Cognitive Variability during Middle-Age: Possible Association with Neurodegeneration and Cognitive Reserve.

abstract：BACKGROUND:The cognitive status is generally considered as a major determinant of rehabilitation outcome in Parkinson's disease (PD). No studies about the effect of cognitive impairment on motor rehabilitation outcomes in PD have been performed before. OBJECTIVE:This study is aimed to evaluate the impact of cognitive ...

journal_title：Frontiers in aging neuroscience

authors： Ferrazzoli D,Ortelli P,Maestri R,Bera R,Giladi N,Ghilardi MF,Pezzoli G,Frazzitta G

更新日期：2016-08-11 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease, for which aging remains the major risk factor. Aging is under a consistent pressure of increasing brain entropy (BEN) due to the progressive brain deteriorations. Noticeably, the brain constantly consumes a large amount of energy to maintain its func...

journal_title：Frontiers in aging neuroscience

authors： Wang Z,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-11-10 00:00:00

abstract：:Cognitive Reserve is the capital of knowledge and experiences that an individual acquires over their life-span. Cognitive Reserve is strictly related to Brain Reserve, which is the ability of the brain to cope with damage. These two concepts could explain many phenomena such as the modality of onset in dementia or the...

journal_title：Frontiers in aging neuroscience

authors： Arcara G,Mondini S,Bisso A,Palmer K,Meneghello F,Semenza C

更新日期：2017-12-22 00:00:00

abstract：:Abnormalities and impairments in axonal transport are suggested to strongly contribute to the pathological alterations underlying AD. The exact mechanisms leading to axonopathy are currently unclear, but it was recently suggested that APP expression itself triggers axonal degeneration. We used APP transgenic mice and ...

journal_title：Frontiers in aging neuroscience

authors： Christensen DZ,Huettenrauch M,Mitkovski M,Pradier L,Wirths O

更新日期：2014-06-27 00:00:00

abstract：BACKGROUND:During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scenario of selected, spo...

journal_title：Frontiers in aging neuroscience

authors： de Pedro-Cuesta J,Martínez-Martín P,Rábano A,Ruiz-Tovar M,Alcalde-Cabero E,Calero M

更新日期：2016-06-13 00:00:00

abstract：INTRODUCTION:Walking in the home and community often involves performance of complex walking tasks. Understanding the control of such tasks is crucial to preserving independence and quality of life in older adults. However, very little research has been conducted in this area. Here, we assess the extent to which two me...

journal_title：Frontiers in aging neuroscience

authors： Clark DJ,Rose DK,Ring SA,Porges EC

更新日期：2014-08-25 00:00:00

abstract：:A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in dementia research has expanded to brain imaging analyses with auditory function. The aim of this study was to investigate the link between hearing ability, which was assessed using pure-tone audiometry, an...

journal_title：Frontiers in aging neuroscience

authors： Uchida Y,Nishita Y,Kato T,Iwata K,Sugiura S,Suzuki H,Sone M,Tange C,Otsuka R,Ando F,Shimokata H,Nakamura A

更新日期：2018-10-16 00:00:00

abstract：:Background: Gray matter (GM) alterations in Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD) have been demonstrated in many neuroimaging studies using voxel-based morphometry (VBM). However, the inconsistent findings between studies cannot be applied to clinical practice as a neu...

journal_title：Frontiers in aging neuroscience

authors： Yang C,Chang J,Liang X,Bao X,Wang R

更新日期：2020-08-12 00:00:00

abstract：:Mitochondrial dysfunction is a common and prominent feature of prion diseases and other neurodegenerative disorders. Mitochondria are dynamic organelles that constantly fuse with one another and subsequently break apart. Defective or superfluous mitochondria are usually eliminated by a form of autophagy, referred to a...

journal_title：Frontiers in aging neuroscience

authors： Zhu T,Chen JL,Wang Q,Shao W,Qi B

更新日期：2018-11-05 00:00:00

abstract：:Microglia are the resident macrophages of the central nervous system. They play key roles in brain development, and physiology during life and aging. Equipped with a variety of molecular sensors and through the various functions they can fulfill, they are critically involved in maintaining the brain's homeostasis. In ...

journal_title：Frontiers in aging neuroscience

authors： Hemonnot AL,Hua J,Ulmann L,Hirbec H

更新日期：2019-08-30 00:00:00

abstract：:Background: Gait disturbance is an early, cardinal feature of Parkinson's disease (PD) associated with falls and reduced physical activity. Progression of gait impairment in Parkinson's disease is not well characterized and a better understanding is imperative to mitigate impairment. Subtle gait impairments progress i...

