Abstract:
:Background: Decreased bone mineral density (BMD) was associated with poorer cognitive function and increased risk of Alzheimer's disease (AD). However, objective evidence for the relationship between osteoporosis and AD in humans has not been extensively described. Objectives: We aimed to evaluate the relationships between BMD and the cortical volumes of brain regions vulnerable to AD; hippocampus, parahippocampal gyrus, precuneus, posterior cingulate, and angular gyrus, using voxel-based morphometry (VBM), to investigate the association between bone loss and AD. Methods: A cohort of 149 consecutive elderly participants who complained of memory disturbance underwent high-resolution structural brain magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA). We used SPM12 software to conduct a voxel-based multiple regression analysis to examine the association between femoral neck BMD values and regional gray matter volume (rGMV) on structural T1-weighted MRI. Results: After adjusting for subject age, gender, total brain volume (TBV), and mini-mental state examination (MMSE) scores, the multiple regression analysis showed significant correlations between BMD loss and rGMV decline in the left precuneus, which is an important neural network hub vulnerable to AD. Conclusion: These data suggest that the bone and brain communicate with each other, as in "bone-brain crosstalk," and that control of BMD factors could contribute to cognitive function and help prevent AD.
journal_name
Front Aging Neuroscijournal_title
Frontiers in aging neuroscienceauthors
Takano Y,Tatewaki Y,Mutoh T,Morota N,Matsudaira I,Thyreau B,Nagasaka T,Odagiri H,Yamamoto S,Arai H,Taki Ydoi
10.3389/fnagi.2020.00178subject
Has Abstractpub_date
2020-06-17 00:00:00pages
178issn
1663-4365journal_volume
12pub_type
杂志文章abstract::It is well known that Alzheimer's disease (AD) is one of the most common progressive neurodegenerative diseases; it begins gradually, and therefore no effective medicine is administered in the beginning. Thus, early diagnosis and prevention of AD are crucial. The present study focused on comparing the plasma protein c...
journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
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doi:10.3389/fnagi.2012.00017
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
pub_type: 杂志文章
doi:10.3389/fnagi.2019.00028
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journal_title:Frontiers in aging neuroscience
pub_type: 杂志文章
doi:10.3389/fnagi.2018.00052
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
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journal_title:Frontiers in aging neuroscience
pub_type: 杂志文章,评审
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