Age-associated changes in the hippocampal-ventral striatum-ventral tegmental loop that impact learning, prediction, and context discrimination.

abstract：Objective:To investigate dysregulated molecules in preoperative cerebrospinal fluid (CSF) of elderly hip fracture patients with postoperative delirium (POD), in order to identify potential pathological mechanisms and biomarkers for pre-stage POD. Materials and Methods:This nested case control study used untargeted met...

journal_title：Frontiers in aging neuroscience

authors： Han Y,Zhang W,Liu J,Song Y,Liu T,Li Z,Wang X,Yang N,Li Y,Han D,Mi X,Zhou Y,Li M,Guo X,Zhong L,Wang G,Yuan Y

更新日期：2020-10-22 00:00:00

abstract：:Alzheimer's disease treatment is still an open problem. The diversity of symptoms, the alterations in common pathophysiology, the existence of asymptomatic cases, the different types of sporadic and familial Alzheimer's and their relevance with other types of dementia and comorbidities, have already created a myth-fea...

journal_title：Frontiers in aging neuroscience

authors： Alexiou A,Mantzavinos VD,Greig NH,Kamal MA

更新日期：2017-03-31 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease, for which aging remains the major risk factor. Aging is under a consistent pressure of increasing brain entropy (BEN) due to the progressive brain deteriorations. Noticeably, the brain constantly consumes a large amount of energy to maintain its func...

journal_title：Frontiers in aging neuroscience

authors： Wang Z,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-11-10 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnagi.2019.00343.]. ...

journal_title：Frontiers in aging neuroscience

authors： Smolek T,Cubinkova V,Brezovakova V,Valachova B,Szalay P,Zilka N,Jadhav S

更新日期：2020-02-18 00:00:00

abstract：:Astrocytes are the most abundant cells of the central nervous system; they have a predominant role in maintaining brain metabolism. In this sense, abnormal metabolic states have been found in different neuropathological diseases. Determination of metabolic states of astrocytes is difficult to model using current exper...

journal_title：Frontiers in aging neuroscience

authors： Martín-Jiménez CA,Salazar-Barreto D,Barreto GE,González J

更新日期：2017-02-13 00:00:00

abstract：:Aging is related to a deterioration of cognitive performance and to multiple alterations in the brain. Even before the beginning of a noticeable cognitive decline, the framework which holds cognitive function experiences these alterations. From a system-vulnerability point of view of cognition, the deterioration assoc...

journal_title：Frontiers in aging neuroscience

authors： Roldán-Tapia MD,Cánovas R,León I,García-Garcia J

更新日期：2017-10-24 00:00:00

abstract：:Reduced pain tolerance may be one of the possible explanations for high prevalence of chronic pain among older people. We hypothesized that age-related alterations in pain tolerance are associated with functioning deterioration of the frontal cortex during normal aging. Twenty-one young and 41 elderly healthy particip...

journal_title：Frontiers in aging neuroscience

authors： Zhou S,Lithfous S,Després O,Pebayle T,Bi X,Dufour A

更新日期：2020-05-27 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of 30,000 patients a year worldwide. The median reported survival time since onset ranges from 24 to 48 months. Riluzole is the only currently approved mildly efficacious treatment. Riluzole received marketing authorization in 1...

journal_title：Frontiers in aging neuroscience

authors： Petrov D,Mansfield C,Moussy A,Hermine O

更新日期：2017-03-22 00:00:00

abstract：:Apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD). Inconsistent results about the role of APOE ε4 alleles on cognitive decline of community non-dementia elderly have been reported. This study aimed to examine the relationship between APOE ε4 allele and cognitive abilities...

journal_title：Frontiers in aging neuroscience

authors： Wang L,Pan X,Fei G,Wang C,Wan W,Sang S,Wang H,Wang Z,Zhong C

更新日期：2019-03-29 00:00:00

abstract：:Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients aged 65 years and older. There are currently no proven neurorestorative treatments for chronic stroke. To address the complex problem of restoring function in ischemic brain tissue, stem...

journal_title：Frontiers in aging neuroscience

authors： He JQ,Sussman ES,Steinberg GK

更新日期：2020-12-14 00:00:00

abstract：:There is no disease-modifying treatment currently available for AD, one of the more impacting neurodegenerative diseases affecting more than 47.5 million people worldwide. The definition of new approaches for the design of proper clinical trials is highly demanded in order to achieve non-confounding results and assess...

