Corrigendum: Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy.

abstract：:Objectives: To explore the transfer effects of cognitive training on working memory among older Chinese adults with mild cognitive impairment (MCI). Methods: Sixty-two MCI participants aged more than 60 years old were recruited by holding recruitment sessions in communities in China [33 for cognitive training, and 29 ...

journal_title：Frontiers in aging neuroscience

authors： Weng W,Liang J,Xue J,Zhu T,Jiang Y,Wang J,Chen S

更新日期：2019-08-14 00:00:00

abstract：:While functioning in multiple domains declines with age, emotional regulation appears to remain preserved in older adults. The Emotion Inhibition (Emotional Stroop) Test requires participants to name the ink color in which neutrally and emotionally valenced words are printed. It was employed in the current investigati...

journal_title：Frontiers in aging neuroscience

authors： Lamonica HM,Keefe RS,Harvey PD,Gold JM,Goldberg TE

更新日期：2010-09-30 00:00:00

abstract：:Life-time experiences are thought to influence the risk to develop the neurodegenerative disorder Alzheimer's disease (AD). In particular, early-life stress (ES) may modulate the onset and progression of AD. There is recent evidence by our group and others that AD-related neuropathological progression and the associat...

journal_title：Frontiers in aging neuroscience

authors： Hoeijmakers L,Amelianchik A,Verhaag F,Kotah J,Lucassen PJ,Korosi A

更新日期：2018-03-07 00:00:00

abstract：:Background: Amyloid beta 1-43 (Aβ43) may be a useful additional biomarker for diagnosing Alzheimer's disease (AD). We have investigated cerebrospinal fluid (CSF) levels of Aβ43 in patients with early-onset AD in contrast to levels in late-onset AD. For comparison, in addition to the 'core' biomarkers, several other an...

journal_title：Frontiers in aging neuroscience

authors： Lauridsen C,Sando SB,Møller I,Berge G,Pomary PK,Grøntvedt GR,Salvesen Ø,Bråthen G,White LR

更新日期：2017-06-28 00:00:00

abstract：:Neuroimaging studies of cognitive and brain aging often yield massive datasets that create many analytic and statistical challenges. In this paper, we discuss and address several limitations in the existing work. (1) Linear models are often used to model the age effects on neuroimaging markers, which may be inadequate...

journal_title：Frontiers in aging neuroscience

authors： Chen H,Zhao B,Cao G,Proges EC,O'Shea A,Woods AJ,Cohen RA

更新日期：2016-07-19 00:00:00

abstract：:Background and Purpose: Subarachnoid hemorrhage (SAH) has long been classified into two main forms, aneurysmal SAH (aSAH) and non-aneurysmal SAH (naSAH), but the related risk factors for aSAH and naSAH are heterogeneous. Our objective was to determine the risk factors for SAH of known or unknown origin with respect to...

journal_title：Frontiers in aging neuroscience

authors： Wang MD,Fu QH,Song MJ,Ma WB,Zhang JH,Wang ZX

更新日期：2021-01-11 00:00:00

abstract：:The network activated during normal route learning shares considerable homology with the network of degeneration in the earliest symptomatic stages of Alzheimer's disease (AD). This inspired the virtual route learning test (VRLT) in which patients learn routes in a virtual reality environment. This study investigated ...

journal_title：Frontiers in aging neuroscience

authors： Pengas G,Williams GB,Acosta-Cabronero J,Ash TW,Hong YT,Izquierdo-Garcia D,Fryer TD,Hodges JR,Nestor PJ

更新日期：2012-07-04 00:00:00

abstract：:Objective: Cerebral small vessel disease (SVD) is associated with increased mortality, disability and cognitive decline, depression in stroke survivors. This study examined the association between SVD burden, defined by a combination of SVD markers, and health-related quality of life (HRQoL) in acute ischemic stroke. ...

journal_title：Frontiers in aging neuroscience

authors： Liang Y,Chen YK,Deng M,Mok VCT,Wang DF,Ungvari GS,Chu CW,Kamiya A,Tang WK

更新日期：2017-11-13 00:00:00

abstract：:Pure akinesia with gait freezing (PAGF) is considered a clinical phenotype of progressive supranuclear palsy. The brain atrophy and cognitive deficits in PAGF are expected to be less prominent than in classical Richardson's syndrome (RS), but this hypothesis has not been explored yet. We reviewed the medical records o...

journal_title：Frontiers in aging neuroscience

authors： Hong JY,Yun HJ,Sunwoo MK,Ham JH,Lee JM,Sohn YH,Lee PH

更新日期：2015-09-29 00:00:00

abstract：:Alzheimer disease (AD) has an insidious onset and heterogeneous clinical symptoms. The well-accepted biomarkers for clinical diagnosis of AD include β-amyloid (Aβ) deposition and pathologic tau level within cerebral spinal fluid (CSF) and imaging AD pathology such as positive emission tomography (PET) imaging of the a...

