Perceived Risk of Mental Health Problems in Primary Care.

abstract：:Objective: To assess the age-related morphometric changes of subcortical structures in healthy people. Materials and Methods: Ultra-high field 7 tesla magnetic resonance (MR) imaging in humans was used to visualize the subcortical structures of healthy young, middle-aged and elderly participants. Using the magnetizati...

journal_title：Frontiers in aging neuroscience

authors： Wang XY,Zhao L,Yu T,Qiao L,Ni DY,Zhang GJ,Li YJ

更新日期：2016-09-26 00:00:00

abstract：:Background: Primary progressive aphasia (PPA) is a clinical syndrome characterized by the neurodegeneration of language brain systems. Three main clinical forms (non-fluent, semantic, and logopenic PPA) have been recognized, but applicability of the classification and the capacity to predict the underlying pathology i...

journal_title：Frontiers in aging neuroscience

authors： Matias-Guiu JA,Díaz-Álvarez J,Ayala JL,Risco-Martín JL,Moreno-Ramos T,Pytel V,Matias-Guiu J,Carreras JL,Cabrera-Martín MN

更新日期：2018-07-31 00:00:00

abstract：:The aim of this study was to develop a fast method for estimating whether a brain volume loss is within the normal range for the respective age of the patient. A readout-segmented diffusion-weighted echo-planar imaging sequence was performed as part of the routine examination at a 3-T scanner. Data without (b0-image) ...

journal_title：Frontiers in aging neuroscience

authors： Klose U,Batra M,Nägele T

更新日期：2013-11-19 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) is a clinical stage indicating a prodromal phase of dementia. This practical concept could be used also for fronto-temporal dementia (FTD). Progranulin (PGRN) has been recently recognized as a useful diagnostic biomarker for fronto-temporal lobe degeneration (FTLD) due to GRN ...

journal_title：Frontiers in aging neuroscience

authors： Moretti DV,Benussi L,Fostinelli S,Ciani M,Binetti G,Ghidoni R

更新日期：2016-02-29 00:00:00

abstract：:Life-time experiences are thought to influence the risk to develop the neurodegenerative disorder Alzheimer's disease (AD). In particular, early-life stress (ES) may modulate the onset and progression of AD. There is recent evidence by our group and others that AD-related neuropathological progression and the associat...

journal_title：Frontiers in aging neuroscience

authors： Hoeijmakers L,Amelianchik A,Verhaag F,Kotah J,Lucassen PJ,Korosi A

更新日期：2018-03-07 00:00:00

abstract：:The acquisition and retention of motor skills is necessary for everyday functioning in the elderly and may be critical in the context of motor rehabilitation. Recent studies indicate that motor training closely followed by sleep may result in better engagement of procedural ("how to") memory consolidation processes in...

journal_title：Frontiers in aging neuroscience

authors： Gal C,Gabitov E,Maaravi-Hesseg R,Karni A,Korman M

更新日期：2019-11-22 00:00:00

abstract：:Current society has to deal with major challenges related to our constantly increasing population of older adults. Since, motor performance generally deteriorates at older age, research investigating the effects of different types of training on motor improvement is particularly important. Here, we tested the effects ...

journal_title：Frontiers in aging neuroscience

authors： Pauwels L,Vancleef K,Swinnen SP,Beets IA

更新日期：2015-08-11 00:00:00

abstract：:Hypertension has a profound influence on the structure and function of blood vessels. Cerebral vessels undergo both structural and functional changes in hypertensive animals. However, dynamic changes of cerebrovasculature and the factors involved in this process are largely unknown. In this study, we explored the dyna...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Mu Z,Lin X,Geng J,Xiao TQ,Zhang Z,Wang Y,Guan Y,Yang GY

更新日期：2017-11-02 00:00:00

abstract：:Cognitive Reserve is the capital of knowledge and experiences that an individual acquires over their life-span. Cognitive Reserve is strictly related to Brain Reserve, which is the ability of the brain to cope with damage. These two concepts could explain many phenomena such as the modality of onset in dementia or the...

journal_title：Frontiers in aging neuroscience

authors： Arcara G,Mondini S,Bisso A,Palmer K,Meneghello F,Semenza C

更新日期：2017-12-22 00:00:00

abstract：:With promising results in recent treatment trials for Alzheimer's disease (AD), it becomes increasingly important to distinguish AD at early stages from other causes for cognitive impairment. However, existing diagnostic methods are either invasive (lumbar punctures, PET) or inaccurate Magnetic Resonance Imaging (MRI)...

journal_title：Frontiers in aging neuroscience

authors： Gurevich P,Stuke H,Kastrup A,Stuke H,Hildebrandt H

更新日期：2017-04-25 00:00:00

abstract：:During aging, human response times (RTs) to unisensory and crossmodal stimuli decrease. However, the elderly benefit more from crossmodal stimulus representations than younger people. The underlying short-latency multisensory integration process is mediated by direct crossmodal connections at the level of primary sens...

