Abstract:
BACKGROUND:During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scenario of selected, sporadic, protein-associated, i.e., conformational, neurodegenerative disorders (NDDs), and their vascular- and metabolic-associated ailments. METHODS:A rationale is adopted, to incorporate selected clinical data and results from animal-model research, complementing epidemiologic evidences reported in two prior articles. FINDINGS:Theory is formulated assuming an underlying conformational transmission mechanism, mediated either by horizontal transfer of mammalian genes coding for specific aggregation-prone proteins, or by xeno-templating between bacterial and host proteins. We build a few population-based and experimentally-testable hypotheses focusing on: (1) non-disposable surgical instruments for sporadic Creutzfeldt-Jakob disease (sCJD) and other rapid progressive neurodegenerative dementia (sRPNDd), multiple system atrophy (MSA), and motor neuron disease (MND); and (2) specific bacterial infections such as B. pertussis and E. coli for all forms, but particularly for late-life sporadic conformational, NDDs, type 2 diabetes mellitus (T2DM), and atherosclerosis where natural protein fibrils present in such organisms as a result of adaptation to the human host induce prion-like mechanisms. CONCLUSION:Implications for cohort alignment and experimental animal research are discussed and research lines proposed.
journal_name
Front Aging Neuroscijournal_title
Frontiers in aging neuroscienceauthors
de Pedro-Cuesta J,Martínez-Martín P,Rábano A,Ruiz-Tovar M,Alcalde-Cabero E,Calero Mdoi
10.3389/fnagi.2016.00138subject
Has Abstractpub_date
2016-06-13 00:00:00pages
138issn
1663-4365journal_volume
8pub_type
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journal_title:Frontiers in aging neuroscience
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