Potential Utility of Retinal Imaging for Alzheimer's Disease: A Review.

abstract：:miR-146a is a microRNA (miRNA) involved in neuroinflammation and aging; alterations in its expression were described in Alzheimer's disease (AD). However, most of the studies conducted so far on this miRNA included a limited number of participants and produced contradictory results. We compared miR-146a levels in plas...

journal_title：Frontiers in aging neuroscience

authors： Maffioletti E,Milanesi E,Ansari A,Zanetti O,Galluzzi S,Geroldi C,Gennarelli M,Bocchio-Chiavetto L

更新日期：2020-01-17 00:00:00

abstract：:Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and terminal stages of dementia with Lewy bodies (DLB) in order to gain un...

journal_title：Frontiers in aging neuroscience

authors： Garcia-Esparcia P,Diaz-Lucena D,Ainciburu M,Torrejón-Escribano B,Carmona M,Llorens F,Ferrer I

更新日期：2018-04-26 00:00:00

abstract：:While aging can lead to significant declines in perceptual and cognitive function, the effects of age on multisensory integration, the process in which the brain combines information across the senses, are less clear. Recent reports suggest that older adults are susceptible to the sound-induced flash illusion (Shams e...

journal_title：Frontiers in aging neuroscience

authors： McGovern DP,Roudaia E,Stapleton J,McGinnity TM,Newell FN

更新日期：2014-09-24 00:00:00

abstract：:Deep learning, a state-of-the-art machine learning approach, has shown outstanding performance over traditional machine learning in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated classific...

journal_title：Frontiers in aging neuroscience

authors： Jo T,Nho K,Saykin AJ

更新日期：2019-08-20 00:00:00

abstract：:Previous research suggests specific deficits in face perception and memory in older adults, which could reflect a dedifferentiation in the context of a general broadening of cognitive architecture with advanced age. Such dedifferentiation could manifest in a less specialized face processing system. A promising tool to...

journal_title：Frontiers in aging neuroscience

authors： Komes J,Schweinberger SR,Wiese H

更新日期：2014-04-04 00:00:00

abstract：:Predicting future brain topography can give insight into neural correlates of aging and neurodegeneration. Due to variability in the aging process, it has been challenging to precisely estimate brain topographical change according to aging. Here, we predict age-related brain metabolic change by generating future brain...

journal_title：Frontiers in aging neuroscience

authors： Choi H,Kang H,Lee DS,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2018-07-12 00:00:00

abstract：:Recent studies have shown that Liuwei Dihuang pills (LWPs) can positively affect learning, memory and neurogenesis. However, the underlying molecular mechanisms are not understood. In the present study, we developed ALWPs, a mixture of Antler and LWPs, and investigated whether ALWPs can affect neuroinflammatory respon...

journal_title：Frontiers in aging neuroscience

authors： Lee JY,Joo B,Nam JH,Nam HY,Lee W,Nam Y,Seo Y,Kang HJ,Cho HJ,Jang YP,Kim J,We YM,Koo JW,Hoe HS

更新日期：2018-09-26 00:00:00

abstract：:Previous studies investigating working memory performance in patients with mild cognitive impairment (MCI) have mainly focused on the neural mechanisms of alterations in activation. To date, very few studies have investigated background network alterations in the working memory state. Therefore, the present study inve...

journal_title：Frontiers in aging neuroscience

authors： Wang P,Li R,Liu B,Wang C,Huang Z,Dai R,Song B,Yuan X,Yu J,Li J

更新日期：2019-06-28 00:00:00

abstract：:Alzheimer's disease (AD) and treatment of the brain in aging require the development of new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large molecule therapeutics that do not cross the blood-brain barrier (BBB). BBB drug delivery is the limiting factor in the future development of ne...

journal_title：Frontiers in aging neuroscience

authors： Pardridge WM

更新日期：2020-01-10 00:00:00

abstract：:The use of progressive resistance training (PRT) to improve gait and balance in people with Parkinson's disease (PD) is an emerging area of interest. However, the main effects of PRT on lower limb functions such as gait, balance, and leg strength in people with PD remain unclear. Therefore, the aim of the meta-analysi...

journal_title：Frontiers in aging neuroscience

authors： Tillman A,Muthalib M,Hendy AM,Johnson LG,Rantalainen T,Kidgell DJ,Enticott PG,Teo WP

