Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities.

abstract：:Aging is associated with cognitive decline and alterations in early perceptual processes. Studies in the auditory and visual sensory modalities have shown that the mismatch negativity [or the mismatch response (MMR)], an event-related potential (ERP) elicited by a deviant stimulus in a background of homogenous events,...

journal_title：Frontiers in aging neuroscience

authors： Strömmer JM,Tarkka IM,Astikainen P

更新日期：2014-10-27 00:00:00

abstract：:A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in dementia research has expanded to brain imaging analyses with auditory function. The aim of this study was to investigate the link between hearing ability, which was assessed using pure-tone audiometry, an...

journal_title：Frontiers in aging neuroscience

authors： Uchida Y,Nishita Y,Kato T,Iwata K,Sugiura S,Suzuki H,Sone M,Tange C,Otsuka R,Ando F,Shimokata H,Nakamura A

更新日期：2018-10-16 00:00:00

abstract：:Aging is related to a deterioration of cognitive performance and to multiple alterations in the brain. Even before the beginning of a noticeable cognitive decline, the framework which holds cognitive function experiences these alterations. From a system-vulnerability point of view of cognition, the deterioration assoc...

journal_title：Frontiers in aging neuroscience

authors： Roldán-Tapia MD,Cánovas R,León I,García-Garcia J

更新日期：2017-10-24 00:00:00

abstract：:Introduction: Falling is one of the primary concerns for people with Parkinson's Disease and occurs predominately during dynamic movements, such as walking. Several methods have been proposed to quantify dynamic balance and to assess fall risk. However, no consensus has been reached concerning which method is most app...

journal_title：Frontiers in aging neuroscience

authors： Siragy T,Nantel J

更新日期：2018-11-22 00:00:00

abstract：:Disruptions in metal ion homeostasis have been described in association with amyotrophic lateral sclerosis (ALS) for a number of years but the precise mechanism of involvement is poorly understood. Metal ions are especially important to familial ALS cases caused by mutations in the metalloenzyme copper-zinc superoxide...

journal_title：Frontiers in aging neuroscience

authors： Bourassa MW,Brown HH,Borchelt DR,Vogt S,Miller LM

更新日期：2014-06-16 00:00:00

abstract：:Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD). Inconsistent results about the role of APOE ε4 alleles on cognitive decline of community non-dementia elderly have been reported. This study aimed to examine the relationship between APOE ε4 allele and cognitive abilities...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Pan X,Fei G,Wang C,Wan W,Sang S,Wang H,Wang Z,Zhong C

更新日期：2019-03-29 00:00:00

abstract：:Aging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer's disease. However, due to mixed findings, it is unclear if changes in resting-state networ...

journal_title：Frontiers in aging neuroscience

authors： Hausman HK,O'Shea A,Kraft JN,Boutzoukas EM,Evangelista ND,Van Etten EJ,Bharadwaj PK,Smith SG,Porges E,Hishaw GA,Wu S,DeKosky S,Alexander GE,Marsiske M,Cohen R,Woods AJ

更新日期：2020-06-12 00:00:00

abstract：Objective:To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 103) over time among cognitively normal older people. Methods:We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with normal...

journal_title：Frontiers in aging neuroscience

authors： Li X,Tong Q,Gao J,Liu C,Alzheimer’s Disease Neuroimaging Initiative.,Liu Y

更新日期：2020-08-14 00:00:00

abstract：:While aging can lead to significant declines in perceptual and cognitive function, the effects of age on multisensory integration, the process in which the brain combines information across the senses, are less clear. Recent reports suggest that older adults are susceptible to the sound-induced flash illusion (Shams e...

journal_title：Frontiers in aging neuroscience

authors： McGovern DP,Roudaia E,Stapleton J,McGinnity TM,Newell FN

更新日期：2014-09-24 00:00:00

abstract：:Despite potential implications for the early detection of impending Alzheimer's disease (AD), very little is known about the differences of large-scale brain networks between amnestic mild cognitive impairment (aMCI) with high cerebral amyloid-beta protein (Aβ) deposition (i.e., aMCI+) and aMCI with no or very little ...

journal_title：Frontiers in aging neuroscience

authors： Yi D,Choe YM,Byun MS,Sohn BK,Seo EH,Han J,Park J,Woo JI,Lee DY

更新日期：2015-02-19 00:00:00

abstract：:Understanding the molecular mechanisms underlying age-associated cognitive impairments will not only contribute to our general knowledge about "aging" biology, but also provide insights for more effective strategies to prevent and improve the quality of life for both normal aging and pathological aging such as Alzheim...

