Promising Effects of Neurorestorative Diets on Motor, Cognitive, and Gastrointestinal Dysfunction after Symptom Development in a Mouse Model of Parkinson's Disease.

abstract：:Previous research suggests specific deficits in face perception and memory in older adults, which could reflect a dedifferentiation in the context of a general broadening of cognitive architecture with advanced age. Such dedifferentiation could manifest in a less specialized face processing system. A promising tool to...

journal_title：Frontiers in aging neuroscience

authors： Komes J,Schweinberger SR,Wiese H

更新日期：2014-04-04 00:00:00

abstract：:Pure akinesia with gait freezing (PAGF) is considered a clinical phenotype of progressive supranuclear palsy. The brain atrophy and cognitive deficits in PAGF are expected to be less prominent than in classical Richardson's syndrome (RS), but this hypothesis has not been explored yet. We reviewed the medical records o...

journal_title：Frontiers in aging neuroscience

authors： Hong JY,Yun HJ,Sunwoo MK,Ham JH,Lee JM,Sohn YH,Lee PH

更新日期：2015-09-29 00:00:00

abstract：:This internal representation of movement of part(s) of the body is involved during Implicit Motor Imagery tasks (IMI); the same representations are employed in the laterality judgment task. Few studies have looked at the consequences of aging, Alzheimer's disease (AD) and mild cognitive impairment (MCI) on the process...

journal_title：Frontiers in aging neuroscience

authors： Bourrelier J,Kubicki A,Rouaud O,Crognier L,Mourey F

更新日期：2015-12-23 00:00:00

abstract：:Stroke is a major public health problem worldwide with a high burden of neurological disability and mortality. Long noncoding RNAs (lncRNAs) have attracted much attention in the past decades because of their newly discovered roles in pathophysiological processes in many diseases. The abundance of lncRNAs in the nervou...

journal_title：Frontiers in aging neuroscience

authors： Fan J,Saft M,Sadanandan N,Gonzales-Portillo B,Park YJ,Sanberg PR,Borlongan CV,Luo Y

更新日期：2020-10-19 00:00:00

abstract：:Disrupted metal homeostasis is a consistent feature of neurodegenerative disease in humans and is recapitulated in mouse models of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and neuronal ceriod lipofuscinosis. While the definitive pathogenesis of neurodegenerative disease in humans r...

journal_title：Frontiers in aging neuroscience

authors： Dang TN,Lim NK,Grubman A,Li QX,Volitakis I,White AR,Crouch PJ

更新日期：2014-02-11 00:00:00

abstract：BACKGROUND:The cognitive status is generally considered as a major determinant of rehabilitation outcome in Parkinson's disease (PD). No studies about the effect of cognitive impairment on motor rehabilitation outcomes in PD have been performed before. OBJECTIVE:This study is aimed to evaluate the impact of cognitive ...

journal_title：Frontiers in aging neuroscience

authors： Ferrazzoli D,Ortelli P,Maestri R,Bera R,Giladi N,Ghilardi MF,Pezzoli G,Frazzitta G

更新日期：2016-08-11 00:00:00

abstract：:Abnormal cerebral blood flow (CBF) and resting-state functional connectivity (rs-FC) are sensitive biomarkers of disease progression and prognosis. This study investigated neural underpinnings of motor and cognitive recovery by longitudinally studying the changes of CBF and FC in pontine infarction (PI). Twenty patien...

journal_title：Frontiers in aging neuroscience

authors： Wei Y,Wu L,Wang Y,Liu J,Miao P,Wang K,Wang C,Cheng J

更新日期：2020-11-19 00:00:00

abstract：:The enteric nervous system (ENS) poses the intrinsic innervation of the gastrointestinal tract and plays a critical role for all stages of postnatal life. There is increasing scientific and clinical interest in acquired or age-related gastrointestinal dysfunctions that can be manifested in diseases such as gut constip...

journal_title：Frontiers in aging neuroscience

authors： Hetz S,Acikgoez A,Moll C,Jahnke HG,Robitzki AA,Metzger R,Metzger M

更新日期：2014-10-15 00:00:00

abstract：:It is well known that Alzheimer's disease (AD) is one of the most common progressive neurodegenerative diseases; it begins gradually, and therefore no effective medicine is administered in the beginning. Thus, early diagnosis and prevention of AD are crucial. The present study focused on comparing the plasma protein c...

journal_title：Frontiers in aging neuroscience

authors： Cheng Z,Yin J,Yuan H,Jin C,Zhang F,Wang Z,Liu X,Wu Y,Wang T,Xiao S

更新日期：2018-12-17 00:00:00

abstract：:Objective: To study the dynamics of clustering semantic fluency responses and switching between clusters. Methods: We conducted a cross-sectional study of participants (N = 60) in a study of patient reported outcomes who were given the Saint Louis University Mental Status test. Sixty-second animal naming tests were sc...

