Involvement of Frontal Functions in Pain Tolerance in Aging: Evidence From Neuropsychological Assessments and Gamma-Band Oscillations.

abstract：:This paper seeks to present a new perspective on the aging brain. Here, we make connections between two key phenomena of brain aging: (1) increased neural noise or random background activity; and (2) slowing of brain activity. Our perspective proposes the possibility that the slowing of neural processing due to decrea...

journal_title：Frontiers in aging neuroscience

authors： Hong SL,Rebec GV

更新日期：2012-09-25 00:00:00

abstract：:It is assumed that DNA sequences are conserved in the diverse cell types present in a multicellular organism like the human being. Thus, in order to compare the sequences in the genome of DNA from different individuals, nucleic acid is commonly isolated from a single tissue. In this regard, blood cells are widely used...

journal_title：Frontiers in aging neuroscience

authors： Avila J,Gómez-Ramos A,Soriano E

更新日期：2014-11-25 00:00:00

abstract：:Background: Two main models have been advanced to explain the asymmetries observed in the representation and processing of emotions. The first model, labeled "the right hemisphere hypothesis," assumes a general dominance of the right hemisphere for all emotions, regardless of affective valence. The second model, named...

journal_title：Frontiers in aging neuroscience

authors： Gainotti G

更新日期：2019-03-19 00:00:00

abstract：:In the face of limited resources and an aging population with increasingly care needs, healthcare systems must identify community-dwelling older adults with mental health problems at higher risk of adverse outcomes such as institutionalization, hospitalization and death, in order to deliver timely and efficient care. ...

journal_title：Frontiers in aging neuroscience

authors： Paúl C,Teixeira L,Azevedo MJ,Alves S,Duarte M,O'Caoimh R,Molloy W

更新日期：2015-11-17 00:00:00

abstract：:Patients with diabetes suffer the higher risk of dementia and the underlying pathological mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we explore whether the cognitive impairment in the diabetic rat is associated with increased blood brain barrier (BBB) permeability and the ch...

journal_title：Frontiers in aging neuroscience

authors： Geng J,Wang L,Zhang L,Qin C,Song Y,Ma Y,Chen Y,Chen S,Wang Y,Zhang Z,Yang GY

更新日期：2018-05-07 00:00:00

abstract：:Over the last few decades, considerable evidence shows that greater levels of aerobic exercise and cardiovascular fitness benefit cognitive performance. However, the degree to which free-living activity in community settings is related to cognitive performance remains unclear, particularly in older adults vulnerable t...

journal_title：Frontiers in aging neuroscience

authors： Wanigatunga AA,Manini TM,Cook DR,Katula J,Fielding RA,Kramer AF,Verghese J,Rapp SR,Sink KM,King AC,Buford TW,Anton S,Nadkarni N,Jennings JM,Reid K,Espeland MA,Gill TM,Pahor M,Nocera JR

更新日期：2018-11-15 00:00:00

abstract：:Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows...

journal_title：Frontiers in aging neuroscience

authors： Stoessel D,Schulte C,Teixeira Dos Santos MC,Scheller D,Rebollo-Mesa I,Deuschle C,Walther D,Schauer N,Berg D,Nogueira da Costa A,Maetzler W

更新日期：2018-03-05 00:00:00

abstract：:Regular physical activity is considered one of the most important factors for lifestyle, for maintaining good health in older ages and increasing life expectancy. Dance is considered an activity that involves coordinating movements with music, as well as brain activation because it is constantly necessary to learn and...

journal_title：Frontiers in aging neuroscience

authors： Douka S,Zilidou VI,Lilou O,Manou V

更新日期：2019-04-05 00:00:00

abstract：:The use of progressive resistance training (PRT) to improve gait and balance in people with Parkinson's disease (PD) is an emerging area of interest. However, the main effects of PRT on lower limb functions such as gait, balance, and leg strength in people with PD remain unclear. Therefore, the aim of the meta-analysi...

journal_title：Frontiers in aging neuroscience

authors： Tillman A,Muthalib M,Hendy AM,Johnson LG,Rantalainen T,Kidgell DJ,Enticott PG,Teo WP

更新日期：2015-03-24 00:00:00

abstract：:Oxidative stress (OS), caused by the imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging, neurodegenerative diseases, and other related adverse conditions, such as ischemia. While ROS/RNS serve as signaling molecules at physiolog...

