Systematic and Comprehensive Automated Ventricle Segmentation on Ventricle Images of the Elderly Patients: A Retrospective Study.

abstract：:The network activated during normal route learning shares considerable homology with the network of degeneration in the earliest symptomatic stages of Alzheimer's disease (AD). This inspired the virtual route learning test (VRLT) in which patients learn routes in a virtual reality environment. This study investigated ...

journal_title：Frontiers in aging neuroscience

authors： Pengas G,Williams GB,Acosta-Cabronero J,Ash TW,Hong YT,Izquierdo-Garcia D,Fryer TD,Hodges JR,Nestor PJ

更新日期：2012-07-04 00:00:00

abstract：:Objective: To study the dynamics of clustering semantic fluency responses and switching between clusters. Methods: We conducted a cross-sectional study of participants (N = 60) in a study of patient reported outcomes who were given the Saint Louis University Mental Status test. Sixty-second animal naming tests were sc...

journal_title：Frontiers in aging neuroscience

authors： Lenio S,Lissemore FM,Sajatovic M,Smyth KA,Tatsuoka C,Woyczynski WA,Lerner AJ

更新日期：2016-10-25 00:00:00

abstract：Background:Studying structural brain aging is important to understand age-related pathologies, as well as to identify the early manifestations of the Alzheimer's disease (AD) continuum. In this study, we investigated the long-term trajectory of physiological and pathological brain aging in a large number of participant...

journal_title：Frontiers in aging neuroscience

authors： Lee JS,Park YH,Park S,Yoon U,Choe Y,Cheon BK,Hahn A,Cho SH,Kim SJ,Kim JP,Jung YH,Park KC,Kim HJ,Jang H,Na DL,Seo SW

更新日期：2019-06-18 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic nigrostriatal neurons, with reductions in the function and amount of dopaminergic synapses. Therefore, synapse loss and membrane-related pathology provide relevant targets for interventions in PD. We previously showed the benefic...

journal_title：Frontiers in aging neuroscience

authors： Perez-Pardo P,de Jong EM,Broersen LM,van Wijk N,Attali A,Garssen J,Kraneveld AD

更新日期：2017-03-20 00:00:00

abstract：:Neurofilament light (NFL) is a putative biomarker of neurodegeneration. This study evaluates the correlative association of NFL with Alzheimer's disease (AD) indices. Relevant studies were identified after a literature search in electronic databases and study selection was based on pre-determined eligibility criteria....

journal_title：Frontiers in aging neuroscience

authors： Jin M,Cao L,Dai YP

更新日期：2019-09-13 00:00:00

abstract：:Deep learning, a state-of-the-art machine learning approach, has shown outstanding performance over traditional machine learning in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated classific...

journal_title：Frontiers in aging neuroscience

authors： Jo T,Nho K,Saykin AJ

更新日期：2019-08-20 00:00:00

abstract：Background and Purpose:To identify clinical, laboratory, and magnetic resonance imaging (MRI) features in predicting incident stroke and dementia in Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Materials and Methods:We enrolled 87 Korean CAD...

journal_title：Frontiers in aging neuroscience

authors： Lee JS,Ko KH,Oh JH,Kim JG,Kang CH,Song SK,Kang SY,Kang JH,Park JH,Koh MJ,Lee HK,Choi JC

更新日期：2020-11-20 00:00:00

abstract：:The cognitive reserve hypothesis claims that the brain can overcome pathology by reinforcing preexistent processes or by developing alternative cognitive strategies. Epidemiological studies have revealed that this reserve can be built throughout life experiences as education or leisure activities. We previously showed...

journal_title：Frontiers in aging neuroscience

authors： Bezzina C,Verret L,Halley H,Dahan L,Rampon C

更新日期：2015-09-23 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder associated with the progressive dysfunction of cognitive ability. Previous research has indicated that the default mode network (DMN) is closely related to cognition and is impaired in Alzheimer's disease. Because recent studies have shown that different frequen...

journal_title：Frontiers in aging neuroscience

authors： Li Y,Yao H,Lin P,Zheng L,Li C,Zhou B,Wang P,Zhang Z,Wang L,An N,Wang J,Zhang X

更新日期：2017-08-03 00:00:00

abstract：:Studies of the neural mechanisms of navigation and context discrimination have generated a powerful heuristic for understanding how neural codes, circuits, and computations contribute to accurate behavior as animals traverse and learn about spatially extended environments. It is assumed that memories are updated as a ...

