Abstract：
:Amyotrophic lateral sclerosis (ALS) is a multisystemic neurodegenerative disorder. Given that peripheral blood mononuclear cells (PBMCs) serve as a "window to the central nervous system" we aimed to answer whether endoplasmic reticulum (ER) stress in ALS-PBMCs is related to disease aggressiveness. We studied ER stress in the PBMCs of 49 patients with ALS and 31 age- and sex-matched healthy controls. The expression of a main ER stress marker, activating transcription factor 6 (ATF6), was significantly higher in ALS compared to controls, but did not correlate with age, disease severity, disease duration and disease progression rate. When ATF6 expression levels were plotted against relative D50 (rD50)-derived disease phases derived from the D50 ALS model, two distinct clusters of patients were observed: cluster 1, with progressively increasing ATF6 expression levels and cluster 2, which demonstrated stable ATF6 expression over the disease course. Individuals in the two clusters did not significantly differ in terms of ALS Functional Rating Scale-Revised (ALSFRS-R), disease aggressiveness, disease duration and subtype. However, patients with the increasing ATF6 level were significantly younger, indicating that aging processes might be related to ER stress in ALS. Our data suggest that the reaction to ER stress during disease course may be compromised in older patients with ALS.
journal_name
Front Aging Neuroscijournal_title
Frontiers in aging neuroscienceauthors
Prell T,Stubendorff B,Le TT,Gaur N,Tadić V,Rödiger A,Witte OW,Grosskreutz Jdoi
10.3389/fnagi.2019.00005subject
Has Abstractpub_date
2019-01-25 00:00:00pages
5issn
1663-4365journal_volume
11pub_type
杂志文章abstract：:Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic nigrostriatal neurons, with reductions in the function and amount of dopaminergic synapses. Therefore, synapse loss and membrane-related pathology provide relevant targets for interventions in PD. We previously showed the benefic...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2017.00057
更新日期：2017-03-20 00:00:00
abstract：:[This corrects the article on p. 7 in vol. 7, PMID: 25762930.]. ...
journal_title：Frontiers in aging neuroscience
pub_type： 已发布勘误
doi：10.3389/fnagi.2015.00079
更新日期：2015-05-12 00:00:00
abstract：:DNA methylation is an essential epigenetic mechanism involving in gene transcription modulation. An age-related increase in promoter methylation has been observed for neuronal activity and memory genes, and participates in neurological disorders. However, the position and precise mechanism of DNA methylation for memor...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2020.00211
更新日期：2020-08-18 00:00:00
abstract：:While aging can lead to significant declines in perceptual and cognitive function, the effects of age on multisensory integration, the process in which the brain combines information across the senses, are less clear. Recent reports suggest that older adults are susceptible to the sound-induced flash illusion (Shams e...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2014.00250
更新日期：2014-09-24 00:00:00
abstract：:The acquisition and retention of motor skills is necessary for everyday functioning in the elderly and may be critical in the context of motor rehabilitation. Recent studies indicate that motor training closely followed by sleep may result in better engagement of procedural ("how to") memory consolidation processes in...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2019.00321
更新日期：2019-11-22 00:00:00
abstract：OBJECTIVE:Early-onset Alzheimer's disease (EAD) shows distinct features from late-onset Alzheimer's disease (LAD). To explore the characteristics of EAD, clinical, neuropsychological, and functional imaging studies have been conducted. However, differences between EAD and LAD are not clear, especially in terms of brain...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2016.00159
更新日期：2016-06-30 00:00:00
abstract：:Deep learning, a state-of-the-art machine learning approach, has shown outstanding performance over traditional machine learning in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated classific...
journal_title：Frontiers in aging neuroscience
pub_type：
doi：10.3389/fnagi.2019.00220
更新日期：2019-08-20 00:00:00
abstract：:Objective: To study the dynamics of clustering semantic fluency responses and switching between clusters. Methods: We conducted a cross-sectional study of participants (N = 60) in a study of patient reported outcomes who were given the Saint Louis University Mental Status test. Sixty-second animal naming tests were sc...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2016.00252
更新日期：2016-10-25 00:00:00
abstract：:Abnormalities and impairments in axonal transport are suggested to strongly contribute to the pathological alterations underlying AD. The exact mechanisms leading to axonopathy are currently unclear, but it was recently suggested that APP expression itself triggers axonal degeneration. We used APP transgenic mice and ...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2014.00139
更新日期：2014-06-27 00:00:00
abstract：:Invertebrate models have advantages for understanding the basis of behavioral aging due to their simple nervous systems and short lifespans. The potential usefulness of Aplysia californica in aging research is apparent from its long history of neurobiological research, but it has been underexploited in this model use....
