Aging Modulates the Hemispheric Specialization during Word Production.

abstract：:Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with in...

journal_title：Frontiers in aging neuroscience

authors： Toricelli M,Evangelista SR,Oliveira LR,Viel TA,Buck HS

更新日期：2019-07-12 00:00:00

abstract：:Background: The brain atrophy and lesion index (BALI) has been developed to assess whole-brain structural deficits that are commonly seen on magnetic resonance imaging (MRI) in aging. It is unclear whether such changes can be detected at younger ages and how they might relate to other exposures. Here, we investigate h...

journal_title：Frontiers in aging neuroscience

authors： Gu T,Fu C,Shen Z,Guo H,Zou M,Chen M,Rockwood K,Song X

更新日期：2019-04-24 00:00:00

abstract：Objective:To investigate dysregulated molecules in preoperative cerebrospinal fluid (CSF) of elderly hip fracture patients with postoperative delirium (POD), in order to identify potential pathological mechanisms and biomarkers for pre-stage POD. Materials and Methods:This nested case control study used untargeted met...

journal_title：Frontiers in aging neuroscience

authors： Han Y,Zhang W,Liu J,Song Y,Liu T,Li Z,Wang X,Yang N,Li Y,Han D,Mi X,Zhou Y,Li M,Guo X,Zhong L,Wang G,Yuan Y

更新日期：2020-10-22 00:00:00

abstract：:Activity-dependent neuroprotective protein (ADNP) is deregulated in Alzheimer's disease (AD) and in schizophrenia and mutated in autism. In mice, ADNP is essential for brain formation and ADNP haploinsufficiency is associated with cognitive and social deficits and tauopathy. Tauopathy, a major pathology in AD, is also...

journal_title：Frontiers in aging neuroscience

authors： Gozes I,Ivashko-Pachima Y

更新日期：2015-10-29 00:00:00

abstract：:During aging, many experience a decline in cognitive function that includes memory loss. The encoding of long-term memories depends on new protein synthesis, and this is also reduced during aging. Thus, it is possible that changes in the regulation of protein synthesis contribute to the memory impairments observed in ...

journal_title：Frontiers in aging neuroscience

authors： Schimanski LA,Barnes CA

更新日期：2010-08-06 00:00:00

abstract：:Understanding speech in the presence of background sound can be challenging for older adults. Speech comprehension in noise appears to depend on working memory and executive-control processes (e.g., Heald and Nusbaum, 2014), and their augmentation through training may have rehabilitative potential for age-related hear...

journal_title：Frontiers in aging neuroscience

authors： Wayne RV,Hamilton C,Jones Huyck J,Johnsrude IS

更新日期：2016-03-22 00:00:00

abstract：:Microglia are dependent on signaling through the colony stimulating factor-1 receptor (CSF-1R/CD115) for growth and survival. Activation of CSF-1R can lead to cell division, while blocking CSF-1R can lead to rapid microglia cell death. CSF-1R has two ligands, the growth factors colony stimulating factor-1 (CSF-1) and ...

journal_title：Frontiers in aging neuroscience

authors： Walker DG,Tang TM,Lue LF

更新日期：2017-08-09 00:00:00

abstract：BACKGROUND:Previous studies reported that old adults, relative to young adults, showed improvement of emotional stability and increased experiences of positive affects. METHODS:In order to better understand the neural underpinnings behind the aging-related enhancement of positive affects, it is necessary to investigat...

journal_title：Frontiers in aging neuroscience

authors： Meng X,Yang J,Cai AY,Ding XS,Liu W,Li H,Yuan JJ

更新日期：2015-08-06 00:00:00

abstract：:Background: Primary progressive aphasia (PPA) is a clinical syndrome characterized by the neurodegeneration of language brain systems. Three main clinical forms (non-fluent, semantic, and logopenic PPA) have been recognized, but applicability of the classification and the capacity to predict the underlying pathology i...

journal_title：Frontiers in aging neuroscience

authors： Matias-Guiu JA,Díaz-Álvarez J,Ayala JL,Risco-Martín JL,Moreno-Ramos T,Pytel V,Matias-Guiu J,Carreras JL,Cabrera-Martín MN

更新日期：2018-07-31 00:00:00

abstract：:Background and Purpose: Previous studies found inconsistent results regarding the relationship between Alzheimer's disease (AD) and catecholamines, such as dopamine (DA), norepinephrine (NE), and epinephrine (EPI). Therefore, the purpose of this study was to perform a systematic review and meta-analysis to evaluate th...

