当前位置： SCI文献检索 > Frontiers in Aging Neuroscience期刊下所有文献 > Does Cognitive Impairment Affect Rehabilitation Outcome in Parkinson's Disease?

Does Cognitive Impairment Affect Rehabilitation Outcome in Parkinson's Disease?

Abstract：

BACKGROUND:The cognitive status is generally considered as a major determinant of rehabilitation outcome in Parkinson's disease (PD). No studies about the effect of cognitive impairment on motor rehabilitation outcomes in PD have been performed before. OBJECTIVE:This study is aimed to evaluate the impact of cognitive decline on rehabilitation outcomes in patients with PD. METHODS:We retrospectively identified 485 patients with PD hospitalized for a 4-week Multidisciplinary Intensive Rehabilitation Treatment (MIRT) between January 2014 and September 2015. According to Mini Mental State Examination (MMSE), patients were divided into: group 1-normal cognition (score 27-30), group 2-mild cognitive impairment (score 21-26), group 3-moderate or severe cognitive impairment (score ≤ 20). According to Frontal Assessment Battery (FAB), subjects were divided into patients with normal (score ≥13.8) and pathological (score <13.8) executive functions. The outcome measures were: Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Disability Scale (PDDS), Six Minutes Walking Test (6MWT), Timed Up and Go Test (TUG) and Berg Balance Scale (BBS). RESULTS:All scales had worse values with the increase of cognitive impairment and passing from normal to pathological executive functions. After rehabilitation, all the outcome measures improved in all groups (p < 0.0001). Between groups, the percentage of improvement was significantly different for total UPDRS (p = 0.0009, best improvement in normal MMSE group; p = 0.019, best improvement in normal FAB group), and BBS (p < 0.0001, all pairwise comparisons significant, best improvement in patients with worse MMSE score; p < 0.0001, best improvement in patients with pathological FAB). TUG (p = 0.006) and BBS (p < 0.0001) improved in patients with pathological FAB score, more than in those with normal FAB score. CONCLUSIONS:Patients gain benefit in the rehabilitative outcomes, regardless of cognition. Our data suggest that rehabilitation could be effective also in Parkinsonian subjects with cognitive impairment, as well as with dysexecutive syndrome.

journal_name

Front Aging Neurosci

journal_title

Frontiers in aging neuroscience

authors

Ferrazzoli D,Ortelli P,Maestri R,Bera R,Giladi N,Ghilardi MF,Pezzoli G,Frazzitta G

doi

10.3389/fnagi.2016.00192

subject

Has Abstract

pub_date

2016-08-11 00:00:00

pages

192

issn

1663-4365

journal_volume

pub_type

杂志文章

在线工具

Does Cognitive Impairment Affect Rehabilitation Outcome in Parkinson's Disease?