Frontotemporal Lobar Degeneration and MicroRNAs.

abstract：:In the face of limited resources and an aging population with increasingly care needs, healthcare systems must identify community-dwelling older adults with mental health problems at higher risk of adverse outcomes such as institutionalization, hospitalization and death, in order to deliver timely and efficient care. ...

journal_title：Frontiers in aging neuroscience

authors： Paúl C,Teixeira L,Azevedo MJ,Alves S,Duarte M,O'Caoimh R,Molloy W

更新日期：2015-11-17 00:00:00

abstract：:Background and Purpose: Previous studies found inconsistent results regarding the relationship between Alzheimer's disease (AD) and catecholamines, such as dopamine (DA), norepinephrine (NE), and epinephrine (EPI). Therefore, the purpose of this study was to perform a systematic review and meta-analysis to evaluate th...

journal_title：Frontiers in aging neuroscience

authors： Pan X,Kaminga AC,Jia P,Wen SW,Acheampong K,Liu A

更新日期：2020-09-11 00:00:00

abstract：:Microglial cells become dystrophic with aging; this phenotypic alteration contributes to basal central nervous system (CNS) neuroinflammation being a risk factor for age related neurodegenerative diseases. In previous studies we have observed that insulin like growth factor 1 (IGF1) gene therapy is a feasible approach...

journal_title：Frontiers in aging neuroscience

authors： Falomir-Lockhart E,Dolcetti FJC,García-Segura LM,Hereñú CB,Bellini MJ

更新日期：2019-03-05 00:00:00

abstract：:Parkinson's disease (PD) is the second most prevalent neurodegenerative disease in ageing individuals. It is now clear that genetic susceptibility and environmental factors play a role in disease etiology and progression. Because environmental factors are involved with the majority of the cases of PD, it is important ...

journal_title：Frontiers in aging neuroscience

authors： Seidl SE,Santiago JA,Bilyk H,Potashkin JA

更新日期：2014-03-07 00:00:00

abstract：:Background: The early progression continuum of Alzheimer's disease (AD) has been considered to advance through subjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI). Altered functional connectivity (FC) in the default mode network (DMN) is reg...

journal_title：Frontiers in aging neuroscience

authors： Xue C,Yuan B,Yue Y,Xu J,Wang S,Wu M,Ji N,Zhou X,Zhao Y,Rao J,Yang W,Xiao C,Chen J

更新日期：2019-11-13 00:00:00

abstract：:The alteration of the functional topological organization in subcortical ischemic vascular cognitive impairment with no dementia (SIVCIND) patients has been illuminated by previous neuroimaging studies. However, in regard to the changes in the structural connectivity of brain networks, little has been reported. In thi...

journal_title：Frontiers in aging neuroscience

authors： Sang L,Liu C,Wang L,Zhang J,Zhang Y,Li P,Qiao L,Li C,Qiu M

更新日期：2020-01-29 00:00:00

abstract：:Latin-American people with dementia will increase to an astounding 368% in 2050, higher than USA and Europe. In addition, to sporadic dementia type like Alzheimer, and vascular dementia (VaD) progression after Cerebrovascular disease is also found. These incidences are increased in Colombia by specific populations aff...

journal_title：Frontiers in aging neuroscience

authors： Cardona-Gómez GP,Lopera F

更新日期：2016-12-20 00:00:00

abstract：INTRODUCTION:Cross-sectional studies have identified long chain omega-3 polyunsaturated fatty acids (eicosapentaenoic acid 20:5n-3 and docosahexaenoic acid 22:6n-3 (O3PUFA) in association with fewer white matter lesions and better executive function in older adults. We hypothesized that O3PUFA are associated with less ...

journal_title：Frontiers in aging neuroscience

authors： Bowman GL,Dodge HH,Mattek N,Barbey AK,Silbert LC,Shinto L,Howieson DB,Kaye JA,Quinn JF

更新日期：2013-12-16 00:00:00

abstract：:The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer's disease (AD). The heavy public burden of AD, along with the urgent to prevent and treat the disease before the irreversible damage to the brain, calls for a sensitive and speci...

