Does Cognitive Impairment Affect Rehabilitation Outcome in Parkinson's Disease?

abstract：:Electroacupuncture (EA) has been reported to have beneficial effects on Alzheimer's disease (AD). BACE1 (β-site amyloid precursor protein-cleaving enzyme 1) is involved in the abnormal production of amyloid-β plaque (Aβ), a hallmark of AD pathophysiology. Thus, the present study investigated the effects of EA on memor...

journal_title：Frontiers in aging neuroscience

authors： Dong WG,Wang F,Chen Y,Zheng XH,Xie YC,Guo WQ,Shi H

更新日期：2015-07-29 00:00:00

abstract：:Alzheimer's disease (AD) is characterized in the late stages by amyloid-β (Aβ) plaques and neurofibrillary tangles. Nevertheless, recent evidence has indicated that early changes in cerebral connectivity could compromise cognitive functions even before the appearance of the classical neuropathological features. Diffus...

journal_title：Frontiers in aging neuroscience

authors： Manno FAM,Isla AG,Manno SHC,Ahmed I,Cheng SH,Barrios FA,Lau C

更新日期：2019-03-22 00:00:00

abstract：:Amyloid-beta (Aβ) in Alzheimer's disease (AD) appeared to be a promising target for disease-modifying therapeutic strategies like passive immunotherapy with anti-Aβ monoclonal antibodies (mAbs). Biochemical markers in cerebrospinal fluid (CSF) include alterations of Aβ that allow the diagnosis of AD. Biomarker strateg...

journal_title：Frontiers in aging neuroscience

authors： Moreth J,Mavoungou C,Schindowski K

更新日期：2013-07-02 00:00:00

abstract：:Parkinson's disease (PD) is a debilitating neurodegenerative disorder defined by a loss of dopamine-producing neurons in the substantia nigra in the brain. It is associated with cytosolic inclusions known as Lewy bodies. The major component of Lewy bodies is aggregated alpha-synuclein. The molecular mechanism of alpha...

journal_title：Frontiers in aging neuroscience

authors： Hernandez SM,Tikhonova EB,Karamyshev AL

更新日期：2020-03-17 00:00:00

abstract：:The globus pallidus occupies a critical position in the indirect pathway of the basal ganglia motor control system. Hyperpolarization-activated cyclic-nucleotide gated (HCN) channels play an important role in the modulation of neuronal excitability. In vivo extracellular single unit recording, behavioral test and immu...

journal_title：Frontiers in aging neuroscience

authors： Hao XM,Xu R,Chen AQ,Sun FJ,Wang Y,Liu HX,Chen H,Xue Y,Chen L

更新日期：2019-07-25 00:00:00

abstract：:Decisions differ in difficulty and rely on perceptual information that varies in richness (complexity); aging affects cognitive function including decision-making, and yet, the interaction between difficulty and perceptual complexity have rarely been addressed in aging. Using a parametric fMRI modulation analysis and ...

journal_title：Frontiers in aging neuroscience

authors： Habak C,Seghier ML,Brûlé J,Fahim MA,Monchi O

更新日期：2019-03-01 00:00:00

abstract：:Latin-American people with dementia will increase to an astounding 368% in 2050, higher than USA and Europe. In addition, to sporadic dementia type like Alzheimer, and vascular dementia (VaD) progression after Cerebrovascular disease is also found. These incidences are increased in Colombia by specific populations aff...

journal_title：Frontiers in aging neuroscience

authors： Cardona-Gómez GP,Lopera F

更新日期：2016-12-20 00:00:00

abstract：:Mitochondrial dysfunction is a common and prominent feature of prion diseases and other neurodegenerative disorders. Mitochondria are dynamic organelles that constantly fuse with one another and subsequently break apart. Defective or superfluous mitochondria are usually eliminated by a form of autophagy, referred to a...

journal_title：Frontiers in aging neuroscience

authors： Zhu T,Chen JL,Wang Q,Shao W,Qi B

更新日期：2018-11-05 00:00:00

abstract：:More than 95% of Alzheimer's disease (AD) belongs to sporadic AD (sAD), and related animal models are the important research tools for investigating the pathogenesis and developing new drugs for sAD. An intracerebroventricular infusion of streptozotocin (ICV-STZ) is commonly employed to generate sporadic AD animal mod...

