Protein-Protein Interactions in Alpha-Synuclein Biogenesis: New Potential Targets in Parkinson's Disease.

abstract：:To expose cortical involvement in age-related changes in motor performance, we compared steadiness (force fluctuations) and fatigability of submaximal isometric contractions with the ankle dorsiflexor muscles in older and young adults and with varying levels of cognitive demand imposed. Sixteen young (20.4 ± 2.1 year:...

journal_title：Frontiers in aging neuroscience

authors： Vanden Noven ML,Pereira HM,Yoon T,Stevens AA,Nielson KA,Hunter SK

更新日期：2014-05-22 00:00:00

abstract：:Acetylcholine (ACh) is known to play an important role in memory functions, and its deficit has been proposed to cause the cognitive decline associated with advanced age and Alzheimer's disease (the cholinergic hypothesis). Although many studies have tested the cholinergic hypothesis for recently acquired memory, only...

journal_title：Frontiers in aging neuroscience

authors： Soma S,Suematsu N,Shimegi S

更新日期：2014-04-08 00:00:00

abstract：:A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in dementia research has expanded to brain imaging analyses with auditory function. The aim of this study was to investigate the link between hearing ability, which was assessed using pure-tone audiometry, an...

journal_title：Frontiers in aging neuroscience

authors： Uchida Y,Nishita Y,Kato T,Iwata K,Sugiura S,Suzuki H,Sone M,Tange C,Otsuka R,Ando F,Shimokata H,Nakamura A

更新日期：2018-10-16 00:00:00

abstract：:Delirium is a common and morbid condition in elderly hospitalized patients. Its pathophysiology is poorly understood but inflammation has been implicated based on a clinical association with systemic infection and surgery and preclinical data showing that systemic inflammation adversely affects hippocampus-dependent m...

journal_title：Frontiers in aging neuroscience

authors： Culley DJ,Snayd M,Baxter MG,Xie Z,Lee IH,Rudolph J,Inouye SK,Marcantonio ER,Crosby G

更新日期：2014-06-10 00:00:00

abstract：:Aggregated tau is a hallmark neuropathological feature in numerous neurodegenerative disorders. Previous studies aiming to validate aggregated tau pathology as a pathogenic driver of neurodegeneration in correlation to characteristic behavioral phenotypes have had shortcomings. Although studies on soluble tau patholog...

journal_title：Frontiers in aging neuroscience

authors： Mahendran TS,Suresh SN,Garimella L,Manjithaya R

更新日期：2020-11-05 00:00:00

abstract：:Neurofilament light (NFL) is a putative biomarker of neurodegeneration. This study evaluates the correlative association of NFL with Alzheimer's disease (AD) indices. Relevant studies were identified after a literature search in electronic databases and study selection was based on pre-determined eligibility criteria....

journal_title：Frontiers in aging neuroscience

authors： Jin M,Cao L,Dai YP

更新日期：2019-09-13 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular ph...

journal_title：Frontiers in aging neuroscience

authors： Finelli MJ

更新日期：2020-09-03 00:00:00

abstract：:Introduction: Cognitive screening in settings such as emergency departments (ED) is frequently carried out using paper-and-pencil tests that require administration by trained staff. These assessments often compete with other clinical duties and thus may not be routinely administered in these busy settings. Literature ...

journal_title：Frontiers in aging neuroscience

authors： Tong T,Chignell M,Tierney MC,Lee JS

更新日期：2016-11-07 00:00:00

abstract：:Background and Purpose: Previous studies of voxel-based morphometry (VBM) have found that patients with type 2 diabetes mellitus (T2DM) exhibit gray matter alterations, but these findings are inconsistent and have not been quantitatively reviewed. Therefore, the aim of this study was to conduct a quantitative meta-ana...

journal_title：Frontiers in aging neuroscience

authors： Liu J,Liu T,Wang W,Ma L,Ma X,Shi S,Gong Q,Wang M

更新日期：2017-05-22 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by a progressive cognitive decline and believed to be driven by the self-aggregation of amyloid-β (Aβ) peptide into oligomers and fibrils that accumulate as senile plaques. It is widely accepted that microglia-mediated inflammation is a significant contributor to disease patho...

journal_title：Frontiers in aging neuroscience

authors： Caldeira C,Cunha C,Vaz AR,Falcão AS,Barateiro A,Seixas E,Fernandes A,Brites D

更新日期：2017-08-31 00:00:00

abstract：:Current society has to deal with major challenges related to our constantly increasing population of older adults. Since, motor performance generally deteriorates at older age, research investigating the effects of different types of training on motor improvement is particularly important. Here, we tested the effects ...

