Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People.

abstract：:Pilot studies using technology-aided programs to promote verbal reminiscence and mild physical activity (i.e., positive forms of engagement) in persons with moderate or severe Alzheimer's disease have provided promising results (Lancioni et al., 2015a,b). The present two studies were aimed at upgrading and/or extendin...

journal_title：Frontiers in aging neuroscience

authors： Lancioni GE,Singh NN,O'Reilly MF,Sigafoos J,D'Amico F,Renna C,Pinto K

更新日期：2016-04-21 00:00:00

abstract：:EEG research conducted in the past 5 years on multiple object processing has begun to define how the aging brain tracks the numerosity of the objects presented in the visual field for different goals. We review the recent EEG findings in healthy older individuals (age range: 65-75 years approximately) on perceptual, a...

journal_title：Frontiers in aging neuroscience

authors： Mazza V,Brignani D

更新日期：2016-03-02 00:00:00

abstract：:Previous research suggests specific deficits in face perception and memory in older adults, which could reflect a dedifferentiation in the context of a general broadening of cognitive architecture with advanced age. Such dedifferentiation could manifest in a less specialized face processing system. A promising tool to...

journal_title：Frontiers in aging neuroscience

authors： Komes J,Schweinberger SR,Wiese H

更新日期：2014-04-04 00:00:00

abstract：:Alzheimer's disease (AD) is characterized in the late stages by amyloid-β (Aβ) plaques and neurofibrillary tangles. Nevertheless, recent evidence has indicated that early changes in cerebral connectivity could compromise cognitive functions even before the appearance of the classical neuropathological features. Diffus...

journal_title：Frontiers in aging neuroscience

authors： Manno FAM,Isla AG,Manno SHC,Ahmed I,Cheng SH,Barrios FA,Lau C

更新日期：2019-03-22 00:00:00

abstract：:The obesity epidemic had spawned considerable interest in understanding peoples' responses to palatable food cues that are plentiful in obesogenic environments. In this paper we examine how trait mindfulness of older, obese adults may moderate brain networks that arise from exposure to such cues. Nineteen older, obese...

journal_title：Frontiers in aging neuroscience

authors： Paolini B,Burdette JH,Laurienti PJ,Morgan AR,Williamson DA,Rejeski WJ

更新日期：2012-06-06 00:00:00

abstract：:Background and Purpose: Subarachnoid hemorrhage (SAH) has long been classified into two main forms, aneurysmal SAH (aSAH) and non-aneurysmal SAH (naSAH), but the related risk factors for aSAH and naSAH are heterogeneous. Our objective was to determine the risk factors for SAH of known or unknown origin with respect to...

journal_title：Frontiers in aging neuroscience

authors： Wang MD,Fu QH,Song MJ,Ma WB,Zhang JH,Wang ZX

更新日期：2021-01-11 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular ph...

journal_title：Frontiers in aging neuroscience

authors： Finelli MJ

更新日期：2020-09-03 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic nigrostriatal neurons, with reductions in the function and amount of dopaminergic synapses. Therefore, synapse loss and membrane-related pathology provide relevant targets for interventions in PD. We previously showed the benefic...

journal_title：Frontiers in aging neuroscience

authors： Perez-Pardo P,de Jong EM,Broersen LM,van Wijk N,Attali A,Garssen J,Kraneveld AD

更新日期：2017-03-20 00:00:00

abstract：:Background: There has been much research devoted to examining the short-term effects of different interventions for improving memory functioning of older adults with memory complaints. Nevertheless, very few studies have examined the long-term effects of these interventions. Thus, the present study compared the sustai...

journal_title：Frontiers in aging neuroscience

authors： Chan AS,Cheung WK,Yeung MK,Lee TL

更新日期：2018-08-07 00:00:00

abstract：:Sustained engagement in mentally challenging activities has been shown to improve memory in older adults. We hypothesized that a busy schedule would be a proxy for an engaged lifestyle and would facilitate cognition. Here, we examined the relationship between busyness and cognition in adults aged 50-89. Participants (...

journal_title：Frontiers in aging neuroscience

authors： Festini SB,McDonough IM,Park DC

更新日期：2016-05-17 00:00:00

abstract：:Centronuclear myopathies (CNMs) are a genetically heterogeneous group of inherited neuromuscular disorders characterized by clinical features of a congenital myopathy and abundant central nuclei as the most prominent histopathological feature. The most common forms of congenital myopathies with central nuclei have bee...

