Pathogenic mechanisms in centronuclear myopathies.

abstract：:Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western countries, has gained more and more attention in Asian countries. The prevalence of RLS is higher in older people and females. RLS is most commonly related to iron deficiency, pregnancy and uremia. The RLS symptoms show a significant ...

journal_title：Frontiers in aging neuroscience

authors： Guo S,Huang J,Jiang H,Han C,Li J,Xu X,Zhang G,Lin Z,Xiong N,Wang T

更新日期：2017-06-02 00:00:00

abstract：:Abnormal cerebral blood flow (CBF) and resting-state functional connectivity (rs-FC) are sensitive biomarkers of disease progression and prognosis. This study investigated neural underpinnings of motor and cognitive recovery by longitudinally studying the changes of CBF and FC in pontine infarction (PI). Twenty patien...

journal_title：Frontiers in aging neuroscience

authors： Wei Y,Wu L,Wang Y,Liu J,Miao P,Wang K,Wang C,Cheng J

更新日期：2020-11-19 00:00:00

abstract：:Background and Objective: Ventricle volume is closely related to hydrocephalus, brain atrophy, Alzheimer's, Parkinson's syndrome, and other diseases. To accurately measure the volume of the ventricles for elderly patients, we use deep learning to establish a systematic and comprehensive automated ventricle segmentatio...

journal_title：Frontiers in aging neuroscience

authors： Zhou X,Ye Q,Jiang Y,Wang M,Niu Z,Menpes-Smith W,Fang EF,Liu Z,Xia J,Yang G

更新日期：2020-12-16 00:00:00

abstract：:Most therapeutic agents are designed to target a molecule or pathway without consideration of the mechanisms involved in the physiological turnover or removal of that target. In light of this and in particular for Alzheimer's disease, a number of therapeutic interventions are presently being developed/investigated whi...

journal_title：Frontiers in aging neuroscience

authors： Morrone CD,Liu M,Black SE,McLaurin J

更新日期：2015-05-05 00:00:00

abstract：BACKGROUND:Previous studies reported that old adults, relative to young adults, showed improvement of emotional stability and increased experiences of positive affects. METHODS:In order to better understand the neural underpinnings behind the aging-related enhancement of positive affects, it is necessary to investigat...

journal_title：Frontiers in aging neuroscience

authors： Meng X,Yang J,Cai AY,Ding XS,Liu W,Li H,Yuan JJ

更新日期：2015-08-06 00:00:00

abstract：:Background and Purpose: Previous studies found inconsistent results regarding the relationship between Alzheimer's disease (AD) and catecholamines, such as dopamine (DA), norepinephrine (NE), and epinephrine (EPI). Therefore, the purpose of this study was to perform a systematic review and meta-analysis to evaluate th...

journal_title：Frontiers in aging neuroscience

authors： Pan X,Kaminga AC,Jia P,Wen SW,Acheampong K,Liu A

更新日期：2020-09-11 00:00:00

abstract：:Background: Primary progressive aphasia (PPA) is a clinical syndrome characterized by the neurodegeneration of language brain systems. Three main clinical forms (non-fluent, semantic, and logopenic PPA) have been recognized, but applicability of the classification and the capacity to predict the underlying pathology i...

journal_title：Frontiers in aging neuroscience

authors： Matias-Guiu JA,Díaz-Álvarez J,Ayala JL,Risco-Martín JL,Moreno-Ramos T,Pytel V,Matias-Guiu J,Carreras JL,Cabrera-Martín MN

更新日期：2018-07-31 00:00:00

abstract：:Several studies have demonstrated through resting-state functional magnetic resonance imaging (fMRI) that functional connectivity changes are important in the recovery from Bell's palsy (BP); however, these studies have only focused on the cortico-cortical connectivity. It is unclear how corticostriatal connectivity r...

journal_title：Frontiers in aging neuroscience

authors： Hu S,Kan H,Kan J,Li C,Yuan A,Xu C,Wang A,Wang Y,Bao X,Shen T,Wu H

更新日期：2019-11-07 00:00:00

abstract：:Aging is related to a deterioration of cognitive performance and to multiple alterations in the brain. Even before the beginning of a noticeable cognitive decline, the framework which holds cognitive function experiences these alterations. From a system-vulnerability point of view of cognition, the deterioration assoc...

journal_title：Frontiers in aging neuroscience

authors： Roldán-Tapia MD,Cánovas R,León I,García-Garcia J

更新日期：2017-10-24 00:00:00

abstract：:[This corrects the article on p. 13 in vol. 8, PMID: 26903857.]. ...

