Plasma Neurofilament Light Chain May Be a Biomarker for the Inverse Association Between Cancers and Neurodegenerative Diseases.

abstract：:The hippocampus is generally reported as one of the regions most impacted by Alzheimer's disease (AD) and is closely associated with memory function and orientation. Undirected functional connectivity (FC) alterations occur in patients with mild cognitive impairment (MCI) and AD, and these alterations have been the su...

journal_title：Frontiers in aging neuroscience

authors： Xue J,Guo H,Gao Y,Wang X,Cui H,Chen Z,Wang B,Xiang J

更新日期：2019-12-03 00:00:00

abstract：:There is a need for rapid and reliable Internet-based screening tools for cognitive assessment in middle-aged and older adults. We report the psychometric properties of an on-line tool designed to screen for cognitive deficits that require further investigation. The tool is composed of measures of memory and executive...

journal_title：Frontiers in aging neuroscience

authors： Troyer AK,Rowe G,Murphy KJ,Levine B,Leach L,Hasher L

更新日期：2014-12-10 00:00:00

abstract：:Background: The early progression continuum of Alzheimer's disease (AD) has been considered to advance through subjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI). Altered functional connectivity (FC) in the default mode network (DMN) is reg...

journal_title：Frontiers in aging neuroscience

authors： Xue C,Yuan B,Yue Y,Xu J,Wang S,Wu M,Ji N,Zhou X,Zhao Y,Rao J,Yang W,Xiao C,Chen J

更新日期：2019-11-13 00:00:00

abstract：:Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows...

journal_title：Frontiers in aging neuroscience

authors： Stoessel D,Schulte C,Teixeira Dos Santos MC,Scheller D,Rebollo-Mesa I,Deuschle C,Walther D,Schauer N,Berg D,Nogueira da Costa A,Maetzler W

更新日期：2018-03-05 00:00:00

abstract：BACKGROUND:Platelet Rich Plasma (PRP) has shown positive and long-lasting effects in patients with tendinopathies. However, information about age-related differences in the clinical outcome is limited. Aim of this retrospective study was to compare the efficacy of PRP therapy in young and elderly subjects suffering for...

journal_title：Frontiers in aging neuroscience

authors： Salini V,Vanni D,Pantalone A,Abate M

更新日期：2015-12-10 00:00:00

abstract：:Disrupted metal homeostasis is a consistent feature of neurodegenerative disease in humans and is recapitulated in mouse models of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and neuronal ceriod lipofuscinosis. While the definitive pathogenesis of neurodegenerative disease in humans r...

journal_title：Frontiers in aging neuroscience

authors： Dang TN,Lim NK,Grubman A,Li QX,Volitakis I,White AR,Crouch PJ

更新日期：2014-02-11 00:00:00

abstract：:DNA methylation is an essential epigenetic mechanism involving in gene transcription modulation. An age-related increase in promoter methylation has been observed for neuronal activity and memory genes, and participates in neurological disorders. However, the position and precise mechanism of DNA methylation for memor...

journal_title：Frontiers in aging neuroscience

authors： Ni C,Qian M,Geng J,Qu Y,Tian Y,Yang N,Li S,Zheng H

更新日期：2020-08-18 00:00:00

abstract：:Objective: Cerebral small vessel disease (SVD) is associated with increased mortality, disability and cognitive decline, depression in stroke survivors. This study examined the association between SVD burden, defined by a combination of SVD markers, and health-related quality of life (HRQoL) in acute ischemic stroke. ...

journal_title：Frontiers in aging neuroscience

authors： Liang Y,Chen YK,Deng M,Mok VCT,Wang DF,Ungvari GS,Chu CW,Kamiya A,Tang WK

更新日期：2017-11-13 00:00:00

abstract：:The use of progressive resistance training (PRT) to improve gait and balance in people with Parkinson's disease (PD) is an emerging area of interest. However, the main effects of PRT on lower limb functions such as gait, balance, and leg strength in people with PD remain unclear. Therefore, the aim of the meta-analysi...

journal_title：Frontiers in aging neuroscience

authors： Tillman A,Muthalib M,Hendy AM,Johnson LG,Rantalainen T,Kidgell DJ,Enticott PG,Teo WP

