The emerging role of nutrition in Parkinson's disease.

abstract：:Aggregated tau is a hallmark neuropathological feature in numerous neurodegenerative disorders. Previous studies aiming to validate aggregated tau pathology as a pathogenic driver of neurodegeneration in correlation to characteristic behavioral phenotypes have had shortcomings. Although studies on soluble tau patholog...

journal_title：Frontiers in aging neuroscience

authors： Mahendran TS,Suresh SN,Garimella L,Manjithaya R

更新日期：2020-11-05 00:00:00

abstract：:Alzheimer disease (AD) has an insidious onset and heterogeneous clinical symptoms. The well-accepted biomarkers for clinical diagnosis of AD include β-amyloid (Aβ) deposition and pathologic tau level within cerebral spinal fluid (CSF) and imaging AD pathology such as positive emission tomography (PET) imaging of the a...

journal_title：Frontiers in aging neuroscience

authors： Jiao F,Yi F,Wang Y,Zhang S,Guo Y,Du W,Gao Y,Ren J,Zhang H,Liu L,Song H,Wang L

更新日期：2020-07-21 00:00:00

abstract：:Previous studies have shown that pupillary response, a physiological measure of cognitive workload, reflects cognitive demand in healthy younger and older adults. However, the relationship between cognitive workload and cognitive demand in Parkinson's disease (PD) remains unclear. The aim of this pilot study was to ex...

journal_title：Frontiers in aging neuroscience

authors： Kahya M,Moon S,Lyons KE,Pahwa R,Akinwuntan AE,Devos H

更新日期：2018-04-10 00:00:00

abstract：:Background: Juvenile amyotrophic lateral sclerosis (jALS) is a rare form of ALS with an onset age of less than 25 years and is frequently thought to be genetic in origin. DDHD1 gene mutations have been reported to be associated with the SPG28 subtype of autosomal recessive HSP but have never been reported in jALS pati...

journal_title：Frontiers in aging neuroscience

authors： Wu C,Fan D

更新日期：2016-12-06 00:00:00

abstract：:Centronuclear myopathies (CNMs) are a genetically heterogeneous group of inherited neuromuscular disorders characterized by clinical features of a congenital myopathy and abundant central nuclei as the most prominent histopathological feature. The most common forms of congenital myopathies with central nuclei have bee...

journal_title：Frontiers in aging neuroscience

authors： Jungbluth H,Gautel M

更新日期：2014-12-19 00:00:00

abstract：:Over the last few decades, considerable evidence shows that greater levels of aerobic exercise and cardiovascular fitness benefit cognitive performance. However, the degree to which free-living activity in community settings is related to cognitive performance remains unclear, particularly in older adults vulnerable t...

journal_title：Frontiers in aging neuroscience

authors： Wanigatunga AA,Manini TM,Cook DR,Katula J,Fielding RA,Kramer AF,Verghese J,Rapp SR,Sink KM,King AC,Buford TW,Anton S,Nadkarni N,Jennings JM,Reid K,Espeland MA,Gill TM,Pahor M,Nocera JR

更新日期：2018-11-15 00:00:00

abstract：Objective:To investigate dysregulated molecules in preoperative cerebrospinal fluid (CSF) of elderly hip fracture patients with postoperative delirium (POD), in order to identify potential pathological mechanisms and biomarkers for pre-stage POD. Materials and Methods:This nested case control study used untargeted met...

journal_title：Frontiers in aging neuroscience

authors： Han Y,Zhang W,Liu J,Song Y,Liu T,Li Z,Wang X,Yang N,Li Y,Han D,Mi X,Zhou Y,Li M,Guo X,Zhong L,Wang G,Yuan Y

更新日期：2020-10-22 00:00:00

abstract：BACKGROUND:A physically active lifestyle has the potential to prevent cognitive decline and dementia, yet the optimal type of physical activity/exercise remains unclear. Dance is of special interest as it complex sensorimotor rhythmic activity with additional cognitive, social, and affective dimensions. OBJECTIVES:To ...

journal_title：Frontiers in aging neuroscience

authors： Merom D,Grunseit A,Eramudugolla R,Jefferis B,Mcneill J,Anstey KJ

更新日期：2016-02-22 00:00:00

abstract：:Disruptions in metal ion homeostasis have been described in association with amyotrophic lateral sclerosis (ALS) for a number of years but the precise mechanism of involvement is poorly understood. Metal ions are especially important to familial ALS cases caused by mutations in the metalloenzyme copper-zinc superoxide...