journal_title：Frontiers in aging neuroscience

authors： Bao J,Mahaman YAR,Liu R,Wang JZ,Zhang Z,Zhang B,Wang X

更新日期：2017-10-31 00:00:00

abstract：:Acetylcholine (ACh) is known to play an important role in memory functions, and its deficit has been proposed to cause the cognitive decline associated with advanced age and Alzheimer's disease (the cholinergic hypothesis). Although many studies have tested the cholinergic hypothesis for recently acquired memory, only...

journal_title：Frontiers in aging neuroscience

authors： Soma S,Suematsu N,Shimegi S

更新日期：2014-04-08 00:00:00

abstract：:The auditory mismatch negativity (MMN) is an event-related potential (ERP) peaking about 100-250 ms after the onset of a deviant tone in a sequence of identical (standard) tones. Depending on the interstimulus interval (ISI) between standard and deviant tones, the MMN is suitable to investigate the pre-attentive audit...

journal_title：Frontiers in aging neuroscience

authors： Laptinskaya D,Thurm F,Küster OC,Fissler P,Schlee W,Kolassa S,von Arnim CAF,Kolassa IT

更新日期：2018-02-02 00:00:00

abstract：:Hypertension has a profound influence on the structure and function of blood vessels. Cerebral vessels undergo both structural and functional changes in hypertensive animals. However, dynamic changes of cerebrovasculature and the factors involved in this process are largely unknown. In this study, we explored the dyna...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Mu Z,Lin X,Geng J,Xiao TQ,Zhang Z,Wang Y,Guan Y,Yang GY

更新日期：2017-11-02 00:00:00

abstract：:Neuroimaging studies of cognitive and brain aging often yield massive datasets that create many analytic and statistical challenges. In this paper, we discuss and address several limitations in the existing work. (1) Linear models are often used to model the age effects on neuroimaging markers, which may be inadequate...

journal_title：Frontiers in aging neuroscience

authors： Chen H,Zhao B,Cao G,Proges EC,O'Shea A,Woods AJ,Cohen RA

更新日期：2016-07-19 00:00:00

abstract：:Introduction: Cognitive screening in settings such as emergency departments (ED) is frequently carried out using paper-and-pencil tests that require administration by trained staff. These assessments often compete with other clinical duties and thus may not be routinely administered in these busy settings. Literature ...

journal_title：Frontiers in aging neuroscience

authors： Tong T,Chignell M,Tierney MC,Lee JS

更新日期：2016-11-07 00:00:00

abstract：:Background: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer'sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important risk factor for AD. H...

journal_title：Frontiers in aging neuroscience

authors： Zhang Q,Wu L,Du C,Xu K,Sun J,Zhang J,Li H,Li X

更新日期：2020-06-30 00:00:00

abstract：:Microglial cells become dystrophic with aging; this phenotypic alteration contributes to basal central nervous system (CNS) neuroinflammation being a risk factor for age related neurodegenerative diseases. In previous studies we have observed that insulin like growth factor 1 (IGF1) gene therapy is a feasible approach...

journal_title：Frontiers in aging neuroscience

authors： Falomir-Lockhart E,Dolcetti FJC,García-Segura LM,Hereñú CB,Bellini MJ

更新日期：2019-03-05 00:00:00

abstract：:Verbal fluency is the ability to produce a satisfying sequence of spoken words during a given time interval. The core of verbal fluency lies in the capacity to manage the executive aspects of language. The standard scores of the semantic verbal fluency test are broadly used in the neuropsychological assessment of the ...

journal_title：Frontiers in aging neuroscience

authors： Bertola L,Mota NB,Copelli M,Rivero T,Diniz BS,Romano-Silva MA,Ribeiro S,Malloy-Diniz LF

更新日期：2014-07-29 00:00:00

abstract：:Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients aged 65 years and older. There are currently no proven neurorestorative treatments for chronic stroke. To address the complex problem of restoring function in ischemic brain tissue, stem...

journal_title：Frontiers in aging neuroscience

authors： He JQ,Sussman ES,Steinberg GK

更新日期：2020-12-14 00:00:00

abstract：:Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, ...

journal_title：Frontiers in aging neuroscience

authors： Sakuma K,Aoi W,Yamaguchi A

更新日期：2014-08-29 00:00:00

abstract：:Aging of the central nervous system (CNS) is one of the major risk factors for the development of neurodegenerative pathologies such as Parkinson's disease (PD) and Alzheimer's disease (AD). The molecular mechanisms underlying the onset of AD and especially PD are not well understood. However, neuroinflammatory respon...