journal_title：Frontiers in aging neuroscience

authors： Liao H,Zhu Z,Peng Y

更新日期：2018-06-22 00:00:00

abstract：:Herpes simplex virus type 1 (HSV1), when present in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE), has been implicated as a major factor in Alzheimer's disease (AD). It is proposed that virus is normally latent in many elderly brains but reactivates periodically (as in the peripheral nervo...

journal_title：Frontiers in aging neuroscience

authors： Itzhaki RF

更新日期：2014-08-11 00:00:00

abstract：:The McGill-R-Thy1-APP transgenic rat is an animal model of the familial form of Alzheimer's disease (AD). This model mirrors several neuropathological hallmarks of the disease, including the accumulation of beta-amyloid and the formation of amyloid plaques (in homozygous animals only), neuroinflammation and the gradua...

journal_title：Frontiers in aging neuroscience

authors： Petrasek T,Vojtechova I,Lobellova V,Popelikova A,Janikova M,Brozka H,Houdek P,Sladek M,Sumova A,Kristofikova Z,Vales K,Stuchlík A

更新日期：2018-08-28 00:00:00

abstract：:Oxidative stress (OS), caused by the imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging, neurodegenerative diseases, and other related adverse conditions, such as ischemia. While ROS/RNS serve as signaling molecules at physiolog...

journal_title：Frontiers in aging neuroscience

authors： Wang X,Michaelis EK

更新日期：2010-03-30 00:00:00

abstract：BACKGROUND:Platelet Rich Plasma (PRP) has shown positive and long-lasting effects in patients with tendinopathies. However, information about age-related differences in the clinical outcome is limited. Aim of this retrospective study was to compare the efficacy of PRP therapy in young and elderly subjects suffering for...

journal_title：Frontiers in aging neuroscience

authors： Salini V,Vanni D,Pantalone A,Abate M

更新日期：2015-12-10 00:00:00

abstract：:Background: Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations of leisure-time PA and psychological distress with dementia-related mortality, and whether the ass...

journal_title：Frontiers in aging neuroscience

authors： Zotcheva E,Selbæk G,Bjertness E,Ernstsen L,Strand BH

更新日期：2018-05-25 00:00:00

abstract：:The decline of cognitive skills throughout healthy or pathological aging can be slowed down by experiences which foster cognitive reserve (CR). Recently, some studies on Alzheimer's disease have suggested that CR may be enhanced by life-long bilingualism. However, the evidence is inconsistent and largely based on retr...

journal_title：Frontiers in aging neuroscience

authors： Calvo N,García AM,Manoiloff L,Ibáñez A

更新日期：2016-01-12 00:00:00

abstract：:The globus pallidus occupies a critical position in the indirect pathway of the basal ganglia motor control system. Hyperpolarization-activated cyclic-nucleotide gated (HCN) channels play an important role in the modulation of neuronal excitability. In vivo extracellular single unit recording, behavioral test and immu...

journal_title：Frontiers in aging neuroscience

authors： Hao XM,Xu R,Chen AQ,Sun FJ,Wang Y,Liu HX,Chen H,Xue Y,Chen L

更新日期：2019-07-25 00:00:00

abstract：:Age related hearing loss (presbycusis) is one of the most common sensory deficits in the aging population. The main subjective ailment in the elderly is the deterioration of speech understanding, especially in a noisy environment, which cannot solely be explained by increased hearing thresholds. The examination method...

journal_title：Frontiers in aging neuroscience

authors： Profant O,Jilek M,Bures Z,Vencovsky V,Kucharova D,Svobodova V,Korynta J,Syka J

更新日期：2019-02-26 00:00:00

abstract：:A common problem in the older population is the risk of falling and related injury, immobility, and reduced survival. Age-related neuronal changes, e.g., decline in gray-and white-matter, affect neuronal, cognitive, and motor functioning. The improvement of these factors might decrease fall events in elderly. Studies ...

journal_title：Frontiers in aging neuroscience

authors： Schättin A,de Bruin ED

更新日期：2016-11-29 00:00:00

abstract：:Background: Smart Aging is a Serious games (SGs) platform in a 3D virtual environment in which users perform a set of screening tests that address various cognitive skills. The tests are structured as 5 tasks of activities of daily life in a familiar environment. The main goal of the present study is to compare a cogn...