更新日期：2015-03-24 00:00:00

abstract：:Similar to humans, the normal aged rat population is not homogeneous in terms of cognitive function. Two distinct subpopulations of aged Sprague-Dawley rats can be identified on the basis of spatial memory performance in the hole-board paradigm. It was the aim of the study to reveal protein changes relevant to aging a...

journal_title：Frontiers in aging neuroscience

authors： Lubec J,Smidak R,Malikovic J,Feyissa DD,Korz V,Höger H,Lubec G

更新日期：2019-07-31 00:00:00

abstract：Objective:To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 103) over time among cognitively normal older people. Methods:We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with normal...

journal_title：Frontiers in aging neuroscience

authors： Li X,Tong Q,Gao J,Liu C,Alzheimer’s Disease Neuroimaging Initiative.,Liu Y

更新日期：2020-08-14 00:00:00

abstract：:Aging is related to a deterioration of cognitive performance and to multiple alterations in the brain. Even before the beginning of a noticeable cognitive decline, the framework which holds cognitive function experiences these alterations. From a system-vulnerability point of view of cognition, the deterioration assoc...

journal_title：Frontiers in aging neuroscience

authors： Roldán-Tapia MD,Cánovas R,León I,García-Garcia J

更新日期：2017-10-24 00:00:00

abstract：:Background: Cognitive frailty (CF) is defined as the simultaneous presence of physical frailty and cognitive impairment among older adults without dementia. Previous studies have revealed that neuropathological changes may contribute to the degeneration of subcortical nuclei in the process of cognitive impairment. How...

journal_title：Frontiers in aging neuroscience

authors： Wan M,Xia R,Lin H,Qiu P,He J,Ye Y,Tao J,Chen L,Zheng G

更新日期：2020-07-28 00:00:00

abstract：:Microglial cells become dystrophic with aging; this phenotypic alteration contributes to basal central nervous system (CNS) neuroinflammation being a risk factor for age related neurodegenerative diseases. In previous studies we have observed that insulin like growth factor 1 (IGF1) gene therapy is a feasible approach...

journal_title：Frontiers in aging neuroscience

authors： Falomir-Lockhart E,Dolcetti FJC,García-Segura LM,Hereñú CB,Bellini MJ

更新日期：2019-03-05 00:00:00

abstract：:Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified...

journal_title：Frontiers in aging neuroscience

authors： Cui L,Hou NN,Wu HM,Zuo X,Lian YZ,Zhang CN,Wang ZF,Zhang X,Zhu JH

更新日期：2020-12-21 00:00:00

abstract：:The hippocampus is negatively affected by aging and neurodegenerative diseases leading to impaired learning and memory abilities. A diverse series of progressive modifications in the intercellular communication among neurons, astrocytes and microglia occur in the hippocampus during aging or inflammation. A detailed un...

journal_title：Frontiers in aging neuroscience

authors： Lana D,Ugolini F,Nosi D,Wenk GL,Giovannini MG

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) is a clinical stage indicating a prodromal phase of dementia. This practical concept could be used also for fronto-temporal dementia (FTD). Progranulin (PGRN) has been recently recognized as a useful diagnostic biomarker for fronto-temporal lobe degeneration (FTLD) due to GRN ...

journal_title：Frontiers in aging neuroscience

authors： Moretti DV,Benussi L,Fostinelli S,Ciani M,Binetti G,Ghidoni R

更新日期：2016-02-29 00:00:00

abstract：:Cardiorespiratory fitness has been shown to protect and enhance cognitive and brain functions, but little is known about the cortical mechanisms that underlie these changes in older adults. In this study, functional near infrared spectroscopy (fNIRS) was used to investigate variations in oxyhemoglobin [HbO2] and in de...

journal_title：Frontiers in aging neuroscience

authors： Albinet CT,Mandrick K,Bernard PL,Perrey S,Blain H

更新日期：2014-10-08 00:00:00

abstract：:The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer's disease (AD), little is known about the initial molecular disturbances that accompany the AD development at olfactory level. We have interrogated the time-depend...

journal_title：Frontiers in aging neuroscience

authors： Lachen-Montes M,González-Morales A,Palomino M,Ausin K,Gómez-Ochoa M,Zelaya MV,Ferrer I,Pérez-Mediavilla A,Fernández-Irigoyen J,Santamaría E