journal_title：Frontiers in aging neuroscience

authors： Jungbluth H,Gautel M

更新日期：2014-12-19 00:00:00

abstract：:Aerobic physical exercise (APE) leads to improved brain functions. To better understand the beneficial effect of APE on the aging brain, a morphometric study was carried out of changes in hippocampal synapses of old (>27 months) Balb/c mice undergoing treadmill training (OTT) for 4 weeks in comparison with old sedenta...

journal_title：Frontiers in aging neuroscience

authors： Fattoretti P,Malatesta M,Cisterna B,Milanese C,Zancanaro C

更新日期：2018-05-16 00:00:00

abstract：:Alzheimer disease (AD) has an insidious onset and heterogeneous clinical symptoms. The well-accepted biomarkers for clinical diagnosis of AD include β-amyloid (Aβ) deposition and pathologic tau level within cerebral spinal fluid (CSF) and imaging AD pathology such as positive emission tomography (PET) imaging of the a...

journal_title：Frontiers in aging neuroscience

authors： Jiao F,Yi F,Wang Y,Zhang S,Guo Y,Du W,Gao Y,Ren J,Zhang H,Liu L,Song H,Wang L

更新日期：2020-07-21 00:00:00

abstract：:Background: Juvenile amyotrophic lateral sclerosis (jALS) is a rare form of ALS with an onset age of less than 25 years and is frequently thought to be genetic in origin. DDHD1 gene mutations have been reported to be associated with the SPG28 subtype of autosomal recessive HSP but have never been reported in jALS pati...

journal_title：Frontiers in aging neuroscience

authors： Wu C,Fan D

更新日期：2016-12-06 00:00:00

abstract：:Early identification of persons at risk for cognitive decline in aging is critical to optimizing treatment to delay or avoid a clinical diagnosis of mild cognitive impairment (MCI) or dementia due to Alzheimer's disease (AD). To accomplish early identification, it is essential that trajectories of cognitive change be ...

journal_title：Frontiers in aging neuroscience

authors： Fleischman DA,Yu L,Arfanakis K,Han SD,Barnes LL,Arvanitakis Z,Boyle PA,Bennett DA

更新日期：2013-06-05 00:00:00

abstract：:There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinical trials for HD are limited by a lack of knowledge of the natural hi...

journal_title：Frontiers in aging neuroscience

authors： Paulsen JS,Long JD,Johnson HJ,Aylward EH,Ross CA,Williams JK,Nance MA,Erwin CJ,Westervelt HJ,Harrington DL,Bockholt HJ,Zhang Y,McCusker EA,Chiu EM,Panegyres PK,PREDICT-HD Investigators and Coordinators of the Huntington Stu

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:The cognitive status is generally considered as a major determinant of rehabilitation outcome in Parkinson's disease (PD). No studies about the effect of cognitive impairment on motor rehabilitation outcomes in PD have been performed before. OBJECTIVE:This study is aimed to evaluate the impact of cognitive ...

journal_title：Frontiers in aging neuroscience

authors： Ferrazzoli D,Ortelli P,Maestri R,Bera R,Giladi N,Ghilardi MF,Pezzoli G,Frazzitta G

更新日期：2016-08-11 00:00:00

abstract：:Although older adults exhibit normal accuracy in performing word retrieval and generation (lexical production; e.g., object naming), they are generally slower in responding than younger adults. To maintain accuracy, older adults recruit compensatory mechanisms and strategies. We focused on two such possible compensato...

journal_title：Frontiers in aging neuroscience

authors： Hoyau E,Boudiaf N,Cousin E,Pichat C,Fournet N,Krainik A,Jaillard A,Baciu M

更新日期：2017-05-09 00:00:00

abstract：:The acquisition and retention of motor skills is necessary for everyday functioning in the elderly and may be critical in the context of motor rehabilitation. Recent studies indicate that motor training closely followed by sleep may result in better engagement of procedural ("how to") memory consolidation processes in...

journal_title：Frontiers in aging neuroscience

authors： Gal C,Gabitov E,Maaravi-Hesseg R,Karni A,Korman M

更新日期：2019-11-22 00:00:00

abstract：:Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished h...

journal_title：Frontiers in aging neuroscience

authors： Hood S,Amir S

更新日期：2017-05-30 00:00:00

abstract：:Aging is associated with cognitive decline and alterations in early perceptual processes. Studies in the auditory and visual sensory modalities have shown that the mismatch negativity [or the mismatch response (MMR)], an event-related potential (ERP) elicited by a deviant stimulus in a background of homogenous events,...

