The neural mechanisms underlying the aging-related enhancement of positive affects: electrophysiological evidences.

abstract：:Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with in...

journal_title：Frontiers in aging neuroscience

authors： Toricelli M,Evangelista SR,Oliveira LR,Viel TA,Buck HS

更新日期：2019-07-12 00:00:00

abstract：:Understanding the molecular mechanisms underlying age-associated cognitive impairments will not only contribute to our general knowledge about "aging" biology, but also provide insights for more effective strategies to prevent and improve the quality of life for both normal aging and pathological aging such as Alzheim...

journal_title：Frontiers in aging neuroscience

authors： Yang W,Zhou X,Ma T

更新日期：2019-09-04 00:00:00

abstract：:The aim of this study was to develop a fast method for estimating whether a brain volume loss is within the normal range for the respective age of the patient. A readout-segmented diffusion-weighted echo-planar imaging sequence was performed as part of the routine examination at a 3-T scanner. Data without (b0-image) ...

journal_title：Frontiers in aging neuroscience

authors： Klose U,Batra M,Nägele T

更新日期：2013-11-19 00:00:00

abstract：:It is assumed that DNA sequences are conserved in the diverse cell types present in a multicellular organism like the human being. Thus, in order to compare the sequences in the genome of DNA from different individuals, nucleic acid is commonly isolated from a single tissue. In this regard, blood cells are widely used...

journal_title：Frontiers in aging neuroscience

authors： Avila J,Gómez-Ramos A,Soriano E

更新日期：2014-11-25 00:00:00

abstract：:Many of the molecular and pathological features associated with human Alzheimer disease (AD) are mirrored in the naturally occurring age-associated neuropathology in the canine species. In aged dogs with declining learned behavior and memory the severity of cognitive dysfunction parallels the progressive build up and ...

journal_title：Frontiers in aging neuroscience

authors： Rusbridge C,Salguero FJ,David MA,Faller KME,Bras JT,Guerreiro RJ,Richard-Londt AC,Grainger D,Head E,Brandner SGP,Summers B,Hardy J,Tayebi M

更新日期：2018-01-30 00:00:00

abstract：:Background and Purpose: Previous studies of voxel-based morphometry (VBM) have found that patients with type 2 diabetes mellitus (T2DM) exhibit gray matter alterations, but these findings are inconsistent and have not been quantitatively reviewed. Therefore, the aim of this study was to conduct a quantitative meta-ana...

journal_title：Frontiers in aging neuroscience

authors： Liu J,Liu T,Wang W,Ma L,Ma X,Shi S,Gong Q,Wang M

更新日期：2017-05-22 00:00:00

abstract：:The recent advent of tau-specific positron emission tomography (PET) has enabled in vivo assessment of tau pathology in Alzheimer's disease (AD). However, because PET scanners have limited spatial resolution, the measured signals of small brain structures or atrophied areas are underestimated by partial volume effects...

journal_title：Frontiers in aging neuroscience

authors： Shigemoto Y,Sone D,Imabayashi E,Maikusa N,Okamura N,Furumoto S,Kudo Y,Ogawa M,Takano H,Yokoi Y,Sakata M,Tsukamoto T,Kato K,Sato N,Matsuda H

更新日期：2018-07-18 00:00:00

abstract：INTRODUCTION:Walking in the home and community often involves performance of complex walking tasks. Understanding the control of such tasks is crucial to preserving independence and quality of life in older adults. However, very little research has been conducted in this area. Here, we assess the extent to which two me...

journal_title：Frontiers in aging neuroscience

authors： Clark DJ,Rose DK,Ring SA,Porges EC

更新日期：2014-08-25 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia diagnosed amongst the elderly. Mild cognitive impairment (MCI) is a condition often indicative of the earliest symptomatology of AD with 10%-15% of MCI patients reportedly progressing to a diagnosis of AD. Individuals with a history of vascular risk factors ...

journal_title：Frontiers in aging neuroscience

authors： Hess NC,Smart NA

更新日期：2017-03-03 00:00:00

abstract：:Previous studies have shown that pupillary response, a physiological measure of cognitive workload, reflects cognitive demand in healthy younger and older adults. However, the relationship between cognitive workload and cognitive demand in Parkinson's disease (PD) remains unclear. The aim of this pilot study was to ex...