journal_title：Frontiers in aging neuroscience

authors： Lenio S,Lissemore FM,Sajatovic M,Smyth KA,Tatsuoka C,Woyczynski WA,Lerner AJ

更新日期：2016-10-25 00:00:00

abstract：:Delirium is a common and morbid condition in elderly hospitalized patients. Its pathophysiology is poorly understood but inflammation has been implicated based on a clinical association with systemic infection and surgery and preclinical data showing that systemic inflammation adversely affects hippocampus-dependent m...

journal_title：Frontiers in aging neuroscience

authors： Culley DJ,Snayd M,Baxter MG,Xie Z,Lee IH,Rudolph J,Inouye SK,Marcantonio ER,Crosby G

更新日期：2014-06-10 00:00:00

abstract：:Background: Amyloid beta 1-43 (Aβ43) may be a useful additional biomarker for diagnosing Alzheimer's disease (AD). We have investigated cerebrospinal fluid (CSF) levels of Aβ43 in patients with early-onset AD in contrast to levels in late-onset AD. For comparison, in addition to the 'core' biomarkers, several other an...

journal_title：Frontiers in aging neuroscience

authors： Lauridsen C,Sando SB,Møller I,Berge G,Pomary PK,Grøntvedt GR,Salvesen Ø,Bråthen G,White LR

更新日期：2017-06-28 00:00:00

abstract：:Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after 2-months, corroborates the epidemiological association previously described between vitamin deficiency and this sensory impairment. However, this strain is prone to early hearing loss, and hence we decided to analyze whether the effects ex...

journal_title：Frontiers in aging neuroscience

authors： Martínez-Vega R,Murillo-Cuesta S,Partearroyo T,Varela-Moreiras G,Varela-Nieto I,Pajares MA

更新日期：2016-08-31 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease, for which aging remains the major risk factor. Aging is under a consistent pressure of increasing brain entropy (BEN) due to the progressive brain deteriorations. Noticeably, the brain constantly consumes a large amount of energy to maintain its func...

journal_title：Frontiers in aging neuroscience

authors： Wang Z,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-11-10 00:00:00

abstract：:Mouse models are key tools for studying cochlear alterations in noise-induced hearing loss (NIHL) and for evaluating new therapies. Stimuli used to induce deafness in mice are usually white and octave band noises that include very low frequencies, considering the large mouse auditory range. We designed different sound...

journal_title：Frontiers in aging neuroscience

authors： Sanz L,Murillo-Cuesta S,Cobo P,Cediel-Algovia R,Contreras J,Rivera T,Varela-Nieto I,Avendaño C

更新日期：2015-02-16 00:00:00

abstract：:Alzheimer's disease (AD) and treatment of the brain in aging require the development of new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large molecule therapeutics that do not cross the blood-brain barrier (BBB). BBB drug delivery is the limiting factor in the future development of ne...

journal_title：Frontiers in aging neuroscience

authors： Pardridge WM

更新日期：2020-01-10 00:00:00

abstract：Background:Studying structural brain aging is important to understand age-related pathologies, as well as to identify the early manifestations of the Alzheimer's disease (AD) continuum. In this study, we investigated the long-term trajectory of physiological and pathological brain aging in a large number of participant...

journal_title：Frontiers in aging neuroscience

authors： Lee JS,Park YH,Park S,Yoon U,Choe Y,Cheon BK,Hahn A,Cho SH,Kim SJ,Kim JP,Jung YH,Park KC,Kim HJ,Jang H,Na DL,Seo SW

更新日期：2019-06-18 00:00:00

abstract：:The global incidence of Alzheimer's disease (AD) is on the rise with the increase in obesity and metabolic disease epidemic. Obesity is co-morbid with the increase in mass of adipose tissue, which secretes numerous molecules that are biologically important. Obesity and its associated conditions are perhaps involved in...

journal_title：Frontiers in aging neuroscience

authors： Pichiah PBT,Sankarganesh D,Arunachalam S,Achiraman S

更新日期：2020-02-13 00:00:00

abstract：:The hippocampus is generally reported as one of the regions most impacted by Alzheimer's disease (AD) and is closely associated with memory function and orientation. Undirected functional connectivity (FC) alterations occur in patients with mild cognitive impairment (MCI) and AD, and these alterations have been the su...

