ADNP: in search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration.

abstract：:Alzheimer's disease treatment is still an open problem. The diversity of symptoms, the alterations in common pathophysiology, the existence of asymptomatic cases, the different types of sporadic and familial Alzheimer's and their relevance with other types of dementia and comorbidities, have already created a myth-fea...

journal_title：Frontiers in aging neuroscience

authors： Alexiou A,Mantzavinos VD,Greig NH,Kamal MA

更新日期：2017-03-31 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) includes a spectrum of disorders characterized by changes of personality and social behavior and, often, a gradual and progressive language dysfunction. In the last years, several efforts have been fulfilled in identifying both genetic mutations and pathological proteins associ...

journal_title：Frontiers in aging neuroscience

authors： Piscopo P,Albani D,Castellano AE,Forloni G,Confaloni A

更新日期：2016-02-09 00:00:00

abstract：:Rational: Alzheimer's disease (AD) is a neurodegenerative pathology characterized by the presence of neuritic plaques and neurofibrillary tangles. Aluminum has been reported to play an important role in the etiology and pathogenesis of this disease. Hence, the present study aimed to evaluate the neuroprotective role o...

journal_title：Frontiers in aging neuroscience

authors： Singh NA,Bhardwaj V,Ravi C,Ramesh N,Mandal AKA,Khan ZA

更新日期：2018-08-13 00:00:00

abstract：INTRODUCTION:Cross-sectional studies have identified long chain omega-3 polyunsaturated fatty acids (eicosapentaenoic acid 20:5n-3 and docosahexaenoic acid 22:6n-3 (O3PUFA) in association with fewer white matter lesions and better executive function in older adults. We hypothesized that O3PUFA are associated with less ...

journal_title：Frontiers in aging neuroscience

authors： Bowman GL,Dodge HH,Mattek N,Barbey AK,Silbert LC,Shinto L,Howieson DB,Kaye JA,Quinn JF

更新日期：2013-12-16 00:00:00

abstract：:Synapse loss occurs early in Alzheimer's disease (AD) patients and animal models. Alterations at synaptic level are a major morphological correlate of the memory deficits and related symptoms of AD. Given the predominant roles of synaptic AMPA receptors (AMPARs) in excitatory synaptic transmission in the brain, change...

journal_title：Frontiers in aging neuroscience

authors： Martín-Belmonte A,Aguado C,Alfaro-Ruíz R,Itakura M,Moreno-Martínez AE,de la Ossa L,Molnár E,Fukazawa Y,Luján R

更新日期：2020-10-06 00:00:00

abstract：:[This corrects the article on p. 13 in vol. 8, PMID: 26903857.]. ...

journal_title：Frontiers in aging neuroscience

authors： Hu YB,Li CB,Song N,Zou Y,Chen SD,Ren RJ,Wang G

更新日期：2017-02-23 00:00:00

abstract：:Aging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer's disease. However, due to mixed findings, it is unclear if changes in resting-state networ...

journal_title：Frontiers in aging neuroscience

authors： Hausman HK,O'Shea A,Kraft JN,Boutzoukas EM,Evangelista ND,Van Etten EJ,Bharadwaj PK,Smith SG,Porges E,Hishaw GA,Wu S,DeKosky S,Alexander GE,Marsiske M,Cohen R,Woods AJ

更新日期：2020-06-12 00:00:00

abstract：:The obesity epidemic had spawned considerable interest in understanding peoples' responses to palatable food cues that are plentiful in obesogenic environments. In this paper we examine how trait mindfulness of older, obese adults may moderate brain networks that arise from exposure to such cues. Nineteen older, obese...

journal_title：Frontiers in aging neuroscience

authors： Paolini B,Burdette JH,Laurienti PJ,Morgan AR,Williamson DA,Rejeski WJ

更新日期：2012-06-06 00:00:00

abstract：:Background: Gray matter (GM) alterations in Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD) have been demonstrated in many neuroimaging studies using voxel-based morphometry (VBM). However, the inconsistent findings between studies cannot be applied to clinical practice as a neu...

journal_title：Frontiers in aging neuroscience

authors： Yang C,Chang J,Liang X,Bao X,Wang R

更新日期：2020-08-12 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of 30,000 patients a year worldwide. The median reported survival time since onset ranges from 24 to 48 months. Riluzole is the only currently approved mildly efficacious treatment. Riluzole received marketing authorization in 1...