journal_title：Frontiers in aging neuroscience

authors： Jiao F,Yi F,Wang Y,Zhang S,Guo Y,Du W,Gao Y,Ren J,Zhang H,Liu L,Song H,Wang L

更新日期：2020-07-21 00:00:00

abstract：:Background and Purpose: This study aimed to investigate the association between insulin resistance (IR) and the overall cerebral small vessel disease (CSVD) burden. Methods: We recruited elderly, nondiabetic, healthy subjects prospectively. The overall effect of CSVD on the brain was described by a validated CSVD scor...

journal_title：Frontiers in aging neuroscience

authors： Yang X,Zhang S,Dong Z,Zi Y,Luo Y,Jin Z,Shi L,Li C,Ren C,Wu D

更新日期：2019-06-12 00:00:00

abstract：:Background: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer'sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important risk factor for AD. H...

journal_title：Frontiers in aging neuroscience

authors： Zhang Q,Wu L,Du C,Xu K,Sun J,Zhang J,Li H,Li X

更新日期：2020-06-30 00:00:00

abstract：:The recent application of graph theory to brain networks promises to shed light on complex diseases such as Parkinson's disease (PD). This study aimed to investigate functional changes in sensorimotor and cognitive networks in Parkinsonian patients, with a focus on inter- and intra-connectivity organization in the dis...

journal_title：Frontiers in aging neuroscience

authors： Koshimori Y,Cho SS,Criaud M,Christopher L,Jacobs M,Ghadery C,Coakeley S,Harris M,Mizrahi R,Hamani C,Lang AE,Houle S,Strafella AP

更新日期：2016-11-10 00:00:00

abstract：:Objective: Late-life depression (LLD) is associated with development of different types of dementia. Identification of LLD patients, who will develop cognitive decline, i.e., the early stage of dementia would help to implement interventions earlier. The purpose of this study was to assess whether structural brain magn...

journal_title：Frontiers in aging neuroscience

authors： Lebedeva AK,Westman E,Borza T,Beyer MK,Engedal K,Aarsland D,Selbaek G,Haberg AK

更新日期：2017-02-02 00:00:00

abstract：:Objectives: Postural control in elderly people is impaired by degradations of sensory, motor, and higher-level adaptive mechanisms. Here, we characterize the effects of a progressive balance training program on these postural control impairments using a brain network model based on system identification techniques. Me...

journal_title：Frontiers in aging neuroscience

authors： Wiesmeier IK,Dalin D,Wehrle A,Granacher U,Muehlbauer T,Dietterle J,Weiller C,Gollhofer A,Maurer C

更新日期：2017-08-11 00:00:00

abstract：:With promising results in recent treatment trials for Alzheimer's disease (AD), it becomes increasingly important to distinguish AD at early stages from other causes for cognitive impairment. However, existing diagnostic methods are either invasive (lumbar punctures, PET) or inaccurate Magnetic Resonance Imaging (MRI)...

journal_title：Frontiers in aging neuroscience

authors： Gurevich P,Stuke H,Kastrup A,Stuke H,Hildebrandt H

更新日期：2017-04-25 00:00:00

abstract：:The alteration of the functional topological organization in subcortical ischemic vascular cognitive impairment with no dementia (SIVCIND) patients has been illuminated by previous neuroimaging studies. However, in regard to the changes in the structural connectivity of brain networks, little has been reported. In thi...

journal_title：Frontiers in aging neuroscience

authors： Sang L,Liu C,Wang L,Zhang J,Zhang Y,Li P,Qiao L,Li C,Qiu M

更新日期：2020-01-29 00:00:00

abstract：:Aberrations in brain microcirculation and the associated increase in blood-brain-barrier (BBB) permeability in addition to neuroinflammation and Aβ deposition observed in Alzheimer's disease (AD) and ischemia have gained considerable attention recently. However, the role of microvascular homeostasis as a pathogenic su...

journal_title：Frontiers in aging neuroscience

authors： Amtul Z,Yang J,Lee TY,Cechetto DF

更新日期：2019-03-27 00:00:00

abstract：:The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer's disease (AD), little is known about the initial molecular disturbances that accompany the AD development at olfactory level. We have interrogated the time-depend...

journal_title：Frontiers in aging neuroscience

authors： Lachen-Montes M,González-Morales A,Palomino M,Ausin K,Gómez-Ochoa M,Zelaya MV,Ferrer I,Pérez-Mediavilla A,Fernández-Irigoyen J,Santamaría E

更新日期：2019-06-11 00:00:00

abstract：:Neuromodulation techniques such as deep brain stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia. However, the outcomes of such treatments appear to be somewhat paradoxical, in that these techniques can both disrupt and enhance memory even when applied t...