journal_title：Frontiers in aging neuroscience

authors： Salvatore C,Cerasa A,Castiglioni I

更新日期：2018-05-24 00:00:00

abstract：:The decline of cognitive skills throughout healthy or pathological aging can be slowed down by experiences which foster cognitive reserve (CR). Recently, some studies on Alzheimer's disease have suggested that CR may be enhanced by life-long bilingualism. However, the evidence is inconsistent and largely based on retr...

journal_title：Frontiers in aging neuroscience

authors： Calvo N,García AM,Manoiloff L,Ibáñez A

更新日期：2016-01-12 00:00:00

abstract：:The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer's disease (AD), little is known about the initial molecular disturbances that accompany the AD development at olfactory level. We have interrogated the time-depend...

journal_title：Frontiers in aging neuroscience

authors： Lachen-Montes M,González-Morales A,Palomino M,Ausin K,Gómez-Ochoa M,Zelaya MV,Ferrer I,Pérez-Mediavilla A,Fernández-Irigoyen J,Santamaría E

更新日期：2019-06-11 00:00:00

abstract：:Centronuclear myopathies (CNMs) are a genetically heterogeneous group of inherited neuromuscular disorders characterized by clinical features of a congenital myopathy and abundant central nuclei as the most prominent histopathological feature. The most common forms of congenital myopathies with central nuclei have bee...

journal_title：Frontiers in aging neuroscience

authors： Jungbluth H,Gautel M

更新日期：2014-12-19 00:00:00

abstract：:Background: There has been much research devoted to examining the short-term effects of different interventions for improving memory functioning of older adults with memory complaints. Nevertheless, very few studies have examined the long-term effects of these interventions. Thus, the present study compared the sustai...

journal_title：Frontiers in aging neuroscience

authors： Chan AS,Cheung WK,Yeung MK,Lee TL

更新日期：2018-08-07 00:00:00

abstract：:The functional neuroanatomy of finger movements has been characterized with neuroimaging in young adults. However, less is known about the aging motor system. Several studies have contrasted movement-related activity in older versus young adults, but there is inconsistency among their findings. To address this, we con...

journal_title：Frontiers in aging neuroscience

authors： Turesky TK,Turkeltaub PE,Eden GF

更新日期：2016-10-17 00:00:00

abstract：:Measurement of the dynamic coupling between spontaneous Blood Oxygenation Level Dependent (BOLD) and cerebral blood flow (CBF) fluctuations has been recently proposed as a method to probe resting-state brain physiology. Here we investigated how the dynamic BOLD-CBF coupling during resting-state is affected by aging. F...

journal_title：Frontiers in aging neuroscience

authors： Chiacchiaretta P,Cerritelli F,Bubbico G,Perrucci MG,Ferretti A

更新日期：2018-04-23 00:00:00

abstract：:This randomized controlled study (ClinicalTrials.gov NCT02007616) investigated the maintenance of training effects of 20 1-hr non-action video game training sessions with selected games from a commercial package on several age-declining cognitive functions and subjective wellbeing after a 3-month no-contact period. Tw...

journal_title：Frontiers in aging neuroscience

authors： Ballesteros S,Mayas J,Prieto A,Toril P,Pita C,Laura Pde L,Reales JM,Waterworth JA

更新日期：2015-04-14 00:00:00

abstract：:Verbal fluency is the ability to produce a satisfying sequence of spoken words during a given time interval. The core of verbal fluency lies in the capacity to manage the executive aspects of language. The standard scores of the semantic verbal fluency test are broadly used in the neuropsychological assessment of the ...

journal_title：Frontiers in aging neuroscience

authors： Bertola L,Mota NB,Copelli M,Rivero T,Diniz BS,Romano-Silva MA,Ribeiro S,Malloy-Diniz LF

更新日期：2014-07-29 00:00:00

abstract：:During aging, human response times (RTs) to unisensory and crossmodal stimuli decrease. However, the elderly benefit more from crossmodal stimulus representations than younger people. The underlying short-latency multisensory integration process is mediated by direct crossmodal connections at the level of primary sens...

journal_title：Frontiers in aging neuroscience

authors： Henschke JU,Ohl FW,Budinger E

更新日期：2018-03-02 00:00:00

abstract：:The microtubule-associated protein tau is closely correlated with hypometabolism in Alzheimer's disease (AD). α-lipoic acid (LA), which is a naturally occurring cofactor in mitochondrial, has been shown to have properties that can inhibit the tau pathology and neuronal damage in our previous research. However, if LA a...

journal_title：Frontiers in aging neuroscience

authors： Zhang YH,Yan XZ,Xu SF,Pang ZQ,Li LB,Yang Y,Fan YG,Wang Z,Yu X,Guo C,Ao Q

