Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation.

abstract：:Alzheimer disease (AD) has an insidious onset and heterogeneous clinical symptoms. The well-accepted biomarkers for clinical diagnosis of AD include β-amyloid (Aβ) deposition and pathologic tau level within cerebral spinal fluid (CSF) and imaging AD pathology such as positive emission tomography (PET) imaging of the a...

journal_title：Frontiers in aging neuroscience

authors： Jiao F,Yi F,Wang Y,Zhang S,Guo Y,Du W,Gao Y,Ren J,Zhang H,Liu L,Song H,Wang L

更新日期：2020-07-21 00:00:00

abstract：:Microglia are the resident macrophages of the central nervous system. They play key roles in brain development, and physiology during life and aging. Equipped with a variety of molecular sensors and through the various functions they can fulfill, they are critically involved in maintaining the brain's homeostasis. In ...

journal_title：Frontiers in aging neuroscience

authors： Hemonnot AL,Hua J,Ulmann L,Hirbec H

更新日期：2019-08-30 00:00:00

abstract：:Neuroimaging studies of cognitive and brain aging often yield massive datasets that create many analytic and statistical challenges. In this paper, we discuss and address several limitations in the existing work. (1) Linear models are often used to model the age effects on neuroimaging markers, which may be inadequate...

journal_title：Frontiers in aging neuroscience

authors： Chen H,Zhao B,Cao G,Proges EC,O'Shea A,Woods AJ,Cohen RA

更新日期：2016-07-19 00:00:00

abstract：:Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and terminal stages of dementia with Lewy bodies (DLB) in order to gain un...

journal_title：Frontiers in aging neuroscience

authors： Garcia-Esparcia P,Diaz-Lucena D,Ainciburu M,Torrejón-Escribano B,Carmona M,Llorens F,Ferrer I

更新日期：2018-04-26 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) includes a spectrum of disorders characterized by changes of personality and social behavior and, often, a gradual and progressive language dysfunction. In the last years, several efforts have been fulfilled in identifying both genetic mutations and pathological proteins associ...

journal_title：Frontiers in aging neuroscience

authors： Piscopo P,Albani D,Castellano AE,Forloni G,Confaloni A

更新日期：2016-02-09 00:00:00

abstract：:Background and purpose: The aggregation of vascular risk factors (VRFs) can aggravate cognitive impairment in stroke-free patients. Metabolites in serum and cerebrospinal fluid (CSF) may irreversibly reflect early functional deterioration. This study evaluated small-molecule metabolites (<1,000 Da) in the serum and CS...

journal_title：Frontiers in aging neuroscience

authors： Peng S,Shen Y,Wang M,Zhang J

更新日期：2020-07-22 00:00:00

abstract：:Background: Mild cognitive impairment (MCI) is the early phase of Alzheimer's disease (AD). The aim of early intervention for MCI is to decrease the rate of conversion from MCI to AD. However, the efficacy of multiple interventions in MCI, and the optimal methods of delivery, remain controversial. We aimed to compare ...

journal_title：Frontiers in aging neuroscience

authors： Lai X,Wen H,Li Y,Lu L,Tang C

更新日期：2020-06-05 00:00:00

abstract：:Early identification of persons at risk for cognitive decline in aging is critical to optimizing treatment to delay or avoid a clinical diagnosis of mild cognitive impairment (MCI) or dementia due to Alzheimer's disease (AD). To accomplish early identification, it is essential that trajectories of cognitive change be ...

journal_title：Frontiers in aging neuroscience

authors： Fleischman DA,Yu L,Arfanakis K,Han SD,Barnes LL,Arvanitakis Z,Boyle PA,Bennett DA

更新日期：2013-06-05 00:00:00

abstract：:Background: The brain atrophy and lesion index (BALI) has been developed to assess whole-brain structural deficits that are commonly seen on magnetic resonance imaging (MRI) in aging. It is unclear whether such changes can be detected at younger ages and how they might relate to other exposures. Here, we investigate h...

journal_title：Frontiers in aging neuroscience

authors： Gu T,Fu C,Shen Z,Guo H,Zou M,Chen M,Rockwood K,Song X

更新日期：2019-04-24 00:00:00

abstract：:Aging is related to a deterioration of cognitive performance and to multiple alterations in the brain. Even before the beginning of a noticeable cognitive decline, the framework which holds cognitive function experiences these alterations. From a system-vulnerability point of view of cognition, the deterioration assoc...

journal_title：Frontiers in aging neuroscience

authors： Roldán-Tapia MD,Cánovas R,León I,García-Garcia J

更新日期：2017-10-24 00:00:00

abstract：:Mitochondrial dysfunction is a common and prominent feature of prion diseases and other neurodegenerative disorders. Mitochondria are dynamic organelles that constantly fuse with one another and subsequently break apart. Defective or superfluous mitochondria are usually eliminated by a form of autophagy, referred to a...