journal_title：Frontiers in aging neuroscience

authors： Bourassa MW,Brown HH,Borchelt DR,Vogt S,Miller LM

更新日期：2014-06-16 00:00:00

abstract：:The global incidence of Alzheimer's disease (AD) is on the rise with the increase in obesity and metabolic disease epidemic. Obesity is co-morbid with the increase in mass of adipose tissue, which secretes numerous molecules that are biologically important. Obesity and its associated conditions are perhaps involved in...

journal_title：Frontiers in aging neuroscience

authors： Pichiah PBT,Sankarganesh D,Arunachalam S,Achiraman S

更新日期：2020-02-13 00:00:00

abstract：:Neuroimaging studies of cognitive and brain aging often yield massive datasets that create many analytic and statistical challenges. In this paper, we discuss and address several limitations in the existing work. (1) Linear models are often used to model the age effects on neuroimaging markers, which may be inadequate...

journal_title：Frontiers in aging neuroscience

authors： Chen H,Zhao B,Cao G,Proges EC,O'Shea A,Woods AJ,Cohen RA

更新日期：2016-07-19 00:00:00

abstract：:Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified...

journal_title：Frontiers in aging neuroscience

authors： Cui L,Hou NN,Wu HM,Zuo X,Lian YZ,Zhang CN,Wang ZF,Zhang X,Zhu JH

更新日期：2020-12-21 00:00:00

abstract：:There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinical trials for HD are limited by a lack of knowledge of the natural hi...

journal_title：Frontiers in aging neuroscience

authors： Paulsen JS,Long JD,Johnson HJ,Aylward EH,Ross CA,Williams JK,Nance MA,Erwin CJ,Westervelt HJ,Harrington DL,Bockholt HJ,Zhang Y,McCusker EA,Chiu EM,Panegyres PK,PREDICT-HD Investigators and Coordinators of the Huntington Stu

更新日期：2014-04-22 00:00:00

abstract：:Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic neurons, and the presence of intracellular insoluble proteinaceous inclusions, known as Lewy Bodies. Although PD etiopathogenesis remains elusive, the leading h...

journal_title：Frontiers in aging neuroscience

authors： Branco DM,Arduino DM,Esteves AR,Silva DF,Cardoso SM,Oliveira CR

更新日期：2010-05-21 00:00:00

abstract：:Aerobic physical exercise (APE) leads to improved brain functions. To better understand the beneficial effect of APE on the aging brain, a morphometric study was carried out of changes in hippocampal synapses of old (>27 months) Balb/c mice undergoing treadmill training (OTT) for 4 weeks in comparison with old sedenta...

journal_title：Frontiers in aging neuroscience

authors： Fattoretti P,Malatesta M,Cisterna B,Milanese C,Zancanaro C

更新日期：2018-05-16 00:00:00

abstract：:Regular physical activity is considered one of the most important factors for lifestyle, for maintaining good health in older ages and increasing life expectancy. Dance is considered an activity that involves coordinating movements with music, as well as brain activation because it is constantly necessary to learn and...

journal_title：Frontiers in aging neuroscience

authors： Douka S,Zilidou VI,Lilou O,Manou V

更新日期：2019-04-05 00:00:00

abstract：:The decline of cognitive skills throughout healthy or pathological aging can be slowed down by experiences which foster cognitive reserve (CR). Recently, some studies on Alzheimer's disease have suggested that CR may be enhanced by life-long bilingualism. However, the evidence is inconsistent and largely based on retr...

journal_title：Frontiers in aging neuroscience

authors： Calvo N,García AM,Manoiloff L,Ibáñez A

更新日期：2016-01-12 00:00:00

abstract：:Background: Little is known about the underlying mechanisms of the similarities in the core features of postoperative delirium (POD) and α-synuclein (α-syn)-related cognitive disorders. We herein investigated associations between fluctuated levels of exosomal α-syn in the plasma and POD presentation in geriatric hip f...

journal_title：Frontiers in aging neuroscience

authors： Yuan Y,Li Z,Yang N,Han Y,Ji X,Han D,Wang X,Li Y,Liu T,Yuan F,He J,Liu Y,Ni C,Zou P,Wang G,Guo X,Zhou Y

更新日期：2020-03-13 00:00:00

abstract：:Associative processes, such as the encoding of associations between words in a list, can enhance episodic memory performance and are thought to deteriorate with age. Here, we examine the nature of age-related deficits in the encoding of associations, by using a free recall paradigm with visual arrays of objects. Fifty...