journal_title：Frontiers in aging neuroscience

authors： Wilson J,Alcock L,Yarnall AJ,Lord S,Lawson RA,Morris R,Taylor JP,Burn DJ,Rochester L,Galna B

更新日期：2020-10-15 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by a progressive cognitive decline and believed to be driven by the self-aggregation of amyloid-β (Aβ) peptide into oligomers and fibrils that accumulate as senile plaques. It is widely accepted that microglia-mediated inflammation is a significant contributor to disease patho...

journal_title：Frontiers in aging neuroscience

authors： Caldeira C,Cunha C,Vaz AR,Falcão AS,Barateiro A,Seixas E,Fernandes A,Brites D

更新日期：2017-08-31 00:00:00

abstract：:While aging can lead to significant declines in perceptual and cognitive function, the effects of age on multisensory integration, the process in which the brain combines information across the senses, are less clear. Recent reports suggest that older adults are susceptible to the sound-induced flash illusion (Shams e...

journal_title：Frontiers in aging neuroscience

authors： McGovern DP,Roudaia E,Stapleton J,McGinnity TM,Newell FN

更新日期：2014-09-24 00:00:00

abstract：:Background: Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations of leisure-time PA and psychological distress with dementia-related mortality, and whether the ass...

journal_title：Frontiers in aging neuroscience

authors： Zotcheva E,Selbæk G,Bjertness E,Ernstsen L,Strand BH

更新日期：2018-05-25 00:00:00

abstract：:Alzheimer's disease (AD) and treatment of the brain in aging require the development of new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large molecule therapeutics that do not cross the blood-brain barrier (BBB). BBB drug delivery is the limiting factor in the future development of ne...

journal_title：Frontiers in aging neuroscience

authors： Pardridge WM

更新日期：2020-01-10 00:00:00

abstract：:Cerebral white matter lesion (WML) is one of the main causes for cognitive impairment and is often caused by chronic cerebral hypoperfusion. A line of evidence has shown that aspirin has neuroprotective effects and produces some benefits in long-term outcome and survival for ischemic stroke patients. However, whether ...

journal_title：Frontiers in aging neuroscience

authors： Chen J,Zuo S,Wang J,Huang J,Zhang X,Liu Y,Zhang Y,Zhao J,Han J,Xiong L,Shi M,Liu Z

更新日期：2014-01-27 00:00:00

abstract：:It is assumed that DNA sequences are conserved in the diverse cell types present in a multicellular organism like the human being. Thus, in order to compare the sequences in the genome of DNA from different individuals, nucleic acid is commonly isolated from a single tissue. In this regard, blood cells are widely used...

journal_title：Frontiers in aging neuroscience

authors： Avila J,Gómez-Ramos A,Soriano E

更新日期：2014-11-25 00:00:00

abstract：Objective:This study was aimed to explore the effects of dietary nutrients on cognitive function among the middle-aged and elderly populations. Methods:A prospective cohort study of 1,385 middle-aged and elderly people was conducted from January 2014 to December 2017. Dietary nutrients were assessed according to the f...

journal_title：Frontiers in aging neuroscience

authors： Tao L,Liu K,Chen S,Yu H,An Y,Wang Y,Zhang X,Wang Y,Qin Z,Xiao R

更新日期：2019-08-29 00:00:00

abstract：:Type 2 diabetes mellitus is associated with neurodegeneration and cerebrovascular disease. However, the precise mechanism underlying the effects of glucose management on brain abnormalities is not fully understood. The differential impacts of glucose alteration on brain changes in patients with and without cognitive i...

journal_title：Frontiers in aging neuroscience

authors： Ogama N,Sakurai T,Kawashima S,Tanikawa T,Tokuda H,Satake S,Miura H,Shimizu A,Kokubo M,Niida S,Toba K,Umegaki H,Kuzuya M

更新日期：2018-09-12 00:00:00

abstract：:Background: Facial emotion recognition (FER) is impaired in individuals with frontotemporal dementia (FTD) and Alzheimer's disease (AD) when compared to healthy older adults. Since deficits in emotion recognition are closely related to caregiver burden or social interactions, researchers have fundamental interest in F...