journal_title：Frontiers in aging neuroscience

authors： Wang X,Michaelis EK

更新日期：2010-03-30 00:00:00

abstract：:Cardiorespiratory fitness has been shown to protect and enhance cognitive and brain functions, but little is known about the cortical mechanisms that underlie these changes in older adults. In this study, functional near infrared spectroscopy (fNIRS) was used to investigate variations in oxyhemoglobin [HbO2] and in de...

journal_title：Frontiers in aging neuroscience

authors： Albinet CT,Mandrick K,Bernard PL,Perrey S,Blain H

更新日期：2014-10-08 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular ph...

journal_title：Frontiers in aging neuroscience

authors： Finelli MJ

更新日期：2020-09-03 00:00:00

abstract：:Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD). Inconsistent results about the role of APOE ε4 alleles on cognitive decline of community non-dementia elderly have been reported. This study aimed to examine the relationship between APOE ε4 allele and cognitive abilities...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Pan X,Fei G,Wang C,Wan W,Sang S,Wang H,Wang Z,Zhong C

更新日期：2019-03-29 00:00:00

abstract：OBJECTIVE:Temporo-parietal cortex thinning is associated to mild cognitive impairment (MCI) due to Alzheimer disease (AD). The increase of EEG upper/low alpha power ratio has been associated with AD-converter MCI subjects. We investigated the association of alpha3/alpha2 ratio with patterns of cortical thickness in MCI...

journal_title：Frontiers in aging neuroscience

authors： Moretti DV,Paternicò D,Binetti G,Zanetti O,Frisoni GB

更新日期：2013-10-25 00:00:00

abstract：:Previous research suggests specific deficits in face perception and memory in older adults, which could reflect a dedifferentiation in the context of a general broadening of cognitive architecture with advanced age. Such dedifferentiation could manifest in a less specialized face processing system. A promising tool to...

journal_title：Frontiers in aging neuroscience

authors： Komes J,Schweinberger SR,Wiese H

更新日期：2014-04-04 00:00:00

abstract：BACKGROUND:Previous studies reported that old adults, relative to young adults, showed improvement of emotional stability and increased experiences of positive affects. METHODS:In order to better understand the neural underpinnings behind the aging-related enhancement of positive affects, it is necessary to investigat...

journal_title：Frontiers in aging neuroscience

authors： Meng X,Yang J,Cai AY,Ding XS,Liu W,Li H,Yuan JJ

更新日期：2015-08-06 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) includes a spectrum of disorders characterized by changes of personality and social behavior and, often, a gradual and progressive language dysfunction. In the last years, several efforts have been fulfilled in identifying both genetic mutations and pathological proteins associ...

journal_title：Frontiers in aging neuroscience

authors： Piscopo P,Albani D,Castellano AE,Forloni G,Confaloni A

更新日期：2016-02-09 00:00:00

abstract：:There is a need for rapid and reliable Internet-based screening tools for cognitive assessment in middle-aged and older adults. We report the psychometric properties of an on-line tool designed to screen for cognitive deficits that require further investigation. The tool is composed of measures of memory and executive...

journal_title：Frontiers in aging neuroscience

authors： Troyer AK,Rowe G,Murphy KJ,Levine B,Leach L,Hasher L

更新日期：2014-12-10 00:00:00

abstract：:Background: The early progression continuum of Alzheimer's disease (AD) has been considered to advance through subjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI). Altered functional connectivity (FC) in the default mode network (DMN) is reg...

journal_title：Frontiers in aging neuroscience

authors： Xue C,Yuan B,Yue Y,Xu J,Wang S,Wu M,Ji N,Zhou X,Zhao Y,Rao J,Yang W,Xiao C,Chen J

更新日期：2019-11-13 00:00:00

abstract：:Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after 2-months, corroborates the epidemiological association previously described between vitamin deficiency and this sensory impairment. However, this strain is prone to early hearing loss, and hence we decided to analyze whether the effects ex...

journal_title：Frontiers in aging neuroscience

authors： Martínez-Vega R,Murillo-Cuesta S,Partearroyo T,Varela-Moreiras G,Varela-Nieto I,Pajares MA

更新日期：2016-08-31 00:00:00

abstract：:Objective: Cerebral small vessel disease (SVD) is associated with increased mortality, disability and cognitive decline, depression in stroke survivors. This study examined the association between SVD burden, defined by a combination of SVD markers, and health-related quality of life (HRQoL) in acute ischemic stroke. ...

