Corrigendum: Aging Changes Effective Connectivity of Motor Networks During Motor Execution and Motor Imagery.

abstract：:Neuromodulation techniques such as deep brain stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia. However, the outcomes of such treatments appear to be somewhat paradoxical, in that these techniques can both disrupt and enhance memory even when applied t...

journal_title：Frontiers in aging neuroscience

authors： Tan SZK,Du R,Perucho JAU,Chopra SS,Vardhanabhuti V,Lim LW

更新日期：2020-09-14 00:00:00

abstract：:It is relevant to unravel the factors that may mediate the cognitive decline observed during aging. Previous reports indicate that education has a positive influence on cognitive performance, while age, female gender and, especially, depressed mood were associated with poorer performances across multiple cognitive dim...

journal_title：Frontiers in aging neuroscience

authors： Santos NC,Costa PS,Cunha P,Portugal-Nunes C,Amorim L,Cotter J,Cerqueira JJ,Palha JA,Sousa N

更新日期：2014-02-24 00:00:00

abstract：:Electroacupuncture (EA) has been reported to have beneficial effects on Alzheimer's disease (AD). BACE1 (β-site amyloid precursor protein-cleaving enzyme 1) is involved in the abnormal production of amyloid-β plaque (Aβ), a hallmark of AD pathophysiology. Thus, the present study investigated the effects of EA on memor...

journal_title：Frontiers in aging neuroscience

authors： Dong WG,Wang F,Chen Y,Zheng XH,Xie YC,Guo WQ,Shi H

更新日期：2015-07-29 00:00:00

abstract：:Parkinson's disease (PD) is a debilitating neurodegenerative disorder defined by a loss of dopamine-producing neurons in the substantia nigra in the brain. It is associated with cytosolic inclusions known as Lewy bodies. The major component of Lewy bodies is aggregated alpha-synuclein. The molecular mechanism of alpha...

journal_title：Frontiers in aging neuroscience

authors： Hernandez SM,Tikhonova EB,Karamyshev AL

更新日期：2020-03-17 00:00:00

abstract：:Delirium is a common and morbid condition in elderly hospitalized patients. Its pathophysiology is poorly understood but inflammation has been implicated based on a clinical association with systemic infection and surgery and preclinical data showing that systemic inflammation adversely affects hippocampus-dependent m...

journal_title：Frontiers in aging neuroscience

authors： Culley DJ,Snayd M,Baxter MG,Xie Z,Lee IH,Rudolph J,Inouye SK,Marcantonio ER,Crosby G

更新日期：2014-06-10 00:00:00

abstract：:Synapse loss occurs early in Alzheimer's disease (AD) patients and animal models. Alterations at synaptic level are a major morphological correlate of the memory deficits and related symptoms of AD. Given the predominant roles of synaptic AMPA receptors (AMPARs) in excitatory synaptic transmission in the brain, change...

journal_title：Frontiers in aging neuroscience

authors： Martín-Belmonte A,Aguado C,Alfaro-Ruíz R,Itakura M,Moreno-Martínez AE,de la Ossa L,Molnár E,Fukazawa Y,Luján R

更新日期：2020-10-06 00:00:00

abstract：:Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques, neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the brain. AD research has, in large part, been dedicated to the understanding of Aβ and NFT deposition as well as to the pharmacological reduction of th...

journal_title：Frontiers in aging neuroscience

authors： Frost GR,Jonas LA,Li YM

更新日期：2019-12-10 00:00:00

abstract：:Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified...

journal_title：Frontiers in aging neuroscience

authors： Cui L,Hou NN,Wu HM,Zuo X,Lian YZ,Zhang CN,Wang ZF,Zhang X,Zhu JH

更新日期：2020-12-21 00:00:00

abstract：:Mouse models are key tools for studying cochlear alterations in noise-induced hearing loss (NIHL) and for evaluating new therapies. Stimuli used to induce deafness in mice are usually white and octave band noises that include very low frequencies, considering the large mouse auditory range. We designed different sound...

journal_title：Frontiers in aging neuroscience

authors： Sanz L,Murillo-Cuesta S,Cobo P,Cediel-Algovia R,Contreras J,Rivera T,Varela-Nieto I,Avendaño C

更新日期：2015-02-16 00:00:00

abstract：:Objectives: To explore the transfer effects of cognitive training on working memory among older Chinese adults with mild cognitive impairment (MCI). Methods: Sixty-two MCI participants aged more than 60 years old were recruited by holding recruitment sessions in communities in China [33 for cognitive training, and 29 ...