journal_title：Frontiers in aging neuroscience

authors： Yang W,Zhou X,Ma T

更新日期：2019-09-04 00:00:00

abstract：:Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients aged 65 years and older. There are currently no proven neurorestorative treatments for chronic stroke. To address the complex problem of restoring function in ischemic brain tissue, stem...

journal_title：Frontiers in aging neuroscience

authors： He JQ,Sussman ES,Steinberg GK

更新日期：2020-12-14 00:00:00

abstract：:The cognitive reserve hypothesis claims that the brain can overcome pathology by reinforcing preexistent processes or by developing alternative cognitive strategies. Epidemiological studies have revealed that this reserve can be built throughout life experiences as education or leisure activities. We previously showed...

journal_title：Frontiers in aging neuroscience

authors： Bezzina C,Verret L,Halley H,Dahan L,Rampon C

更新日期：2015-09-23 00:00:00

abstract：:Hypertension has a profound influence on the structure and function of blood vessels. Cerebral vessels undergo both structural and functional changes in hypertensive animals. However, dynamic changes of cerebrovasculature and the factors involved in this process are largely unknown. In this study, we explored the dyna...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Mu Z,Lin X,Geng J,Xiao TQ,Zhang Z,Wang Y,Guan Y,Yang GY

更新日期：2017-11-02 00:00:00

abstract：:Background: Two main models have been advanced to explain the asymmetries observed in the representation and processing of emotions. The first model, labeled "the right hemisphere hypothesis," assumes a general dominance of the right hemisphere for all emotions, regardless of affective valence. The second model, named...

journal_title：Frontiers in aging neuroscience

authors： Gainotti G

更新日期：2019-03-19 00:00:00

abstract：:Ishigami and Klein (2010) showed that scores of the three attention networks (alerting, orienting, and executive control) measured with the two versions of the Attention Network Test (ANT; Fan et al., 2002; Callejas et al., 2005) were robust over 10 sessions of repeated testing even though practice effects were consis...

journal_title：Frontiers in aging neuroscience

authors： Ishigami Y,Klein RM

更新日期：2011-11-15 00:00:00

abstract：:Patients with diabetes suffer the higher risk of dementia and the underlying pathological mechanism of cognitive dysfunction in diabetes is not fully understood. In this study, we explore whether the cognitive impairment in the diabetic rat is associated with increased blood brain barrier (BBB) permeability and the ch...

journal_title：Frontiers in aging neuroscience

authors： Geng J,Wang L,Zhang L,Qin C,Song Y,Ma Y,Chen Y,Chen S,Wang Y,Zhang Z,Yang GY

更新日期：2018-05-07 00:00:00

abstract：:Mouse models are key tools for studying cochlear alterations in noise-induced hearing loss (NIHL) and for evaluating new therapies. Stimuli used to induce deafness in mice are usually white and octave band noises that include very low frequencies, considering the large mouse auditory range. We designed different sound...

journal_title：Frontiers in aging neuroscience

authors： Sanz L,Murillo-Cuesta S,Cobo P,Cediel-Algovia R,Contreras J,Rivera T,Varela-Nieto I,Avendaño C

更新日期：2015-02-16 00:00:00

abstract：OBJECTIVE:Early-onset Alzheimer's disease (EAD) shows distinct features from late-onset Alzheimer's disease (LAD). To explore the characteristics of EAD, clinical, neuropsychological, and functional imaging studies have been conducted. However, differences between EAD and LAD are not clear, especially in terms of brain...

journal_title：Frontiers in aging neuroscience

authors： Chung J,Yoo K,Kim E,Na DL,Jeong Y

更新日期：2016-06-30 00:00:00

abstract：:Introduction: Cognitive screening in settings such as emergency departments (ED) is frequently carried out using paper-and-pencil tests that require administration by trained staff. These assessments often compete with other clinical duties and thus may not be routinely administered in these busy settings. Literature ...

journal_title：Frontiers in aging neuroscience

authors： Tong T,Chignell M,Tierney MC,Lee JS

更新日期：2016-11-07 00:00:00

abstract：:miR-146a is a microRNA (miRNA) involved in neuroinflammation and aging; alterations in its expression were described in Alzheimer's disease (AD). However, most of the studies conducted so far on this miRNA included a limited number of participants and produced contradictory results. We compared miR-146a levels in plas...