journal_title：Frontiers in aging neuroscience

authors： Kahya M,Moon S,Lyons KE,Pahwa R,Akinwuntan AE,Devos H

更新日期：2018-04-10 00:00:00

abstract：:The global incidence of Alzheimer's disease (AD) is on the rise with the increase in obesity and metabolic disease epidemic. Obesity is co-morbid with the increase in mass of adipose tissue, which secretes numerous molecules that are biologically important. Obesity and its associated conditions are perhaps involved in...

journal_title：Frontiers in aging neuroscience

authors： Pichiah PBT,Sankarganesh D,Arunachalam S,Achiraman S

更新日期：2020-02-13 00:00:00

abstract：:Background and Purpose: Previous studies found inconsistent results regarding the relationship between Alzheimer's disease (AD) and catecholamines, such as dopamine (DA), norepinephrine (NE), and epinephrine (EPI). Therefore, the purpose of this study was to perform a systematic review and meta-analysis to evaluate th...

journal_title：Frontiers in aging neuroscience

authors： Pan X,Kaminga AC,Jia P,Wen SW,Acheampong K,Liu A

更新日期：2020-09-11 00:00:00

abstract：:Symptoms in late-onset neuromuscular disorders initiate only from midlife onward and progress with age. These disorders are primarily determined by identified hereditable mutations, but their late-onset symptom manifestation is not fully understood. Here, we review recent research developments on the late-onset autoso...

journal_title：Frontiers in aging neuroscience

authors： Raz Y,Raz V

更新日期：2014-11-10 00:00:00

abstract：:The association between decline in physical function and age-related conditions, such as reduced cognitive performance and vascular disease, may be explained by genetic influence on shared biological pathways of importance for aging. The apolipoprotein E (APOE) gene is well-known for its association with Alzheimer's d...

journal_title：Frontiers in aging neuroscience

authors： Skoog I,Hörder H,Frändin K,Johansson L,Östling S,Blennow K,Zetterberg H,Zettergren A

更新日期：2016-10-04 00:00:00

abstract：:A defining pathophysiological hallmark of Alzheimer's disease (AD) is the amyloid plaque; an extracellular deposit of aggregated fibrillar Aβ1-42 peptides. Amyloid plaques are hard, brittle structures scattered throughout the hippocampus and cerebral cortex and are thought to cause hyperphosphorylation of tau, neurofi...

journal_title：Frontiers in aging neuroscience

authors： Velasco-Estevez M,Mampay M,Boutin H,Chaney A,Warn P,Sharp A,Burgess E,Moeendarbary E,Dev KK,Sheridan GK

更新日期：2018-10-22 00:00:00

abstract：:The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) and their effects on cognition have rarely been investigated. We aimed to examine brain iron deposition in svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we aimed to investigate the correl...

journal_title：Frontiers in aging neuroscience

authors： Sun Y,Ge X,Han X,Cao W,Wang Y,Ding W,Cao M,Zhang Y,Xu Q,Zhou Y,Xu J

更新日期：2017-03-30 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular ph...

journal_title：Frontiers in aging neuroscience

authors： Finelli MJ

更新日期：2020-09-03 00:00:00

abstract：:Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and ...

journal_title：Frontiers in aging neuroscience

authors： Cloyd RA,Koren SA,Abisambra JF

更新日期：2018-12-13 00:00:00

abstract：:Age-related hearing deficits are a leading cause of disability among the aged. While some forms of hearing deficits are peripheral in origin, others are centrally mediated. One such deficit is the ability to localize sounds, a critical component for segregating different acoustic objects and events, which is dependent...

journal_title：Frontiers in aging neuroscience

authors： Engle JR,Recanzone GH

更新日期：2013-01-04 00:00:00

abstract：:Alzheimer's disease (AD) is characterized in the late stages by amyloid-β (Aβ) plaques and neurofibrillary tangles. Nevertheless, recent evidence has indicated that early changes in cerebral connectivity could compromise cognitive functions even before the appearance of the classical neuropathological features. Diffus...

journal_title：Frontiers in aging neuroscience

authors： Manno FAM,Isla AG,Manno SHC,Ahmed I,Cheng SH,Barrios FA,Lau C

更新日期：2019-03-22 00:00:00

abstract：:Introduction: Falling is one of the primary concerns for people with Parkinson's Disease and occurs predominately during dynamic movements, such as walking. Several methods have been proposed to quantify dynamic balance and to assess fall risk. However, no consensus has been reached concerning which method is most app...