journal_title：Frontiers in aging neuroscience

authors： Weng W,Liang J,Xue J,Zhu T,Jiang Y,Wang J,Chen S

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Platelet Rich Plasma (PRP) has shown positive and long-lasting effects in patients with tendinopathies. However, information about age-related differences in the clinical outcome is limited. Aim of this retrospective study was to compare the efficacy of PRP therapy in young and elderly subjects suffering for...

journal_title：Frontiers in aging neuroscience

authors： Salini V,Vanni D,Pantalone A,Abate M

更新日期：2015-12-10 00:00:00

abstract：:Acetylcholine (ACh) is known to play an important role in memory functions, and its deficit has been proposed to cause the cognitive decline associated with advanced age and Alzheimer's disease (the cholinergic hypothesis). Although many studies have tested the cholinergic hypothesis for recently acquired memory, only...

journal_title：Frontiers in aging neuroscience

authors： Soma S,Suematsu N,Shimegi S

更新日期：2014-04-08 00:00:00

abstract：:Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, ...

journal_title：Frontiers in aging neuroscience

authors： Sakuma K,Aoi W,Yamaguchi A

更新日期：2014-08-29 00:00:00

abstract：:Background: Gait disturbance is an early, cardinal feature of Parkinson's disease (PD) associated with falls and reduced physical activity. Progression of gait impairment in Parkinson's disease is not well characterized and a better understanding is imperative to mitigate impairment. Subtle gait impairments progress i...

journal_title：Frontiers in aging neuroscience

authors： Wilson J,Alcock L,Yarnall AJ,Lord S,Lawson RA,Morris R,Taylor JP,Burn DJ,Rochester L,Galna B

更新日期：2020-10-15 00:00:00

abstract：:The aggregation of α-synuclein (α-syn) is considered the key pathogenic event in many neurological disorders such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, giving rise to a whole category of neurodegenerative diseases known as synucleinopathies. Although the molecular basis of...

journal_title：Frontiers in aging neuroscience

authors： Ardah MT,Paleologou KE,Lv G,Abul Khair SB,Kazim AS,Minhas ST,Al-Tel TH,Al-Hayani AA,Haque ME,Eliezer D,El-Agnaf OM

更新日期：2014-08-05 00:00:00

abstract：:Alzheimer's disease (AD) is associated with cognitive and non-cognitive symptoms for which there are currently no effective therapies. We have previously reported that cotinine, a natural product obtained from tobacco leaves, prevented memory loss and diminished amyloid-β (Aβ) plaque pathology in transgenic 6799 mice ...

journal_title：Frontiers in aging neuroscience

authors： Patel S,Grizzell JA,Holmes R,Zeitlin R,Solomon R,Sutton TL,Rohani A,Charry LC,Iarkov A,Mori T,Echeverria Moran V

更新日期：2014-07-23 00:00:00

abstract：:Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransmitter synthesis, myelination of neurons, and mitochondrial function. Redox cycling between ferrous and ferric iron is utilized in biology for various electron transfer reactions essential t...

journal_title：Frontiers in aging neuroscience

authors： Hare D,Ayton S,Bush A,Lei P

更新日期：2013-07-18 00:00:00

abstract：:As the population ages and dementia becomes a growing healthcare concern, it is increasingly important to identify targets for intervention to delay or attenuate cognitive decline. Research has shown that the most successful interventions aim at altering lifestyle factors. Thus, this study examined how involvement in ...

journal_title：Frontiers in aging neuroscience

authors： Seider TR,Fieo RA,O'Shea A,Porges EC,Woods AJ,Cohen RA

更新日期：2016-05-02 00:00:00

abstract：:[This corrects the article on p. 7 in vol. 7, PMID: 25762930.]. ...

journal_title：Frontiers in aging neuroscience

authors： Sanz L,Murillo-Cuesta S,Cobo P,Cediel R,Contreras J,Rivera T,Varela-Nieto I,Avendaño C

更新日期：2015-05-12 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by a progressive cognitive decline and believed to be driven by the self-aggregation of amyloid-β (Aβ) peptide into oligomers and fibrils that accumulate as senile plaques. It is widely accepted that microglia-mediated inflammation is a significant contributor to disease patho...

journal_title：Frontiers in aging neuroscience

authors： Caldeira C,Cunha C,Vaz AR,Falcão AS,Barateiro A,Seixas E,Fernandes A,Brites D

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:The cognitive status is generally considered as a major determinant of rehabilitation outcome in Parkinson's disease (PD). No studies about the effect of cognitive impairment on motor rehabilitation outcomes in PD have been performed before. OBJECTIVE:This study is aimed to evaluate the impact of cognitive ...