更新日期：2020-08-21 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) is a clinical stage indicating a prodromal phase of dementia. This practical concept could be used also for fronto-temporal dementia (FTD). Progranulin (PGRN) has been recently recognized as a useful diagnostic biomarker for fronto-temporal lobe degeneration (FTLD) due to GRN ...

journal_title：Frontiers in aging neuroscience

authors： Moretti DV,Benussi L,Fostinelli S,Ciani M,Binetti G,Ghidoni R

更新日期：2016-02-29 00:00:00

abstract：:Introduction: Cognitive screening in settings such as emergency departments (ED) is frequently carried out using paper-and-pencil tests that require administration by trained staff. These assessments often compete with other clinical duties and thus may not be routinely administered in these busy settings. Literature ...

journal_title：Frontiers in aging neuroscience

authors： Tong T,Chignell M,Tierney MC,Lee JS

更新日期：2016-11-07 00:00:00

abstract：:The auditory mismatch negativity (MMN) is an event-related potential (ERP) peaking about 100-250 ms after the onset of a deviant tone in a sequence of identical (standard) tones. Depending on the interstimulus interval (ISI) between standard and deviant tones, the MMN is suitable to investigate the pre-attentive audit...

journal_title：Frontiers in aging neuroscience

authors： Laptinskaya D,Thurm F,Küster OC,Fissler P,Schlee W,Kolassa S,von Arnim CAF,Kolassa IT

更新日期：2018-02-02 00:00:00

abstract：:There is a need for rapid and reliable Internet-based screening tools for cognitive assessment in middle-aged and older adults. We report the psychometric properties of an on-line tool designed to screen for cognitive deficits that require further investigation. The tool is composed of measures of memory and executive...

journal_title：Frontiers in aging neuroscience

authors： Troyer AK,Rowe G,Murphy KJ,Levine B,Leach L,Hasher L

更新日期：2014-12-10 00:00:00

abstract：:Background: Due to the lack of objective measures for assessing tinnitus, its clinical evaluation largely relies on the use of questionnaires and psychoacoustic tests. A global assessment of tinnitus burden would largely benefit from holistic approaches that not only incorporate measures of tinnitus but also take into...

journal_title：Frontiers in aging neuroscience

authors： Müller K,Edvall NK,Idrizbegovic E,Huhn R,Cima R,Persson V,Leineweber C,Westerlund H,Langguth B,Schlee W,Canlon B,Cederroth CR

更新日期：2016-11-22 00:00:00

abstract：:Background and Objective: Ventricle volume is closely related to hydrocephalus, brain atrophy, Alzheimer's, Parkinson's syndrome, and other diseases. To accurately measure the volume of the ventricles for elderly patients, we use deep learning to establish a systematic and comprehensive automated ventricle segmentatio...

journal_title：Frontiers in aging neuroscience

authors： Zhou X,Ye Q,Jiang Y,Wang M,Niu Z,Menpes-Smith W,Fang EF,Liu Z,Xia J,Yang G

更新日期：2020-12-16 00:00:00

abstract：:Neuroimaging studies of cognitive and brain aging often yield massive datasets that create many analytic and statistical challenges. In this paper, we discuss and address several limitations in the existing work. (1) Linear models are often used to model the age effects on neuroimaging markers, which may be inadequate...

journal_title：Frontiers in aging neuroscience

authors： Chen H,Zhao B,Cao G,Proges EC,O'Shea A,Woods AJ,Cohen RA

更新日期：2016-07-19 00:00:00

abstract：:We examined whether baseline self-reported physical activity is associated with the efficacy of cognitive behavioral therapy for insomnia (CBT-I) in older veterans. Community-dwelling veterans aged 60 years and older with insomnia received CBT-I in a randomized controlled trial. Participants who received active treatm...

journal_title：Frontiers in aging neuroscience

authors： Yeung T,Martin JL,Fung CH,Fiorentino L,Dzierzewski JM,Rodriguez Tapia JC,Song Y,Josephson K,Jouldjian S,Mitchell MN,Alessi C

更新日期：2018-09-13 00:00:00

abstract：:Background: The early progression continuum of Alzheimer's disease (AD) has been considered to advance through subjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI). Altered functional connectivity (FC) in the default mode network (DMN) is reg...

journal_title：Frontiers in aging neuroscience

authors： Xue C,Yuan B,Yue Y,Xu J,Wang S,Wu M,Ji N,Zhou X,Zhao Y,Rao J,Yang W,Xiao C,Chen J

更新日期：2019-11-13 00:00:00