Variations in brain DNA.

abstract：:Aging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer's disease. However, due to mixed findings, it is unclear if changes in resting-state networ...

journal_title：Frontiers in aging neuroscience

authors： Hausman HK,O'Shea A,Kraft JN,Boutzoukas EM,Evangelista ND,Van Etten EJ,Bharadwaj PK,Smith SG,Porges E,Hishaw GA,Wu S,DeKosky S,Alexander GE,Marsiske M,Cohen R,Woods AJ

更新日期：2020-06-12 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular ph...

journal_title：Frontiers in aging neuroscience

authors： Finelli MJ

更新日期：2020-09-03 00:00:00

abstract：:Objective: To assess the age-related morphometric changes of subcortical structures in healthy people. Materials and Methods: Ultra-high field 7 tesla magnetic resonance (MR) imaging in humans was used to visualize the subcortical structures of healthy young, middle-aged and elderly participants. Using the magnetizati...

journal_title：Frontiers in aging neuroscience

authors： Wang XY,Zhao L,Yu T,Qiao L,Ni DY,Zhang GJ,Li YJ

更新日期：2016-09-26 00:00:00

abstract：:Microglial cells become dystrophic with aging; this phenotypic alteration contributes to basal central nervous system (CNS) neuroinflammation being a risk factor for age related neurodegenerative diseases. In previous studies we have observed that insulin like growth factor 1 (IGF1) gene therapy is a feasible approach...

journal_title：Frontiers in aging neuroscience

authors： Falomir-Lockhart E,Dolcetti FJC,García-Segura LM,Hereñú CB,Bellini MJ

更新日期：2019-03-05 00:00:00

abstract：:There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinical trials for HD are limited by a lack of knowledge of the natural hi...

journal_title：Frontiers in aging neuroscience

authors： Paulsen JS,Long JD,Johnson HJ,Aylward EH,Ross CA,Williams JK,Nance MA,Erwin CJ,Westervelt HJ,Harrington DL,Bockholt HJ,Zhang Y,McCusker EA,Chiu EM,Panegyres PK,PREDICT-HD Investigators and Coordinators of the Huntington Stu

更新日期：2014-04-22 00:00:00

abstract：:Alzheimer's disease (AD) and treatment of the brain in aging require the development of new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large molecule therapeutics that do not cross the blood-brain barrier (BBB). BBB drug delivery is the limiting factor in the future development of ne...

journal_title：Frontiers in aging neuroscience

authors： Pardridge WM

更新日期：2020-01-10 00:00:00

abstract：:Background and Purpose: Previous studies found inconsistent results regarding the relationship between Alzheimer's disease (AD) and catecholamines, such as dopamine (DA), norepinephrine (NE), and epinephrine (EPI). Therefore, the purpose of this study was to perform a systematic review and meta-analysis to evaluate th...

journal_title：Frontiers in aging neuroscience

authors： Pan X,Kaminga AC,Jia P,Wen SW,Acheampong K,Liu A

更新日期：2020-09-11 00:00:00

abstract：:Background: Decreased bone mineral density (BMD) was associated with poorer cognitive function and increased risk of Alzheimer's disease (AD). However, objective evidence for the relationship between osteoporosis and AD in humans has not been extensively described. Objectives: We aimed to evaluate the relationships be...

journal_title：Frontiers in aging neuroscience

authors： Takano Y,Tatewaki Y,Mutoh T,Morota N,Matsudaira I,Thyreau B,Nagasaka T,Odagiri H,Yamamoto S,Arai H,Taki Y

更新日期：2020-06-17 00:00:00

abstract：:Abnormalities and impairments in axonal transport are suggested to strongly contribute to the pathological alterations underlying AD. The exact mechanisms leading to axonopathy are currently unclear, but it was recently suggested that APP expression itself triggers axonal degeneration. We used APP transgenic mice and ...

journal_title：Frontiers in aging neuroscience

authors： Christensen DZ,Huettenrauch M,Mitkovski M,Pradier L,Wirths O

更新日期：2014-06-27 00:00:00

abstract：:DNA methylation is an essential epigenetic mechanism involving in gene transcription modulation. An age-related increase in promoter methylation has been observed for neuronal activity and memory genes, and participates in neurological disorders. However, the position and precise mechanism of DNA methylation for memor...