journal_title：Frontiers in aging neuroscience

authors： Zhu T,Chen JL,Wang Q,Shao W,Qi B

更新日期：2018-11-05 00:00:00

abstract：:Predicting future brain topography can give insight into neural correlates of aging and neurodegeneration. Due to variability in the aging process, it has been challenging to precisely estimate brain topographical change according to aging. Here, we predict age-related brain metabolic change by generating future brain...

journal_title：Frontiers in aging neuroscience

authors： Choi H,Kang H,Lee DS,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2018-07-12 00:00:00

abstract：:Aerobic physical exercise (APE) leads to improved brain functions. To better understand the beneficial effect of APE on the aging brain, a morphometric study was carried out of changes in hippocampal synapses of old (>27 months) Balb/c mice undergoing treadmill training (OTT) for 4 weeks in comparison with old sedenta...

journal_title：Frontiers in aging neuroscience

authors： Fattoretti P,Malatesta M,Cisterna B,Milanese C,Zancanaro C

更新日期：2018-05-16 00:00:00

abstract：:The enteric nervous system (ENS) poses the intrinsic innervation of the gastrointestinal tract and plays a critical role for all stages of postnatal life. There is increasing scientific and clinical interest in acquired or age-related gastrointestinal dysfunctions that can be manifested in diseases such as gut constip...

journal_title：Frontiers in aging neuroscience

authors： Hetz S,Acikgoez A,Moll C,Jahnke HG,Robitzki AA,Metzger R,Metzger M

更新日期：2014-10-15 00:00:00

abstract：:Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive and neuropsychiatric...

journal_title：Frontiers in aging neuroscience

authors： Tan RH,Devenney E,Kiernan MC,Halliday GM,Hodges JR,Hornberger M

更新日期：2015-07-02 00:00:00

abstract：:In the face of limited resources and an aging population with increasingly care needs, healthcare systems must identify community-dwelling older adults with mental health problems at higher risk of adverse outcomes such as institutionalization, hospitalization and death, in order to deliver timely and efficient care. ...

journal_title：Frontiers in aging neuroscience

authors： Paúl C,Teixeira L,Azevedo MJ,Alves S,Duarte M,O'Caoimh R,Molloy W

更新日期：2015-11-17 00:00:00

abstract：:A defining pathophysiological hallmark of Alzheimer's disease (AD) is the amyloid plaque; an extracellular deposit of aggregated fibrillar Aβ1-42 peptides. Amyloid plaques are hard, brittle structures scattered throughout the hippocampus and cerebral cortex and are thought to cause hyperphosphorylation of tau, neurofi...

journal_title：Frontiers in aging neuroscience

authors： Velasco-Estevez M,Mampay M,Boutin H,Chaney A,Warn P,Sharp A,Burgess E,Moeendarbary E,Dev KK,Sheridan GK

更新日期：2018-10-22 00:00:00

abstract：:The association between decline in physical function and age-related conditions, such as reduced cognitive performance and vascular disease, may be explained by genetic influence on shared biological pathways of importance for aging. The apolipoprotein E (APOE) gene is well-known for its association with Alzheimer's d...

journal_title：Frontiers in aging neuroscience

authors： Skoog I,Hörder H,Frändin K,Johansson L,Östling S,Blennow K,Zetterberg H,Zettergren A

更新日期：2016-10-04 00:00:00

abstract：:Similar to humans, the normal aged rat population is not homogeneous in terms of cognitive function. Two distinct subpopulations of aged Sprague-Dawley rats can be identified on the basis of spatial memory performance in the hole-board paradigm. It was the aim of the study to reveal protein changes relevant to aging a...

journal_title：Frontiers in aging neuroscience

authors： Lubec J,Smidak R,Malikovic J,Feyissa DD,Korz V,Höger H,Lubec G

更新日期：2019-07-31 00:00:00

abstract：:Age related hearing loss (presbycusis) is one of the most common sensory deficits in the aging population. The main subjective ailment in the elderly is the deterioration of speech understanding, especially in a noisy environment, which cannot solely be explained by increased hearing thresholds. The examination method...

journal_title：Frontiers in aging neuroscience

authors： Profant O,Jilek M,Bures Z,Vencovsky V,Kucharova D,Svobodova V,Korynta J,Syka J

更新日期：2019-02-26 00:00:00

abstract：:Cardiorespiratory fitness has been shown to protect and enhance cognitive and brain functions, but little is known about the cortical mechanisms that underlie these changes in older adults. In this study, functional near infrared spectroscopy (fNIRS) was used to investigate variations in oxyhemoglobin [HbO2] and in de...