journal_title：Frontiers in aging neuroscience

authors： Bottiroli S,Tassorelli C,Lamonica M,Zucchella C,Cavallini E,Bernini S,Sinforiani E,Pazzi S,Cristiani P,Vecchi T,Tost D,Sandrini G

更新日期：2017-11-21 00:00:00

abstract：:Cognitive demands for postural control increase with aging and cognitive-motor interference (CMI) exists for a number of walking situations, especially with visuo-spatial cognitive tasks. Such interference also influences spatial learning abilities among older adults; however, this is rarely considered in research on ...

journal_title：Frontiers in aging neuroscience

authors： Agathos CP,Ramanoël S,Bécu M,Bernardin D,Habas C,Arleo A

更新日期：2020-11-12 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia diagnosed amongst the elderly. Mild cognitive impairment (MCI) is a condition often indicative of the earliest symptomatology of AD with 10%-15% of MCI patients reportedly progressing to a diagnosis of AD. Individuals with a history of vascular risk factors ...

journal_title：Frontiers in aging neuroscience

authors： Hess NC,Smart NA

更新日期：2017-03-03 00:00:00

abstract：:Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified...

journal_title：Frontiers in aging neuroscience

authors： Cui L,Hou NN,Wu HM,Zuo X,Lian YZ,Zhang CN,Wang ZF,Zhang X,Zhu JH

更新日期：2020-12-21 00:00:00

abstract：:EEG research conducted in the past 5 years on multiple object processing has begun to define how the aging brain tracks the numerosity of the objects presented in the visual field for different goals. We review the recent EEG findings in healthy older individuals (age range: 65-75 years approximately) on perceptual, a...

journal_title：Frontiers in aging neuroscience

authors： Mazza V,Brignani D

更新日期：2016-03-02 00:00:00

abstract：:Cognitive Reserve is the capital of knowledge and experiences that an individual acquires over their life-span. Cognitive Reserve is strictly related to Brain Reserve, which is the ability of the brain to cope with damage. These two concepts could explain many phenomena such as the modality of onset in dementia or the...

journal_title：Frontiers in aging neuroscience

authors： Arcara G,Mondini S,Bisso A,Palmer K,Meneghello F,Semenza C

更新日期：2017-12-22 00:00:00

abstract：:Associative processes, such as the encoding of associations between words in a list, can enhance episodic memory performance and are thought to deteriorate with age. Here, we examine the nature of age-related deficits in the encoding of associations, by using a free recall paradigm with visual arrays of objects. Fifty...

journal_title：Frontiers in aging neuroscience

authors： Suzin G,Ravona-Springer R,Ash EL,Davelaar EJ,Usher M

更新日期：2019-11-12 00:00:00

abstract：:Background: Facial emotion recognition (FER) is impaired in individuals with frontotemporal dementia (FTD) and Alzheimer's disease (AD) when compared to healthy older adults. Since deficits in emotion recognition are closely related to caregiver burden or social interactions, researchers have fundamental interest in F...

journal_title：Frontiers in aging neuroscience

authors： Park S,Kim T,Shin SA,Kim YK,Sohn BK,Park HJ,Youn JH,Lee JY

更新日期：2017-11-30 00:00:00

abstract：:Deep learning, a state-of-the-art machine learning approach, has shown outstanding performance over traditional machine learning in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated classific...

journal_title：Frontiers in aging neuroscience

authors： Jo T,Nho K,Saykin AJ

更新日期：2019-08-20 00:00:00

abstract：:This paper seeks to present a new perspective on the aging brain. Here, we make connections between two key phenomena of brain aging: (1) increased neural noise or random background activity; and (2) slowing of brain activity. Our perspective proposes the possibility that the slowing of neural processing due to decrea...

journal_title：Frontiers in aging neuroscience

authors： Hong SL,Rebec GV

更新日期：2012-09-25 00:00:00

abstract：:Alzheimer's disease (AD) and treatment of the brain in aging require the development of new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large molecule therapeutics that do not cross the blood-brain barrier (BBB). BBB drug delivery is the limiting factor in the future development of ne...

journal_title：Frontiers in aging neuroscience

authors： Pardridge WM

更新日期：2020-01-10 00:00:00

abstract：:Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and ...

journal_title：Frontiers in aging neuroscience

authors： Cloyd RA,Koren SA,Abisambra JF

更新日期：2018-12-13 00:00:00