The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss.

abstract：:Background: There has been much research devoted to examining the short-term effects of different interventions for improving memory functioning of older adults with memory complaints. Nevertheless, very few studies have examined the long-term effects of these interventions. Thus, the present study compared the sustai...

journal_title：Frontiers in aging neuroscience

authors： Chan AS,Cheung WK,Yeung MK,Lee TL

更新日期：2018-08-07 00:00:00

abstract：:The network activated during normal route learning shares considerable homology with the network of degeneration in the earliest symptomatic stages of Alzheimer's disease (AD). This inspired the virtual route learning test (VRLT) in which patients learn routes in a virtual reality environment. This study investigated ...

journal_title：Frontiers in aging neuroscience

authors： Pengas G,Williams GB,Acosta-Cabronero J,Ash TW,Hong YT,Izquierdo-Garcia D,Fryer TD,Hodges JR,Nestor PJ

更新日期：2012-07-04 00:00:00

abstract：:Mitochondrial dysfunction is a common and prominent feature of prion diseases and other neurodegenerative disorders. Mitochondria are dynamic organelles that constantly fuse with one another and subsequently break apart. Defective or superfluous mitochondria are usually eliminated by a form of autophagy, referred to a...

journal_title：Frontiers in aging neuroscience

authors： Zhu T,Chen JL,Wang Q,Shao W,Qi B

更新日期：2018-11-05 00:00:00

abstract：:Microglia and astrocytes can quench metal toxicity to maintain tissue homeostasis, but with age, increasing glial dystrophy alongside metal dyshomeostasis may predispose the aged brain to acquire neurodegenerative diseases. The aim of the present study was to investigate age-related changes in brain metal deposition a...

journal_title：Frontiers in aging neuroscience

authors： Ashraf A,Michaelides C,Walker TA,Ekonomou A,Suessmilch M,Sriskanthanathan A,Abraha S,Parkes A,Parkes HG,Geraki K,So PW

更新日期：2019-12-19 00:00:00

abstract：:Predicting future brain topography can give insight into neural correlates of aging and neurodegeneration. Due to variability in the aging process, it has been challenging to precisely estimate brain topographical change according to aging. Here, we predict age-related brain metabolic change by generating future brain...

journal_title：Frontiers in aging neuroscience

authors： Choi H,Kang H,Lee DS,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2018-07-12 00:00:00

abstract：BACKGROUND:Previous studies reported that old adults, relative to young adults, showed improvement of emotional stability and increased experiences of positive affects. METHODS:In order to better understand the neural underpinnings behind the aging-related enhancement of positive affects, it is necessary to investigat...

journal_title：Frontiers in aging neuroscience

authors： Meng X,Yang J,Cai AY,Ding XS,Liu W,Li H,Yuan JJ

更新日期：2015-08-06 00:00:00

abstract：:The FOXO family of transcription factors is central to the regulation of organismal longevity and cellular survival. Several studies have indicated that FOXO factors lie at the center of a complex network of upstream pathways, cofactors and downstream targets (FOXO-interaction networks), which may have developmental a...

journal_title：Frontiers in aging neuroscience

authors： Parmentier F,Lejeune FX,Neri C

更新日期：2013-06-13 00:00:00

abstract：:Neuroimaging-based age prediction using machine learning is proposed as a biomarker of brain aging, relating to cognitive performance, health outcomes and progression of neurodegenerative disease. However, even leading age-prediction algorithms contain measurement error, motivating efforts to improve experimental pipe...

journal_title：Frontiers in aging neuroscience

authors： Lancaster J,Lorenz R,Leech R,Cole JH

更新日期：2018-02-12 00:00:00

abstract：:Ishigami and Klein (2010) showed that scores of the three attention networks (alerting, orienting, and executive control) measured with the two versions of the Attention Network Test (ANT; Fan et al., 2002; Callejas et al., 2005) were robust over 10 sessions of repeated testing even though practice effects were consis...

journal_title：Frontiers in aging neuroscience

authors： Ishigami Y,Klein RM

更新日期：2011-11-15 00:00:00

abstract：:The emotions evoked by music can enhance recognition of excerpts. It has been suggested that memory is better for high than for low arousing music (Eschrich et al., 2005; Samson et al., 2009), but it remains unclear whether positively (Eschrich et al., 2008) or negatively valenced music (Aubé et al., 2013; Vieillard a...

journal_title：Frontiers in aging neuroscience

authors： Alonso I,Dellacherie D,Samson S

更新日期：2015-03-12 00:00:00

abstract：:Ageing disorders can be defined as the progressive and cumulative outcome of several defective cellular mechanisms as well as metabolic pathways, consequently resulting in degeneration. Environment plays an important role in its pathogenesis. In contrast, developmental disorders arise from inherited mutations and usua...