journal_title：Frontiers in aging neuroscience

authors： Pan X,Kaminga AC,Jia P,Wen SW,Acheampong K,Liu A

更新日期：2020-09-11 00:00:00

abstract：:Invertebrate models have advantages for understanding the basis of behavioral aging due to their simple nervous systems and short lifespans. The potential usefulness of Aplysia californica in aging research is apparent from its long history of neurobiological research, but it has been underexploited in this model use....

journal_title：Frontiers in aging neuroscience

authors： Kempsell AT,Fieber LA

更新日期：2014-05-09 00:00:00

abstract：:Age-related hearing deficits are a leading cause of disability among the aged. While some forms of hearing deficits are peripheral in origin, others are centrally mediated. One such deficit is the ability to localize sounds, a critical component for segregating different acoustic objects and events, which is dependent...

journal_title：Frontiers in aging neuroscience

authors： Engle JR,Recanzone GH

更新日期：2013-01-04 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary tangles. Copper, iron,...

journal_title：Frontiers in aging neuroscience

authors： Wong BX,Hung YH,Bush AI,Duce JA

更新日期：2014-05-15 00:00:00

abstract：:The aggregation of α-synuclein (α-syn) is considered the key pathogenic event in many neurological disorders such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, giving rise to a whole category of neurodegenerative diseases known as synucleinopathies. Although the molecular basis of...

journal_title：Frontiers in aging neuroscience

authors： Ardah MT,Paleologou KE,Lv G,Abul Khair SB,Kazim AS,Minhas ST,Al-Tel TH,Al-Hayani AA,Haque ME,Eliezer D,El-Agnaf OM

更新日期：2014-08-05 00:00:00

abstract：:Abnormalities and impairments in axonal transport are suggested to strongly contribute to the pathological alterations underlying AD. The exact mechanisms leading to axonopathy are currently unclear, but it was recently suggested that APP expression itself triggers axonal degeneration. We used APP transgenic mice and ...

journal_title：Frontiers in aging neuroscience

authors： Christensen DZ,Huettenrauch M,Mitkovski M,Pradier L,Wirths O

更新日期：2014-06-27 00:00:00

abstract：:Objective: Increased variability in cognition with age has been argued as an indication of pathological processes. Focusing on early detection of neurodegenerative disorders, we investigated variability in cognition in healthy middle-aged adults. In order to understand possible determinants of this variability, we als...

journal_title：Frontiers in aging neuroscience

authors： Ferreira D,Machado A,Molina Y,Nieto A,Correia R,Westman E,Barroso J

更新日期：2017-06-09 00:00:00

abstract：:While aging can lead to significant declines in perceptual and cognitive function, the effects of age on multisensory integration, the process in which the brain combines information across the senses, are less clear. Recent reports suggest that older adults are susceptible to the sound-induced flash illusion (Shams e...

journal_title：Frontiers in aging neuroscience

authors： McGovern DP,Roudaia E,Stapleton J,McGinnity TM,Newell FN

更新日期：2014-09-24 00:00:00

abstract：:The acquisition and retention of motor skills is necessary for everyday functioning in the elderly and may be critical in the context of motor rehabilitation. Recent studies indicate that motor training closely followed by sleep may result in better engagement of procedural ("how to") memory consolidation processes in...

journal_title：Frontiers in aging neuroscience

authors： Gal C,Gabitov E,Maaravi-Hesseg R,Karni A,Korman M

更新日期：2019-11-22 00:00:00

abstract：:A common problem in the older population is the risk of falling and related injury, immobility, and reduced survival. Age-related neuronal changes, e.g., decline in gray-and white-matter, affect neuronal, cognitive, and motor functioning. The improvement of these factors might decrease fall events in elderly. Studies ...

journal_title：Frontiers in aging neuroscience

authors： Schättin A,de Bruin ED

更新日期：2016-11-29 00:00:00

abstract：:There is no disease-modifying treatment currently available for AD, one of the more impacting neurodegenerative diseases affecting more than 47.5 million people worldwide. The definition of new approaches for the design of proper clinical trials is highly demanded in order to achieve non-confounding results and assess...

journal_title：Frontiers in aging neuroscience

authors： Salvatore C,Cerasa A,Castiglioni I

更新日期：2018-05-24 00:00:00

abstract：:Neuroinflammation and autophagy dysfunction are closely related to the development of neurodegeneration such as Parkinson's disease (PD). However, the role of autophagy in microglia polarization and neuroinflammation is poorly understood. TNF-α, which is highly toxic to dopaminergic neurons, is implicated as a major m...

