Comparison of regional brain atrophy and cognitive impairment between pure akinesia with gait freezing and Richardson's syndrome.

abstract：:Life-time experiences are thought to influence the risk to develop the neurodegenerative disorder Alzheimer's disease (AD). In particular, early-life stress (ES) may modulate the onset and progression of AD. There is recent evidence by our group and others that AD-related neuropathological progression and the associat...

journal_title：Frontiers in aging neuroscience

authors： Hoeijmakers L,Amelianchik A,Verhaag F,Kotah J,Lucassen PJ,Korosi A

更新日期：2018-03-07 00:00:00

abstract：:Synapse loss occurs early in Alzheimer's disease (AD) patients and animal models. Alterations at synaptic level are a major morphological correlate of the memory deficits and related symptoms of AD. Given the predominant roles of synaptic AMPA receptors (AMPARs) in excitatory synaptic transmission in the brain, change...

journal_title：Frontiers in aging neuroscience

authors： Martín-Belmonte A,Aguado C,Alfaro-Ruíz R,Itakura M,Moreno-Martínez AE,de la Ossa L,Molnár E,Fukazawa Y,Luján R

更新日期：2020-10-06 00:00:00

abstract：:Predicting future brain topography can give insight into neural correlates of aging and neurodegeneration. Due to variability in the aging process, it has been challenging to precisely estimate brain topographical change according to aging. Here, we predict age-related brain metabolic change by generating future brain...

journal_title：Frontiers in aging neuroscience

authors： Choi H,Kang H,Lee DS,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2018-07-12 00:00:00

abstract：:This study investigated age-related changes in the neural bases of sequential strategy interference. Sequential strategy interference refers to decreased strategy interference (i.e., poorer performance when the cued strategy is not the best) after executing a poorer strategy relative to after a better strategy. Young ...

journal_title：Frontiers in aging neuroscience

authors： Roquet A,Hinault T,Badier JM,Lemaire P

更新日期：2018-08-08 00:00:00

abstract：:Herpes simplex virus type 1 (HSV1), when present in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE), has been implicated as a major factor in Alzheimer's disease (AD). It is proposed that virus is normally latent in many elderly brains but reactivates periodically (as in the peripheral nervo...

journal_title：Frontiers in aging neuroscience

authors： Itzhaki RF

更新日期：2014-08-11 00:00:00

abstract：:Aberrations in brain microcirculation and the associated increase in blood-brain-barrier (BBB) permeability in addition to neuroinflammation and Aβ deposition observed in Alzheimer's disease (AD) and ischemia have gained considerable attention recently. However, the role of microvascular homeostasis as a pathogenic su...

journal_title：Frontiers in aging neuroscience

authors： Amtul Z,Yang J,Lee TY,Cechetto DF

更新日期：2019-03-27 00:00:00

abstract：:Disruptions in metal ion homeostasis have been described in association with amyotrophic lateral sclerosis (ALS) for a number of years but the precise mechanism of involvement is poorly understood. Metal ions are especially important to familial ALS cases caused by mutations in the metalloenzyme copper-zinc superoxide...

journal_title：Frontiers in aging neuroscience

authors： Bourassa MW,Brown HH,Borchelt DR,Vogt S,Miller LM

更新日期：2014-06-16 00:00:00

abstract：:Inter-temporal choice depends on multiple, interacting systems, some of which may be compromised with age. Some of these systems may be responsible for ongoing trial-by-trial choice strategies. Some may represent the consequences of action. Some may be necessary for the coupling between anticipated consequences and st...

journal_title：Frontiers in aging neuroscience

authors： Breton YA,Seeland KD,Redish AD

更新日期：2015-03-27 00:00:00

abstract：:The hippocampus is negatively affected by aging and neurodegenerative diseases leading to impaired learning and memory abilities. A diverse series of progressive modifications in the intercellular communication among neurons, astrocytes and microglia occur in the hippocampus during aging or inflammation. A detailed un...

journal_title：Frontiers in aging neuroscience

authors： Lana D,Ugolini F,Nosi D,Wenk GL,Giovannini MG

更新日期：2017-09-11 00:00:00

abstract：:Background: Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations of leisure-time PA and psychological distress with dementia-related mortality, and whether the ass...

journal_title：Frontiers in aging neuroscience

authors： Zotcheva E,Selbæk G,Bjertness E,Ernstsen L,Strand BH

更新日期：2018-05-25 00:00:00

abstract：:Background: Hypersensitivity to general anesthetics may predict poor postoperative outcomes, especially among the older subjects. Therefore, it is essential to elucidate the mechanism underlying hypersensitivity to volatile anesthetics in the aging population. Given the fact that isoflurane sensitivity increases with ...