更新日期：2019-06-11 00:00:00

abstract：:Aerobic physical exercise (APE) leads to improved brain functions. To better understand the beneficial effect of APE on the aging brain, a morphometric study was carried out of changes in hippocampal synapses of old (>27 months) Balb/c mice undergoing treadmill training (OTT) for 4 weeks in comparison with old sedenta...

journal_title：Frontiers in aging neuroscience

authors： Fattoretti P,Malatesta M,Cisterna B,Milanese C,Zancanaro C

更新日期：2018-05-16 00:00:00

abstract：:Parkinson's disease (PD) is a debilitating neurodegenerative disorder defined by a loss of dopamine-producing neurons in the substantia nigra in the brain. It is associated with cytosolic inclusions known as Lewy bodies. The major component of Lewy bodies is aggregated alpha-synuclein. The molecular mechanism of alpha...

journal_title：Frontiers in aging neuroscience

authors： Hernandez SM,Tikhonova EB,Karamyshev AL

更新日期：2020-03-17 00:00:00

abstract：:Aging is associated with impairment of sensorial functions and with the onset of neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) bioavailability progressively decreases, we see a direct correlation with sensory impairment and cognitive performance in older humans. Age-related...

journal_title：Frontiers in aging neuroscience

authors： Rodríguez-de la Rosa L,Lassaletta L,Calvino M,Murillo-Cuesta S,Varela-Nieto I

更新日期：2017-12-12 00:00:00

abstract：:A common problem in the older population is the risk of falling and related injury, immobility, and reduced survival. Age-related neuronal changes, e.g., decline in gray-and white-matter, affect neuronal, cognitive, and motor functioning. The improvement of these factors might decrease fall events in elderly. Studies ...

journal_title：Frontiers in aging neuroscience

authors： Schättin A,de Bruin ED

更新日期：2016-11-29 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular ph...

journal_title：Frontiers in aging neuroscience

authors： Finelli MJ

更新日期：2020-09-03 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of 30,000 patients a year worldwide. The median reported survival time since onset ranges from 24 to 48 months. Riluzole is the only currently approved mildly efficacious treatment. Riluzole received marketing authorization in 1...

journal_title：Frontiers in aging neuroscience

authors： Petrov D,Mansfield C,Moussy A,Hermine O

更新日期：2017-03-22 00:00:00

abstract：:Activity-dependent neuroprotective protein (ADNP) is deregulated in Alzheimer's disease (AD) and in schizophrenia and mutated in autism. In mice, ADNP is essential for brain formation and ADNP haploinsufficiency is associated with cognitive and social deficits and tauopathy. Tauopathy, a major pathology in AD, is also...

journal_title：Frontiers in aging neuroscience

authors： Gozes I,Ivashko-Pachima Y

更新日期：2015-10-29 00:00:00

abstract：:[This corrects the article on p. 13 in vol. 8, PMID: 26903857.]. ...

journal_title：Frontiers in aging neuroscience

authors： Hu YB,Li CB,Song N,Zou Y,Chen SD,Ren RJ,Wang G

更新日期：2017-02-23 00:00:00

abstract：:Oxidative stress (OS), caused by the imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging, neurodegenerative diseases, and other related adverse conditions, such as ischemia. While ROS/RNS serve as signaling molecules at physiolog...

journal_title：Frontiers in aging neuroscience

authors： Wang X,Michaelis EK

更新日期：2010-03-30 00:00:00

abstract：:With promising results in recent treatment trials for Alzheimer's disease (AD), it becomes increasingly important to distinguish AD at early stages from other causes for cognitive impairment. However, existing diagnostic methods are either invasive (lumbar punctures, PET) or inaccurate Magnetic Resonance Imaging (MRI)...

journal_title：Frontiers in aging neuroscience

authors： Gurevich P,Stuke H,Kastrup A,Stuke H,Hildebrandt H

更新日期：2017-04-25 00:00:00

abstract：:The globus pallidus occupies a critical position in the indirect pathway of the basal ganglia motor control system. Hyperpolarization-activated cyclic-nucleotide gated (HCN) channels play an important role in the modulation of neuronal excitability. In vivo extracellular single unit recording, behavioral test and immu...

journal_title：Frontiers in aging neuroscience

authors： Hao XM,Xu R,Chen AQ,Sun FJ,Wang Y,Liu HX,Chen H,Xue Y,Chen L

更新日期：2019-07-25 00:00:00