journal_title：Frontiers in aging neuroscience

authors： Xue J,Guo H,Gao Y,Wang X,Cui H,Chen Z,Wang B,Xiang J

更新日期：2019-12-03 00:00:00

abstract：:Background: Mild cognitive impairment (MCI) is the early phase of Alzheimer's disease (AD). The aim of early intervention for MCI is to decrease the rate of conversion from MCI to AD. However, the efficacy of multiple interventions in MCI, and the optimal methods of delivery, remain controversial. We aimed to compare ...

journal_title：Frontiers in aging neuroscience

authors： Lai X,Wen H,Li Y,Lu L,Tang C

更新日期：2020-06-05 00:00:00

abstract：:Patients with diabetes suffer the higher risk of dementia and the underlying pathological mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we explore whether the cognitive impairment in the diabetic rat is associated with increased blood brain barrier (BBB) permeability and the ch...

journal_title：Frontiers in aging neuroscience

authors： Geng J,Wang L,Zhang L,Qin C,Song Y,Ma Y,Chen Y,Chen S,Wang Y,Zhang Z,Yang GY

更新日期：2018-05-07 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) increases risk for dementia, including Alzheimer's disease (AD). Many previous studies of brain changes underlying cognitive impairment in T2DM have applied conventional structural magnetic resonance imaging (MRI) to detect macrostructural changes associated with cerebrovascular disease...

journal_title：Frontiers in aging neuroscience

authors： Bangen KJ,Werhane ML,Weigand AJ,Edmonds EC,Delano-Wood L,Thomas KR,Nation DA,Evangelista ND,Clark AL,Liu TT,Bondi MW

更新日期：2018-09-10 00:00:00

abstract：:Associative processes, such as the encoding of associations between words in a list, can enhance episodic memory performance and are thought to deteriorate with age. Here, we examine the nature of age-related deficits in the encoding of associations, by using a free recall paradigm with visual arrays of objects. Fifty...

journal_title：Frontiers in aging neuroscience

authors： Suzin G,Ravona-Springer R,Ash EL,Davelaar EJ,Usher M

更新日期：2019-11-12 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary tangles. Copper, iron,...

journal_title：Frontiers in aging neuroscience

authors： Wong BX,Hung YH,Bush AI,Duce JA

更新日期：2014-05-15 00:00:00

abstract：:Objectives: Postural control in elderly people is impaired by degradations of sensory, motor, and higher-level adaptive mechanisms. Here, we characterize the effects of a progressive balance training program on these postural control impairments using a brain network model based on system identification techniques. Me...

journal_title：Frontiers in aging neuroscience

authors： Wiesmeier IK,Dalin D,Wehrle A,Granacher U,Muehlbauer T,Dietterle J,Weiller C,Gollhofer A,Maurer C

更新日期：2017-08-11 00:00:00

abstract：:Tinnitus, the phantom perception of sound without a corresponding external sound, is a frequent disorder which causes significant morbidity. So far there is no treatment available that reliably reduces the tinnitus perception. The research is hampered by the large heterogeneity of tinnitus and the fact that the tinnit...

journal_title：Frontiers in aging neuroscience

authors： Schlee W,Pryss RC,Probst T,Schobel J,Bachmeier A,Reichert M,Langguth B

更新日期：2016-12-15 00:00:00

abstract：Objective:Studies have shown preliminary support for mindfulness-based interventions benefitting people with dementia and their caregivers. However, most studies focus on these two groups separately. This study examined whether it would be possible and beneficial for people with dementia and their caregiver to jointly ...

journal_title：Frontiers in aging neuroscience

authors： Berk L,Warmenhoven F,Stiekema APM,van Oorsouw K,van Os J,de Vugt M,van Boxtel M

更新日期：2019-04-24 00:00:00

abstract：:During aging, many experience a decline in cognitive function that includes memory loss. The encoding of long-term memories depends on new protein synthesis, and this is also reduced during aging. Thus, it is possible that changes in the regulation of protein synthesis contribute to the memory impairments observed in ...

journal_title：Frontiers in aging neuroscience

authors： Schimanski LA,Barnes CA

更新日期：2010-08-06 00:00:00

abstract：:Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and ...

journal_title：Frontiers in aging neuroscience

authors： Cloyd RA,Koren SA,Abisambra JF

更新日期：2018-12-13 00:00:00

abstract：:Regular physical activity is considered one of the most important factors for lifestyle, for maintaining good health in older ages and increasing life expectancy. Dance is considered an activity that involves coordinating movements with music, as well as brain activation because it is constantly necessary to learn and...

journal_title：Frontiers in aging neuroscience

authors： Douka S,Zilidou VI,Lilou O,Manou V

更新日期：2019-04-05 00:00:00