journal_title：Frontiers in aging neuroscience

authors： Ferrazzoli D,Ortelli P,Maestri R,Bera R,Giladi N,Ghilardi MF,Pezzoli G,Frazzitta G

更新日期：2016-08-11 00:00:00

abstract：:Background: The brain atrophy and lesion index (BALI) has been developed to assess whole-brain structural deficits that are commonly seen on magnetic resonance imaging (MRI) in aging. It is unclear whether such changes can be detected at younger ages and how they might relate to other exposures. Here, we investigate h...

journal_title：Frontiers in aging neuroscience

authors： Gu T,Fu C,Shen Z,Guo H,Zou M,Chen M,Rockwood K,Song X

更新日期：2019-04-24 00:00:00

abstract：:Cerebral white matter lesion (WML) is one of the main causes for cognitive impairment and is often caused by chronic cerebral hypoperfusion. A line of evidence has shown that aspirin has neuroprotective effects and produces some benefits in long-term outcome and survival for ischemic stroke patients. However, whether ...

journal_title：Frontiers in aging neuroscience

authors： Chen J,Zuo S,Wang J,Huang J,Zhang X,Liu Y,Zhang Y,Zhao J,Han J,Xiong L,Shi M,Liu Z

更新日期：2014-01-27 00:00:00

abstract：:Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after 2-months, corroborates the epidemiological association previously described between vitamin deficiency and this sensory impairment. However, this strain is prone to early hearing loss, and hence we decided to analyze whether the effects ex...

journal_title：Frontiers in aging neuroscience

authors： Martínez-Vega R,Murillo-Cuesta S,Partearroyo T,Varela-Moreiras G,Varela-Nieto I,Pajares MA

更新日期：2016-08-31 00:00:00

abstract：:Cognitive Reserve is the capital of knowledge and experiences that an individual acquires over their life-span. Cognitive Reserve is strictly related to Brain Reserve, which is the ability of the brain to cope with damage. These two concepts could explain many phenomena such as the modality of onset in dementia or the...

journal_title：Frontiers in aging neuroscience

authors： Arcara G,Mondini S,Bisso A,Palmer K,Meneghello F,Semenza C

更新日期：2017-12-22 00:00:00

abstract：Background:Age-related cognitive decline begins in middle age and persists with age. Leukocyte telomere length (LTL) decreases with age and is enhanced by inflammation and oxidative stress. However, whether shorter LTL correlates with cognitive decline remains controversial. Aims:We aimed to investigate the relationsh...

journal_title：Frontiers in aging neuroscience

authors： Linghui D,Shi Q,Chi C,Xiaolei L,Lixing Z,Zhiliang Z,Birong D

更新日期：2020-10-30 00:00:00

abstract：:Inter-temporal choice depends on multiple, interacting systems, some of which may be compromised with age. Some of these systems may be responsible for ongoing trial-by-trial choice strategies. Some may represent the consequences of action. Some may be necessary for the coupling between anticipated consequences and st...

journal_title：Frontiers in aging neuroscience

authors： Breton YA,Seeland KD,Redish AD

更新日期：2015-03-27 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic nigrostriatal neurons, with reductions in the function and amount of dopaminergic synapses. Therefore, synapse loss and membrane-related pathology provide relevant targets for interventions in PD. We previously showed the benefic...

journal_title：Frontiers in aging neuroscience

authors： Perez-Pardo P,de Jong EM,Broersen LM,van Wijk N,Attali A,Garssen J,Kraneveld AD

更新日期：2017-03-20 00:00:00

abstract：:Symptoms in late-onset neuromuscular disorders initiate only from midlife onward and progress with age. These disorders are primarily determined by identified hereditable mutations, but their late-onset symptom manifestation is not fully understood. Here, we review recent research developments on the late-onset autoso...

journal_title：Frontiers in aging neuroscience

authors： Raz Y,Raz V

更新日期：2014-11-10 00:00:00

abstract：:Age-related cognitive decline has been linked to a diverse set of neurobiological mechanisms, including bidirectional changes in proteins critical for neuron function. Importantly, these alterations are not uniform across the brain. For example, the hippocampus (HPC) and prefrontal cortex (PFC) show distinct patterns ...

journal_title：Frontiers in aging neuroscience

authors： Hernandez AR,Hernandez CM,Campos K,Truckenbrod L,Federico Q,Moon B,McQuail JA,Maurer AP,Bizon JL,Burke SN

更新日期：2018-12-03 00:00:00