Abstract:
:Objective: To assess the age-related morphometric changes of subcortical structures in healthy people. Materials and Methods: Ultra-high field 7 tesla magnetic resonance (MR) imaging in humans was used to visualize the subcortical structures of healthy young, middle-aged and elderly participants. Using the magnetization-prepared two rapid acquisition gradient echo (MP2RAGE) sequence, we assessed the visibility of the margins of the thalamus and white matter in the thalamus, as well as the anterior commissure (AC) and posterior commissure (PC) length, the maximal height of the thalamus, the half width of the third ventricle and the distance between the AC and the center of the mammillothalamic tract (MTT) at the level of the AC-PC plane. All quantitative data were statistically evaluated. Results: The AC-PC length did not differ significantly among the three groups. The maximal height of the thalamus decreased with age (rs(53) = -0.719, p < 0.001). The half width of the third ventricle (rs(53) = 0.705, p < 0.001) and the distance between the AC and the center of the MTT (rs(53) = 0.485, p < 0.001) increased with age. The distance between the AC and the center of the MTT of the young and the elderly participants differed significantly (p = 0.007). Conclusion: The AC-PC length is not a good candidate for proportional correction during atlas-to-patient registration. The maximal height of the thalamus and the half width of the third ventricle correlated strongly with age, and the MTT position in relation to the AC shifted posteriorly as age increased. These age-related morphometric changes of subcortical structures should be considered in targeting for functional neurosurgery.
journal_name
Front Aging Neuroscijournal_title
Frontiers in aging neuroscienceauthors
Wang XY,Zhao L,Yu T,Qiao L,Ni DY,Zhang GJ,Li YJdoi
10.3389/fnagi.2016.00224subject
Has Abstractpub_date
2016-09-26 00:00:00pages
224issn
1663-4365journal_volume
8pub_type
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pub_type: 已发布勘误
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journal_title:Frontiers in aging neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnagi.2014.00323
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doi:10.3389/fnagi.2017.00125
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doi:10.3389/fnagi.2015.00178
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