journal_title：Frontiers in aging neuroscience

authors： Maffioletti E,Milanesi E,Ansari A,Zanetti O,Galluzzi S,Geroldi C,Gennarelli M,Bocchio-Chiavetto L

更新日期：2020-01-17 00:00:00

abstract：:Cognitive demands for postural control increase with aging and cognitive-motor interference (CMI) exists for a number of walking situations, especially with visuo-spatial cognitive tasks. Such interference also influences spatial learning abilities among older adults; however, this is rarely considered in research on ...

journal_title：Frontiers in aging neuroscience

authors： Agathos CP,Ramanoël S,Bécu M,Bernardin D,Habas C,Arleo A

更新日期：2020-11-12 00:00:00

abstract：:Microglial cells become dystrophic with aging; this phenotypic alteration contributes to basal central nervous system (CNS) neuroinflammation being a risk factor for age related neurodegenerative diseases. In previous studies we have observed that insulin like growth factor 1 (IGF1) gene therapy is a feasible approach...

journal_title：Frontiers in aging neuroscience

authors： Falomir-Lockhart E,Dolcetti FJC,García-Segura LM,Hereñú CB,Bellini MJ

更新日期：2019-03-05 00:00:00

abstract：INTRODUCTION:Walking in the home and community often involves performance of complex walking tasks. Understanding the control of such tasks is crucial to preserving independence and quality of life in older adults. However, very little research has been conducted in this area. Here, we assess the extent to which two me...

journal_title：Frontiers in aging neuroscience

authors： Clark DJ,Rose DK,Ring SA,Porges EC

更新日期：2014-08-25 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of 30,000 patients a year worldwide. The median reported survival time since onset ranges from 24 to 48 months. Riluzole is the only currently approved mildly efficacious treatment. Riluzole received marketing authorization in 1...

journal_title：Frontiers in aging neuroscience

authors： Petrov D,Mansfield C,Moussy A,Hermine O

更新日期：2017-03-22 00:00:00

abstract：:The aggregation of α-synuclein (α-syn) is considered the key pathogenic event in many neurological disorders such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, giving rise to a whole category of neurodegenerative diseases known as synucleinopathies. Although the molecular basis of...

journal_title：Frontiers in aging neuroscience

authors： Ardah MT,Paleologou KE,Lv G,Abul Khair SB,Kazim AS,Minhas ST,Al-Tel TH,Al-Hayani AA,Haque ME,Eliezer D,El-Agnaf OM

更新日期：2014-08-05 00:00:00

abstract：BACKGROUND:During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scenario of selected, spo...

journal_title：Frontiers in aging neuroscience

authors： de Pedro-Cuesta J,Martínez-Martín P,Rábano A,Ruiz-Tovar M,Alcalde-Cabero E,Calero M

更新日期：2016-06-13 00:00:00

abstract：:To expose cortical involvement in age-related changes in motor performance, we compared steadiness (force fluctuations) and fatigability of submaximal isometric contractions with the ankle dorsiflexor muscles in older and young adults and with varying levels of cognitive demand imposed. Sixteen young (20.4 ± 2.1 year:...

journal_title：Frontiers in aging neuroscience

authors： Vanden Noven ML,Pereira HM,Yoon T,Stevens AA,Nielson KA,Hunter SK

更新日期：2014-05-22 00:00:00

abstract：:Late adulthood is associated with atrophy of brain areas, which contribute to cognitive deterioration and increase the risk of depression. On the other hand, aerobic exercise can improve learning and memory function, ameliorate mood, and prevent neurodegenerative changes. This study demonstrates the effect of Nordic w...

journal_title：Frontiers in aging neuroscience

authors： Domaszewska K,Koper M,Wochna K,Czerniak U,Marciniak K,Wilski M,Bukowska D

更新日期：2020-10-19 00:00:00

abstract：:The enteric nervous system (ENS) poses the intrinsic innervation of the gastrointestinal tract and plays a critical role for all stages of postnatal life. There is increasing scientific and clinical interest in acquired or age-related gastrointestinal dysfunctions that can be manifested in diseases such as gut constip...

journal_title：Frontiers in aging neuroscience

authors： Hetz S,Acikgoez A,Moll C,Jahnke HG,Robitzki AA,Metzger R,Metzger M

更新日期：2014-10-15 00:00:00