journal_title：Frontiers in aging neuroscience

authors： Pauwels L,Vancleef K,Swinnen SP,Beets IA

更新日期：2015-08-11 00:00:00

abstract：:Background: Due to the lack of objective measures for assessing tinnitus, its clinical evaluation largely relies on the use of questionnaires and psychoacoustic tests. A global assessment of tinnitus burden would largely benefit from holistic approaches that not only incorporate measures of tinnitus but also take into...

journal_title：Frontiers in aging neuroscience

authors： Müller K,Edvall NK,Idrizbegovic E,Huhn R,Cima R,Persson V,Leineweber C,Westerlund H,Langguth B,Schlee W,Canlon B,Cederroth CR

更新日期：2016-11-22 00:00:00

abstract：:This paper seeks to present a new perspective on the aging brain. Here, we make connections between two key phenomena of brain aging: (1) increased neural noise or random background activity; and (2) slowing of brain activity. Our perspective proposes the possibility that the slowing of neural processing due to decrea...

journal_title：Frontiers in aging neuroscience

authors： Hong SL,Rebec GV

更新日期：2012-09-25 00:00:00

abstract：:Background: Little is known about the underlying mechanisms of the similarities in the core features of postoperative delirium (POD) and α-synuclein (α-syn)-related cognitive disorders. We herein investigated associations between fluctuated levels of exosomal α-syn in the plasma and POD presentation in geriatric hip f...

journal_title：Frontiers in aging neuroscience

authors： Yuan Y,Li Z,Yang N,Han Y,Ji X,Han D,Wang X,Li Y,Liu T,Yuan F,He J,Liu Y,Ni C,Zou P,Wang G,Guo X,Zhou Y

更新日期：2020-03-13 00:00:00

abstract：:Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic neurons, and the presence of intracellular insoluble proteinaceous inclusions, known as Lewy Bodies. Although PD etiopathogenesis remains elusive, the leading h...

journal_title：Frontiers in aging neuroscience

authors： Branco DM,Arduino DM,Esteves AR,Silva DF,Cardoso SM,Oliveira CR

更新日期：2010-05-21 00:00:00

abstract：:Measurement of the dynamic coupling between spontaneous Blood Oxygenation Level Dependent (BOLD) and cerebral blood flow (CBF) fluctuations has been recently proposed as a method to probe resting-state brain physiology. Here we investigated how the dynamic BOLD-CBF coupling during resting-state is affected by aging. F...

journal_title：Frontiers in aging neuroscience

authors： Chiacchiaretta P,Cerritelli F,Bubbico G,Perrucci MG,Ferretti A

更新日期：2018-04-23 00:00:00

abstract：:The association between decline in physical function and age-related conditions, such as reduced cognitive performance and vascular disease, may be explained by genetic influence on shared biological pathways of importance for aging. The apolipoprotein E (APOE) gene is well-known for its association with Alzheimer's d...

journal_title：Frontiers in aging neuroscience

authors： Skoog I,Hörder H,Frändin K,Johansson L,Östling S,Blennow K,Zetterberg H,Zettergren A

更新日期：2016-10-04 00:00:00

abstract：:Background and Purpose: Olfactory dysfunction (OD) is a common non-motor symptom of Parkinson disease (PD). However, the relationship between OD and neuropathologic proteins in cerebrospinal fluid (CSF) from PD patients remains unclear. Methods: 166 PD patients were included in the study. Overall olfactory function wa...

journal_title：Frontiers in aging neuroscience

authors： Guo P,Wang RD,Lian TH,Ding DY,Zhang YN,Zhang WJ,Li DN,Li LX,Li JH,Guan HY,Yu SY,Liu L,Hu Y,Zuo LJ,Yu QJ,Wang XM,Zhang W

更新日期：2020-12-11 00:00:00

abstract：:Alzheimer's disease (AD) is characterized in the late stages by amyloid-β (Aβ) plaques and neurofibrillary tangles. Nevertheless, recent evidence has indicated that early changes in cerebral connectivity could compromise cognitive functions even before the appearance of the classical neuropathological features. Diffus...

journal_title：Frontiers in aging neuroscience

authors： Manno FAM,Isla AG,Manno SHC,Ahmed I,Cheng SH,Barrios FA,Lau C

更新日期：2019-03-22 00:00:00

abstract：:In the face of limited resources and an aging population with increasingly care needs, healthcare systems must identify community-dwelling older adults with mental health problems at higher risk of adverse outcomes such as institutionalization, hospitalization and death, in order to deliver timely and efficient care. ...

journal_title：Frontiers in aging neuroscience

authors： Paúl C,Teixeira L,Azevedo MJ,Alves S,Duarte M,O'Caoimh R,Molloy W

更新日期：2015-11-17 00:00:00

abstract：:Alzheimer disease (AD) has an insidious onset and heterogeneous clinical symptoms. The well-accepted biomarkers for clinical diagnosis of AD include β-amyloid (Aβ) deposition and pathologic tau level within cerebral spinal fluid (CSF) and imaging AD pathology such as positive emission tomography (PET) imaging of the a...