journal_title：Frontiers in aging neuroscience

authors： Henschke JU,Ohl FW,Budinger E

更新日期：2018-03-02 00:00:00

abstract：:Objective: Late-life depression (LLD) is associated with development of different types of dementia. Identification of LLD patients, who will develop cognitive decline, i.e., the early stage of dementia would help to implement interventions earlier. The purpose of this study was to assess whether structural brain magn...

journal_title：Frontiers in aging neuroscience

authors： Lebedeva AK,Westman E,Borza T,Beyer MK,Engedal K,Aarsland D,Selbaek G,Haberg AK

更新日期：2017-02-02 00:00:00

abstract：:There is no disease-modifying treatment currently available for AD, one of the more impacting neurodegenerative diseases affecting more than 47.5 million people worldwide. The definition of new approaches for the design of proper clinical trials is highly demanded in order to achieve non-confounding results and assess...

journal_title：Frontiers in aging neuroscience

authors： Salvatore C,Cerasa A,Castiglioni I

更新日期：2018-05-24 00:00:00

abstract：:It is relevant to unravel the factors that may mediate the cognitive decline observed during aging. Previous reports indicate that education has a positive influence on cognitive performance, while age, female gender and, especially, depressed mood were associated with poorer performances across multiple cognitive dim...

journal_title：Frontiers in aging neuroscience

authors： Santos NC,Costa PS,Cunha P,Portugal-Nunes C,Amorim L,Cotter J,Cerqueira JJ,Palha JA,Sousa N

更新日期：2014-02-24 00:00:00

abstract：:The McGill-R-Thy1-APP transgenic rat is an animal model of the familial form of Alzheimer's disease (AD). This model mirrors several neuropathological hallmarks of the disease, including the accumulation of beta-amyloid and the formation of amyloid plaques (in homozygous animals only), neuroinflammation and the gradua...

journal_title：Frontiers in aging neuroscience

authors： Petrasek T,Vojtechova I,Lobellova V,Popelikova A,Janikova M,Brozka H,Houdek P,Sladek M,Sumova A,Kristofikova Z,Vales K,Stuchlík A

更新日期：2018-08-28 00:00:00

abstract：:Manganese (Mn) is an essential metal and has important physiological functions for human health. However, exposure to excess levels of Mn in occupational settings or from environmental sources has been associated with a neurological syndrome comprising cognitive deficits, neuropsychological abnormalities and parkinson...

journal_title：Frontiers in aging neuroscience

authors： Guilarte TR

更新日期：2013-06-24 00:00:00

abstract：:Tinnitus, the phantom perception of sound without a corresponding external sound, is a frequent disorder which causes significant morbidity. So far there is no treatment available that reliably reduces the tinnitus perception. The research is hampered by the large heterogeneity of tinnitus and the fact that the tinnit...

journal_title：Frontiers in aging neuroscience

authors： Schlee W,Pryss RC,Probst T,Schobel J,Bachmeier A,Reichert M,Langguth B

更新日期：2016-12-15 00:00:00

abstract：:Aging is associated with cognitive decline and alterations in early perceptual processes. Studies in the auditory and visual sensory modalities have shown that the mismatch negativity [or the mismatch response (MMR)], an event-related potential (ERP) elicited by a deviant stimulus in a background of homogenous events,...

journal_title：Frontiers in aging neuroscience

authors： Strömmer JM,Tarkka IM,Astikainen P

更新日期：2014-10-27 00:00:00

abstract：:Neurons with histopathological changes consistent with granulovacuolar degeneration (GVD) were found in brain sections from aged cynomolgus monkeys (Macaca fascicularis) with clinical and pathological signs of cognitive aging. To our knowledge, this is the first reported description of GVD in non-human primates. GVD-l...

journal_title：Frontiers in aging neuroscience

authors： Darusman HS,Agungpriyono DR,Kusumaputri VA,Sajuthi D,Schapiro SJ,Hau J

更新日期：2019-03-07 00:00:00

abstract：:We examined whether baseline self-reported physical activity is associated with the efficacy of cognitive behavioral therapy for insomnia (CBT-I) in older veterans. Community-dwelling veterans aged 60 years and older with insomnia received CBT-I in a randomized controlled trial. Participants who received active treatm...

journal_title：Frontiers in aging neuroscience

authors： Yeung T,Martin JL,Fung CH,Fiorentino L,Dzierzewski JM,Rodriguez Tapia JC,Song Y,Josephson K,Jouldjian S,Mitchell MN,Alessi C