journal_title：Frontiers in aging neuroscience

authors： Sharma K,Sharma NK,Anand A

更新日期：2014-07-10 00:00:00

abstract：:Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD). Inconsistent results about the role of APOE ε4 alleles on cognitive decline of community non-dementia elderly have been reported. This study aimed to examine the relationship between APOE ε4 allele and cognitive abilities...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Pan X,Fei G,Wang C,Wan W,Sang S,Wang H,Wang Z,Zhong C

更新日期：2019-03-29 00:00:00

abstract：:Background: The early progression continuum of Alzheimer's disease (AD) has been considered to advance through subjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI). Altered functional connectivity (FC) in the default mode network (DMN) is reg...

journal_title：Frontiers in aging neuroscience

authors： Xue C,Yuan B,Yue Y,Xu J,Wang S,Wu M,Ji N,Zhou X,Zhao Y,Rao J,Yang W,Xiao C,Chen J

更新日期：2019-11-13 00:00:00

abstract：INTRODUCTION:Cross-sectional studies have identified long chain omega-3 polyunsaturated fatty acids (eicosapentaenoic acid 20:5n-3 and docosahexaenoic acid 22:6n-3 (O3PUFA) in association with fewer white matter lesions and better executive function in older adults. We hypothesized that O3PUFA are associated with less ...

journal_title：Frontiers in aging neuroscience

authors： Bowman GL,Dodge HH,Mattek N,Barbey AK,Silbert LC,Shinto L,Howieson DB,Kaye JA,Quinn JF

更新日期：2013-12-16 00:00:00

abstract：:This study aimed to explore the effects of open- and closed-skill exercise interventions on the neurocognitive performance of executive functions in the elderly. Sixty-four healthy elderly males were randomly assigned to either a closed-skill (bike riding or brisk walking/jogging, n = 22), open-skill (table tennis, n ...

journal_title：Frontiers in aging neuroscience

authors： Tsai CL,Pan CY,Chen FC,Tseng YT

更新日期：2017-09-12 00:00:00

abstract：:A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in dementia research has expanded to brain imaging analyses with auditory function. The aim of this study was to investigate the link between hearing ability, which was assessed using pure-tone audiometry, an...

journal_title：Frontiers in aging neuroscience

authors： Uchida Y,Nishita Y,Kato T,Iwata K,Sugiura S,Suzuki H,Sone M,Tange C,Otsuka R,Ando F,Shimokata H,Nakamura A

更新日期：2018-10-16 00:00:00

abstract：:Background: Gait disturbance is an early, cardinal feature of Parkinson's disease (PD) associated with falls and reduced physical activity. Progression of gait impairment in Parkinson's disease is not well characterized and a better understanding is imperative to mitigate impairment. Subtle gait impairments progress i...

journal_title：Frontiers in aging neuroscience

authors： Wilson J,Alcock L,Yarnall AJ,Lord S,Lawson RA,Morris R,Taylor JP,Burn DJ,Rochester L,Galna B

更新日期：2020-10-15 00:00:00

abstract：:While aging can lead to significant declines in perceptual and cognitive function, the effects of age on multisensory integration, the process in which the brain combines information across the senses, are less clear. Recent reports suggest that older adults are susceptible to the sound-induced flash illusion (Shams e...

journal_title：Frontiers in aging neuroscience

authors： McGovern DP,Roudaia E,Stapleton J,McGinnity TM,Newell FN

更新日期：2014-09-24 00:00:00

abstract：:Late adulthood is associated with atrophy of brain areas, which contribute to cognitive deterioration and increase the risk of depression. On the other hand, aerobic exercise can improve learning and memory function, ameliorate mood, and prevent neurodegenerative changes. This study demonstrates the effect of Nordic w...

journal_title：Frontiers in aging neuroscience

authors： Domaszewska K,Koper M,Wochna K,Czerniak U,Marciniak K,Wilski M,Bukowska D

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) is a clinical stage indicating a prodromal phase of dementia. This practical concept could be used also for fronto-temporal dementia (FTD). Progranulin (PGRN) has been recently recognized as a useful diagnostic biomarker for fronto-temporal lobe degeneration (FTLD) due to GRN ...

journal_title：Frontiers in aging neuroscience

authors： Moretti DV,Benussi L,Fostinelli S,Ciani M,Binetti G,Ghidoni R

更新日期：2016-02-29 00:00:00

abstract：:Tinnitus, the phantom perception of sound without a corresponding external sound, is a frequent disorder which causes significant morbidity. So far there is no treatment available that reliably reduces the tinnitus perception. The research is hampered by the large heterogeneity of tinnitus and the fact that the tinnit...

