI is to decrease the rate of conversion from MCI to AD. However, the efficacy of multiple interventions in MCI, and the optimal methods of delivery, remain controversial. We aimed to compare ...

journal_title：Frontiers in aging neuroscience

authors： Lai X,Wen H,Li Y,Lu L,Tang C

更新日期：2020-06-05 00:00:00

abstract：Background:Despite known associations of lower serum uric acid (UA) with Alzheimer's disease (AD) dementia or AD-related cognitive impairment, little is known regarding the underlying patho-mechanisms. We aimed to examine the relationships of serum UA with in vivo AD pathologies including cerebral beta-amyloid (Aβ) and...

journal_title：Frontiers in aging neuroscience

authors： Kim JW,Byun MS,Yi D,Lee JH,Jeon SY,Ko K,Jung G,Lee HN,Lee JY,Sohn CH,Lee YS,Shin SA,Kim YK,Lee DY,KBASE Research Group.

更新日期：2020-06-05 00:00:00

abstract：:Reduced pain tolerance may be one of the possible explanations for high prevalence of chronic pain among older people. We hypothesized that age-related alterations in pain tolerance are associated with functioning deterioration of the frontal cortex during normal aging. Twenty-one young and 41 elderly healthy particip...

journal_title：Frontiers in aging neuroscience

authors： Zhou S,Lithfous S,Després O,Pebayle T,Bi X,Dufour A

更新日期：2020-05-27 00:00:00

abstract：:Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary small vessel disease, with reported frequencies of 2-5/100,000 individuals. Recently, it has been reported that some patients with NOTCH3 gene mutations show atypical clinical ...

journal_title：Frontiers in aging neuroscience

authors： Okada T,Washida K,Irie K,Saito S,Noguchi M,Tomita T,Koga M,Toyoda K,Okazaki S,Koizumi T,Mizuta I,Mizuno T,Ihara M

更新日期：2020-05-14 00:00:00

abstract：:Hearing loss is an important risk factor for dementia. However, the mechanisms that relate these disorders are still unknown. As a proxy of this relationship, we studied the structural brain changes associated with functional impairment in activities of daily living in subjects with age related hearing loss, or presby...

journal_title：Frontiers in aging neuroscience

authors： Belkhiria C,Vergara RC,San Martin S,Leiva A,Martinez M,Marcenaro B,Andrade M,Delano PH,Delgado C

更新日期：2020-04-28 00:00:00

abstract：:Parkinson's disease (PD) is a debilitating neurodegenerative disorder defined by a loss of dopamine-producing neurons in the substantia nigra in the brain. It is associated with cytosolic inclusions known as Lewy bodies. The major component of Lewy bodies is aggregated alpha-synuclein. The molecular mechanism of alpha...

journal_title：Frontiers in aging neuroscience

authors： Hernandez SM,Tikhonova EB,Karamyshev AL

更新日期：2020-03-17 00:00:00