journal_title：Frontiers in aging neuroscience

authors： Gong C,Zhang D,Ou W,Ou M,Liang P,Liao D,Zhang W,Zhu T,Liu J,Zhou C

更新日期：2020-12-03 00:00:00

abstract：:Oxidative stress (OS), caused by the imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging, neurodegenerative diseases, and other related adverse conditions, such as ischemia. While ROS/RNS serve as signaling molecules at physiolog...

journal_title：Frontiers in aging neuroscience

authors： Wang X,Michaelis EK

更新日期：2010-03-30 00:00:00

abstract：Background and Purpose:To identify clinical, laboratory, and magnetic resonance imaging (MRI) features in predicting incident stroke and dementia in Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Materials and Methods:We enrolled 87 Korean CAD...

journal_title：Frontiers in aging neuroscience

authors： Lee JS,Ko KH,Oh JH,Kim JG,Kang CH,Song SK,Kang SY,Kang JH,Park JH,Koh MJ,Lee HK,Choi JC

更新日期：2020-11-20 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is a significant complication of surgery, particularly in elderly patients. Emerging researches showed that long non-coding RNA (lncRNA) may play a vital role in the pathogenesis of POCD. Here we aimed to identify potential key lncRNAs involved in the development of POCD. Lnc...

journal_title：Frontiers in aging neuroscience

authors： Li M,Chen C,Zhang W,Gao R,Wang Q,Chen H,Zhang S,Mao X,Leblanc M,Behensky A,Zhang Z,Gan L,Yu H,Zhu T,Liu J

更新日期：2019-07-17 00:00:00

abstract：:Background and Purpose: Olfactory dysfunction (OD) is a common non-motor symptom of Parkinson disease (PD). However, the relationship between OD and neuropathologic proteins in cerebrospinal fluid (CSF) from PD patients remains unclear. Methods: 166 PD patients were included in the study. Overall olfactory function wa...

journal_title：Frontiers in aging neuroscience

authors： Guo P,Wang RD,Lian TH,Ding DY,Zhang YN,Zhang WJ,Li DN,Li LX,Li JH,Guan HY,Yu SY,Liu L,Hu Y,Zuo LJ,Yu QJ,Wang XM,Zhang W

更新日期：2020-12-11 00:00:00

abstract：:Patients with diabetes suffer the higher risk of dementia and the underlying pathological mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we explore whether the cognitive impairment in the diabetic rat is associated with increased blood brain barrier (BBB) permeability and the ch...

journal_title：Frontiers in aging neuroscience

authors： Geng J,Wang L,Zhang L,Qin C,Song Y,Ma Y,Chen Y,Chen S,Wang Y,Zhang Z,Yang GY

更新日期：2018-05-07 00:00:00

abstract：:Abnormal cerebral blood flow (CBF) and resting-state functional connectivity (rs-FC) are sensitive biomarkers of disease progression and prognosis. This study investigated neural underpinnings of motor and cognitive recovery by longitudinally studying the changes of CBF and FC in pontine infarction (PI). Twenty patien...

journal_title：Frontiers in aging neuroscience

authors： Wei Y,Wu L,Wang Y,Liu J,Miao P,Wang K,Wang C,Cheng J

更新日期：2020-11-19 00:00:00

abstract：:Background: There has been much research devoted to examining the short-term effects of different interventions for improving memory functioning of older adults with memory complaints. Nevertheless, very few studies have examined the long-term effects of these interventions. Thus, the present study compared the sustai...

journal_title：Frontiers in aging neuroscience

authors： Chan AS,Cheung WK,Yeung MK,Lee TL

更新日期：2018-08-07 00:00:00

abstract：:The aggregation of α-synuclein (α-syn) is considered the key pathogenic event in many neurological disorders such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, giving rise to a whole category of neurodegenerative diseases known as synucleinopathies. Although the molecular basis of...

journal_title：Frontiers in aging neuroscience

authors： Ardah MT,Paleologou KE,Lv G,Abul Khair SB,Kazim AS,Minhas ST,Al-Tel TH,Al-Hayani AA,Haque ME,Eliezer D,El-Agnaf OM

更新日期：2014-08-05 00:00:00

abstract：:Alzheimer's disease (AD) is characterized in the late stages by amyloid-β (Aβ) plaques and neurofibrillary tangles. Nevertheless, recent evidence has indicated that early changes in cerebral connectivity could compromise cognitive functions even before the appearance of the classical neuropathological features. Diffus...