journal_title：Frontiers in aging neuroscience

authors： Siragy T,Nantel J

更新日期：2018-11-22 00:00:00

abstract：:The emotions evoked by music can enhance recognition of excerpts. It has been suggested that memory is better for high than for low arousing music (Eschrich et al., 2005; Samson et al., 2009), but it remains unclear whether positively (Eschrich et al., 2008) or negatively valenced music (Aubé et al., 2013; Vieillard a...

journal_title：Frontiers in aging neuroscience

authors： Alonso I,Dellacherie D,Samson S

更新日期：2015-03-12 00:00:00

abstract：:Many cognitive abilities decline with aging, making it difficult to detect pathological changes against a background of natural changes in cognition. Most of the tests to assess cognitive decline are artificial tasks that have little resemblance to the problems faced by people in everyday life. This means both that pe...

journal_title：Frontiers in aging neuroscience

authors： Mazurek A,Bhoopathy RM,Read JC,Gallagher P,Smulders TV

更新日期：2015-05-18 00:00:00

abstract：:Background: Primary progressive aphasia (PPA) is a clinical syndrome characterized by the neurodegeneration of language brain systems. Three main clinical forms (non-fluent, semantic, and logopenic PPA) have been recognized, but applicability of the classification and the capacity to predict the underlying pathology i...

journal_title：Frontiers in aging neuroscience

authors： Matias-Guiu JA,Díaz-Álvarez J,Ayala JL,Risco-Martín JL,Moreno-Ramos T,Pytel V,Matias-Guiu J,Carreras JL,Cabrera-Martín MN

更新日期：2018-07-31 00:00:00

abstract：:Inflammation is a major component of neurodegenerative diseases. Microglia are the innate immune cells in the central nervous system (CNS). In the healthy brain, microglia contribute to tissue homeostasis and regulation of synaptic plasticity. Under disease conditions, they play a key role in the development and maint...

journal_title：Frontiers in aging neuroscience

authors： Obst J,Simon E,Mancuso R,Gomez-Nicola D

更新日期：2017-06-23 00:00:00

abstract：:Introduction: Cognitive screening in settings such as emergency departments (ED) is frequently carried out using paper-and-pencil tests that require administration by trained staff. These assessments often compete with other clinical duties and thus may not be routinely administered in these busy settings. Literature ...

journal_title：Frontiers in aging neuroscience

authors： Tong T,Chignell M,Tierney MC,Lee JS

更新日期：2016-11-07 00:00:00

abstract：:Neuroimaging studies of cognitive and brain aging often yield massive datasets that create many analytic and statistical challenges. In this paper, we discuss and address several limitations in the existing work. (1) Linear models are often used to model the age effects on neuroimaging markers, which may be inadequate...

journal_title：Frontiers in aging neuroscience

authors： Chen H,Zhao B,Cao G,Proges EC,O'Shea A,Woods AJ,Cohen RA

更新日期：2016-07-19 00:00:00

abstract：:A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in dementia research has expanded to brain imaging analyses with auditory function. The aim of this study was to investigate the link between hearing ability, which was assessed using pure-tone audiometry, an...

journal_title：Frontiers in aging neuroscience

authors： Uchida Y,Nishita Y,Kato T,Iwata K,Sugiura S,Suzuki H,Sone M,Tange C,Otsuka R,Ando F,Shimokata H,Nakamura A

更新日期：2018-10-16 00:00:00

abstract：:Verbal fluency is the ability to produce a satisfying sequence of spoken words during a given time interval. The core of verbal fluency lies in the capacity to manage the executive aspects of language. The standard scores of the semantic verbal fluency test are broadly used in the neuropsychological assessment of the ...

journal_title：Frontiers in aging neuroscience

authors： Bertola L,Mota NB,Copelli M,Rivero T,Diniz BS,Romano-Silva MA,Ribeiro S,Malloy-Diniz LF

更新日期：2014-07-29 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by a progressive cognitive decline and believed to be driven by the self-aggregation of amyloid-β (Aβ) peptide into oligomers and fibrils that accumulate as senile plaques. It is widely accepted that microglia-mediated inflammation is a significant contributor to disease patho...

journal_title：Frontiers in aging neuroscience

authors： Caldeira C,Cunha C,Vaz AR,Falcão AS,Barateiro A,Seixas E,Fernandes A,Brites D

更新日期：2017-08-31 00:00:00