journal_title：Frontiers in aging neuroscience

authors： Jin MM,Wang F,Qi D,Liu WW,Gu C,Mao CJ,Yang YP,Zhao Z,Hu LF,Liu CF

更新日期：2018-11-20 00:00:00

abstract：:The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) and their effects on cognition have rarely been investigated. We aimed to examine brain iron deposition in svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we aimed to investigate the correl...

journal_title：Frontiers in aging neuroscience

authors： Sun Y,Ge X,Han X,Cao W,Wang Y,Ding W,Cao M,Zhang Y,Xu Q,Zhou Y,Xu J

更新日期：2017-03-30 00:00:00

abstract：:Objective: Late-life depression (LLD) is associated with development of different types of dementia. Identification of LLD patients, who will develop cognitive decline, i.e., the early stage of dementia would help to implement interventions earlier. The purpose of this study was to assess whether structural brain magn...

journal_title：Frontiers in aging neuroscience

authors： Lebedeva AK,Westman E,Borza T,Beyer MK,Engedal K,Aarsland D,Selbaek G,Haberg AK

更新日期：2017-02-02 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by a progressive cognitive decline and believed to be driven by the self-aggregation of amyloid-β (Aβ) peptide into oligomers and fibrils that accumulate as senile plaques. It is widely accepted that microglia-mediated inflammation is a significant contributor to disease patho...

journal_title：Frontiers in aging neuroscience

authors： Caldeira C,Cunha C,Vaz AR,Falcão AS,Barateiro A,Seixas E,Fernandes A,Brites D

更新日期：2017-08-31 00:00:00

abstract：:The hippocampus is negatively affected by aging and neurodegenerative diseases leading to impaired learning and memory abilities. A diverse series of progressive modifications in the intercellular communication among neurons, astrocytes and microglia occur in the hippocampus during aging or inflammation. A detailed un...

journal_title：Frontiers in aging neuroscience

authors： Lana D,Ugolini F,Nosi D,Wenk GL,Giovannini MG

更新日期：2017-09-11 00:00:00

abstract：:Mitochondrial dysfunction is a common and prominent feature of prion diseases and other neurodegenerative disorders. Mitochondria are dynamic organelles that constantly fuse with one another and subsequently break apart. Defective or superfluous mitochondria are usually eliminated by a form of autophagy, referred to a...

journal_title：Frontiers in aging neuroscience

authors： Zhu T,Chen JL,Wang Q,Shao W,Qi B

更新日期：2018-11-05 00:00:00

abstract：:Background: Facial emotion recognition (FER) is impaired in individuals with frontotemporal dementia (FTD) and Alzheimer's disease (AD) when compared to healthy older adults. Since deficits in emotion recognition are closely related to caregiver burden or social interactions, researchers have fundamental interest in F...

journal_title：Frontiers in aging neuroscience

authors： Park S,Kim T,Shin SA,Kim YK,Sohn BK,Park HJ,Youn JH,Lee JY

更新日期：2017-11-30 00:00:00

abstract：:Sustained engagement in mentally challenging activities has been shown to improve memory in older adults. We hypothesized that a busy schedule would be a proxy for an engaged lifestyle and would facilitate cognition. Here, we examined the relationship between busyness and cognition in adults aged 50-89. Participants (...

journal_title：Frontiers in aging neuroscience

authors： Festini SB,McDonough IM,Park DC

更新日期：2016-05-17 00:00:00

abstract：:Introduction: Falling is one of the primary concerns for people with Parkinson's Disease and occurs predominately during dynamic movements, such as walking. Several methods have been proposed to quantify dynamic balance and to assess fall risk. However, no consensus has been reached concerning which method is most app...

journal_title：Frontiers in aging neuroscience

authors： Siragy T,Nantel J

更新日期：2018-11-22 00:00:00

abstract：:Background: Little is known about the underlying mechanisms of the similarities in the core features of postoperative delirium (POD) and α-synuclein (α-syn)-related cognitive disorders. We herein investigated associations between fluctuated levels of exosomal α-syn in the plasma and POD presentation in geriatric hip f...

journal_title：Frontiers in aging neuroscience

authors： Yuan Y,Li Z,Yang N,Han Y,Ji X,Han D,Wang X,Li Y,Liu T,Yuan F,He J,Liu Y,Ni C,Zou P,Wang G,Guo X,Zhou Y

更新日期：2020-03-13 00:00:00