journal_title：Frontiers in aging neuroscience

authors： Park S,Kim T,Shin SA,Kim YK,Sohn BK,Park HJ,Youn JH,Lee JY

更新日期：2017-11-30 00:00:00

abstract：:Manganese (Mn) is an essential metal and has important physiological functions for human health. However, exposure to excess levels of Mn in occupational settings or from environmental sources has been associated with a neurological syndrome comprising cognitive deficits, neuropsychological abnormalities and parkinson...

journal_title：Frontiers in aging neuroscience

authors： Guilarte TR

更新日期：2013-06-24 00:00:00

abstract：:Glial cells have a variety of functions in the brain, ranging from immune defense against external and endogenous hazardous stimuli, regulation of synaptic formation, calcium homeostasis, and metabolic support for neurons. Their dysregulation can contribute to the development of neurodegenerative disorders, including ...

journal_title：Frontiers in aging neuroscience

authors： Ries M,Sastre M

更新日期：2016-07-05 00:00:00

abstract：:Objectives: To explore the transfer effects of cognitive training on working memory among older Chinese adults with mild cognitive impairment (MCI). Methods: Sixty-two MCI participants aged more than 60 years old were recruited by holding recruitment sessions in communities in China [33 for cognitive training, and 29 ...

journal_title：Frontiers in aging neuroscience

authors： Weng W,Liang J,Xue J,Zhu T,Jiang Y,Wang J,Chen S

更新日期：2019-08-14 00:00:00

abstract：:Understanding speech in the presence of background sound can be challenging for older adults. Speech comprehension in noise appears to depend on working memory and executive-control processes (e.g., Heald and Nusbaum, 2014), and their augmentation through training may have rehabilitative potential for age-related hear...

journal_title：Frontiers in aging neuroscience

authors： Wayne RV,Hamilton C,Jones Huyck J,Johnsrude IS

更新日期：2016-03-22 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) includes a spectrum of disorders characterized by changes of personality and social behavior and, often, a gradual and progressive language dysfunction. In the last years, several efforts have been fulfilled in identifying both genetic mutations and pathological proteins associ...

journal_title：Frontiers in aging neuroscience

authors： Piscopo P,Albani D,Castellano AE,Forloni G,Confaloni A

更新日期：2016-02-09 00:00:00

abstract：:The semantic verbal fluency task is broadly used in the neuropsychological assessment of elderly subjects. Even some studies have identified differences in verbal fluency clustering and switching measures between subjects with normal aging and a clinical condition such as mild cognitive impairment (MCI) and Alzheimer'...

journal_title：Frontiers in aging neuroscience

authors： Bertola L,Cunha Lima ML,Romano-Silva MA,de Moraes EN,Diniz BS,Malloy-Diniz LF

更新日期：2014-07-01 00:00:00

abstract：:Studies of the neural mechanisms of navigation and context discrimination have generated a powerful heuristic for understanding how neural codes, circuits, and computations contribute to accurate behavior as animals traverse and learn about spatially extended environments. It is assumed that memories are updated as a ...

journal_title：Frontiers in aging neuroscience

authors： Penner MR,Mizumori SJ

更新日期：2012-08-08 00:00:00

abstract：:Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransmitter synthesis, myelination of neurons, and mitochondrial function. Redox cycling between ferrous and ferric iron is utilized in biology for various electron transfer reactions essential t...

journal_title：Frontiers in aging neuroscience

authors： Hare D,Ayton S,Bush A,Lei P

更新日期：2013-07-18 00:00:00

abstract：:Cognitive demands for postural control increase with aging and cognitive-motor interference (CMI) exists for a number of walking situations, especially with visuo-spatial cognitive tasks. Such interference also influences spatial learning abilities among older adults; however, this is rarely considered in research on ...

journal_title：Frontiers in aging neuroscience

authors： Agathos CP,Ramanoël S,Bécu M,Bernardin D,Habas C,Arleo A

更新日期：2020-11-12 00:00:00

abstract：:Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western countries, has gained more and more attention in Asian countries. The prevalence of RLS is higher in older people and females. RLS is most commonly related to iron deficiency, pregnancy and uremia. The RLS symptoms show a significant ...

journal_title：Frontiers in aging neuroscience

authors： Guo S,Huang J,Jiang H,Han C,Li J,Xu X,Zhang G,Lin Z,Xiong N,Wang T

更新日期：2017-06-02 00:00:00