journal_title：Frontiers in aging neuroscience

authors： Petrov D,Mansfield C,Moussy A,Hermine O

更新日期：2017-03-22 00:00:00

abstract：:Alzheimer's disease (AD) is associated with cognitive and non-cognitive symptoms for which there are currently no effective therapies. We have previously reported that cotinine, a natural product obtained from tobacco leaves, prevented memory loss and diminished amyloid-β (Aβ) plaque pathology in transgenic 6799 mice ...

journal_title：Frontiers in aging neuroscience

authors： Patel S,Grizzell JA,Holmes R,Zeitlin R,Solomon R,Sutton TL,Rohani A,Charry LC,Iarkov A,Mori T,Echeverria Moran V

更新日期：2014-07-23 00:00:00

abstract：:Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and ...

journal_title：Frontiers in aging neuroscience

authors： Cloyd RA,Koren SA,Abisambra JF

更新日期：2018-12-13 00:00:00

abstract：:The acquisition and retention of motor skills is necessary for everyday functioning in the elderly and may be critical in the context of motor rehabilitation. Recent studies indicate that motor training closely followed by sleep may result in better engagement of procedural ("how to") memory consolidation processes in...

journal_title：Frontiers in aging neuroscience

authors： Gal C,Gabitov E,Maaravi-Hesseg R,Karni A,Korman M

更新日期：2019-11-22 00:00:00

abstract：:Oxidative stress (OS) contributes to Alzheimer's disease (AD) pathology. OS can be a result of increased reactive oxygen/nitrogen species, reduced antioxidants, oxidatively damaged molecules, and/or a combination of these factors. Scientific literature is scarce for the markers of OS-specific for detecting AD at an ea...

journal_title：Frontiers in aging neuroscience

authors： Arslan J,Jamshed H,Qureshi H

更新日期：2020-07-27 00:00:00

abstract：:Recent studies have shown that Liuwei Dihuang pills (LWPs) can positively affect learning, memory and neurogenesis. However, the underlying molecular mechanisms are not understood. In the present study, we developed ALWPs, a mixture of Antler and LWPs, and investigated whether ALWPs can affect neuroinflammatory respon...

journal_title：Frontiers in aging neuroscience

authors： Lee JY,Joo B,Nam JH,Nam HY,Lee W,Nam Y,Seo Y,Kang HJ,Cho HJ,Jang YP,Kim J,We YM,Koo JW,Hoe HS

更新日期：2018-09-26 00:00:00

abstract：:Hearing loss is an important risk factor for dementia. However, the mechanisms that relate these disorders are still unknown. As a proxy of this relationship, we studied the structural brain changes associated with functional impairment in activities of daily living in subjects with age related hearing loss, or presby...

journal_title：Frontiers in aging neuroscience

authors： Belkhiria C,Vergara RC,San Martin S,Leiva A,Martinez M,Marcenaro B,Andrade M,Delano PH,Delgado C

更新日期：2020-04-28 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic nigrostriatal neurons, with reductions in the function and amount of dopaminergic synapses. Therefore, synapse loss and membrane-related pathology provide relevant targets for interventions in PD. We previously showed the benefic...

journal_title：Frontiers in aging neuroscience

authors： Perez-Pardo P,de Jong EM,Broersen LM,van Wijk N,Attali A,Garssen J,Kraneveld AD

更新日期：2017-03-20 00:00:00

abstract：Objective:Studies have shown preliminary support for mindfulness-based interventions benefitting people with dementia and their caregivers. However, most studies focus on these two groups separately. This study examined whether it would be possible and beneficial for people with dementia and their caregiver to jointly ...

journal_title：Frontiers in aging neuroscience

authors： Berk L,Warmenhoven F,Stiekema APM,van Oorsouw K,van Os J,de Vugt M,van Boxtel M

更新日期：2019-04-24 00:00:00

abstract：:The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer's disease (AD). The heavy public burden of AD, along with the urgent to prevent and treat the disease before the irreversible damage to the brain, calls for a sensitive and speci...