journal_title：Frontiers in aging neuroscience

authors： Tan SZK,Du R,Perucho JAU,Chopra SS,Vardhanabhuti V,Lim LW

更新日期：2020-09-14 00:00:00

abstract：:Background: Mild cognitive impairment (MCI) is the early phase of Alzheimer's disease (AD). The aim of early intervention for MCI is to decrease the rate of conversion from MCI to AD. However, the efficacy of multiple interventions in MCI, and the optimal methods of delivery, remain controversial. We aimed to compare ...

journal_title：Frontiers in aging neuroscience

authors： Lai X,Wen H,Li Y,Lu L,Tang C

更新日期：2020-06-05 00:00:00

abstract：:A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in dementia research has expanded to brain imaging analyses with auditory function. The aim of this study was to investigate the link between hearing ability, which was assessed using pure-tone audiometry, an...

journal_title：Frontiers in aging neuroscience

authors： Uchida Y,Nishita Y,Kato T,Iwata K,Sugiura S,Suzuki H,Sone M,Tange C,Otsuka R,Ando F,Shimokata H,Nakamura A

更新日期：2018-10-16 00:00:00

abstract：:Exercise may be the most commonly offered yet least consistently followed therapeutic advice for people with Parkinson's disease (PD). Epidemiological studies of prospectively followed cohorts have shown a lower risk for later developing PD in healthy people who report moderate to high levels of physical activity, and...

journal_title：Frontiers in aging neuroscience

authors： Crotty GF,Schwarzschild MA

更新日期：2020-06-19 00:00:00

abstract：:Alzheimer's disease (AD) still remains an enigma for researchers and clinicians. The onset of AD is insidious, gradually progressive and multifactorial. The recent accumulated scientific evidences suggests that the pathological changes resemble the autoimmune-driven self-sustaining inflammatory process as a result of ...

journal_title：Frontiers in aging neuroscience

authors： Talwar P,Kushwaha S,Gupta R,Agarwal R

更新日期：2019-10-23 00:00:00

abstract：:This internal representation of movement of part(s) of the body is involved during Implicit Motor Imagery tasks (IMI); the same representations are employed in the laterality judgment task. Few studies have looked at the consequences of aging, Alzheimer's disease (AD) and mild cognitive impairment (MCI) on the process...

journal_title：Frontiers in aging neuroscience

authors： Bourrelier J,Kubicki A,Rouaud O,Crognier L,Mourey F

更新日期：2015-12-23 00:00:00

abstract：:Memory encoding and retrieval problems are inherent to aging. To date, however, the effect of aging upon the neural correlates of forming memory traces remains poorly understood. Resting-state fMRI connectivity can be used to investigate initial consolidation. We compared within and between network connectivity differ...

journal_title：Frontiers in aging neuroscience

authors： Jacobs HI,Dillen KN,Risius O,Göreci Y,Onur OA,Fink GR,Kukolja J

更新日期：2015-01-09 00:00:00

abstract：Background:Age-related cognitive decline begins in middle age and persists with age. Leukocyte telomere length (LTL) decreases with age and is enhanced by inflammation and oxidative stress. However, whether shorter LTL correlates with cognitive decline remains controversial. Aims:We aimed to investigate the relationsh...

journal_title：Frontiers in aging neuroscience

authors： Linghui D,Shi Q,Chi C,Xiaolei L,Lixing Z,Zhiliang Z,Birong D

更新日期：2020-10-30 00:00:00

abstract：:Although older adults exhibit normal accuracy in performing word retrieval and generation (lexical production; e.g., object naming), they are generally slower in responding than younger adults. To maintain accuracy, older adults recruit compensatory mechanisms and strategies. We focused on two such possible compensato...

journal_title：Frontiers in aging neuroscience

authors： Hoyau E,Boudiaf N,Cousin E,Pichat C,Fournet N,Krainik A,Jaillard A,Baciu M

更新日期：2017-05-09 00:00:00

abstract：:An inverse association may exist between cancers and neurodegenerative diseases, although convenient biomarkers for verifying this inverse association are lacking. Plasma neurofilament light chain (NfL) is a novel biomarker for neurodegenerative diseases, such as Alzheimer's disease (AD), but it has not been measured ...

journal_title：Frontiers in aging neuroscience

authors： Liu S,Huang Z,Zhang L,Pan J,Lei Q,Meng Y,Li Z

更新日期：2020-01-29 00:00:00

abstract：:Understanding speech in the presence of background sound can be challenging for older adults. Speech comprehension in noise appears to depend on working memory and executive-control processes (e.g., Heald and Nusbaum, 2014), and their augmentation through training may have rehabilitative potential for age-related hear...

journal_title：Frontiers in aging neuroscience

authors： Wayne RV,Hamilton C,Jones Huyck J,Johnsrude IS

更新日期：2016-03-22 00:00:00