journal_title：Frontiers in aging neuroscience

authors： Albinet CT,Mandrick K,Bernard PL,Perrey S,Blain H

更新日期：2014-10-08 00:00:00

abstract：BACKGROUND:The cognitive status is generally considered as a major determinant of rehabilitation outcome in Parkinson's disease (PD). No studies about the effect of cognitive impairment on motor rehabilitation outcomes in PD have been performed before. OBJECTIVE:This study is aimed to evaluate the impact of cognitive ...

journal_title：Frontiers in aging neuroscience

authors： Ferrazzoli D,Ortelli P,Maestri R,Bera R,Giladi N,Ghilardi MF,Pezzoli G,Frazzitta G

更新日期：2016-08-11 00:00:00

abstract：:The obesity epidemic had spawned considerable interest in understanding peoples' responses to palatable food cues that are plentiful in obesogenic environments. In this paper we examine how trait mindfulness of older, obese adults may moderate brain networks that arise from exposure to such cues. Nineteen older, obese...

journal_title：Frontiers in aging neuroscience

authors： Paolini B,Burdette JH,Laurienti PJ,Morgan AR,Williamson DA,Rejeski WJ

更新日期：2012-06-06 00:00:00

abstract：:The hippocampus is negatively affected by aging and neurodegenerative diseases leading to impaired learning and memory abilities. A diverse series of progressive modifications in the intercellular communication among neurons, astrocytes and microglia occur in the hippocampus during aging or inflammation. A detailed un...

journal_title：Frontiers in aging neuroscience

authors： Lana D,Ugolini F,Nosi D,Wenk GL,Giovannini MG

更新日期：2017-09-11 00:00:00

abstract：:Background: Amyloid beta 1-43 (Aβ43) may be a useful additional biomarker for diagnosing Alzheimer's disease (AD). We have investigated cerebrospinal fluid (CSF) levels of Aβ43 in patients with early-onset AD in contrast to levels in late-onset AD. For comparison, in addition to the 'core' biomarkers, several other an...

journal_title：Frontiers in aging neuroscience

authors： Lauridsen C,Sando SB,Møller I,Berge G,Pomary PK,Grøntvedt GR,Salvesen Ø,Bråthen G,White LR

更新日期：2017-06-28 00:00:00

abstract：:Microglia can transform into proinflammatory/classically activated (M1) or anti-inflammatory/alternatively activated (M2) phenotypes following environmental signals related to physiological conditions or brain lesions. An adequate transition from the M1 (proinflammatory) to M2 (immunoregulatory) phenotype is necessary...

journal_title：Frontiers in aging neuroscience

authors： Labandeira-Garcia JL,Rodríguez-Perez AI,Garrido-Gil P,Rodriguez-Pallares J,Lanciego JL,Guerra MJ

更新日期：2017-05-03 00:00:00

abstract：:Alzheimer's disease (AD) is characterized in the late stages by amyloid-β (Aβ) plaques and neurofibrillary tangles. Nevertheless, recent evidence has indicated that early changes in cerebral connectivity could compromise cognitive functions even before the appearance of the classical neuropathological features. Diffus...

journal_title：Frontiers in aging neuroscience

authors： Manno FAM,Isla AG,Manno SHC,Ahmed I,Cheng SH,Barrios FA,Lau C

更新日期：2019-03-22 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease, for which aging remains the major risk factor. Aging is under a consistent pressure of increasing brain entropy (BEN) due to the progressive brain deteriorations. Noticeably, the brain constantly consumes a large amount of energy to maintain its func...

journal_title：Frontiers in aging neuroscience

authors： Wang Z,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-11-10 00:00:00

abstract：:Measurement of the dynamic coupling between spontaneous Blood Oxygenation Level Dependent (BOLD) and cerebral blood flow (CBF) fluctuations has been recently proposed as a method to probe resting-state brain physiology. Here we investigated how the dynamic BOLD-CBF coupling during resting-state is affected by aging. F...

journal_title：Frontiers in aging neuroscience

authors： Chiacchiaretta P,Cerritelli F,Bubbico G,Perrucci MG,Ferretti A

更新日期：2018-04-23 00:00:00

abstract：:Activity-dependent neuroprotective protein (ADNP) is deregulated in Alzheimer's disease (AD) and in schizophrenia and mutated in autism. In mice, ADNP is essential for brain formation and ADNP haploinsufficiency is associated with cognitive and social deficits and tauopathy. Tauopathy, a major pathology in AD, is also...

journal_title：Frontiers in aging neuroscience

authors： Gozes I,Ivashko-Pachima Y

更新日期：2015-10-29 00:00:00