journal_title：Frontiers in aging neuroscience

authors： Penner MR,Mizumori SJ

更新日期：2012-08-08 00:00:00

abstract：:Aging is related to a deterioration of cognitive performance and to multiple alterations in the brain. Even before the beginning of a noticeable cognitive decline, the framework which holds cognitive function experiences these alterations. From a system-vulnerability point of view of cognition, the deterioration assoc...

journal_title：Frontiers in aging neuroscience

authors： Roldán-Tapia MD,Cánovas R,León I,García-Garcia J

更新日期：2017-10-24 00:00:00

abstract：:Previous studies have showed that spatial memory declines with age but have not clarified the relevance of different landmark cues for specifying heading directions among different age groups. This study examined differences between younger, middle-aged and older adults in route learning and memory tasks after they na...

journal_title：Frontiers in aging neuroscience

authors： Zhong JY,Moffat SD

更新日期：2016-05-27 00:00:00

abstract：:Background: There has been much research devoted to examining the short-term effects of different interventions for improving memory functioning of older adults with memory complaints. Nevertheless, very few studies have examined the long-term effects of these interventions. Thus, the present study compared the sustai...

journal_title：Frontiers in aging neuroscience

authors： Chan AS,Cheung WK,Yeung MK,Lee TL

更新日期：2018-08-07 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1 or Steinert's disease) and type 2 (DM2) are multisystem disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the most prominent neuromuscular features of these diseases, while other clinical manifestations such as cardiomyopathy, insulin resistance and cat...

journal_title：Frontiers in aging neuroscience

authors： Mateos-Aierdi AJ,Goicoechea M,Aiastui A,Fernández-Torrón R,Garcia-Puga M,Matheu A,López de Munain A

更新日期：2015-07-09 00:00:00

abstract：:The enteric nervous system (ENS) poses the intrinsic innervation of the gastrointestinal tract and plays a critical role for all stages of postnatal life. There is increasing scientific and clinical interest in acquired or age-related gastrointestinal dysfunctions that can be manifested in diseases such as gut constip...

journal_title：Frontiers in aging neuroscience

authors： Hetz S,Acikgoez A,Moll C,Jahnke HG,Robitzki AA,Metzger R,Metzger M

更新日期：2014-10-15 00:00:00

abstract：:Synapse loss occurs early in Alzheimer's disease (AD) patients and animal models. Alterations at synaptic level are a major morphological correlate of the memory deficits and related symptoms of AD. Given the predominant roles of synaptic AMPA receptors (AMPARs) in excitatory synaptic transmission in the brain, change...

journal_title：Frontiers in aging neuroscience

authors： Martín-Belmonte A,Aguado C,Alfaro-Ruíz R,Itakura M,Moreno-Martínez AE,de la Ossa L,Molnár E,Fukazawa Y,Luján R

更新日期：2020-10-06 00:00:00

abstract：:There is no disease-modifying treatment currently available for AD, one of the more impacting neurodegenerative diseases affecting more than 47.5 million people worldwide. The definition of new approaches for the design of proper clinical trials is highly demanded in order to achieve non-confounding results and assess...

journal_title：Frontiers in aging neuroscience

authors： Salvatore C,Cerasa A,Castiglioni I

更新日期：2018-05-24 00:00:00

abstract：:Inter-temporal choice depends on multiple, interacting systems, some of which may be compromised with age. Some of these systems may be responsible for ongoing trial-by-trial choice strategies. Some may represent the consequences of action. Some may be necessary for the coupling between anticipated consequences and st...

journal_title：Frontiers in aging neuroscience

authors： Breton YA,Seeland KD,Redish AD

更新日期：2015-03-27 00:00:00

abstract：:Age related hearing loss (presbycusis) is one of the most common sensory deficits in the aging population. The main subjective ailment in the elderly is the deterioration of speech understanding, especially in a noisy environment, which cannot solely be explained by increased hearing thresholds. The examination method...

journal_title：Frontiers in aging neuroscience

authors： Profant O,Jilek M,Bures Z,Vencovsky V,Kucharova D,Svobodova V,Korynta J,Syka J

更新日期：2019-02-26 00:00:00

abstract：BACKGROUND:Previous studies reported that old adults, relative to young adults, showed improvement of emotional stability and increased experiences of positive affects. METHODS:In order to better understand the neural underpinnings behind the aging-related enhancement of positive affects, it is necessary to investigat...

