Electrophysiological Advances on Multiple Object Processing in Aging.

abstract：:Disrupted metal homeostasis is a consistent feature of neurodegenerative disease in humans and is recapitulated in mouse models of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and neuronal ceriod lipofuscinosis. While the definitive pathogenesis of neurodegenerative disease in humans r...

journal_title：Frontiers in aging neuroscience

authors： Dang TN,Lim NK,Grubman A,Li QX,Volitakis I,White AR,Crouch PJ

更新日期：2014-02-11 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a multisystemic neurodegenerative disorder. Given that peripheral blood mononuclear cells (PBMCs) serve as a "window to the central nervous system" we aimed to answer whether endoplasmic reticulum (ER) stress in ALS-PBMCs is related to disease aggressiveness. We studied ER stress...

journal_title：Frontiers in aging neuroscience

authors： Prell T,Stubendorff B,Le TT,Gaur N,Tadić V,Rödiger A,Witte OW,Grosskreutz J

更新日期：2019-01-25 00:00:00

abstract：:Verbal fluency is the ability to produce a satisfying sequence of spoken words during a given time interval. The core of verbal fluency lies in the capacity to manage the executive aspects of language. The standard scores of the semantic verbal fluency test are broadly used in the neuropsychological assessment of the ...

journal_title：Frontiers in aging neuroscience

authors： Bertola L,Mota NB,Copelli M,Rivero T,Diniz BS,Romano-Silva MA,Ribeiro S,Malloy-Diniz LF

更新日期：2014-07-29 00:00:00

abstract：:Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic neurons, and the presence of intracellular insoluble proteinaceous inclusions, known as Lewy Bodies. Although PD etiopathogenesis remains elusive, the leading h...

journal_title：Frontiers in aging neuroscience

authors： Branco DM,Arduino DM,Esteves AR,Silva DF,Cardoso SM,Oliveira CR

更新日期：2010-05-21 00:00:00

abstract：:Rational: Alzheimer's disease (AD) is a neurodegenerative pathology characterized by the presence of neuritic plaques and neurofibrillary tangles. Aluminum has been reported to play an important role in the etiology and pathogenesis of this disease. Hence, the present study aimed to evaluate the neuroprotective role o...

journal_title：Frontiers in aging neuroscience

authors： Singh NA,Bhardwaj V,Ravi C,Ramesh N,Mandal AKA,Khan ZA

更新日期：2018-08-13 00:00:00

abstract：OBJECTIVE:Temporo-parietal cortex thinning is associated to mild cognitive impairment (MCI) due to Alzheimer disease (AD). The increase of EEG upper/low alpha power ratio has been associated with AD-converter MCI subjects. We investigated the association of alpha3/alpha2 ratio with patterns of cortical thickness in MCI...

journal_title：Frontiers in aging neuroscience

authors： Moretti DV,Paternicò D,Binetti G,Zanetti O,Frisoni GB

更新日期：2013-10-25 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic nigrostriatal neurons, with reductions in the function and amount of dopaminergic synapses. Therefore, synapse loss and membrane-related pathology provide relevant targets for interventions in PD. We previously showed the benefic...

journal_title：Frontiers in aging neuroscience

authors： Perez-Pardo P,de Jong EM,Broersen LM,van Wijk N,Attali A,Garssen J,Kraneveld AD

更新日期：2017-03-20 00:00:00

abstract：:Alzheimer's disease (AD) still remains an enigma for researchers and clinicians. The onset of AD is insidious, gradually progressive and multifactorial. The recent accumulated scientific evidences suggests that the pathological changes resemble the autoimmune-driven self-sustaining inflammatory process as a result of ...

journal_title：Frontiers in aging neuroscience

authors： Talwar P,Kushwaha S,Gupta R,Agarwal R

更新日期：2019-10-23 00:00:00

abstract：:Inflammation is a major component of neurodegenerative diseases. Microglia are the innate immune cells in the central nervous system (CNS). In the healthy brain, microglia contribute to tissue homeostasis and regulation of synaptic plasticity. Under disease conditions, they play a key role in the development and maint...

journal_title：Frontiers in aging neuroscience

authors： Obst J,Simon E,Mancuso R,Gomez-Nicola D

更新日期：2017-06-23 00:00:00

abstract：:Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished h...