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scenario of selected, spo...

journal_title：Frontiers in aging neuroscience

authors： de Pedro-Cuesta J,Martínez-Martín P,Rábano A,Ruiz-Tovar M,Alcalde-Cabero E,Calero M

更新日期：2016-06-13 00:00:00

abstract：OBJECTIVE:Early-onset Alzheimer's disease (EAD) shows distinct features from late-onset Alzheimer's disease (LAD). To explore the characteristics of EAD, clinical, neuropsychological, and functional imaging studies have been conducted. However, differences between EAD and LAD are not clear, especially in terms of brain...

journal_title：Frontiers in aging neuroscience

authors： Chung J,Yoo K,Kim E,Na DL,Jeong Y

更新日期：2016-06-30 00:00:00

abstract：:Centronuclear myopathies (CNMs) are a genetically heterogeneous group of inherited neuromuscular disorders characterized by clinical features of a congenital myopathy and abundant central nuclei as the most prominent histopathological feature. The most common forms of congenital myopathies with central nuclei have bee...

journal_title：Frontiers in aging neuroscience

authors： Jungbluth H,Gautel M

更新日期：2014-12-19 00:00:00

abstract：:Neurofilament light (NFL) is a putative biomarker of neurodegeneration. This study evaluates the correlative association of NFL with Alzheimer's disease (AD) indices. Relevant studies were identified after a literature search in electronic databases and study selection was based on pre-determined eligibility criteria....

journal_title：Frontiers in aging neuroscience

authors： Jin M,Cao L,Dai YP

更新日期：2019-09-13 00:00:00

abstract：:Background: There has been much research devoted to examining the short-term effects of different interventions for improving memory functioning of older adults with memory complaints. Nevertheless, very few studies have examined the long-term effects of these interventions. Thus, the present study compared the sustai...

journal_title：Frontiers in aging neuroscience

authors： Chan AS,Cheung WK,Yeung MK,Lee TL

更新日期：2018-08-07 00:00:00

abstract：:Objective: Late-life depression (LLD) is associated with development of different types of dementia. Identification of LLD patients, who will develop cognitive decline, i.e., the early stage of dementia would help to implement interventions earlier. The purpose of this study was to assess whether structural brain magn...

journal_title：Frontiers in aging neuroscience

authors： Lebedeva AK,Westman E,Borza T,Beyer MK,Engedal K,Aarsland D,Selbaek G,Haberg AK

更新日期：2017-02-02 00:00:00

abstract：:Hypertension has a profound influence on the structure and function of blood vessels. Cerebral vessels undergo both structural and functional changes in hypertensive animals. However, dynamic changes of cerebrovasculature and the factors involved in this process are largely unknown. In this study, we explored the dyna...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Mu Z,Lin X,Geng J,Xiao TQ,Zhang Z,Wang Y,Guan Y,Yang GY

更新日期：2017-11-02 00:00:00

abstract：:Aging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer's disease. However, due to mixed findings, it is unclear if changes in resting-state networ...

journal_title：Frontiers in aging neuroscience

authors： Hausman HK,O'Shea A,Kraft JN,Boutzoukas EM,Evangelista ND,Van Etten EJ,Bharadwaj PK,Smith SG,Porges E,Hishaw GA,Wu S,DeKosky S,Alexander GE,Marsiske M,Cohen R,Woods AJ

更新日期：2020-06-12 00:00:00

abstract：:During aging, many experience a decline in cognitive function that includes memory loss. The encoding of long-term memories depends on new protein synthesis, and this is also reduced during aging. Thus, it is possible that changes in the regulation of protein synthesis contribute to the memory impairments observed in ...

journal_title：Frontiers in aging neuroscience

authors： Schimanski LA,Barnes CA

更新日期：2010-08-06 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia diagnosed amongst the elderly. Mild cognitive impairment (MCI) is a condition often indicative of the earliest symptomatology of AD with 10%-15% of MCI patients reportedly progressing to a diagnosis of AD. Individuals with a history of vascular risk factors ...

journal_title：Frontiers in aging neuroscience

authors： Hess NC,Smart NA

更新日期：2017-03-03 00:00:00

abstract：:Aberrations in brain microcirculation and the associated increase in blood-brain-barrier (BBB) permeability in addition to neuroinflammation and Aβ deposition observed in Alzheimer's disease (AD) and ischemia have gained considerable attention recently. However, the role of microvascular homeostasis as a pathogenic su...