journal_title：Frontiers in aging neuroscience

authors： Suzin G,Ravona-Springer R,Ash EL,Davelaar EJ,Usher M

更新日期：2019-11-12 00:00:00

abstract：:Recent studies have shown that Liuwei Dihuang pills (LWPs) can positively affect learning, memory and neurogenesis. However, the underlying molecular mechanisms are not understood. In the present study, we developed ALWPs, a mixture of Antler and LWPs, and investigated whether ALWPs can affect neuroinflammatory respon...

journal_title：Frontiers in aging neuroscience

authors： Lee JY,Joo B,Nam JH,Nam HY,Lee W,Nam Y,Seo Y,Kang HJ,Cho HJ,Jang YP,Kim J,We YM,Koo JW,Hoe HS

更新日期：2018-09-26 00:00:00

abstract：:Background: Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Variants in the LRRK2 gene have been shown to be associated with PD. However, the clinical characteristics of LRRK2-related PD are heterogeneous. In our study, we performed a comprehensive pooled analysis of the association betw...

journal_title：Frontiers in aging neuroscience

authors： Shu L,Zhang Y,Pan H,Xu Q,Guo J,Tang B,Sun Q

更新日期：2018-09-19 00:00:00

abstract：:Background: Cognitive frailty (CF) is defined as the simultaneous presence of physical frailty and cognitive impairment among older adults without dementia. Previous studies have revealed that neuropathological changes may contribute to the degeneration of subcortical nuclei in the process of cognitive impairment. How...

journal_title：Frontiers in aging neuroscience

authors： Wan M,Xia R,Lin H,Qiu P,He J,Ye Y,Tao J,Chen L,Zheng G

更新日期：2020-07-28 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a multisystemic neurodegenerative disorder. Given that peripheral blood mononuclear cells (PBMCs) serve as a "window to the central nervous system" we aimed to answer whether endoplasmic reticulum (ER) stress in ALS-PBMCs is related to disease aggressiveness. We studied ER stress...

journal_title：Frontiers in aging neuroscience

authors： Prell T,Stubendorff B,Le TT,Gaur N,Tadić V,Rödiger A,Witte OW,Grosskreutz J

更新日期：2019-01-25 00:00:00

abstract：:Deep learning, a state-of-the-art machine learning approach, has shown outstanding performance over traditional machine learning in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated classific...

journal_title：Frontiers in aging neuroscience

authors： Jo T,Nho K,Saykin AJ

更新日期：2019-08-20 00:00:00

abstract：:The obesity epidemic had spawned considerable interest in understanding peoples' responses to palatable food cues that are plentiful in obesogenic environments. In this paper we examine how trait mindfulness of older, obese adults may moderate brain networks that arise from exposure to such cues. Nineteen older, obese...

journal_title：Frontiers in aging neuroscience

authors： Paolini B,Burdette JH,Laurienti PJ,Morgan AR,Williamson DA,Rejeski WJ

更新日期：2012-06-06 00:00:00

abstract：:This study investigated age-related changes in the neural bases of sequential strategy interference. Sequential strategy interference refers to decreased strategy interference (i.e., poorer performance when the cued strategy is not the best) after executing a poorer strategy relative to after a better strategy. Young ...

journal_title：Frontiers in aging neuroscience

authors： Roquet A,Hinault T,Badier JM,Lemaire P

更新日期：2018-08-08 00:00:00

abstract：:This paper seeks to present a new perspective on the aging brain. Here, we make connections between two key phenomena of brain aging: (1) increased neural noise or random background activity; and (2) slowing of brain activity. Our perspective proposes the possibility that the slowing of neural processing due to decrea...

journal_title：Frontiers in aging neuroscience

authors： Hong SL,Rebec GV

更新日期：2012-09-25 00:00:00

abstract：:Cardiorespiratory fitness has been shown to protect and enhance cognitive and brain functions, but little is known about the cortical mechanisms that underlie these changes in older adults. In this study, functional near infrared spectroscopy (fNIRS) was used to investigate variations in oxyhemoglobin [HbO2] and in de...

journal_title：Frontiers in aging neuroscience

authors： Albinet CT,Mandrick K,Bernard PL,Perrey S,Blain H

更新日期：2014-10-08 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease, for which aging remains the major risk factor. Aging is under a consistent pressure of increasing brain entropy (BEN) due to the progressive brain deteriorations. Noticeably, the brain constantly consumes a large amount of energy to maintain its func...

journal_title：Frontiers in aging neuroscience

authors： Wang Z,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-11-10 00:00:00

abstract：:Oxidative stress (OS), caused by the imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging, neurodegenerative diseases, and other related adverse conditions, such as ischemia. While ROS/RNS serve as signaling molecules at physiolog...

journal_title：Frontiers in aging neuroscience

authors： Wang X,Michaelis EK

更新日期：2010-03-30 00:00:00