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2014.00084
更新日期：2014-05-09 00:00:00
abstract：:The aim of this study was to develop a fast method for estimating whether a brain volume loss is within the normal range for the respective age of the patient. A readout-segmented diffusion-weighted echo-planar imaging sequence was performed as part of the routine examination at a 3-T scanner. Data without (b0-image) ...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2013.00078
更新日期：2013-11-19 00:00:00
abstract：:The aggregation of α-synuclein (α-syn) is considered the key pathogenic event in many neurological disorders such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, giving rise to a whole category of neurodegenerative diseases known as synucleinopathies. Although the molecular basis of...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2014.00197
更新日期：2014-08-05 00:00:00
abstract：:A defining pathophysiological hallmark of Alzheimer's disease (AD) is the amyloid plaque; an extracellular deposit of aggregated fibrillar Aβ1-42 peptides. Amyloid plaques are hard, brittle structures scattered throughout the hippocampus and cerebral cortex and are thought to cause hyperphosphorylation of tau, neurofi...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2018.00332
更新日期：2018-10-22 00:00:00
abstract：:Associative processes, such as the encoding of associations between words in a list, can enhance episodic memory performance and are thought to deteriorate with age. Here, we examine the nature of age-related deficits in the encoding of associations, by using a free recall paradigm with visual arrays of objects. Fifty...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2019.00306
更新日期：2019-11-12 00:00:00
abstract：:Alzheimer's disease (AD) is characterized by a progressive cognitive decline and believed to be driven by the self-aggregation of amyloid-β (Aβ) peptide into oligomers and fibrils that accumulate as senile plaques. It is widely accepted that microglia-mediated inflammation is a significant contributor to disease patho...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2017.00277
更新日期：2017-08-31 00:00:00
abstract：:Pilot studies using technology-aided programs to promote verbal reminiscence and mild physical activity (i.e., positive forms of engagement) in persons with moderate or severe Alzheimer's disease have provided promising results (Lancioni et al., 2015a,b). The present two studies were aimed at upgrading and/or extendin...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2016.00087
更新日期：2016-04-21 00:00:00
abstract：:Background: Hypersensitivity to general anesthetics may predict poor postoperative outcomes, especially among the older subjects. Therefore, it is essential to elucidate the mechanism underlying hypersensitivity to volatile anesthetics in the aging population. Given the fact that isoflurane sensitivity increases with ...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2020.583542
更新日期：2020-12-03 00:00:00
abstract：:Aging is associated with cognitive decline and alterations in early perceptual processes. Studies in the auditory and visual sensory modalities have shown that the mismatch negativity [or the mismatch response (MMR)], an event-related potential (ERP) elicited by a deviant stimulus in a background of homogenous events,...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2014.00293
更新日期：2014-10-27 00:00:00
abstract：:Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, ...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章,评审
doi：10.3389/fnagi.2014.00230
更新日期：2014-08-29 00:00:00
abstract：:The emotions evoked by music can enhance recognition of excerpts. It has been suggested that memory is better for high than for low arousing music (Eschrich et al., 2005; Samson et al., 2009), but it remains unclear whether positively (Eschrich et al., 2008) or negatively valenced music (Aubé et al., 2013; Vieillard a...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2015.00023
更新日期：2015-03-12 00:00:00
abstract：:[This corrects the article DOI: 10.3389/fnagi.2019.00343.]. ...
journal_title：Frontiers in aging neuroscience
pub_type： 已发布勘误
doi：10.3389/fnagi.2020.00030
更新日期：2020-02-18 00:00:00
abstract：:Cognitive Reserve is the capital of knowledge and experiences that an individual acquires over their life-span. Cognitive Reserve is strictly related to Brain Reserve, which is the ability of the brain to cope with damage. These two concepts could explain many phenomena such as the modality of onset in dementia or the...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2017.00429
更新日期：2017-12-22 00:00:00
abstract：:Age-related cognitive decline has been linked to a diverse set of neurobiological mechanisms, including bidirectional changes in proteins critical for neuron function. Importantly, these alterations are not uniform across the brain. For example, the hippocampus (HPC) and prefrontal cortex (PFC) show distinct patterns ...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2018.00391
更新日期：2018-12-03 00:00:00
abstract：:Delirium is a common and morbid condition in elderly hospitalized patients. Its pathophysiology is poorly understood but inflammation has been implicated based on a clinical association with systemic infection and surgery and preclinical data showing that systemic inflammation adversely affects hippocampus-dependent m...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2014.00107
更新日期：2014-06-10 00:00:00
abstract：:Previous studies have shown that pupillary response, a physiological measure of cognitive workload, reflects cognitive demand in healthy younger and older adults. However, the relationship between cognitive workload and cognitive demand in Parkinson's disease (PD) remains unclear. The aim of this pilot study was to ex...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2018.00090
更新日期：2018-04-10 00:00:00
abstract：:The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer's disease (AD), little is known about the initial molecular disturbances that accompany the AD development at olfactory level. We have interrogated the time-depend...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2019.00141
更新日期：2019-06-11 00:00:00
abstract：:Current society has to deal with major challenges related to our constantly increasing population of older adults. Since, motor performance generally deteriorates at older age, research investigating the effects of different types of training on motor improvement is particularly important. Here, we tested the effects ...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2015.00157
更新日期：2015-08-11 00:00:00
abstract：:Background: Facial emotion recognition (FER) is impaired in individuals with frontotemporal dementia (FTD) and Alzheimer's disease (AD) when compared to healthy older adults. Since deficits in emotion recognition are closely related to caregiver burden or social interactions, researchers have fundamental interest in F...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2017.00389
更新日期：2017-11-30 00:00:00
abstract：:Background: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer'sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important risk factor for AD. H...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2020.00183
更新日期：2020-06-30 00:00:00
abstract：:Individuals with Parkinson's disease (PD) mainly suffer from motor impairments which increase the risk of falls and lead to a decline of quality of life. Several studies investigated the long-term effect of dance for people with PD. The aims of the present study were to investigate (i) the short-term effects of dance ...
journal_title：Frontiers in aging neuroscience
pub_type： 杂志文章
doi：10.3389/fnagi.2011.00014
更新日期：2011-10-10 00:00:00