更新日期：2018-09-13 00:00:00

abstract：:Over the last few decades, considerable evidence shows that greater levels of aerobic exercise and cardiovascular fitness benefit cognitive performance. However, the degree to which free-living activity in community settings is related to cognitive performance remains unclear, particularly in older adults vulnerable t...

journal_title：Frontiers in aging neuroscience

authors： Wanigatunga AA,Manini TM,Cook DR,Katula J,Fielding RA,Kramer AF,Verghese J,Rapp SR,Sink KM,King AC,Buford TW,Anton S,Nadkarni N,Jennings JM,Reid K,Espeland MA,Gill TM,Pahor M,Nocera JR

更新日期：2018-11-15 00:00:00

abstract：:Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified...

journal_title：Frontiers in aging neuroscience

authors： Cui L,Hou NN,Wu HM,Zuo X,Lian YZ,Zhang CN,Wang ZF,Zhang X,Zhu JH

更新日期：2020-12-21 00:00:00

abstract：:Cerebral white matter lesion (WML) is one of the main causes for cognitive impairment and is often caused by chronic cerebral hypoperfusion. A line of evidence has shown that aspirin has neuroprotective effects and produces some benefits in long-term outcome and survival for ischemic stroke patients. However, whether ...

journal_title：Frontiers in aging neuroscience

authors： Chen J,Zuo S,Wang J,Huang J,Zhang X,Liu Y,Zhang Y,Zhao J,Han J,Xiong L,Shi M,Liu Z

更新日期：2014-01-27 00:00:00

abstract：:This study aimed to explore the effects of open- and closed-skill exercise interventions on the neurocognitive performance of executive functions in the elderly. Sixty-four healthy elderly males were randomly assigned to either a closed-skill (bike riding or brisk walking/jogging, n = 22), open-skill (table tennis, n ...

journal_title：Frontiers in aging neuroscience

authors： Tsai CL,Pan CY,Chen FC,Tseng YT

更新日期：2017-09-12 00:00:00

abstract：:Many of the molecular and pathological features associated with human Alzheimer disease (AD) are mirrored in the naturally occurring age-associated neuropathology in the canine species. In aged dogs with declining learned behavior and memory the severity of cognitive dysfunction parallels the progressive build up and ...

journal_title：Frontiers in aging neuroscience

authors： Rusbridge C,Salguero FJ,David MA,Faller KME,Bras JT,Guerreiro RJ,Richard-Londt AC,Grainger D,Head E,Brandner SGP,Summers B,Hardy J,Tayebi M

更新日期：2018-01-30 00:00:00

abstract：Objective:To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 103) over time among cognitively normal older people. Methods:We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with normal...

journal_title：Frontiers in aging neuroscience

authors： Li X,Tong Q,Gao J,Liu C,Alzheimer’s Disease Neuroimaging Initiative.,Liu Y

更新日期：2020-08-14 00:00:00

abstract：:Neuroinflammation and autophagy dysfunction are closely related to the development of neurodegeneration such as Parkinson's disease (PD). However, the role of autophagy in microglia polarization and neuroinflammation is poorly understood. TNF-α, which is highly toxic to dopaminergic neurons, is implicated as a major m...

journal_title：Frontiers in aging neuroscience

authors： Jin MM,Wang F,Qi D,Liu WW,Gu C,Mao CJ,Yang YP,Zhao Z,Hu LF,Liu CF

更新日期：2018-11-20 00:00:00

abstract：:Objectives/Background: Systemic inflammation can affect cognitive performance over time. The current study examined associations between systemic inflammation and cognitive performance among African Americans and Whites urban adults, stratifying by sex, and age group and by race. Patients/Methods: Among 1,555-1,719 Wh...

journal_title：Frontiers in aging neuroscience

authors： Beydoun MA,Dore GA,Canas JA,Liang H,Beydoun HA,Evans MK,Zonderman AB

更新日期：2018-10-09 00:00:00

abstract：:Measurement of the dynamic coupling between spontaneous Blood Oxygenation Level Dependent (BOLD) and cerebral blood flow (CBF) fluctuations has been recently proposed as a method to probe resting-state brain physiology. Here we investigated how the dynamic BOLD-CBF coupling during resting-state is affected by aging. F...

journal_title：Frontiers in aging neuroscience

authors： Chiacchiaretta P,Cerritelli F,Bubbico G,Perrucci MG,Ferretti A

更新日期：2018-04-23 00:00:00

abstract：:Centronuclear myopathies (CNMs) are a genetically heterogeneous group of inherited neuromuscular disorders characterized by clinical features of a congenital myopathy and abundant central nuclei as the most prominent histopathological feature. The most common forms of congenital myopathies with central nuclei have bee...

journal_title：Frontiers in aging neuroscience

authors： Jungbluth H,Gautel M

更新日期：2014-12-19 00:00:00