journal_title：Frontiers in aging neuroscience

authors： Hu YB,Li CB,Song N,Zou Y,Chen SD,Ren RJ,Wang G

更新日期：2017-02-23 00:00:00

abstract：:The aggregation of α-synuclein (α-syn) is considered the key pathogenic event in many neurological disorders such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, giving rise to a whole category of neurodegenerative diseases known as synucleinopathies. Although the molecular basis of...

journal_title：Frontiers in aging neuroscience

authors： Ardah MT,Paleologou KE,Lv G,Abul Khair SB,Kazim AS,Minhas ST,Al-Tel TH,Al-Hayani AA,Haque ME,Eliezer D,El-Agnaf OM

更新日期：2014-08-05 00:00:00

abstract：:Age related hearing loss (presbycusis) is one of the most common sensory deficits in the aging population. The main subjective ailment in the elderly is the deterioration of speech understanding, especially in a noisy environment, which cannot solely be explained by increased hearing thresholds. The examination method...

journal_title：Frontiers in aging neuroscience

authors： Profant O,Jilek M,Bures Z,Vencovsky V,Kucharova D,Svobodova V,Korynta J,Syka J

更新日期：2019-02-26 00:00:00

abstract：:Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with in...

journal_title：Frontiers in aging neuroscience

authors： Toricelli M,Evangelista SR,Oliveira LR,Viel TA,Buck HS

更新日期：2019-07-12 00:00:00

abstract：:Neurofilament light (NFL) is a putative biomarker of neurodegeneration. This study evaluates the correlative association of NFL with Alzheimer's disease (AD) indices. Relevant studies were identified after a literature search in electronic databases and study selection was based on pre-determined eligibility criteria....

journal_title：Frontiers in aging neuroscience

authors： Jin M,Cao L,Dai YP

更新日期：2019-09-13 00:00:00

abstract：:Background: Amyloid beta 1-43 (Aβ43) may be a useful additional biomarker for diagnosing Alzheimer's disease (AD). We have investigated cerebrospinal fluid (CSF) levels of Aβ43 in patients with early-onset AD in contrast to levels in late-onset AD. For comparison, in addition to the 'core' biomarkers, several other an...

journal_title：Frontiers in aging neuroscience

authors： Lauridsen C,Sando SB,Møller I,Berge G,Pomary PK,Grøntvedt GR,Salvesen Ø,Bråthen G,White LR

更新日期：2017-06-28 00:00:00

abstract：:Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD). Inconsistent results about the role of APOE ε4 alleles on cognitive decline of community non-dementia elderly have been reported. This study aimed to examine the relationship between APOE ε4 allele and cognitive abilities...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Pan X,Fei G,Wang C,Wan W,Sang S,Wang H,Wang Z,Zhong C

更新日期：2019-03-29 00:00:00

abstract：:Parkinson's disease (PD) is a debilitating neurodegenerative disorder defined by a loss of dopamine-producing neurons in the substantia nigra in the brain. It is associated with cytosolic inclusions known as Lewy bodies. The major component of Lewy bodies is aggregated alpha-synuclein. The molecular mechanism of alpha...

journal_title：Frontiers in aging neuroscience

authors： Hernandez SM,Tikhonova EB,Karamyshev AL

更新日期：2020-03-17 00:00:00

abstract：:It is assumed that DNA sequences are conserved in the diverse cell types present in a multicellular organism like the human being. Thus, in order to compare the sequences in the genome of DNA from different individuals, nucleic acid is commonly isolated from a single tissue. In this regard, blood cells are widely used...

journal_title：Frontiers in aging neuroscience

authors： Avila J,Gómez-Ramos A,Soriano E

更新日期：2014-11-25 00:00:00

abstract：:Activity-dependent neuroprotective protein (ADNP) is deregulated in Alzheimer's disease (AD) and in schizophrenia and mutated in autism. In mice, ADNP is essential for brain formation and ADNP haploinsufficiency is associated with cognitive and social deficits and tauopathy. Tauopathy, a major pathology in AD, is also...

journal_title：Frontiers in aging neuroscience

authors： Gozes I,Ivashko-Pachima Y

更新日期：2015-10-29 00:00:00

abstract：:Aggregated tau is a hallmark neuropathological feature in numerous neurodegenerative disorders. Previous studies aiming to validate aggregated tau pathology as a pathogenic driver of neurodegeneration in correlation to characteristic behavioral phenotypes have had shortcomings. Although studies on soluble tau patholog...