journal_title：Frontiers in aging neuroscience

authors： Ni C,Qian M,Geng J,Qu Y,Tian Y,Yang N,Li S,Zheng H

更新日期：2020-08-18 00:00:00

abstract：:Background: Primary progressive aphasia (PPA) is a clinical syndrome characterized by the neurodegeneration of language brain systems. Three main clinical forms (non-fluent, semantic, and logopenic PPA) have been recognized, but applicability of the classification and the capacity to predict the underlying pathology i...

journal_title：Frontiers in aging neuroscience

authors： Matias-Guiu JA,Díaz-Álvarez J,Ayala JL,Risco-Martín JL,Moreno-Ramos T,Pytel V,Matias-Guiu J,Carreras JL,Cabrera-Martín MN

更新日期：2018-07-31 00:00:00

abstract：:Neuroinflammation and autophagy dysfunction are closely related to the development of neurodegeneration such as Parkinson's disease (PD). However, the role of autophagy in microglia polarization and neuroinflammation is poorly understood. TNF-α, which is highly toxic to dopaminergic neurons, is implicated as a major m...

journal_title：Frontiers in aging neuroscience

authors： Jin MM,Wang F,Qi D,Liu WW,Gu C,Mao CJ,Yang YP,Zhao Z,Hu LF,Liu CF

更新日期：2018-11-20 00:00:00

abstract：:The microtubule-associated protein tau is closely correlated with hypometabolism in Alzheimer's disease (AD). α-lipoic acid (LA), which is a naturally occurring cofactor in mitochondrial, has been shown to have properties that can inhibit the tau pathology and neuronal damage in our previous research. However, if LA a...

journal_title：Frontiers in aging neuroscience

authors： Zhang YH,Yan XZ,Xu SF,Pang ZQ,Li LB,Yang Y,Fan YG,Wang Z,Yu X,Guo C,Ao Q

更新日期：2020-08-21 00:00:00

abstract：:Background: Due to the lack of objective measures for assessing tinnitus, its clinical evaluation largely relies on the use of questionnaires and psychoacoustic tests. A global assessment of tinnitus burden would largely benefit from holistic approaches that not only incorporate measures of tinnitus but also take into...

journal_title：Frontiers in aging neuroscience

authors： Müller K,Edvall NK,Idrizbegovic E,Huhn R,Cima R,Persson V,Leineweber C,Westerlund H,Langguth B,Schlee W,Canlon B,Cederroth CR

更新日期：2016-11-22 00:00:00

abstract：:Background: Cognitive frailty (CF) is defined as the simultaneous presence of physical frailty and cognitive impairment among older adults without dementia. Previous studies have revealed that neuropathological changes may contribute to the degeneration of subcortical nuclei in the process of cognitive impairment. How...

journal_title：Frontiers in aging neuroscience

authors： Wan M,Xia R,Lin H,Qiu P,He J,Ye Y,Tao J,Chen L,Zheng G

更新日期：2020-07-28 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of 30,000 patients a year worldwide. The median reported survival time since onset ranges from 24 to 48 months. Riluzole is the only currently approved mildly efficacious treatment. Riluzole received marketing authorization in 1...

journal_title：Frontiers in aging neuroscience

authors： Petrov D,Mansfield C,Moussy A,Hermine O

更新日期：2017-03-22 00:00:00

abstract：:Background: Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations of leisure-time PA and psychological distress with dementia-related mortality, and whether the ass...

journal_title：Frontiers in aging neuroscience

authors： Zotcheva E,Selbæk G,Bjertness E,Ernstsen L,Strand BH

更新日期：2018-05-25 00:00:00

abstract：Background:Age-related cognitive decline begins in middle age and persists with age. Leukocyte telomere length (LTL) decreases with age and is enhanced by inflammation and oxidative stress. However, whether shorter LTL correlates with cognitive decline remains controversial. Aims:We aimed to investigate the relationsh...

journal_title：Frontiers in aging neuroscience

authors： Linghui D,Shi Q,Chi C,Xiaolei L,Lixing Z,Zhiliang Z,Birong D

更新日期：2020-10-30 00:00:00

abstract：:Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and terminal stages of dementia with Lewy bodies (DLB) in order to gain un...

journal_title：Frontiers in aging neuroscience

authors： Garcia-Esparcia P,Diaz-Lucena D,Ainciburu M,Torrejón-Escribano B,Carmona M,Llorens F,Ferrer I

更新日期：2018-04-26 00:00:00

abstract：:Regular physical activity is considered one of the most important factors for lifestyle, for maintaining good health in older ages and increasing life expectancy. Dance is considered an activity that involves coordinating movements with music, as well as brain activation because it is constantly necessary to learn and...

