IGF1 Gene Therapy Modifies Microglia in the Striatum of Senile Rats.

abstract：:Neuroinflammation and autophagy dysfunction are closely related to the development of neurodegeneration such as Parkinson's disease (PD). However, the role of autophagy in microglia polarization and neuroinflammation is poorly understood. TNF-α, which is highly toxic to dopaminergic neurons, is implicated as a major m...

journal_title：Frontiers in aging neuroscience

authors： Jin MM,Wang F,Qi D,Liu WW,Gu C,Mao CJ,Yang YP,Zhao Z,Hu LF,Liu CF

更新日期：2018-11-20 00:00:00

abstract：:Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after 2-months, corroborates the epidemiological association previously described between vitamin deficiency and this sensory impairment. However, this strain is prone to early hearing loss, and hence we decided to analyze whether the effects ex...

journal_title：Frontiers in aging neuroscience

authors： Martínez-Vega R,Murillo-Cuesta S,Partearroyo T,Varela-Moreiras G,Varela-Nieto I,Pajares MA

更新日期：2016-08-31 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease, for which aging remains the major risk factor. Aging is under a consistent pressure of increasing brain entropy (BEN) due to the progressive brain deteriorations. Noticeably, the brain constantly consumes a large amount of energy to maintain its func...

journal_title：Frontiers in aging neuroscience

authors： Wang Z,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-11-10 00:00:00

abstract：:Age-related hearing deficits are a leading cause of disability among the aged. While some forms of hearing deficits are peripheral in origin, others are centrally mediated. One such deficit is the ability to localize sounds, a critical component for segregating different acoustic objects and events, which is dependent...

journal_title：Frontiers in aging neuroscience

authors： Engle JR,Recanzone GH

更新日期：2013-01-04 00:00:00

abstract：:Previous studies have showed that spatial memory declines with age but have not clarified the relevance of different landmark cues for specifying heading directions among different age groups. This study examined differences between younger, middle-aged and older adults in route learning and memory tasks after they na...

journal_title：Frontiers in aging neuroscience

authors： Zhong JY,Moffat SD

更新日期：2016-05-27 00:00:00

abstract：:It is common wisdom that practice makes perfect; but why do some adults learn better than others? Here, we investigate individuals' cognitive and social profiles to test which variables account for variability in learning ability across the lifespan. In particular, we focused on visual learning using tasks that test t...

journal_title：Frontiers in aging neuroscience

authors： Christian J,Goldstone A,Kuai SG,Chin W,Abrams D,Kourtzi Z

更新日期：2015-06-10 00:00:00

abstract：:Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients aged 65 years and older. There are currently no proven neurorestorative treatments for chronic stroke. To address the complex problem of restoring function in ischemic brain tissue, stem...

journal_title：Frontiers in aging neuroscience

authors： He JQ,Sussman ES,Steinberg GK

更新日期：2020-12-14 00:00:00

abstract：:Tinnitus, the phantom perception of sound without a corresponding external sound, is a frequent disorder which causes significant morbidity. So far there is no treatment available that reliably reduces the tinnitus perception. The research is hampered by the large heterogeneity of tinnitus and the fact that the tinnit...

journal_title：Frontiers in aging neuroscience

authors： Schlee W,Pryss RC,Probst T,Schobel J,Bachmeier A,Reichert M,Langguth B

更新日期：2016-12-15 00:00:00

abstract：:Aging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer's disease. However, due to mixed findings, it is unclear if changes in resting-state networ...

journal_title：Frontiers in aging neuroscience

authors： Hausman HK,O'Shea A,Kraft JN,Boutzoukas EM,Evangelista ND,Van Etten EJ,Bharadwaj PK,Smith SG,Porges E,Hishaw GA,Wu S,DeKosky S,Alexander GE,Marsiske M,Cohen R,Woods AJ

更新日期：2020-06-12 00:00:00

abstract：:Background and Purpose: Subarachnoid hemorrhage (SAH) has long been classified into two main forms, aneurysmal SAH (aSAH) and non-aneurysmal SAH (naSAH), but the related risk factors for aSAH and naSAH are heterogeneous. Our objective was to determine the risk factors for SAH of known or unknown origin with respect to...