journal_title：Frontiers in aging neuroscience

authors： Mahendran TS,Suresh SN,Garimella L,Manjithaya R

更新日期：2020-11-05 00:00:00

abstract：:The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer's disease (AD). The heavy public burden of AD, along with the urgent to prevent and treat the disease before the irreversible damage to the brain, calls for a sensitive and speci...

journal_title：Frontiers in aging neuroscience

authors： Liao H,Zhu Z,Peng Y

更新日期：2018-06-22 00:00:00

abstract：:Although older adults exhibit normal accuracy in performing word retrieval and generation (lexical production; e.g., object naming), they are generally slower in responding than younger adults. To maintain accuracy, older adults recruit compensatory mechanisms and strategies. We focused on two such possible compensato...

journal_title：Frontiers in aging neuroscience

authors： Hoyau E,Boudiaf N,Cousin E,Pichat C,Fournet N,Krainik A,Jaillard A,Baciu M

更新日期：2017-05-09 00:00:00

abstract：:Verbal fluency is the ability to produce a satisfying sequence of spoken words during a given time interval. The core of verbal fluency lies in the capacity to manage the executive aspects of language. The standard scores of the semantic verbal fluency test are broadly used in the neuropsychological assessment of the ...

journal_title：Frontiers in aging neuroscience

authors： Bertola L,Mota NB,Copelli M,Rivero T,Diniz BS,Romano-Silva MA,Ribeiro S,Malloy-Diniz LF

更新日期：2014-07-29 00:00:00

abstract：:Alzheimer's disease treatment is still an open problem. The diversity of symptoms, the alterations in common pathophysiology, the existence of asymptomatic cases, the different types of sporadic and familial Alzheimer's and their relevance with other types of dementia and comorbidities, have already created a myth-fea...

journal_title：Frontiers in aging neuroscience

authors： Alexiou A,Mantzavinos VD,Greig NH,Kamal MA

更新日期：2017-03-31 00:00:00

abstract：:Recent work suggests that the brain can be conceptualized as a network comprised of groups of sub-networks or modules. The extent of segregation between modules can be quantified with a modularity metric, where networks with high modularity have dense connections within modules and sparser connections between modules....

journal_title：Frontiers in aging neuroscience

authors： Baniqued PL,Gallen CL,Voss MW,Burzynska AZ,Wong CN,Cooke GE,Duffy K,Fanning J,Ehlers DK,Salerno EA,Aguiñaga S,McAuley E,Kramer AF,D'Esposito M

更新日期：2018-01-04 00:00:00

abstract：:Deep learning, a state-of-the-art machine learning approach, has shown outstanding performance over traditional machine learning in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated classific...

journal_title：Frontiers in aging neuroscience

authors： Jo T,Nho K,Saykin AJ

更新日期：2019-08-20 00:00:00

abstract：:Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive and neuropsychiatric...

journal_title：Frontiers in aging neuroscience

authors： Tan RH,Devenney E,Kiernan MC,Halliday GM,Hodges JR,Hornberger M

更新日期：2015-07-02 00:00:00

abstract：:Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques, neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the brain. AD research has, in large part, been dedicated to the understanding of Aβ and NFT deposition as well as to the pharmacological reduction of th...

journal_title：Frontiers in aging neuroscience

authors： Frost GR,Jonas LA,Li YM

更新日期：2019-12-10 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial pathology causing common brain spectrum disorders in affected patients. These mixed neurological disorders not only include structural AD brain changes but also cerebrovascular lesions. The main aim of the present issue is to find the factors shared by the two pathologies. ...

journal_title：Frontiers in aging neuroscience

authors： Guglielmotto M,Monteleone D,Vasciaveo V,Repetto IE,Manassero G,Tabaton M,Tamagno E

更新日期：2017-09-29 00:00:00

abstract：:Early identification of persons at risk for cognitive decline in aging is critical to optimizing treatment to delay or avoid a clinical diagnosis of mild cognitive impairment (MCI) or dementia due to Alzheimer's disease (AD). To accomplish early identification, it is essential that trajectories of cognitive change be ...

journal_title：Frontiers in aging neuroscience

authors： Fleischman DA,Yu L,Arfanakis K,Han SD,Barnes LL,Arvanitakis Z,Boyle PA,Bennett DA

更新日期：2013-06-05 00:00:00