journal_title：Frontiers in aging neuroscience

authors： Manno FAM,Isla AG,Manno SHC,Ahmed I,Cheng SH,Barrios FA,Lau C

更新日期：2019-03-22 00:00:00

abstract：:Aerobic physical exercise (APE) leads to improved brain functions. To better understand the beneficial effect of APE on the aging brain, a morphometric study was carried out of changes in hippocampal synapses of old (>27 months) Balb/c mice undergoing treadmill training (OTT) for 4 weeks in comparison with old sedenta...

journal_title：Frontiers in aging neuroscience

authors： Fattoretti P,Malatesta M,Cisterna B,Milanese C,Zancanaro C

更新日期：2018-05-16 00:00:00

abstract：:A common problem in the older population is the risk of falling and related injury, immobility, and reduced survival. Age-related neuronal changes, e.g., decline in gray-and white-matter, affect neuronal, cognitive, and motor functioning. The improvement of these factors might decrease fall events in elderly. Studies ...

journal_title：Frontiers in aging neuroscience

authors： Schättin A,de Bruin ED

更新日期：2016-11-29 00:00:00

abstract：:Microglia are dependent on signaling through the colony stimulating factor-1 receptor (CSF-1R/CD115) for growth and survival. Activation of CSF-1R can lead to cell division, while blocking CSF-1R can lead to rapid microglia cell death. CSF-1R has two ligands, the growth factors colony stimulating factor-1 (CSF-1) and ...

journal_title：Frontiers in aging neuroscience

authors： Walker DG,Tang TM,Lue LF

更新日期：2017-08-09 00:00:00

abstract：:Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients aged 65 years and older. There are currently no proven neurorestorative treatments for chronic stroke. To address the complex problem of restoring function in ischemic brain tissue, stem...

journal_title：Frontiers in aging neuroscience

authors： He JQ,Sussman ES,Steinberg GK

更新日期：2020-12-14 00:00:00

abstract：:Aging is associated with impairment of sensorial functions and with the onset of neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) bioavailability progressively decreases, we see a direct correlation with sensory impairment and cognitive performance in older humans. Age-related...

journal_title：Frontiers in aging neuroscience

authors： Rodríguez-de la Rosa L,Lassaletta L,Calvino M,Murillo-Cuesta S,Varela-Nieto I

更新日期：2017-12-12 00:00:00

abstract：:Background: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer'sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important risk factor for AD. H...

journal_title：Frontiers in aging neuroscience

authors： Zhang Q,Wu L,Du C,Xu K,Sun J,Zhang J,Li H,Li X

更新日期：2020-06-30 00:00:00

abstract：:We examined whether baseline self-reported physical activity is associated with the efficacy of cognitive behavioral therapy for insomnia (CBT-I) in older veterans. Community-dwelling veterans aged 60 years and older with insomnia received CBT-I in a randomized controlled trial. Participants who received active treatm...

journal_title：Frontiers in aging neuroscience

authors： Yeung T,Martin JL,Fung CH,Fiorentino L,Dzierzewski JM,Rodriguez Tapia JC,Song Y,Josephson K,Jouldjian S,Mitchell MN,Alessi C

更新日期：2018-09-13 00:00:00

abstract：:Background: Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Variants in the LRRK2 gene have been shown to be associated with PD. However, the clinical characteristics of LRRK2-related PD are heterogeneous. In our study, we performed a comprehensive pooled analysis of the association betw...

journal_title：Frontiers in aging neuroscience

authors： Shu L,Zhang Y,Pan H,Xu Q,Guo J,Tang B,Sun Q

更新日期：2018-09-19 00:00:00

abstract：:Hearing loss is an important risk factor for dementia. However, the mechanisms that relate these disorders are still unknown. As a proxy of this relationship, we studied the structural brain changes associated with functional impairment in activities of daily living in subjects with age related hearing loss, or presby...

journal_title：Frontiers in aging neuroscience

authors： Belkhiria C,Vergara RC,San Martin S,Leiva A,Martinez M,Marcenaro B,Andrade M,Delano PH,Delgado C

更新日期：2020-04-28 00:00:00

abstract：:Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary small vessel disease, with reported frequencies of 2-5/100,000 individuals. Recently, it has been reported that some patients with NOTCH3 gene mutations show atypical clinical ...

journal_title：Frontiers in aging neuroscience

authors： Okada T,Washida K,Irie K,Saito S,Noguchi M,Tomita T,Koga M,Toyoda K,Okazaki S,Koizumi T,Mizuta I,Mizuno T,Ihara M

更新日期：2020-05-14 00:00:00