journal_title：Frontiers in aging neuroscience

authors： Strömmer JM,Tarkka IM,Astikainen P

更新日期：2014-10-27 00:00:00

abstract：:It is assumed that DNA sequences are conserved in the diverse cell types present in a multicellular organism like the human being. Thus, in order to compare the sequences in the genome of DNA from different individuals, nucleic acid is commonly isolated from a single tissue. In this regard, blood cells are widely used...

journal_title：Frontiers in aging neuroscience

authors： Avila J,Gómez-Ramos A,Soriano E

更新日期：2014-11-25 00:00:00

abstract：:[This corrects the article on p. 13 in vol. 8, PMID: 26903857.]. ...

journal_title：Frontiers in aging neuroscience

authors： Hu YB,Li CB,Song N,Zou Y,Chen SD,Ren RJ,Wang G

更新日期：2017-02-23 00:00:00

abstract：:Mitochondrial dysfunction is a common and prominent feature of prion diseases and other neurodegenerative disorders. Mitochondria are dynamic organelles that constantly fuse with one another and subsequently break apart. Defective or superfluous mitochondria are usually eliminated by a form of autophagy, referred to a...

journal_title：Frontiers in aging neuroscience

authors： Zhu T,Chen JL,Wang Q,Shao W,Qi B

更新日期：2018-11-05 00:00:00

abstract：:Objective: Late-life depression (LLD) is associated with development of different types of dementia. Identification of LLD patients, who will develop cognitive decline, i.e., the early stage of dementia would help to implement interventions earlier. The purpose of this study was to assess whether structural brain magn...

journal_title：Frontiers in aging neuroscience

authors： Lebedeva AK,Westman E,Borza T,Beyer MK,Engedal K,Aarsland D,Selbaek G,Haberg AK

更新日期：2017-02-02 00:00:00

abstract：:Activity-dependent neuroprotective protein (ADNP) is deregulated in Alzheimer's disease (AD) and in schizophrenia and mutated in autism. In mice, ADNP is essential for brain formation and ADNP haploinsufficiency is associated with cognitive and social deficits and tauopathy. Tauopathy, a major pathology in AD, is also...

journal_title：Frontiers in aging neuroscience

authors： Gozes I,Ivashko-Pachima Y

更新日期：2015-10-29 00:00:00

abstract：:Background: Little is known about the underlying mechanisms of the similarities in the core features of postoperative delirium (POD) and α-synuclein (α-syn)-related cognitive disorders. We herein investigated associations between fluctuated levels of exosomal α-syn in the plasma and POD presentation in geriatric hip f...

journal_title：Frontiers in aging neuroscience

authors： Yuan Y,Li Z,Yang N,Han Y,Ji X,Han D,Wang X,Li Y,Liu T,Yuan F,He J,Liu Y,Ni C,Zou P,Wang G,Guo X,Zhou Y

更新日期：2020-03-13 00:00:00

abstract：:Cerebral white matter lesion (WML) is one of the main causes for cognitive impairment and is often caused by chronic cerebral hypoperfusion. A line of evidence has shown that aspirin has neuroprotective effects and produces some benefits in long-term outcome and survival for ischemic stroke patients. However, whether ...

journal_title：Frontiers in aging neuroscience

authors： Chen J,Zuo S,Wang J,Huang J,Zhang X,Liu Y,Zhang Y,Zhao J,Han J,Xiong L,Shi M,Liu Z

更新日期：2014-01-27 00:00:00

abstract：:Aggregated tau is a hallmark neuropathological feature in numerous neurodegenerative disorders. Previous studies aiming to validate aggregated tau pathology as a pathogenic driver of neurodegeneration in correlation to characteristic behavioral phenotypes have had shortcomings. Although studies on soluble tau patholog...

journal_title：Frontiers in aging neuroscience

authors： Mahendran TS,Suresh SN,Garimella L,Manjithaya R

更新日期：2020-11-05 00:00:00

abstract：:Objective: To assess the age-related morphometric changes of subcortical structures in healthy people. Materials and Methods: Ultra-high field 7 tesla magnetic resonance (MR) imaging in humans was used to visualize the subcortical structures of healthy young, middle-aged and elderly participants. Using the magnetizati...

journal_title：Frontiers in aging neuroscience

authors： Wang XY,Zhao L,Yu T,Qiao L,Ni DY,Zhang GJ,Li YJ

更新日期：2016-09-26 00:00:00