journal_title：Frontiers in aging neuroscience

authors： Liang Y,Chen YK,Deng M,Mok VCT,Wang DF,Ungvari GS,Chu CW,Kamiya A,Tang WK

更新日期：2017-11-13 00:00:00

abstract：:Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic neurons, and the presence of intracellular insoluble proteinaceous inclusions, known as Lewy Bodies. Although PD etiopathogenesis remains elusive, the leading h...

journal_title：Frontiers in aging neuroscience

authors： Branco DM,Arduino DM,Esteves AR,Silva DF,Cardoso SM,Oliveira CR

更新日期：2010-05-21 00:00:00

abstract：:Neuroimaging-based age prediction using machine learning is proposed as a biomarker of brain aging, relating to cognitive performance, health outcomes and progression of neurodegenerative disease. However, even leading age-prediction algorithms contain measurement error, motivating efforts to improve experimental pipe...

journal_title：Frontiers in aging neuroscience

authors： Lancaster J,Lorenz R,Leech R,Cole JH

更新日期：2018-02-12 00:00:00

abstract：:Pure akinesia with gait freezing (PAGF) is considered a clinical phenotype of progressive supranuclear palsy. The brain atrophy and cognitive deficits in PAGF are expected to be less prominent than in classical Richardson's syndrome (RS), but this hypothesis has not been explored yet. We reviewed the medical records o...

journal_title：Frontiers in aging neuroscience

authors： Hong JY,Yun HJ,Sunwoo MK,Ham JH,Lee JM,Sohn YH,Lee PH

更新日期：2015-09-29 00:00:00

abstract：:This study aimed to explore the effects of open- and closed-skill exercise interventions on the neurocognitive performance of executive functions in the elderly. Sixty-four healthy elderly males were randomly assigned to either a closed-skill (bike riding or brisk walking/jogging, n = 22), open-skill (table tennis, n ...

journal_title：Frontiers in aging neuroscience

authors： Tsai CL,Pan CY,Chen FC,Tseng YT

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scenario of selected, spo...

journal_title：Frontiers in aging neuroscience

authors： de Pedro-Cuesta J,Martínez-Martín P,Rábano A,Ruiz-Tovar M,Alcalde-Cabero E,Calero M

更新日期：2016-06-13 00:00:00

abstract：:Abnormalities and impairments in axonal transport are suggested to strongly contribute to the pathological alterations underlying AD. The exact mechanisms leading to axonopathy are currently unclear, but it was recently suggested that APP expression itself triggers axonal degeneration. We used APP transgenic mice and ...

journal_title：Frontiers in aging neuroscience

authors： Christensen DZ,Huettenrauch M,Mitkovski M,Pradier L,Wirths O

更新日期：2014-06-27 00:00:00

abstract：:The semantic verbal fluency task is broadly used in the neuropsychological assessment of elderly subjects. Even some studies have identified differences in verbal fluency clustering and switching measures between subjects with normal aging and a clinical condition such as mild cognitive impairment (MCI) and Alzheimer'...

journal_title：Frontiers in aging neuroscience

authors： Bertola L,Cunha Lima ML,Romano-Silva MA,de Moraes EN,Diniz BS,Malloy-Diniz LF

更新日期：2014-07-01 00:00:00

abstract：:Recent studies have shown that Liuwei Dihuang pills (LWPs) can positively affect learning, memory and neurogenesis. However, the underlying molecular mechanisms are not understood. In the present study, we developed ALWPs, a mixture of Antler and LWPs, and investigated whether ALWPs can affect neuroinflammatory respon...

journal_title：Frontiers in aging neuroscience

authors： Lee JY,Joo B,Nam JH,Nam HY,Lee W,Nam Y,Seo Y,Kang HJ,Cho HJ,Jang YP,Kim J,We YM,Koo JW,Hoe HS

更新日期：2018-09-26 00:00:00

abstract：:With promising results in recent treatment trials for Alzheimer's disease (AD), it becomes increasingly important to distinguish AD at early stages from other causes for cognitive impairment. However, existing diagnostic methods are either invasive (lumbar punctures, PET) or inaccurate Magnetic Resonance Imaging (MRI)...

journal_title：Frontiers in aging neuroscience

authors： Gurevich P,Stuke H,Kastrup A,Stuke H,Hildebrandt H

更新日期：2017-04-25 00:00:00