journal_title：Frontiers in aging neuroscience

authors： Wang MD,Fu QH,Song MJ,Ma WB,Zhang JH,Wang ZX

更新日期：2021-01-11 00:00:00

abstract：:Objectives: Postural control in elderly people is impaired by degradations of sensory, motor, and higher-level adaptive mechanisms. Here, we characterize the effects of a progressive balance training program on these postural control impairments using a brain network model based on system identification techniques. Me...

journal_title：Frontiers in aging neuroscience

authors： Wiesmeier IK,Dalin D,Wehrle A,Granacher U,Muehlbauer T,Dietterle J,Weiller C,Gollhofer A,Maurer C

更新日期：2017-08-11 00:00:00

abstract：:The dorsal raphe nucleus (DRN) has been repeatedly implicated as having a significant relationship with depression, along with its serotoninergic innervation. However, functional connectivity of the DRN in depression is not well understood. The current study aimed to isolate functional connectivity of the DRN distinct...

journal_title：Frontiers in aging neuroscience

authors： Ikuta T,Matsuo K,Harada K,Nakashima M,Hobara T,Higuchi N,Higuchi F,Otsuki K,Shibata T,Watanuki T,Matsubara T,Yamagata H,Watanabe Y

更新日期：2017-08-02 00:00:00

abstract：:Inter-temporal choice depends on multiple, interacting systems, some of which may be compromised with age. Some of these systems may be responsible for ongoing trial-by-trial choice strategies. Some may represent the consequences of action. Some may be necessary for the coupling between anticipated consequences and st...

journal_title：Frontiers in aging neuroscience

authors： Breton YA,Seeland KD,Redish AD

更新日期：2015-03-27 00:00:00

abstract：:Exercise may be the most commonly offered yet least consistently followed therapeutic advice for people with Parkinson's disease (PD). Epidemiological studies of prospectively followed cohorts have shown a lower risk for later developing PD in healthy people who report moderate to high levels of physical activity, and...

journal_title：Frontiers in aging neuroscience

authors： Crotty GF,Schwarzschild MA

更新日期：2020-06-19 00:00:00

abstract：:The hippocampus is generally reported as one of the regions most impacted by Alzheimer's disease (AD) and is closely associated with memory function and orientation. Undirected functional connectivity (FC) alterations occur in patients with mild cognitive impairment (MCI) and AD, and these alterations have been the su...

journal_title：Frontiers in aging neuroscience

authors： Xue J,Guo H,Gao Y,Wang X,Cui H,Chen Z,Wang B,Xiang J

更新日期：2019-12-03 00:00:00

abstract：:The recent advent of tau-specific positron emission tomography (PET) has enabled in vivo assessment of tau pathology in Alzheimer's disease (AD). However, because PET scanners have limited spatial resolution, the measured signals of small brain structures or atrophied areas are underestimated by partial volume effects...

journal_title：Frontiers in aging neuroscience

authors： Shigemoto Y,Sone D,Imabayashi E,Maikusa N,Okamura N,Furumoto S,Kudo Y,Ogawa M,Takano H,Yokoi Y,Sakata M,Tsukamoto T,Kato K,Sato N,Matsuda H

更新日期：2018-07-18 00:00:00

abstract：:Neuroimaging-based age prediction using machine learning is proposed as a biomarker of brain aging, relating to cognitive performance, health outcomes and progression of neurodegenerative disease. However, even leading age-prediction algorithms contain measurement error, motivating efforts to improve experimental pipe...

journal_title：Frontiers in aging neuroscience

authors： Lancaster J,Lorenz R,Leech R,Cole JH

更新日期：2018-02-12 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1 or Steinert's disease) and type 2 (DM2) are multisystem disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the most prominent neuromuscular features of these diseases, while other clinical manifestations such as cardiomyopathy, insulin resistance and cat...

journal_title：Frontiers in aging neuroscience

authors： Mateos-Aierdi AJ,Goicoechea M,Aiastui A,Fernández-Torrón R,Garcia-Puga M,Matheu A,López de Munain A

更新日期：2015-07-09 00:00:00

abstract：:Background: The brain atrophy and lesion index (BALI) has been developed to assess whole-brain structural deficits that are commonly seen on magnetic resonance imaging (MRI) in aging. It is unclear whether such changes can be detected at younger ages and how they might relate to other exposures. Here, we investigate h...