journal_title：Frontiers in aging neuroscience

authors： Hood S,Amir S

更新日期：2017-05-30 00:00:00

abstract：:An inverse association may exist between cancers and neurodegenerative diseases, although convenient biomarkers for verifying this inverse association are lacking. Plasma neurofilament light chain (NfL) is a novel biomarker for neurodegenerative diseases, such as Alzheimer's disease (AD), but it has not been measured ...

journal_title：Frontiers in aging neuroscience

authors： Liu S,Huang Z,Zhang L,Pan J,Lei Q,Meng Y,Li Z

更新日期：2020-01-29 00:00:00

abstract：:Abnormalities and impairments in axonal transport are suggested to strongly contribute to the pathological alterations underlying AD. The exact mechanisms leading to axonopathy are currently unclear, but it was recently suggested that APP expression itself triggers axonal degeneration. We used APP transgenic mice and ...

journal_title：Frontiers in aging neuroscience

authors： Christensen DZ,Huettenrauch M,Mitkovski M,Pradier L,Wirths O

更新日期：2014-06-27 00:00:00

abstract：:Background: The early progression continuum of Alzheimer's disease (AD) has been considered to advance through subjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI). Altered functional connectivity (FC) in the default mode network (DMN) is reg...

journal_title：Frontiers in aging neuroscience

authors： Xue C,Yuan B,Yue Y,Xu J,Wang S,Wu M,Ji N,Zhou X,Zhao Y,Rao J,Yang W,Xiao C,Chen J

更新日期：2019-11-13 00:00:00

abstract：:The FOXO family of transcription factors is central to the regulation of organismal longevity and cellular survival. Several studies have indicated that FOXO factors lie at the center of a complex network of upstream pathways, cofactors and downstream targets (FOXO-interaction networks), which may have developmental a...

journal_title：Frontiers in aging neuroscience

authors： Parmentier F,Lejeune FX,Neri C

更新日期：2013-06-13 00:00:00

abstract：:The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer's disease (AD). The heavy public burden of AD, along with the urgent to prevent and treat the disease before the irreversible damage to the brain, calls for a sensitive and speci...

journal_title：Frontiers in aging neuroscience

authors： Liao H,Zhu Z,Peng Y

更新日期：2018-06-22 00:00:00

abstract：INTRODUCTION:Walking in the home and community often involves performance of complex walking tasks. Understanding the control of such tasks is crucial to preserving independence and quality of life in older adults. However, very little research has been conducted in this area. Here, we assess the extent to which two me...

journal_title：Frontiers in aging neuroscience

authors： Clark DJ,Rose DK,Ring SA,Porges EC

更新日期：2014-08-25 00:00:00

abstract：:Background: Mild cognitive impairment (MCI) is the early phase of Alzheimer's disease (AD). The aim of early intervention for MCI is to decrease the rate of conversion from MCI to AD. However, the efficacy of multiple interventions in MCI, and the optimal methods of delivery, remain controversial. We aimed to compare ...

journal_title：Frontiers in aging neuroscience

authors： Lai X,Wen H,Li Y,Lu L,Tang C

更新日期：2020-06-05 00:00:00

abstract：:Parkinson's disease (PD) is characterized by non-motor symptoms as well as motor deficits. The non-motor symptoms rarely appear individually and occur simultaneously with motor deficits or independently. However, a comprehensive research on the non-motor symptoms using an experimental model of PD remains poorly unders...

journal_title：Frontiers in aging neuroscience

authors： Han NR,Kim YK,Ahn S,Hwang TY,Lee H,Park HJ

更新日期：2021-01-13 00:00:00

abstract：:Background: The brain atrophy and lesion index (BALI) has been developed to assess whole-brain structural deficits that are commonly seen on magnetic resonance imaging (MRI) in aging. It is unclear whether such changes can be detected at younger ages and how they might relate to other exposures. Here, we investigate h...

journal_title：Frontiers in aging neuroscience

authors： Gu T,Fu C,Shen Z,Guo H,Zou M,Chen M,Rockwood K,Song X

更新日期：2019-04-24 00:00:00

abstract：:Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransmitter synthesis, myelination of neurons, and mitochondrial function. Redox cycling between ferrous and ferric iron is utilized in biology for various electron transfer reactions essential t...

journal_title：Frontiers in aging neuroscience

authors： Hare D,Ayton S,Bush A,Lei P

更新日期：2013-07-18 00:00:00

abstract：:Age-related hearing deficits are a leading cause of disability among the aged. While some forms of hearing deficits are peripheral in origin, others are centrally mediated. One such deficit is the ability to localize sounds, a critical component for segregating different acoustic objects and events, which is dependent...