journal_title：Frontiers in aging neuroscience

authors： Spittau B

更新日期：2017-06-14 00:00:00

abstract：:Patients with diabetes suffer the higher risk of dementia and the underlying pathological mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we explore whether the cognitive impairment in the diabetic rat is associated with increased blood brain barrier (BBB) permeability and the ch...

journal_title：Frontiers in aging neuroscience

authors： Geng J,Wang L,Zhang L,Qin C,Song Y,Ma Y,Chen Y,Chen S,Wang Y,Zhang Z,Yang GY

更新日期：2018-05-07 00:00:00

abstract：Background:Despite known associations of lower serum uric acid (UA) with Alzheimer's disease (AD) dementia or AD-related cognitive impairment, little is known regarding the underlying patho-mechanisms. We aimed to examine the relationships of serum UA with in vivo AD pathologies including cerebral beta-amyloid (Aβ) and...

journal_title：Frontiers in aging neuroscience

authors： Kim JW,Byun MS,Yi D,Lee JH,Jeon SY,Ko K,Jung G,Lee HN,Lee JY,Sohn CH,Lee YS,Shin SA,Kim YK,Lee DY,KBASE Research Group.

更新日期：2020-06-05 00:00:00

abstract：:Backgrounds: Frailty and cognitive impairment are critical geriatric syndromes. In previous studies, both conditions have been identified in old-age adults as increased risk factors for mortality. However, the combined effect of these two syndromes in predicting mortality among people with advanced age is not well und...

journal_title：Frontiers in aging neuroscience

authors： Hao Q,Dong B,Yang M,Dong B,Wei Y

更新日期：2018-10-18 00:00:00

abstract：:In the face of limited resources and an aging population with increasingly care needs, healthcare systems must identify community-dwelling older adults with mental health problems at higher risk of adverse outcomes such as institutionalization, hospitalization and death, in order to deliver timely and efficient care. ...

journal_title：Frontiers in aging neuroscience

authors： Paúl C,Teixeira L,Azevedo MJ,Alves S,Duarte M,O'Caoimh R,Molloy W

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scenario of selected, spo...

journal_title：Frontiers in aging neuroscience

authors： de Pedro-Cuesta J,Martínez-Martín P,Rábano A,Ruiz-Tovar M,Alcalde-Cabero E,Calero M

更新日期：2016-06-13 00:00:00

abstract：:The alteration of the functional topological organization in subcortical ischemic vascular cognitive impairment with no dementia (SIVCIND) patients has been illuminated by previous neuroimaging studies. However, in regard to the changes in the structural connectivity of brain networks, little has been reported. In thi...

journal_title：Frontiers in aging neuroscience

authors： Sang L,Liu C,Wang L,Zhang J,Zhang Y,Li P,Qiao L,Li C,Qiu M

更新日期：2020-01-29 00:00:00

abstract：:Abnormal cerebral blood flow (CBF) and resting-state functional connectivity (rs-FC) are sensitive biomarkers of disease progression and prognosis. This study investigated neural underpinnings of motor and cognitive recovery by longitudinally studying the changes of CBF and FC in pontine infarction (PI). Twenty patien...

journal_title：Frontiers in aging neuroscience

authors： Wei Y,Wu L,Wang Y,Liu J,Miao P,Wang K,Wang C,Cheng J

更新日期：2020-11-19 00:00:00

abstract：:Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified...

journal_title：Frontiers in aging neuroscience

authors： Cui L,Hou NN,Wu HM,Zuo X,Lian YZ,Zhang CN,Wang ZF,Zhang X,Zhu JH

更新日期：2020-12-21 00:00:00

abstract：:This internal representation of movement of part(s) of the body is involved during Implicit Motor Imagery tasks (IMI); the same representations are employed in the laterality judgment task. Few studies have looked at the consequences of aging, Alzheimer's disease (AD) and mild cognitive impairment (MCI) on the process...

journal_title：Frontiers in aging neuroscience

authors： Bourrelier J,Kubicki A,Rouaud O,Crognier L,Mourey F

更新日期：2015-12-23 00:00:00

abstract：:Inter-temporal choice depends on multiple, interacting systems, some of which may be compromised with age. Some of these systems may be responsible for ongoing trial-by-trial choice strategies. Some may represent the consequences of action. Some may be necessary for the coupling between anticipated consequences and st...

journal_title：Frontiers in aging neuroscience

authors： Breton YA,Seeland KD,Redish AD

更新日期：2015-03-27 00:00:00