journal_title：Frontiers in aging neuroscience

authors： Gu T,Fu C,Shen Z,Guo H,Zou M,Chen M,Rockwood K,Song X

更新日期：2019-04-24 00:00:00

abstract：:Mitochondrial dysfunction is a common and prominent feature of prion diseases and other neurodegenerative disorders. Mitochondria are dynamic organelles that constantly fuse with one another and subsequently break apart. Defective or superfluous mitochondria are usually eliminated by a form of autophagy, referred to a...

journal_title：Frontiers in aging neuroscience

authors： Zhu T,Chen JL,Wang Q,Shao W,Qi B

更新日期：2018-11-05 00:00:00

abstract：:Verbal fluency is the ability to produce a satisfying sequence of spoken words during a given time interval. The core of verbal fluency lies in the capacity to manage the executive aspects of language. The standard scores of the semantic verbal fluency test are broadly used in the neuropsychological assessment of the ...

journal_title：Frontiers in aging neuroscience

authors： Bertola L,Mota NB,Copelli M,Rivero T,Diniz BS,Romano-Silva MA,Ribeiro S,Malloy-Diniz LF

更新日期：2014-07-29 00:00:00

abstract：:Background: The early progression continuum of Alzheimer's disease (AD) has been considered to advance through subjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI). Altered functional connectivity (FC) in the default mode network (DMN) is reg...

journal_title：Frontiers in aging neuroscience

authors： Xue C,Yuan B,Yue Y,Xu J,Wang S,Wu M,Ji N,Zhou X,Zhao Y,Rao J,Yang W,Xiao C,Chen J

更新日期：2019-11-13 00:00:00

abstract：:Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and terminal stages of dementia with Lewy bodies (DLB) in order to gain un...

journal_title：Frontiers in aging neuroscience

authors： Garcia-Esparcia P,Diaz-Lucena D,Ainciburu M,Torrejón-Escribano B,Carmona M,Llorens F,Ferrer I

更新日期：2018-04-26 00:00:00

abstract：:Symptoms in late-onset neuromuscular disorders initiate only from midlife onward and progress with age. These disorders are primarily determined by identified hereditable mutations, but their late-onset symptom manifestation is not fully understood. Here, we review recent research developments on the late-onset autoso...

journal_title：Frontiers in aging neuroscience

authors： Raz Y,Raz V

更新日期：2014-11-10 00:00:00

abstract：:Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished h...

journal_title：Frontiers in aging neuroscience

authors： Hood S,Amir S

更新日期：2017-05-30 00:00:00

abstract：:To expose cortical involvement in age-related changes in motor performance, we compared steadiness (force fluctuations) and fatigability of submaximal isometric contractions with the ankle dorsiflexor muscles in older and young adults and with varying levels of cognitive demand imposed. Sixteen young (20.4 ± 2.1 year:...

journal_title：Frontiers in aging neuroscience

authors： Vanden Noven ML,Pereira HM,Yoon T,Stevens AA,Nielson KA,Hunter SK

更新日期：2014-05-22 00:00:00

abstract：:Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, ...

journal_title：Frontiers in aging neuroscience

authors： Sakuma K,Aoi W,Yamaguchi A

更新日期：2014-08-29 00:00:00

abstract：:An inverse association may exist between cancers and neurodegenerative diseases, although convenient biomarkers for verifying this inverse association are lacking. Plasma neurofilament light chain (NfL) is a novel biomarker for neurodegenerative diseases, such as Alzheimer's disease (AD), but it has not been measured ...

journal_title：Frontiers in aging neuroscience

authors： Liu S,Huang Z,Zhang L,Pan J,Lei Q,Meng Y,Li Z

更新日期：2020-01-29 00:00:00

abstract：:Oxidative stress (OS) contributes to Alzheimer's disease (AD) pathology. OS can be a result of increased reactive oxygen/nitrogen species, reduced antioxidants, oxidatively damaged molecules, and/or a combination of these factors. Scientific literature is scarce for the markers of OS-specific for detecting AD at an ea...

journal_title：Frontiers in aging neuroscience

authors： Arslan J,Jamshed H,Qureshi H

更新日期：2020-07-27 00:00:00

abstract：:Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with in...

journal_title：Frontiers in aging neuroscience

authors： Toricelli M,Evangelista SR,Oliveira LR,Viel TA,Buck HS

更新日期：2019-07-12 00:00:00