journal_title：Frontiers in aging neuroscience

authors： Schlee W,Pryss RC,Probst T,Schobel J,Bachmeier A,Reichert M,Langguth B

更新日期：2016-12-15 00:00:00

abstract：:Pure akinesia with gait freezing (PAGF) is considered a clinical phenotype of progressive supranuclear palsy. The brain atrophy and cognitive deficits in PAGF are expected to be less prominent than in classical Richardson's syndrome (RS), but this hypothesis has not been explored yet. We reviewed the medical records o...

journal_title：Frontiers in aging neuroscience

authors： Hong JY,Yun HJ,Sunwoo MK,Ham JH,Lee JM,Sohn YH,Lee PH

更新日期：2015-09-29 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is a significant complication of surgery, particularly in elderly patients. Emerging researches showed that long non-coding RNA (lncRNA) may play a vital role in the pathogenesis of POCD. Here we aimed to identify potential key lncRNAs involved in the development of POCD. Lnc...

journal_title：Frontiers in aging neuroscience

authors： Li M,Chen C,Zhang W,Gao R,Wang Q,Chen H,Zhang S,Mao X,Leblanc M,Behensky A,Zhang Z,Gan L,Yu H,Zhu T,Liu J

更新日期：2019-07-17 00:00:00

abstract：:Patients with diabetes suffer the higher risk of dementia and the underlying pathological mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we explore whether the cognitive impairment in the diabetic rat is associated with increased blood brain barrier (BBB) permeability and the ch...

journal_title：Frontiers in aging neuroscience

authors： Geng J,Wang L,Zhang L,Qin C,Song Y,Ma Y,Chen Y,Chen S,Wang Y,Zhang Z,Yang GY

更新日期：2018-05-07 00:00:00

abstract：:We examined whether baseline self-reported physical activity is associated with the efficacy of cognitive behavioral therapy for insomnia (CBT-I) in older veterans. Community-dwelling veterans aged 60 years and older with insomnia received CBT-I in a randomized controlled trial. Participants who received active treatm...

journal_title：Frontiers in aging neuroscience

authors： Yeung T,Martin JL,Fung CH,Fiorentino L,Dzierzewski JM,Rodriguez Tapia JC,Song Y,Josephson K,Jouldjian S,Mitchell MN,Alessi C

更新日期：2018-09-13 00:00:00

abstract：:Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques, neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the brain. AD research has, in large part, been dedicated to the understanding of Aβ and NFT deposition as well as to the pharmacological reduction of th...

journal_title：Frontiers in aging neuroscience

authors： Frost GR,Jonas LA,Li YM

更新日期：2019-12-10 00:00:00

abstract：:Cognitive Reserve is the capital of knowledge and experiences that an individual acquires over their life-span. Cognitive Reserve is strictly related to Brain Reserve, which is the ability of the brain to cope with damage. These two concepts could explain many phenomena such as the modality of onset in dementia or the...

journal_title：Frontiers in aging neuroscience

authors： Arcara G,Mondini S,Bisso A,Palmer K,Meneghello F,Semenza C

更新日期：2017-12-22 00:00:00

abstract：:The recent advent of tau-specific positron emission tomography (PET) has enabled in vivo assessment of tau pathology in Alzheimer's disease (AD). However, because PET scanners have limited spatial resolution, the measured signals of small brain structures or atrophied areas are underestimated by partial volume effects...

journal_title：Frontiers in aging neuroscience

authors： Shigemoto Y,Sone D,Imabayashi E,Maikusa N,Okamura N,Furumoto S,Kudo Y,Ogawa M,Takano H,Yokoi Y,Sakata M,Tsukamoto T,Kato K,Sato N,Matsuda H

更新日期：2018-07-18 00:00:00

abstract：:Objectives/Background: Systemic inflammation can affect cognitive performance over time. The current study examined associations between systemic inflammation and cognitive performance among African Americans and Whites urban adults, stratifying by sex, and age group and by race. Patients/Methods: Among 1,555-1,719 Wh...

journal_title：Frontiers in aging neuroscience

authors： Beydoun MA,Dore GA,Canas JA,Liang H,Beydoun HA,Evans MK,Zonderman AB

更新日期：2018-10-09 00:00:00

abstract：:miR-146a is a microRNA (miRNA) involved in neuroinflammation and aging; alterations in its expression were described in Alzheimer's disease (AD). However, most of the studies conducted so far on this miRNA included a limited number of participants and produced contradictory results. We compared miR-146a levels in plas...

journal_title：Frontiers in aging neuroscience

authors： Maffioletti E,Milanesi E,Ansari A,Zanetti O,Galluzzi S,Geroldi C,Gennarelli M,Bocchio-Chiavetto L

更新日期：2020-01-17 00:00:00