journal_title：Frontiers in aging neuroscience

authors： Jiao F,Yi F,Wang Y,Zhang S,Guo Y,Du W,Gao Y,Ren J,Zhang H,Liu L,Song H,Wang L

更新日期：2020-07-21 00:00:00

abstract：:More than 95% of Alzheimer's disease (AD) belongs to sporadic AD (sAD), and related animal models are the important research tools for investigating the pathogenesis and developing new drugs for sAD. An intracerebroventricular infusion of streptozotocin (ICV-STZ) is commonly employed to generate sporadic AD animal mod...

journal_title：Frontiers in aging neuroscience

authors： Bao J,Mahaman YAR,Liu R,Wang JZ,Zhang Z,Zhang B,Wang X

更新日期：2017-10-31 00:00:00

abstract：:Background: Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Variants in the LRRK2 gene have been shown to be associated with PD. However, the clinical characteristics of LRRK2-related PD are heterogeneous. In our study, we performed a comprehensive pooled analysis of the association betw...

journal_title：Frontiers in aging neuroscience

authors： Shu L,Zhang Y,Pan H,Xu Q,Guo J,Tang B,Sun Q

更新日期：2018-09-19 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1 or Steinert's disease) and type 2 (DM2) are multisystem disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the most prominent neuromuscular features of these diseases, while other clinical manifestations such as cardiomyopathy, insulin resistance and cat...

journal_title：Frontiers in aging neuroscience

authors： Mateos-Aierdi AJ,Goicoechea M,Aiastui A,Fernández-Torrón R,Garcia-Puga M,Matheu A,López de Munain A

更新日期：2015-07-09 00:00:00

abstract：:Herpes simplex virus type 1 (HSV1), when present in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE), has been implicated as a major factor in Alzheimer's disease (AD). It is proposed that virus is normally latent in many elderly brains but reactivates periodically (as in the peripheral nervo...

journal_title：Frontiers in aging neuroscience

authors： Itzhaki RF

更新日期：2014-08-11 00:00:00

abstract：:Recent work suggests that the brain can be conceptualized as a network comprised of groups of sub-networks or modules. The extent of segregation between modules can be quantified with a modularity metric, where networks with high modularity have dense connections within modules and sparser connections between modules....

journal_title：Frontiers in aging neuroscience

authors： Baniqued PL,Gallen CL,Voss MW,Burzynska AZ,Wong CN,Cooke GE,Duffy K,Fanning J,Ehlers DK,Salerno EA,Aguiñaga S,McAuley E,Kramer AF,D'Esposito M

更新日期：2018-01-04 00:00:00

abstract：:Type 2 diabetes mellitus is associated with neurodegeneration and cerebrovascular disease. However, the precise mechanism underlying the effects of glucose management on brain abnormalities is not fully understood. The differential impacts of glucose alteration on brain changes in patients with and without cognitive i...

journal_title：Frontiers in aging neuroscience

authors： Ogama N,Sakurai T,Kawashima S,Tanikawa T,Tokuda H,Satake S,Miura H,Shimizu A,Kokubo M,Niida S,Toba K,Umegaki H,Kuzuya M

更新日期：2018-09-12 00:00:00

abstract：:Disruptions in metal ion homeostasis have been described in association with amyotrophic lateral sclerosis (ALS) for a number of years but the precise mechanism of involvement is poorly understood. Metal ions are especially important to familial ALS cases caused by mutations in the metalloenzyme copper-zinc superoxide...

journal_title：Frontiers in aging neuroscience

authors： Bourassa MW,Brown HH,Borchelt DR,Vogt S,Miller LM

更新日期：2014-06-16 00:00:00

abstract：:Background: Amnestic mild cognitive impairment (aMCI) is a heterogeneous condition. Based on clinical symptoms, aMCI could be categorized into single-domain aMCI (SD-aMCI, only memory deficit) and multi-domain aMCI (MD-aMCI, one or more cognitive domain deficit). As core intrinsic functional architecture, inter-hemisp...

journal_title：Frontiers in aging neuroscience

authors： Luo X,Li K,Zeng Q,Huang P,Jiaerken Y,Qiu T,Xu X,Zhou J,Xu J,Zhang M

更新日期：2018-06-05 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnagi.2019.00343.]. ...

journal_title：Frontiers in aging neuroscience

authors： Smolek T,Cubinkova V,Brezovakova V,Valachova B,Szalay P,Zilka N,Jadhav S

更新日期：2020-02-18 00:00:00