journal_title：Frontiers in aging neuroscience

authors： Liao H,Zhu Z,Peng Y

更新日期：2018-06-22 00:00:00

abstract：:This randomized controlled study (ClinicalTrials.gov NCT02007616) investigated the maintenance of training effects of 20 1-hr non-action video game training sessions with selected games from a commercial package on several age-declining cognitive functions and subjective wellbeing after a 3-month no-contact period. Tw...

journal_title：Frontiers in aging neuroscience

authors： Ballesteros S,Mayas J,Prieto A,Toril P,Pita C,Laura Pde L,Reales JM,Waterworth JA

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:A physically active lifestyle has the potential to prevent cognitive decline and dementia, yet the optimal type of physical activity/exercise remains unclear. Dance is of special interest as it complex sensorimotor rhythmic activity with additional cognitive, social, and affective dimensions. OBJECTIVES:To ...

journal_title：Frontiers in aging neuroscience

authors： Merom D,Grunseit A,Eramudugolla R,Jefferis B,Mcneill J,Anstey KJ

更新日期：2016-02-22 00:00:00

abstract：:Neuromodulation techniques such as deep brain stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia. However, the outcomes of such treatments appear to be somewhat paradoxical, in that these techniques can both disrupt and enhance memory even when applied t...

journal_title：Frontiers in aging neuroscience

authors： Tan SZK,Du R,Perucho JAU,Chopra SS,Vardhanabhuti V,Lim LW

更新日期：2020-09-14 00:00:00

abstract：:Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows...

journal_title：Frontiers in aging neuroscience

authors： Stoessel D,Schulte C,Teixeira Dos Santos MC,Scheller D,Rebollo-Mesa I,Deuschle C,Walther D,Schauer N,Berg D,Nogueira da Costa A,Maetzler W

更新日期：2018-03-05 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnagi.2019.00312.]. ...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Zhang Y,Zhang J,Sang L,Li P,Yan R,Qiu M,Liu C

更新日期：2020-07-08 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary tangles. Copper, iron,...

journal_title：Frontiers in aging neuroscience

authors： Wong BX,Hung YH,Bush AI,Duce JA

更新日期：2014-05-15 00:00:00

abstract：:Sustained engagement in mentally challenging activities has been shown to improve memory in older adults. We hypothesized that a busy schedule would be a proxy for an engaged lifestyle and would facilitate cognition. Here, we examined the relationship between busyness and cognition in adults aged 50-89. Participants (...

journal_title：Frontiers in aging neuroscience

authors： Festini SB,McDonough IM,Park DC

更新日期：2016-05-17 00:00:00

abstract：:Aggregated tau is a hallmark neuropathological feature in numerous neurodegenerative disorders. Previous studies aiming to validate aggregated tau pathology as a pathogenic driver of neurodegeneration in correlation to characteristic behavioral phenotypes have had shortcomings. Although studies on soluble tau patholog...

journal_title：Frontiers in aging neuroscience

authors： Mahendran TS,Suresh SN,Garimella L,Manjithaya R

更新日期：2020-11-05 00:00:00

abstract：:Abnormalities and impairments in axonal transport are suggested to strongly contribute to the pathological alterations underlying AD. The exact mechanisms leading to axonopathy are currently unclear, but it was recently suggested that APP expression itself triggers axonal degeneration. We used APP transgenic mice and ...

journal_title：Frontiers in aging neuroscience

authors： Christensen DZ,Huettenrauch M,Mitkovski M,Pradier L,Wirths O

更新日期：2014-06-27 00:00:00

abstract：:Many cognitive abilities decline with aging, making it difficult to detect pathological changes against a background of natural changes in cognition. Most of the tests to assess cognitive decline are artificial tasks that have little resemblance to the problems faced by people in everyday life. This means both that pe...

journal_title：Frontiers in aging neuroscience

authors： Mazurek A,Bhoopathy RM,Read JC,Gallagher P,Smulders TV

更新日期：2015-05-18 00:00:00

abstract：BACKGROUND:Previous studies reported that old adults, relative to young adults, showed improvement of emotional stability and increased experiences of positive affects. METHODS:In order to better understand the neural underpinnings behind the aging-related enhancement of positive affects, it is necessary to investigat...

journal_title：Frontiers in aging neuroscience

authors： Meng X,Yang J,Cai AY,Ding XS,Liu W,Li H,Yuan JJ

更新日期：2015-08-06 00:00:00