journal_title：Frontiers in aging neuroscience

authors： Amtul Z,Yang J,Lee TY,Cechetto DF

更新日期：2019-03-27 00:00:00

abstract：:As the population ages and dementia becomes a growing healthcare concern, it is increasingly important to identify targets for intervention to delay or attenuate cognitive decline. Research has shown that the most successful interventions aim at altering lifestyle factors. Thus, this study examined how involvement in ...

journal_title：Frontiers in aging neuroscience

authors： Seider TR,Fieo RA,O'Shea A,Porges EC,Woods AJ,Cohen RA

更新日期：2016-05-02 00:00:00

abstract：:It is relevant to unravel the factors that may mediate the cognitive decline observed during aging. Previous reports indicate that education has a positive influence on cognitive performance, while age, female gender and, especially, depressed mood were associated with poorer performances across multiple cognitive dim...

journal_title：Frontiers in aging neuroscience

authors： Santos NC,Costa PS,Cunha P,Portugal-Nunes C,Amorim L,Cotter J,Cerqueira JJ,Palha JA,Sousa N

更新日期：2014-02-24 00:00:00

abstract：:Background: The rs405509 polymorphism ofthe apolipoprotein E (APOE) promoter is related to Alzheimer'sdisease (AD). The T/T allele of rs405509 is known to decrease the transcription of the APOE gene and lead to impairments in specific brain structural networks with aging; thus, it is an important risk factor for AD. H...

journal_title：Frontiers in aging neuroscience

authors： Zhang Q,Wu L,Du C,Xu K,Sun J,Zhang J,Li H,Li X

更新日期：2020-06-30 00:00:00

abstract：:This study aimed to explore the effects of open- and closed-skill exercise interventions on the neurocognitive performance of executive functions in the elderly. Sixty-four healthy elderly males were randomly assigned to either a closed-skill (bike riding or brisk walking/jogging, n = 22), open-skill (table tennis, n ...

journal_title：Frontiers in aging neuroscience

authors： Tsai CL,Pan CY,Chen FC,Tseng YT

更新日期：2017-09-12 00:00:00

abstract：:[This corrects the article on p. 7 in vol. 7, PMID: 25762930.]. ...

journal_title：Frontiers in aging neuroscience

authors： Sanz L,Murillo-Cuesta S,Cobo P,Cediel R,Contreras J,Rivera T,Varela-Nieto I,Avendaño C

更新日期：2015-05-12 00:00:00

abstract：:Latin-American people with dementia will increase to an astounding 368% in 2050, higher than USA and Europe. In addition, to sporadic dementia type like Alzheimer, and vascular dementia (VaD) progression after Cerebrovascular disease is also found. These incidences are increased in Colombia by specific populations aff...

journal_title：Frontiers in aging neuroscience

authors： Cardona-Gómez GP,Lopera F

更新日期：2016-12-20 00:00:00

abstract：:Mouse models are key tools for studying cochlear alterations in noise-induced hearing loss (NIHL) and for evaluating new therapies. Stimuli used to induce deafness in mice are usually white and octave band noises that include very low frequencies, considering the large mouse auditory range. We designed different sound...

journal_title：Frontiers in aging neuroscience

authors： Sanz L,Murillo-Cuesta S,Cobo P,Cediel-Algovia R,Contreras J,Rivera T,Varela-Nieto I,Avendaño C

更新日期：2015-02-16 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is a significant complication of surgery, particularly in elderly patients. Emerging researches showed that long non-coding RNA (lncRNA) may play a vital role in the pathogenesis of POCD. Here we aimed to identify potential key lncRNAs involved in the development of POCD. Lnc...

journal_title：Frontiers in aging neuroscience

authors： Li M,Chen C,Zhang W,Gao R,Wang Q,Chen H,Zhang S,Mao X,Leblanc M,Behensky A,Zhang Z,Gan L,Yu H,Zhu T,Liu J

更新日期：2019-07-17 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary tangles. Copper, iron,...

journal_title：Frontiers in aging neuroscience

authors： Wong BX,Hung YH,Bush AI,Duce JA

更新日期：2014-05-15 00:00:00