journal_title：Frontiers in aging neuroscience

authors： Meng X,Yang J,Cai AY,Ding XS,Liu W,Li H,Yuan JJ

更新日期：2015-08-06 00:00:00

abstract：:To expose cortical involvement in age-related changes in motor performance, we compared steadiness (force fluctuations) and fatigability of submaximal isometric contractions with the ankle dorsiflexor muscles in older and young adults and with varying levels of cognitive demand imposed. Sixteen young (20.4 ± 2.1 year:...

journal_title：Frontiers in aging neuroscience

authors： Vanden Noven ML,Pereira HM,Yoon T,Stevens AA,Nielson KA,Hunter SK

更新日期：2014-05-22 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial pathology causing common brain spectrum disorders in affected patients. These mixed neurological disorders not only include structural AD brain changes but also cerebrovascular lesions. The main aim of the present issue is to find the factors shared by the two pathologies. ...

journal_title：Frontiers in aging neuroscience

authors： Guglielmotto M,Monteleone D,Vasciaveo V,Repetto IE,Manassero G,Tabaton M,Tamagno E

更新日期：2017-09-29 00:00:00

abstract：:Aging is associated with impairment of sensorial functions and with the onset of neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) bioavailability progressively decreases, we see a direct correlation with sensory impairment and cognitive performance in older humans. Age-related...

journal_title：Frontiers in aging neuroscience

authors： Rodríguez-de la Rosa L,Lassaletta L,Calvino M,Murillo-Cuesta S,Varela-Nieto I

更新日期：2017-12-12 00:00:00

abstract：:Aging of the central nervous system (CNS) is one of the major risk factors for the development of neurodegenerative pathologies such as Parkinson's disease (PD) and Alzheimer's disease (AD). The molecular mechanisms underlying the onset of AD and especially PD are not well understood. However, neuroinflammatory respon...

journal_title：Frontiers in aging neuroscience

authors： Spittau B

更新日期：2017-06-14 00:00:00

abstract：:In the face of limited resources and an aging population with increasingly care needs, healthcare systems must identify community-dwelling older adults with mental health problems at higher risk of adverse outcomes such as institutionalization, hospitalization and death, in order to deliver timely and efficient care. ...

journal_title：Frontiers in aging neuroscience

authors： Paúl C,Teixeira L,Azevedo MJ,Alves S,Duarte M,O'Caoimh R,Molloy W

更新日期：2015-11-17 00:00:00

abstract：:Acetylcholine (ACh) is known to play an important role in memory functions, and its deficit has been proposed to cause the cognitive decline associated with advanced age and Alzheimer's disease (the cholinergic hypothesis). Although many studies have tested the cholinergic hypothesis for recently acquired memory, only...

journal_title：Frontiers in aging neuroscience

authors： Soma S,Suematsu N,Shimegi S

更新日期：2014-04-08 00:00:00

abstract：:Neurons with histopathological changes consistent with granulovacuolar degeneration (GVD) were found in brain sections from aged cynomolgus monkeys (Macaca fascicularis) with clinical and pathological signs of cognitive aging. To our knowledge, this is the first reported description of GVD in non-human primates. GVD-l...

journal_title：Frontiers in aging neuroscience

authors： Darusman HS,Agungpriyono DR,Kusumaputri VA,Sajuthi D,Schapiro SJ,Hau J

更新日期：2019-03-07 00:00:00

abstract：:It is common wisdom that practice makes perfect; but why do some adults learn better than others? Here, we investigate individuals' cognitive and social profiles to test which variables account for variability in learning ability across the lifespan. In particular, we focused on visual learning using tasks that test t...

journal_title：Frontiers in aging neuroscience

authors： Christian J,Goldstone A,Kuai SG,Chin W,Abrams D,Kourtzi Z

更新日期：2015-06-10 00:00:00

abstract：:[This corrects the article on p. 13 in vol. 8, PMID: 26903857.]. ...

journal_title：Frontiers in aging neuroscience

authors： Hu YB,Li CB,Song N,Zou Y,Chen SD,Ren RJ,Wang G

更新日期：2017-02-23 00:00:00

abstract：:Microglia and astrocytes can quench metal toxicity to maintain tissue homeostasis, but with age, increasing glial dystrophy alongside metal dyshomeostasis may predispose the aged brain to acquire neurodegenerative diseases. The aim of the present study was to investigate age-related changes in brain metal deposition a...

journal_title：Frontiers in aging neuroscience

authors： Ashraf A,Michaelides C,Walker TA,Ekonomou A,Suessmilch M,Sriskanthanathan A,Abraha S,Parkes A,Parkes HG,Geraki K,So PW

更新日期：2019-12-19 00:00:00