journal_title：Frontiers in aging neuroscience

authors： Engle JR,Recanzone GH

更新日期：2013-01-04 00:00:00

abstract：:Aberrations in brain microcirculation and the associated increase in blood-brain-barrier (BBB) permeability in addition to neuroinflammation and Aβ deposition observed in Alzheimer's disease (AD) and ischemia have gained considerable attention recently. However, the role of microvascular homeostasis as a pathogenic su...

journal_title：Frontiers in aging neuroscience

authors： Amtul Z,Yang J,Lee TY,Cechetto DF

更新日期：2019-03-27 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) includes a spectrum of disorders characterized by changes of personality and social behavior and, often, a gradual and progressive language dysfunction. In the last years, several efforts have been fulfilled in identifying both genetic mutations and pathological proteins associ...

journal_title：Frontiers in aging neuroscience

authors： Piscopo P,Albani D,Castellano AE,Forloni G,Confaloni A

更新日期：2016-02-09 00:00:00

abstract：:Objective: To study the dynamics of clustering semantic fluency responses and switching between clusters. Methods: We conducted a cross-sectional study of participants (N = 60) in a study of patient reported outcomes who were given the Saint Louis University Mental Status test. Sixty-second animal naming tests were sc...

journal_title：Frontiers in aging neuroscience

authors： Lenio S,Lissemore FM,Sajatovic M,Smyth KA,Tatsuoka C,Woyczynski WA,Lerner AJ

更新日期：2016-10-25 00:00:00

abstract：:Recent work suggests that the brain can be conceptualized as a network comprised of groups of sub-networks or modules. The extent of segregation between modules can be quantified with a modularity metric, where networks with high modularity have dense connections within modules and sparser connections between modules....

journal_title：Frontiers in aging neuroscience

authors： Baniqued PL,Gallen CL,Voss MW,Burzynska AZ,Wong CN,Cooke GE,Duffy K,Fanning J,Ehlers DK,Salerno EA,Aguiñaga S,McAuley E,Kramer AF,D'Esposito M

更新日期：2018-01-04 00:00:00

abstract：:Individuals with Parkinson's disease (PD) mainly suffer from motor impairments which increase the risk of falls and lead to a decline of quality of life. Several studies investigated the long-term effect of dance for people with PD. The aims of the present study were to investigate (i) the short-term effects of dance ...

journal_title：Frontiers in aging neuroscience

authors： Heiberger L,Maurer C,Amtage F,Mendez-Balbuena I,Schulte-Mönting J,Hepp-Reymond MC,Kristeva R

更新日期：2011-10-10 00:00:00

abstract：:The functional neuroanatomy of finger movements has been characterized with neuroimaging in young adults. However, less is known about the aging motor system. Several studies have contrasted movement-related activity in older versus young adults, but there is inconsistency among their findings. To address this, we con...

journal_title：Frontiers in aging neuroscience

authors： Turesky TK,Turkeltaub PE,Eden GF

更新日期：2016-10-17 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1 or Steinert's disease) and type 2 (DM2) are multisystem disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the most prominent neuromuscular features of these diseases, while other clinical manifestations such as cardiomyopathy, insulin resistance and cat...

journal_title：Frontiers in aging neuroscience

authors： Mateos-Aierdi AJ,Goicoechea M,Aiastui A,Fernández-Torrón R,Garcia-Puga M,Matheu A,López de Munain A

更新日期：2015-07-09 00:00:00

abstract：:Disruptions in metal ion homeostasis have been described in association with amyotrophic lateral sclerosis (ALS) for a number of years but the precise mechanism of involvement is poorly understood. Metal ions are especially important to familial ALS cases caused by mutations in the metalloenzyme copper-zinc superoxide...

journal_title：Frontiers in aging neuroscience

authors： Bourassa MW,Brown HH,Borchelt DR,Vogt S,Miller LM

更新日期：2014-06-16 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) is a severe neurodegenerative disorder that is diagnosed with increasing frequency in clinical setting. Currently, no therapy is available and in addition the molecular basis of the disease are far from being elucidated. Consequently, it is of pivotal importance to develop reli...

journal_title：Frontiers in aging neuroscience

authors： Tunesi M,Fusco F,Fiordaliso F,Corbelli A,Biella G,Raimondi MT

更新日期：2016-06-22 00:00:00