journal_title：Frontiers in aging neuroscience

authors： Douka S,Zilidou VI,Lilou O,Manou V

更新日期：2019-04-05 00:00:00

abstract：:Exercise may be the most commonly offered yet least consistently followed therapeutic advice for people with Parkinson's disease (PD). Epidemiological studies of prospectively followed cohorts have shown a lower risk for later developing PD in healthy people who report moderate to high levels of physical activity, and...

journal_title：Frontiers in aging neuroscience

authors： Crotty GF,Schwarzschild MA

更新日期：2020-06-19 00:00:00

abstract：:Rational: Alzheimer's disease (AD) is a neurodegenerative pathology characterized by the presence of neuritic plaques and neurofibrillary tangles. Aluminum has been reported to play an important role in the etiology and pathogenesis of this disease. Hence, the present study aimed to evaluate the neuroprotective role o...

journal_title：Frontiers in aging neuroscience

authors： Singh NA,Bhardwaj V,Ravi C,Ramesh N,Mandal AKA,Khan ZA

更新日期：2018-08-13 00:00:00

abstract：:Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished h...

journal_title：Frontiers in aging neuroscience

authors： Hood S,Amir S

更新日期：2017-05-30 00:00:00

abstract：:Abnormal cerebral blood flow (CBF) and resting-state functional connectivity (rs-FC) are sensitive biomarkers of disease progression and prognosis. This study investigated neural underpinnings of motor and cognitive recovery by longitudinally studying the changes of CBF and FC in pontine infarction (PI). Twenty patien...

journal_title：Frontiers in aging neuroscience

authors： Wei Y,Wu L,Wang Y,Liu J,Miao P,Wang K,Wang C,Cheng J

更新日期：2020-11-19 00:00:00

abstract：:There is a need for rapid and reliable Internet-based screening tools for cognitive assessment in middle-aged and older adults. We report the psychometric properties of an on-line tool designed to screen for cognitive deficits that require further investigation. The tool is composed of measures of memory and executive...

journal_title：Frontiers in aging neuroscience

authors： Troyer AK,Rowe G,Murphy KJ,Levine B,Leach L,Hasher L

更新日期：2014-12-10 00:00:00

abstract：:To expose cortical involvement in age-related changes in motor performance, we compared steadiness (force fluctuations) and fatigability of submaximal isometric contractions with the ankle dorsiflexor muscles in older and young adults and with varying levels of cognitive demand imposed. Sixteen young (20.4 ± 2.1 year:...

journal_title：Frontiers in aging neuroscience

authors： Vanden Noven ML,Pereira HM,Yoon T,Stevens AA,Nielson KA,Hunter SK

更新日期：2014-05-22 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder associated with the progressive dysfunction of cognitive ability. Previous research has indicated that the default mode network (DMN) is closely related to cognition and is impaired in Alzheimer's disease. Because recent studies have shown that different frequen...

journal_title：Frontiers in aging neuroscience

authors： Li Y,Yao H,Lin P,Zheng L,Li C,Zhou B,Wang P,Zhang Z,Wang L,An N,Wang J,Zhang X

更新日期：2017-08-03 00:00:00

abstract：:Disruptions in metal ion homeostasis have been described in association with amyotrophic lateral sclerosis (ALS) for a number of years but the precise mechanism of involvement is poorly understood. Metal ions are especially important to familial ALS cases caused by mutations in the metalloenzyme copper-zinc superoxide...

journal_title：Frontiers in aging neuroscience

authors： Bourassa MW,Brown HH,Borchelt DR,Vogt S,Miller LM

更新日期：2014-06-16 00:00:00

abstract：Objective:This study was aimed to explore the effects of dietary nutrients on cognitive function among the middle-aged and elderly populations. Methods:A prospective cohort study of 1,385 middle-aged and elderly people was conducted from January 2014 to December 2017. Dietary nutrients were assessed according to the f...

journal_title：Frontiers in aging neuroscience

authors： Tao L,Liu K,Chen S,Yu H,An Y,Wang Y,Zhang X,Wang Y,Qin Z,Xiao R

更新日期：2019-08-29 00:00:00

abstract：:Studies of the neural mechanisms of navigation and context discrimination have generated a powerful heuristic for understanding how neural codes, circuits, and computations contribute to accurate behavior as animals traverse and learn about spatially extended environments. It is assumed that memories are updated as a ...

journal_title：Frontiers in aging neuroscience

authors： Penner MR,Mizumori SJ

更新日期：2012-08-08 00:00:00